Abstract:
:In contrast to the previous belief that autoreactive B cells are eliminated from the normal repertoire of B cells, many autoreactive B cells actually escape clonal deletion and develop into mature B cells. These autoreactive B cells in healthy individuals perform some beneficial functions in the host and are homeostatically regulated by regulatory T and B cells or other mechanisms to prevent autoimmune diseases. Autoreactive B-1 cells constitutively produce polyreactive natural antibodies for tissue homeostasis. Recently, autoreactive follicular B cells were reported to participate actively in the germinal center reaction. Furthermore, the selection and usefulness of autoreactive marginal zone (MZ) B cells found in autoimmune diseases are not well understood, although the repertoire of MZ B-cell receptors (BCRs) is presumed to be biased to detect bacterial antigens. In this review, we discuss the autoreactive B-cell populations among all three major B-cell subsets and their regulation in immune responses and diseases.
journal_name
Cell Mol Immunoljournal_title
Cellular & molecular immunologyauthors
Lee S,Ko Y,Kim TJdoi
10.1038/s41423-020-0445-4subject
Has Abstractpub_date
2020-06-01 00:00:00pages
561-569issue
6eissn
1672-7681issn
2042-0226pii
10.1038/s41423-020-0445-4journal_volume
17pub_type
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