The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection.

abstract：:We evaluated the antitumor effect of combined therapy with tegafur/uracil (UFT) plus leucovorin (LV) (UFT/LV) and protein-bound polysaccharide, PSK, in three mouse models of transplantable tumors. UFT/LV showed antitumor effect against Meth A sarcoma, and the antitumor effect was enhanced when PSK given concomitantly....

journal_title：Cellular & molecular immunology

authors： Katoh R,Ooshiro M

更新日期：2007-08-01 00:00:00

abstract：:Efficient immune responses against invading pathogens often involve coordination between cells from both the innate and adaptive immune systems. For multiple decades, it has been believed that CD8+ memory T cells and natural killer (NK) cells constantly and uniformly recirculate. Only recently was the existence of non...

journal_title：Cellular & molecular immunology

authors： Sun H,Sun C,Xiao W,Sun R

更新日期：2019-03-01 00:00:00

abstract：:Transplantation of mesenchymal stem cells (MSCs) has been recently studied in animal models, and in clinical trials of patients with fulminant hepatic failure, end-stage liver diseases and inherited metabolic disorders. Modulatory cytokines produced by MSCs can inhibit immunocyte proliferation and migration to the liv...

journal_title：Cellular & molecular immunology

authors： Lin H,Xu R,Zhang Z,Chen L,Shi M,Wang FS

更新日期：2011-01-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified as the receptor for dioxin. Almost half a century after its discovery, AHR is now recognized as a receptor for multiple physiological ligands, with important roles in health and disease. In this review, we discuss the r...

journal_title：Cellular & molecular immunology

authors： Barroso A,Mahler JV,Fonseca-Castro PH,Quintana FJ

更新日期：2021-02-01 00:00:00

abstract：:The combination of immunotherapy and chemotherapy is regarded as a promising approach for the treatment of certain types of cancer. However, the underlying mechanisms need to be fully investigated to guide the design of more efficient protocols for cancer chemoimmunotherapy. It is well known that danger-associated mol...

journal_title：Cellular & molecular immunology

authors： Fang H,Ang B,Xu X,Huang X,Wu Y,Sun Y,Wang W,Li N,Cao X,Wan T

更新日期：2014-03-01 00:00:00

abstract：:Activation of the TAK1 signalosome is crucial for mediating the innate immune response to pathogen invasion and is regulated by multiple layers of posttranslational modifications, including ubiquitination, SUMOylation, and phosphorylation; however, the underlying molecular mechanism is not fully understood. In this st...

journal_title：Cellular & molecular immunology

authors： Gu Z,Chen X,Yang W,Qi Y,Yu H,Wang X,Gong Y,Chen Q,Zhong B,Dai L,Qi S,Zhang Z,Zhang H,Hu H

更新日期：2020-11-12 00:00:00

abstract：:Dendritic cells (DCs) are the most potent professional antigen-presenting cells, and capable of stimulating naïve T cells and driving primary immune responses. DCs are poised to capture antigen, migrate to draining lymphoid organs, and after a process of maturation, select antigen-specific lymphocytes to which they pr...

journal_title：Cellular & molecular immunology

authors： Sun K,Wang L,Zhang Y

更新日期：2006-06-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of small non-coding regulatory RNAs, and changes in miRNAs are involved in tumor origin and progression. Studies have shown that miR-20a is overexpressed in human ovarian cancer tissues and that this miRNA enhances long-term cellular proliferation and invasion capabilities. In this study...

journal_title：Cellular & molecular immunology

authors： Xie J,Liu M,Li Y,Nie Y,Mi Q,Zhao S

更新日期：2014-09-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) has been recognized as an activator of nuclear factor kappaB (NF-kappaB), a factor implicated in the protection of many cell types from apoptosis. We and others have presented evidence to suggest that Fas-induced apoptosis may be an important aspect of the resolution of inflamma...

journal_title：Cellular & molecular immunology

authors： Qin Y,Auh S,Blokh L,Long C,Gagnon I,Hamann KJ

更新日期：2007-02-01 00:00:00

abstract：:In previous research, chimerical BPI23-Fcgamma1 gene which consisted of human bactericidal/permeability increasing protein (BPI) gene of encoding the functional N terminus (amino acid residues 1 to 199) of human BPI and Fcgamma1 gene of encoding the Fc segment of human immunoglobulin G1 was successfully reconstructed ...

journal_title：Cellular & molecular immunology

authors： Li J,Kong Q,Lv Z,Guan Y,Qiu Y,Li C,Sun M,Liu Z,An Y

更新日期：2008-12-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a good model for human multiple sclerosis (MS) research. However, there are some defects in the traditional models. Here, we improved the model by using the human myelin basic protein (MBP) as antigen. EAE was induced by immunization of female Wistar rats with human M...

journal_title：Cellular & molecular immunology

authors： Guo L,Li Y,Lin H,Ji X,Li J,Que L,Zhang Y,Rong Y,Wang J

更新日期：2004-10-01 00:00:00

abstract：:Innate lymphoid cells (ILCs), including natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer (LTi) cells, comprise the first line of innate immune defense against pathogens and tumors. Over the past decade, accumulating evidence has demonstrated immunological memory in ILC subsets: for example, ...

journal_title：Cellular & molecular immunology

authors： Wang X,Peng H,Tian Z

更新日期：2019-05-01 00:00:00

abstract：:Kupffer cells (KCs), the liver resident macrophages accounting for 80-90% of the total population of fixed tissue macrophages in the body, not only play a key role in host defense via removing particulate materials from the portal circulation, but may also contribute to the pathogenesis of various liver diseases. We h...

journal_title：Cellular & molecular immunology

authors： Miller AM,Zhang JX

更新日期：2009-12-01 00:00:00

abstract：:Recognition of viral dsRNA by Toll-like receptor 3 (TLR3) leads to the induction of downstream antiviral effectors and the innate antiviral immune response. Here, we identified the zinc-finger FYVE domain-containing protein ZFYVE1, a guanylate-binding protein (GBP), as a positive regulator of TLR3-mediated signaling. ...

journal_title：Cellular & molecular immunology

authors： Zhong X,Feng L,Xu WH,Wu X,Ding YD,Zhou Y,Lei CQ,Shu HB

更新日期：2020-07-01 00:00:00

abstract：:Previously, we demonstrated that macrophages from thrombospondin 1 (TSP1)-deficient mice have a reduced inflammatory phenotype, suggesting that TSP1 plays a role in macrophage activation. In this study, we determined how TSP1 regulates macrophage function. We found that recombinant or purified platelet human TSP1 trea...

journal_title：Cellular & molecular immunology

authors： Li Y,Qi X,Tong X,Wang S

更新日期：2013-11-01 00:00:00

abstract：:Immunization with inactivated autoreactive T cells (T cell vaccination) selected from individual's own T cell repertoire provides a unique in vivo setting for testing immune regulation that is known to involve interactions of a variety of related surface molecules (1). It induces regulatory immune responses that close...

journal_title：Cellular & molecular immunology

authors： Zhang J

更新日期：2004-10-01 00:00:00

abstract：:The nuclear receptor superfamily and the transcriptional factors associated with cytokines are inherently different families of signaling molecules and activate gene transcription by binding to their respective responsive element. However, it has become increasingly clear from our works and others that nuclear recepto...

journal_title：Cellular & molecular immunology

authors： Wang L,Zhang X,Farrar WL,Yang X

更新日期：2004-12-01 00:00:00

abstract：:In order to investigate immunogenicity in the induction of humoral and cellular immune responses, severe acute respiratory syndrome associated coronavirus (SARS-CoV)-N gene recombinant replication-defective adenoviral vector, rAd-N, was generated and immunized BALB/c mice in a pcDNA3.1-N prime-rAd-N boost regimen. Aft...

journal_title：Cellular & molecular immunology

authors： Ma C,Yao K,Zhou F,Zhu M

更新日期：2006-12-01 00:00:00

abstract：:Interleukin-22 (IL-22) is a recently identified T cell-derived cytokine whose biological significance remains obscure. Previously, we have shown that IL-22 plays a protective role in T cell-mediated hepatitis induced by Concanavalin A (Con A), acting as a survival factor for hepatocytes. In the present paper, we demon...

journal_title：Cellular & molecular immunology

authors： Pan H,Hong F,Radaeva S,Gao B

更新日期：2004-02-01 00:00:00

abstract：:The liver is an important immunological organ that controls systemic tolerance. The liver harbors professional and unconventional antigen-presenting cells that are crucial for tolerance induction and maintenance. Orchestrating the immune response in homeostasis depends on a healthy and well-toned immunological liver m...

journal_title：Cellular & molecular immunology

authors： Horst AK,Kumashie KG,Neumann K,Diehl L,Tiegs G

更新日期：2021-01-01 00:00:00

abstract：:To elucidate the structures of SLA-DR (swine leukocyte antigen DR) genes of three Chinese pig strains (Gz, Bm and Yn), the SLA-DRA and SLA-DRB cDNA were amplified by RT-PCR and subjected to determine the sequences. The whole structures of SLA-DRA alleles are identical among three strains, consisting of 759 nucleotides...

journal_title：Cellular & molecular immunology

authors： Chen F,Xie J,Zhou Y,Li N,Chou KY

更新日期：2004-06-01 00:00:00

abstract：:Acute morphine administration is known to alter the course of herpes simplex virus infection. In this study, the effect of acute morphine administration on the reactivation of latent herpes was investigated in a mouse model. Because of the important role of cytolytic T lymphocyte (CTL) activity in the inhibition of he...

journal_title：Cellular & molecular immunology

authors： Mojadadi S,Jamali A,Khansarinejad B,Soleimanjahi H,Bamdad T

更新日期：2009-04-01 00:00:00

abstract：:It is well-documented that alcohol drinking together with hepatitis viral infection accelerates liver injury; however the underlying mechanisms remain unknown. In this paper, we demonstrated that primary hepatocytes from transgenic mice overexpressing hepatitis B virus X protein (HBX) were more susceptible to ethanol-...

journal_title：Cellular & molecular immunology

authors： Kim WH,Hong F,Jaruga B,Zhang ZS,Fan SJ,Liang TJ,Gao B

更新日期：2005-02-01 00:00:00

abstract：:In addition to serving as molecular chaperones, heat shock proteins (HSPs) have been implicated in autoimmune diseases, antigen presentation and tumor immunity. Extensive work in the last 10 years has also suggested that HSPs such as Hsp60, Hsp70, Hsp90 and gp96, may be potent activators of the innate immune system ca...

journal_title：Cellular & molecular immunology

authors： Tsan MF,Gao B

更新日期：2004-08-01 00:00:00

abstract：:Many monoclonal antibodies (mAbs) have been extensively used in the clinic, such as rituximab to treat lymphoma. However, resistance and non-responsiveness to mAb treatment have been challenging for this line of therapy. Complement is one of the main mediators of antibody-based cancer therapy via the complement-depend...

journal_title：Cellular & molecular immunology

authors： You T,Hu W,Ge X,Shen J,Qin X

更新日期：2011-03-01 00:00:00

abstract：:Apoptotic cell transfer has been found to be able to facilitate engraftment of allograft. However, the underlying mechanisms remain to be fully understood. Here we demonstrate that intravenous administration of donor apoptotic splenocytes can promote pancreatic islet engraftment by inducing generation of tolerogenic d...

journal_title：Cellular & molecular immunology

authors： Wu C,Zhang Y,Jiang Y,Wang Q,Long Y,Wang C,Cao X,Chen G

更新日期：2013-09-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is an important factor in the induction of colon cancer, but its mechanism is unclear. Colitis and colitis-associated colorectal cancer (CAC) models induced using both dextran sulfate sodium (DSS) and the azoxymethane/DSS protocol were established in wild-type (WT) and CTRP4 transgenic...

journal_title：Cellular & molecular immunology

authors： Luo Y,Wu X,Ma Z,Tan W,Wang L,Na D,Zhang G,Yin A,Huang H,Xia D,Zhang Y,Shi X,Wang L

更新日期：2016-09-01 00:00:00

abstract：:Transplantable experimental tumor models were constructed to study the activities of recombinant human interleukin-15 (rhIL-15) against tumor recurrence and metastasis. The results showed that tumor nodule formation was retarded and tumor growth was inhibited in the subcutaneous tumor model of LA795 lung adenocarcinom...

journal_title：Cellular & molecular immunology

authors： Tang F,Zhao LT,Jiang Y,Ba de N,Cui LX,He W

更新日期：2008-06-01 00:00:00

abstract：:Infection with human immunodeficiency virus (HIV) disrupts the balance among γδ T cell subsets, with increasing Vδ1+ cells and substantial depletion of circulating Vδ2+ cells. Depletion is an indirect effect of HIV in CD4-negative Vδ2 cells, but is specific for phosphoantigen-responsive subpopulations identified by th...

journal_title：Cellular & molecular immunology

authors： Li H,Chaudhry S,Poonia B,Shao Y,Pauza CD

更新日期：2013-01-01 00:00:00

abstract：:Circulating monocyte subsets with distinct functions play important roles in hepatitis C virus (HCV) infection. However, the mechanisms have not been well studied. In this study, we analyzed the distributions and phenotypic characteristics of three circulating monocyte subsets-CD14(++)CD16(-), CD14(++)CD16(+) and CD14...

journal_title：Cellular & molecular immunology

authors： Zheng J,Liang H,Xu C,Xu Q,Zhang T,Shen T,Lu F

更新日期：2014-05-01 00:00:00