Abstract：
:Immunization with inactivated autoreactive T cells (T cell vaccination) selected from individual's own T cell repertoire provides a unique in vivo setting for testing immune regulation that is known to involve interactions of a variety of related surface molecules (1). It induces regulatory immune responses that closely resemble the in vivo situation where the immune system is challenged by clonal activation and expansion of given T cell populations in various autoimmune diseases. T cell vaccination provides a powerful means of eliciting natural reactions of the immune system in response to clonal expansion of T cells, which can be used as a therapeutic approach to suppress or eliminate specific pathogenic autoreactive T cells in autoimmune conditions. Clinical trials using T cell vaccination to deplete autoreactive T cells in human autoimmune conditions have begun to reveal the pathologic relevance of various autoimmune T cell populations in the disease processes, providing a unique opportunity to test the autoimmune theories in a clinical setting.
journal_name
Cell Mol Immunoljournal_title
Cellular & molecular immunologyauthors
Zhang Jsubject
Has Abstractpub_date
2004-10-01 00:00:00pages
321-7issue
5eissn
1672-7681issn
2042-0226journal_volume
1pub_type
杂志文章,评审abstract：:The concept of stem cells, their physiological existence, the intricate anatomical localization, the known and the unknown functions, and their exclusive utility for the purpose of regenerative medicine, are all now encompassed within an emergent question, 'how compatible these cells are immunologically?' Indeed, the ...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/cmi.2008.13
更新日期：2008-04-01 00:00:00
abstract：:Epstein-Barr virus (EBV), a potential oncogenic herpesvirus, has been found to be associated with several malignancies. It's critical to elicit cellular immunity of the body to fight against EBV-associated tumor development. Using dendritic cells (DCs) loaded with latent membrane protein 2A (LMP2A) to elicit T cell re...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2008.45
更新日期：2008-10-01 00:00:00
abstract：:Complications arising from abnormal immune responses are the major causes of mortality and morbidity in diabetic patients. CD4+CD25+T regulatory cells (Tregs) play pivotal roles in controlling immune homeostasis, immunity and tolerance. The effect of hyperglycemia on CD4+CD25+Tregs has not yet been addressed. Here we ...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2011.37
更新日期：2012-01-01 00:00:00
abstract：:Epigenetic regulation of gene expression in cancer cells has been extensively studied in recent decades, resulting in the FDA approval of multiple epigenetic agents for treating different cancer types. Recent studies have revealed novel roles of epigenetic dysregulation in altering the phenotypes of immune cells and t...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/s41423-020-0505-9
更新日期：2020-09-01 00:00:00
abstract：:The uterus in early pregnancy is a non-lymphoid organ that is enriched in natural killer (NK) cells. Studies to address the role of these abundant human NK cells at the maternal/fetal interface have focused on their response to the major histocompatibility complex (MHC) molecules on fetal trophoblast cells that they c...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/cmi.2014.53
更新日期：2014-09-01 00:00:00
abstract：:We evaluated the antitumor effect of combined therapy with tegafur/uracil (UFT) plus leucovorin (LV) (UFT/LV) and protein-bound polysaccharide, PSK, in three mouse models of transplantable tumors. UFT/LV showed antitumor effect against Meth A sarcoma, and the antitumor effect was enhanced when PSK given concomitantly....
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：
更新日期：2007-08-01 00:00:00
abstract：:The liver is an important immunological organ that controls systemic tolerance. The liver harbors professional and unconventional antigen-presenting cells that are crucial for tolerance induction and maintenance. Orchestrating the immune response in homeostasis depends on a healthy and well-toned immunological liver m...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/s41423-020-00568-6
更新日期：2021-01-01 00:00:00
abstract：:Despite impressive results obtained in animal models, the clinical use of Fas ligand (FasL) as an anticancer drug is limited by severe toxicity. Systemic toxicity of death ligands may be prevented by using genes encoding membrane-bound death ligands and by targeted transgene expression through either targeted transduc...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,收录出版
doi：10.1038/cmi.2009.38
更新日期：2009-08-01 00:00:00
abstract：:Epigenetic modifications to histones dictate the differentiation of naïve CD4+ T cells into different subsets of effector T helper (TH) cells. The histone methyltransferase enhancer of zeste homolog 2 (EZH2) has been implicated in the mechanism regulating the differentiation of TH1, TH2 and regulatory T (Treg) cells. ...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/s41423-019-0219-z
更新日期：2020-03-01 00:00:00
abstract：:Psoriasis is a chronic inflammatory skin disease with a strong genetic background and is triggered by environmental factors. Available evidence supports CD6, a lymphocyte surface receptor mostly expressed by T cells, as a putative target in autoimmunity. Accordingly, a humanized anti-CD6 antibody has been assayed for ...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2017.119
更新日期：2018-10-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：
更新日期：2006-02-01 00:00:00
abstract：:Previous studies have shown that the CC chemokine receptor CCR5 is downregulated on monocyte/macrophage (MO/Mphi) surfaces in head and neck squamous cell carcinoma (HNSCC) patients (stage IIIB). Ligands (RANTES, MIP-1alpha and MIP-1beta) of this chemokine receptor were also secreted in lesser quantity from MO/Mphi of ...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2010.29
更新日期：2010-09-01 00:00:00
abstract：:Previous study showed that aerosolized signal transducer and activator of transcription-1 (STAT1) antisense oligodeoxynucleotide (ASON) inhibited the expression of STAT1 and ICAM-1 mRNA and protein in alveolar macrophages (AMs) and decreased the concentrations of TGF-beta, PDGF and TNF-alpha in bronchioalveolar lavage...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2009.7
更新日期：2009-02-01 00:00:00
abstract：:Vγ2Vδ2 T (also known as Vγ9Vδ2 T) cells exist only in primates, and in humans represent a major γδ T-cell sub-population in the total population of circulating γδ T cells. Results from recent studies suggest that while (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) phosphoantigen from Mycobacterium tuberculos...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/cmi.2012.46
更新日期：2013-01-01 00:00:00
abstract：:Infection with human immunodeficiency virus (HIV) disrupts the balance among γδ T cell subsets, with increasing Vδ1+ cells and substantial depletion of circulating Vδ2+ cells. Depletion is an indirect effect of HIV in CD4-negative Vδ2 cells, but is specific for phosphoantigen-responsive subpopulations identified by th...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/cmi.2012.50
更新日期：2013-01-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：
更新日期：2006-10-01 00:00:00
abstract：:B cells are generally considered to be positive regulators of the immune response because of their capability to produce antibodies, including autoantibodies. The production of antibodies facilitates optimal CD4(+) T-cell activation because B cells serve as antigen-presenting cells and exert other modulatory functions...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/cmi.2012.60
更新日期：2013-03-01 00:00:00
abstract：:Transplantable experimental tumor models were constructed to study the activities of recombinant human interleukin-15 (rhIL-15) against tumor recurrence and metastasis. The results showed that tumor nodule formation was retarded and tumor growth was inhibited in the subcutaneous tumor model of LA795 lung adenocarcinom...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2008.23
更新日期：2008-06-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/cmi.2017.118
更新日期：2018-04-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/s41423-020-0465-0
更新日期：2020-06-01 00:00:00
abstract：:Innate lymphoid cells (ILCs), including natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer (LTi) cells, comprise the first line of innate immune defense against pathogens and tumors. Over the past decade, accumulating evidence has demonstrated immunological memory in ILC subsets: for example, ...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/s41423-019-0212-6
更新日期：2019-05-01 00:00:00
abstract：:T follicular helper (Tfh) cells were discovered just over a decade ago as germinal centre T cells that help B cells make antibodies. Included in this role is affinity maturation and isotype switching. It is here that their functions become less clear. Tfh cells principally produce IL-21 which inhibits class switching ...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/cmi.2012.31
更新日期：2012-09-01 00:00:00
abstract：:Efficient immune responses against invading pathogens often involve coordination between cells from both the innate and adaptive immune systems. For multiple decades, it has been believed that CD8+ memory T cells and natural killer (NK) cells constantly and uniformly recirculate. Only recently was the existence of non...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/s41423-018-0192-y
更新日期：2019-03-01 00:00:00
abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been redetected after discharge in some coronavirus disease 2019 (COVID-19) patients. The reason for the recurrent positivity of the test and the potential public health concern due to this occurrence are still unknown. Here, we analyzed the viral data a...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/s41423-020-00550-2
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVE:Plasma phospholipid transfer protein (PLTP) is a key determinant of lipoprotein metabolism, and both animal and human studies converge to indicate that PLTP promotes atherogenesis and its thromboembolic complications. Moreover, it has recently been reported that PLTP modulates inflammation and immune response...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2015.75
更新日期：2016-11-01 00:00:00
abstract：:Potential crosslinks between inflammation and leukaemia have been discussed for some time, but experimental evidence to support this dogma is scarce. In particular, it is important to understand the mechanisms responsible for potential upregulation of proto-oncogenic growth factor expressions by inflammatory mediators...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2014.113
更新日期：2016-01-01 00:00:00
abstract：:Tumor necrosis factor alpha (TNF-alpha) has been recognized as an activator of nuclear factor kappaB (NF-kappaB), a factor implicated in the protection of many cell types from apoptosis. We and others have presented evidence to suggest that Fas-induced apoptosis may be an important aspect of the resolution of inflamma...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：
更新日期：2007-02-01 00:00:00
abstract：:A complex process including both the innate and acquired immune responses results in allograft rejection. Some chemokine receptors and their ligands play essential roles not only for leukocyte migration into the graft but also in facilitating dendritic and T cell trafficking between lymph nodes and the transplant in t...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：
更新日期：2005-10-01 00:00:00
abstract：:Diabetes-associated periodontitis (DP) aggravates diabetic complications and increases mortality from diabetes. DP is caused by diabetes-enhanced host immune-inflammatory responses to bacterial insult. In this study, we found that persistently elevated CCL2 levels in combination with proinflammatory monocyte infiltrat...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/s41423-020-0500-1
更新日期：2020-07-16 00:00:00
abstract：:Viral RNAs produced during viral infection are recognized by the cytoplasmic RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5). A central adapter protein downstream of RIG-I and MDA5 is the mitochondrial membrane protein virus-induced signaling adaptor (VISA), w...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2010.36
更新日期：2010-09-01 00:00:00
