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Type I and II interferons enhance dendritic cell maturation and migration capacity by regulating CD38 and CD74 that have synergistic effects with TLR agonists.

Abstract：

:The major limitation for the maturation of dendritic cells (DCs) using Toll-like receptor (TLR) agonists is their decreased ability to migrate into lymph nodes compared with conventional DCs. CD38 can be used as a multifunctional marker to modulate migration, survival and Th1 responses of DCs. CD74 has been shown to negatively regulate DC migration. The goal of this study was to investigate the combinations of TLR agonists and interferons (IFNs) that most effectively regulate CD38 and CD74 expression on DCs. Synergistic TLR agonist stimulation in combination with IFN-α and IFN-γ was the best method for regulating CD38 and CD74 expression and inducing the highest secretion of IL-12p70. An in vitro migration assay showed that DCs treated with this combination had significantly enhanced migratory ability, similar to that observed in cells expressing CD38, CD74 and CCR7. The results of this study suggest that an alternative maturation protocol in which two TLR ligands are combined with type I and II IFNs generates potent DCs that have both a high migratory capacity and high IL-12p70 production.

journal_name

Cell Mol Immunol

journal_title

Cellular & molecular immunology

authors

Nguyen-Pham TN,Lim MS,Nguyen TA,Lee YK,Jin CJ,Lee HJ,Hong CY,Ahn JS,Yang DH,Kim YK,Chung IJ,Park BC,Kim HJ,Lee JJ

doi

10.1038/cmi.2011.7

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

341-7

issue

4

eissn

1672-7681

issn

2042-0226

pii

cmi20117

journal_volume

8

pub_type

杂志文章

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