Chemoattractants and cytokines in primary ciliary dyskinesia and cystic fibrosis: key players in chronic respiratory diseases.

Abstract:

:Patients with primary ciliary dyskinesia (PCD) and cystic fibrosis (CF), two inherited disorders, suffer from recurrent airway infections characterized by persistent bacterial colonization and uncontrollable inflammation. Although present in high counts, neutrophils fail to clear infection in the airways. High levels of C-X-C motif chemokine ligand 8/interleukin-8 (CXCL8/IL-8), the most potent chemokine to attract neutrophils to sites of infection, are detected in the sputum of both patient groups and might cause the high neutrophil influx in the airways. Furthermore, in CF, airway neutrophils are highly activated because of the genetic defect and the high levels of proinflammatory chemoattractants and cytokines (e.g., CXCL8/IL-8, tumor necrosis factor-α and IL-17). The overactive state of neutrophils leads to lung damage and fuels the vicious circle of infection, excessive inflammation and tissue damage. The inflammatory process in CF airways is well characterized, whereas the lung pathology in PCD is far less studied. The knowledge of CF lung pathology could be useful to guide molecular investigations of the inflammatory processes in PCD lungs. Current available therapies can not completely remedy the chronic airway infections in these diseases. This review gives an overview of the role that chemoattractants and cytokines play in these neutrophil-dominated lung pathologies. Finally, the most frequently applied treatments in CF and PCD and new experimental therapies to reduce neutrophil-dominated airway inflammation are described.

journal_name

Cell Mol Immunol

authors

Cockx M,Gouwy M,Van Damme J,Struyf S

doi

10.1038/cmi.2017.118

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

312-323

issue

4

eissn

1672-7681

issn

2042-0226

pii

10.1038/cmi.2017.118

journal_volume

15

pub_type

杂志文章,评审
  • The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway.

    abstract::Inflammasomes are important for maintaining intestinal homeostasis, and dysbiosis contributes to the pathology of inflammatory bowel disease (IBD) and increases the risk for colorectal cancer. Inflammasome defects contribute to chronic intestinal inflammation and increase the susceptibility to colitis in mice. However...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/cmi.2016.35

    authors: Ratsimandresy RA,Indramohan M,Dorfleutner A,Stehlik C

    更新日期:2017-01-01 00:00:00

  • Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy.

    abstract::Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers, the majority of patients with solid tumors do not respond well, but the underlying reason remains unclear. Here, we studied ovarian cancer (OvCa), a tumor type generally resistant to current immunotherapies, to investigate PD-1-inde...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/s41423-019-0305-2

    authors: Cai D,Li J,Liu D,Hong S,Qiao Q,Sun Q,Li P,Lyu N,Sun T,Xie S,Guo L,Ni L,Jin L,Dong C

    更新日期:2020-03-01 00:00:00

  • Inflammation-induced inhibition of chaperone-mediated autophagy maintains the immunosuppressive function of murine mesenchymal stromal cells.

    abstract::Macroautophagy has been implicated in modulating the therapeutic function of mesenchymal stromal cells (MSCs). However, the biological function of chaperone-mediated autophagy (CMA) in MSCs remains elusive. Here, we found that CMA was inhibited in MSCs in response to the proinflammatory cytokines interferon-γ (IFN-γ) ...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/s41423-019-0345-7

    authors: Zhang J,Huang J,Gu Y,Xue M,Qian F,Wang B,Yang W,Yu H,Wang Q,Guo X,Ding X,Wang J,Jin M,Zhang Y

    更新日期:2020-01-03 00:00:00

  • The complement system in liver diseases.

    abstract::The complement system plays an important role in mediating both acquired and innate responses to defend against microbial infection, and in disposing immunoglobins and apoptotic cells. The liver (mainly hepatocytes) is responsible for biosynthesis of about 80-90% of plasma complement components and expresses a variety...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:

    authors: Qin X,Gao B

    更新日期:2006-10-01 00:00:00

  • T cell vaccination as an immunotherapy for autoimmune diseases.

    abstract::Immunization with inactivated autoreactive T cells (T cell vaccination) selected from individual's own T cell repertoire provides a unique in vivo setting for testing immune regulation that is known to involve interactions of a variety of related surface molecules (1). It induces regulatory immune responses that close...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:

    authors: Zhang J

    更新日期:2004-10-01 00:00:00

  • The aryl hydrocarbon receptor and the gut-brain axis.

    abstract::The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified as the receptor for dioxin. Almost half a century after its discovery, AHR is now recognized as a receptor for multiple physiological ligands, with important roles in health and disease. In this review, we discuss the r...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/s41423-020-00585-5

    authors: Barroso A,Mahler JV,Fonseca-Castro PH,Quintana FJ

    更新日期:2021-02-01 00:00:00

  • Short-term memory of danger signals or environmental stimuli in mesenchymal stem cells: implications for therapeutic potential.

    abstract::Mesenchymal stem/stromal cells (MSCs) possess some characteristics of immune cells, including a pro-inflammatory phenotype, an immunosuppressive phenotype, antibacterial properties and the expression of Toll-like receptor proteins. Here we show that, similar to immune cells, MSCs retain information from danger signals...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/cmi.2015.11

    authors: Liu GY,Liu Y,Lu Y,Qin YR,Di GH,Lei YH,Liu HX,Li YQ,Wu C,Hu XW,Duan HF

    更新日期:2016-05-01 00:00:00

  • Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients.

    abstract::B cells play an important role in the clearance of hepatitis B virus (HBV) and protection against reinfection. However, the functional characteristics of these cells that are associated with the outcome of chronic HBV infection remain unknown. We comprehensively investigated the frequency, phenotype, and function of p...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/cmi.2015.25

    authors: Xu X,Shang Q,Chen X,Nie W,Zou Z,Huang A,Meng M,Jin L,Xu R,Zhang JY,Fu J,Wang L,Tang Z,Xie Y,Yang X,Zhang Z,Wang FS

    更新日期:2015-05-01 00:00:00

  • Identification and characterization of peptides mimicking the epitopes of metalloprotease of Schistosoma japonicum.

    abstract::In an attempt to isolate and characterize peptides mimicking epitopes of metalloprotease and explore their immunological protection against Schistosoma japonicum (S. japonicum), polyclonal anti-metalloprotease sera was prepared to screen a 12-mer random peptide library to isolate phages binding specially to antisera I...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:

    authors: Tang L,Chen Y,Wang L,Zhang S,Zeng X,Yi X

    更新日期:2005-06-01 00:00:00

  • The classical and regulatory functions of C1q in immunity and autoimmunity.

    abstract::A classical function of C1q is to bind immune complexes and initiate complement activation producing membrane lytic complexes, opsonins and anaphylatoxins. This classical pathway of complement activation is also elicited when C1q binds some other ligands. Besides complement activation, C1q also regulates cell differen...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/cmi.2008.2

    authors: Lu JH,Teh BK,Wang Ld,Wang YN,Tan YS,Lai MC,Reid KB

    更新日期:2008-02-01 00:00:00

  • Plasmacytoid dendritic cells act as the most competent cell type in linking antiviral innate and adaptive immune responses.

    abstract::Appropriate in vivo control of plasmacytoid dendritic cell (pDC) recruitment and activation is a fundamental requirement for defense against viral infection. During this process, a pivotal event that influences the outcome of viral infection is the production of high levels of type I interferon by pDCs. In particular,...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:

    authors: Zhang Z,Wang FS

    更新日期:2005-12-01 00:00:00

  • Chemokine receptors and transplantation.

    abstract::A complex process including both the innate and acquired immune responses results in allograft rejection. Some chemokine receptors and their ligands play essential roles not only for leukocyte migration into the graft but also in facilitating dendritic and T cell trafficking between lymph nodes and the transplant in t...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:

    authors: Tan J,Zhou G

    更新日期:2005-10-01 00:00:00

  • Regulation of TWIK-related potassium channel-1 (Trek1) restitutes intestinal epithelial barrier function.

    abstract::The disruption of epithelial barrier integrity is an important factor in the pathogenesis of various immune disorders. However, the restitution of the compromised barrier functions is difficult. This study investigates the regulation of TWIK-related potassium channel-1 (Trek1) in the restitution of intestinal epitheli...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/cmi.2014.137

    authors: Huang H,Liu JQ,Yu Y,Mo LH,Ge RT,Zhang HP,Liu ZG,Zheng PY,Yang PC

    更新日期:2016-01-01 00:00:00

  • Stem cell niche, the microenvironment and immunological crosstalk.

    abstract::The concept of stem cells, their physiological existence, the intricate anatomical localization, the known and the unknown functions, and their exclusive utility for the purpose of regenerative medicine, are all now encompassed within an emergent question, 'how compatible these cells are immunologically?' Indeed, the ...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/cmi.2008.13

    authors: Sujata L,Chaudhuri S

    更新日期:2008-04-01 00:00:00

  • The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases.

    abstract::Metagenomic approaches are currently being used to decipher the genome of the microbiota (microbiome), and, in parallel, functional studies are being performed to analyze the effects of the microbiota on the host. Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/cmi.2010.67

    authors: Tlaskalová-Hogenová H,Stěpánková R,Kozáková H,Hudcovic T,Vannucci L,Tučková L,Rossmann P,Hrnčíř T,Kverka M,Zákostelská Z,Klimešová K,Přibylová J,Bártová J,Sanchez D,Fundová P,Borovská D,Srůtková D,Zídek Z,Schwarzer M

    更新日期:2011-03-01 00:00:00

  • Regulatory B cells in autoimmune diseases.

    abstract::B cells are generally considered to be positive regulators of the immune response because of their capability to produce antibodies, including autoantibodies. The production of antibodies facilitates optimal CD4(+) T-cell activation because B cells serve as antigen-presenting cells and exert other modulatory functions...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/cmi.2012.60

    authors: Yang M,Rui K,Wang S,Lu L

    更新日期:2013-03-01 00:00:00

  • Molecular mechanisms regulating NLRP3 inflammasome activation.

    abstract::Inflammasomes are multi-protein signaling complexes that trigger the activation of inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome complexes, the NLRP3 inflammasome is best characterized and has been linked with various human autoinflammatory and autoimmune diseases. Thus, the NL...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/cmi.2015.95

    authors: Jo EK,Kim JK,Shin DM,Sasakawa C

    更新日期:2016-03-01 00:00:00

  • Enhancement of antitumor immunity by low-dose total body irradiationis associated with selectively decreasing the proportion and number of T regulatory cells.

    abstract::Low-dose total body irradiation (LTBI) is used in the treatment of some cancers mainly for immune enhancement rather than cell killing. However, the mechanism underlying LTBI remains unknown. In this study, by analyzing the immune patterns of lymphocytes, we found that the percentage and absolute number of CD4(+)CD25(...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/cmi.2009.117

    authors: Liu R,Xiong S,Zhang L,Chu Y

    更新日期:2010-03-01 00:00:00

  • Dust mite allergen-specific immunotherapy increases IL4 DNA methylation and induces Der p-specific T cell tolerance in children with allergic asthma.

    abstract::Allergen-specific immunotherapy (allergen-SIT) is a highly effective treatment for children with allergic asthma (AA), an immune-mediated chronic disease leading to bronchial muscle hypertrophy and airway obstruction in response to specific allergens. T helper cells and secreted cytokines play important roles in the p...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/cmi.2017.26

    authors: Wang CM,Chang CB,Chan MW,Wen ZH,Wu SF

    更新日期:2018-11-01 00:00:00

  • Imbalance of interleukin 18 and interleukin 18 binding protein in patients with lupus nephritis.

    abstract::To evaluate the balance status of interleukin 18 (IL-18) and interleukin 18 binding protein (IL-18BP) in circulation in patients with lupus nephritis (LN) and primary nephrotic syndrome (PNS), plasma levels as well as mRNA expression in peripheral blood mononuclear cells (PBMCs) of IL-18 and IL-18BP were measured by E...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:

    authors: Liang D,Ma W,Yao C,Liu H,Chen X

    更新日期:2006-08-01 00:00:00

  • The rLrp of Mycobacterium tuberculosis inhibits proinflammatory cytokine production and downregulates APC function in mouse macrophages via a TLR2-mediated PI3K/Akt pathway activation-dependent mechanism.

    abstract::We demonstrate that Mycobacterium tuberculosis recombinant leucine-responsive regulatory protein (rLrp) inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-α), interleukin-6, and interleukin-12 production and blocks the nuclear translocation of subunits of the nuclear-receptor transcription fact...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/cmi.2015.58

    authors: Liu Y,Li JY,Chen ST,Huang HR,Cai H

    更新日期:2016-11-01 00:00:00

  • Implications of the immunoregulatory functions of mesenchymal stem cells in the treatment of human liver diseases.

    abstract::Transplantation of mesenchymal stem cells (MSCs) has been recently studied in animal models, and in clinical trials of patients with fulminant hepatic failure, end-stage liver diseases and inherited metabolic disorders. Modulatory cytokines produced by MSCs can inhibit immunocyte proliferation and migration to the liv...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/cmi.2010.57

    authors: Lin H,Xu R,Zhang Z,Chen L,Shi M,Wang FS

    更新日期:2011-01-01 00:00:00

  • Exhaustion and senescence: two crucial dysfunctional states of T cells in the tumor microenvironment.

    abstract::The failure of a massive influx of tumor-infiltrating T lymphocytes to eradicate tumor cells in the tumor microenvironment is mainly due to the dysfunction of T cells hyporesponsive to tumors. T-cell exhaustion and senescence induced by malignant tumors are two important dysfunctional states that coexist in cancer pat...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/s41423-019-0344-8

    authors: Zhao Y,Shao Q,Peng G

    更新日期:2020-01-01 00:00:00

  • PI3K/AKT mediated p53 down-regulation participates in CpG DNA inhibition of spontaneous B cell apoptosis.

    abstract::The unmethylated CpG DNA can prevent spontaneous apoptosis of B cells. However, the precise mechanisms by which CpG DNA blocks apoptosis remain unclear. In this study, we showed B cell apoptosis was significantly inhibited by addition of CpG DNA. Treatment of CpG DNA could reduce the expression of caspase 3, increase ...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/cmi.2009.24

    authors: Zhou Y,Zhen H,Mei Y,Wang Y,Feng J,Xu S,Fu X

    更新日期:2009-06-01 00:00:00

  • Ovarian tumor-associated microRNA-20a decreases natural killer cell cytotoxicity by downregulating MICA/B expression.

    abstract::MicroRNAs (miRNAs) are a class of small non-coding regulatory RNAs, and changes in miRNAs are involved in tumor origin and progression. Studies have shown that miR-20a is overexpressed in human ovarian cancer tissues and that this miRNA enhances long-term cellular proliferation and invasion capabilities. In this study...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/cmi.2014.30

    authors: Xie J,Liu M,Li Y,Nie Y,Mi Q,Zhao S

    更新日期:2014-09-01 00:00:00

  • Homeostasis and regulation of autoreactive B cells.

    abstract::In contrast to the previous belief that autoreactive B cells are eliminated from the normal repertoire of B cells, many autoreactive B cells actually escape clonal deletion and develop into mature B cells. These autoreactive B cells in healthy individuals perform some beneficial functions in the host and are homeostat...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/s41423-020-0445-4

    authors: Lee S,Ko Y,Kim TJ

    更新日期:2020-06-01 00:00:00

  • Transcriptional crosstalk between nuclear receptors and cytokine signal transduction pathways in immunity.

    abstract::The nuclear receptor superfamily and the transcriptional factors associated with cytokines are inherently different families of signaling molecules and activate gene transcription by binding to their respective responsive element. However, it has become increasingly clear from our works and others that nuclear recepto...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:

    authors: Wang L,Zhang X,Farrar WL,Yang X

    更新日期:2004-12-01 00:00:00

  • The role of the T follicular helper cells in allergic disease.

    abstract::T follicular helper (Tfh) cells were discovered just over a decade ago as germinal centre T cells that help B cells make antibodies. Included in this role is affinity maturation and isotype switching. It is here that their functions become less clear. Tfh cells principally produce IL-21 which inhibits class switching ...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/cmi.2012.31

    authors: Kemeny DM

    更新日期:2012-09-01 00:00:00

  • High levels of circulating GM-CSF+CD4+ T cells are predictive of poor outcomes in sepsis patients: a prospective cohort study.

    abstract::Granulocyte colony-stimulating factor (GM-CSF), produced by CD4+ T cells, has recently been implicated in the pathogenesis of inflammatory diseases, such as multiple sclerosis and juvenile arthritis. However, the role of GM-CSF-producing CD4+ T cells in sepsis remains unknown. This study reports peripheral changes in ...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/s41423-018-0164-2

    authors: Huang H,Wang S,Jiang T,Fan R,Zhang Z,Mu J,Li K,Wang Y,Jin L,Lin F,Xia J,Sun L,Xu B,Ji C,Chen J,Chang J,Tu B,Song B,Zhang C,Wang FS,Xu R

    更新日期:2019-06-01 00:00:00

  • Delayed allogeneic skin graft rejection in CD26-deficient mice.

    abstract::Organ transplantation is an effective therapeutic tool for treating many terminal diseases. However, one of the biggest challenges of transplantation is determining how to achieve the long-term survival of the allogeneic or xenogeneic transplant by, for example, preventing transplant rejection. In the current study, C...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/s41423-018-0009-z

    authors: Zhao X,Zhang K,Daniel P,Wisbrun N,Fuchs H,Fan H

    更新日期:2019-06-01 00:00:00