Abstract：
:Psoriasis is a chronic inflammatory skin condition that has a fairly wide range of clinical presentations. Plaque psoriasis, which is the most common manifestation of psoriasis, is located on one end of the spectrum, dominated by adaptive immune responses, whereas the rarer pustular psoriasis lies on the opposite end, dominated by innate and autoinflammatory immune responses. In recent years, genetic studies have identified six genetic variants that predispose to pustular psoriasis, and these have highlighted the role of IL-36 cytokines as central to pustular psoriasis pathogenesis. In this review, we discuss the presentation and clinical subtypes of pustular psoriasis, contribution of genetic predisposing variants, critical role of the IL-36 family of cytokines in disease pathophysiology, and treatment perspectives for pustular psoriasis. We further outline the application of appropriate mouse models for the study of pustular psoriasis and address the outstanding questions and issues related to our understanding of the mechanisms involved in pustular psoriasis.
journal_name
Cell Mol Immunoljournal_title
Cellular & molecular immunologyauthors
Uppala R,Tsoi LC,Harms PW,Wang B,Billi AC,Maverakis E,Michelle Kahlenberg J,Ward NL,Gudjonsson JEdoi
10.1038/s41423-020-0519-3subject
Has Abstractpub_date
2021-02-01 00:00:00pages
307-317issue
2eissn
1672-7681issn
2042-0226pii
10.1038/s41423-020-0519-3journal_volume
18pub_type
杂志文章,评审abstract：:Immunization with inactivated autoreactive T cells (T cell vaccination) selected from individual's own T cell repertoire provides a unique in vivo setting for testing immune regulation that is known to involve interactions of a variety of related surface molecules (1). It induces regulatory immune responses that close...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：
更新日期：2004-10-01 00:00:00
abstract：:The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified as the receptor for dioxin. Almost half a century after its discovery, AHR is now recognized as a receptor for multiple physiological ligands, with important roles in health and disease. In this review, we discuss the r...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
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abstract：:Mesenchymal stem/stromal cells (MSCs) possess some characteristics of immune cells, including a pro-inflammatory phenotype, an immunosuppressive phenotype, antibacterial properties and the expression of Toll-like receptor proteins. Here we show that, similar to immune cells, MSCs retain information from danger signals...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2015.11
更新日期：2016-05-01 00:00:00
abstract：:Recognition of viral dsRNA by Toll-like receptor 3 (TLR3) leads to the induction of downstream antiviral effectors and the innate antiviral immune response. Here, we identified the zinc-finger FYVE domain-containing protein ZFYVE1, a guanylate-binding protein (GBP), as a positive regulator of TLR3-mediated signaling. ...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/s41423-019-0265-6
更新日期：2020-07-01 00:00:00
abstract：:The outcome of hepatitis B viral (HBV) infection is determined by the complex interactions between replicating HBV and the immune system. While the role of the adaptive immune system in the resolution of HBV infection has been studied extensively, the contribution of innate immune mechanisms remains to be defined. Her...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2017.43
更新日期：2017-12-01 00:00:00
abstract：:The nuclear receptor superfamily and the transcriptional factors associated with cytokines are inherently different families of signaling molecules and activate gene transcription by binding to their respective responsive element. However, it has become increasingly clear from our works and others that nuclear recepto...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：
更新日期：2004-12-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/s41423-018-0192-y
更新日期：2019-03-01 00:00:00
abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been redetected after discharge in some coronavirus disease 2019 (COVID-19) patients. The reason for the recurrent positivity of the test and the potential public health concern due to this occurrence are still unknown. Here, we analyzed the viral data a...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/s41423-020-00550-2
更新日期：2020-11-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章
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更新日期：2016-11-01 00:00:00
abstract：:Hypoxia is a major characteristic of the tumor microenvironment, and its effects on immune cells are proposed to be important factors for the process of tumor immune escape. It has been reported that hypoxia affects the function of dendritic cells and the antitumor function of T cells. Here we discuss the effects of h...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2009.105
更新日期：2010-01-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章,收录出版
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更新日期：2009-08-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 已发布勘误
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更新日期：2020-03-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：
更新日期：2005-06-01 00:00:00
abstract：:Cytomegaloviruses (CMVs), members of the herpesvirus family, have evolved a variety of mechanisms to evade the immune response to survive in infected hosts and to establish latent infection. They effectively hide infected cells from the effector mechanisms of adaptive immunity by eliminating cellular proteins (major h...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/cmi.2014.85
更新日期：2015-03-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/s41423-020-00557-9
更新日期：2020-10-15 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2009.15
更新日期：2009-04-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2010.29
更新日期：2010-09-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：
更新日期：2006-02-01 00:00:00
abstract：:Natural killer (NK) cells are bone marrow-derived lymphocytes. They produce cytokines that regulate the development of acquired immunity. In view of their accumulation at the maternal-fetal interface, uterine natural killer (uNK) cells are also thought to play essential roles during pregnancy. Our results compared the...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：
更新日期：2006-04-01 00:00:00
abstract：:Many monoclonal antibodies (mAbs) have been extensively used in the clinic, such as rituximab to treat lymphoma. However, resistance and non-responsiveness to mAb treatment have been challenging for this line of therapy. Complement is one of the main mediators of antibody-based cancer therapy via the complement-depend...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2010.35
更新日期：2011-03-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：
更新日期：2005-04-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章
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更新日期：2008-10-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
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更新日期：2020-08-31 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：
更新日期：2006-06-01 00:00:00
abstract：:Innate lymphoid cells (ILCs), as an important component of the innate immune system, arise from a common lymphoid progenitor and are located in mucosal barriers and various tissues, including the intestine, skin, lung, and adipose tissue. ILCs are heterogeneous subsets of lymphocytes that have emerging roles in orches...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
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abstract：:Interleukin-22 (IL-22) is a recently identified T cell-derived cytokine whose biological significance remains obscure. Previously, we have shown that IL-22 plays a protective role in T cell-mediated hepatitis induced by Concanavalin A (Con A), acting as a survival factor for hepatocytes. In the present paper, we demon...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：
更新日期：2004-02-01 00:00:00
abstract：:Experimental autoimmune encephalomyelitis (EAE) is a good model for human multiple sclerosis (MS) research. However, there are some defects in the traditional models. Here, we improved the model by using the human myelin basic protein (MBP) as antigen. EAE was induced by immunization of female Wistar rats with human M...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：
更新日期：2004-10-01 00:00:00
abstract：:Viral encephalitis is a devastating disease with high mortality, and survivors often suffer from severe neurological complications. Microglia are innate immune cells of the central nervous system (CNS) parenchyma whose turnover is reliant on local proliferation. Microglia express a diverse range of proteins, which all...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
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更新日期：2021-02-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章
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更新日期：2018-04-01 00:00:00
abstract：:Decidual natural killer (dNK) cells express an array of activation receptors to regulate placental immunity and development during early pregnancy. We investigated the functional character of human dNK cells during the first and second trimester of gestation and the interaction between dNK and trophoblast cells. Altho...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2015.66
更新日期：2017-02-01 00:00:00
