Activation of the Ig Iα1 promoter by the transcription factor Ets-1 triggers Ig Iα1-Cα1 germline transcription in epithelial cancer cells.

abstract：:The interactions of CD4+ T cells and B cells are fundamental for the generation of protective antibody responses, as well as for the development of harmful autoimmune diseases. Recent studies of human tissues and blood samples have established a new subset of CD4+ B helper T cells named peripheral helper T (Tph) cells...

journal_title：Cellular & molecular immunology

authors： Yoshitomi H,Ueno H

更新日期：2020-08-31 00:00:00

abstract：:Efficient immune responses against invading pathogens often involve coordination between cells from both the innate and adaptive immune systems. For multiple decades, it has been believed that CD8+ memory T cells and natural killer (NK) cells constantly and uniformly recirculate. Only recently was the existence of non...

journal_title：Cellular & molecular immunology

authors： Sun H,Sun C,Xiao W,Sun R

更新日期：2019-03-01 00:00:00

abstract：:The failure of a massive influx of tumor-infiltrating T lymphocytes to eradicate tumor cells in the tumor microenvironment is mainly due to the dysfunction of T cells hyporesponsive to tumors. T-cell exhaustion and senescence induced by malignant tumors are two important dysfunctional states that coexist in cancer pat...

journal_title：Cellular & molecular immunology

authors： Zhao Y,Shao Q,Peng G

更新日期：2020-01-01 00:00:00

abstract：:4-1BB (CD137) is a strong enhancer of the proliferation of CD8+ T cells. Since these cells require increased production of energy and biomass to support their proliferation, we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism. We found that treatment with agonistic anti-4-1BB mAb promoted ...

journal_title：Cellular & molecular immunology

authors： Choi BK,Lee DY,Lee DG,Kim YH,Kim SH,Oh HS,Han C,Kwon BS

更新日期：2017-09-01 00:00:00

abstract：:The human immunodeficiency virus-1 (HIV-1) envelope protein gp120 is the major contributor to the pathogenesis of HIV-associated neurocognitive disorder (HAND). Neuroinflammation plays a pivotal role in gp120-induced neuropathology, but how gp120 triggers neuroinflammatory processes and subsequent neuronal death remai...

journal_title：Cellular & molecular immunology

authors： He X,Yang W,Zeng Z,Wei Y,Gao J,Zhang B,Li L,Liu L,Wan Y,Zeng Q,Gong Z,Liu L,Zhang H,Li Y,Yang S,Hu T,Wu L,Masliah E,Huang S,Cao H

更新日期：2020-03-01 00:00:00

abstract：:Kupffer cells (KCs), the liver resident macrophages accounting for 80-90% of the total population of fixed tissue macrophages in the body, not only play a key role in host defense via removing particulate materials from the portal circulation, but may also contribute to the pathogenesis of various liver diseases. We h...

journal_title：Cellular & molecular immunology

authors： Miller AM,Zhang JX

更新日期：2009-12-01 00:00:00

abstract：:Age-related thymic involution causes a decreased output of thymocytes from the thymus, thereby resulting in impairment of T cell-mediated immunity. While alterations in the T cell and non-haematopoietic stromal compartments have been described, the effects of thymic involution on thymic dendritic cells (DC) are not cl...

journal_title：Cellular & molecular immunology

authors： van Dommelen SL,Rizzitelli A,Chidgey A,Boyd R,Shortman K,Wu L

更新日期：2010-03-01 00:00:00

abstract：:Bispecific antibodies (bsAbs) refer to a large family of molecules that recognize two different epitopes or antigens. Although a series of challenges, especially immunogenicity and chain mispairing issues, once hindered the development of bsAbs, they have been gradually overcome with the help of rapidly developing tec...

journal_title：Cellular & molecular immunology

authors： Li H,Er Saw P,Song E

更新日期：2020-05-01 00:00:00

abstract：:Intestinal stem cells may have important roles in the maintenance of epithelial integrity during tissue repair. Alemtuzumab is a humanized anti-CD52 lymphocytic antibody that is increasingly being used to induce immunosuppression; intestinal barrier function is impaired during treatment with alemtuzumab. We investigat...

journal_title：Cellular & molecular immunology

authors： Li Q,Zhang Q,Wang C,Jiang S,Li N,Li J

更新日期：2011-07-01 00:00:00

abstract：:In contrast to the previous belief that autoreactive B cells are eliminated from the normal repertoire of B cells, many autoreactive B cells actually escape clonal deletion and develop into mature B cells. These autoreactive B cells in healthy individuals perform some beneficial functions in the host and are homeostat...

journal_title：Cellular & molecular immunology

authors： Lee S,Ko Y,Kim TJ

更新日期：2020-06-01 00:00:00

abstract：:Metagenomic approaches are currently being used to decipher the genome of the microbiota (microbiome), and, in parallel, functional studies are being performed to analyze the effects of the microbiota on the host. Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization...

journal_title：Cellular & molecular immunology

authors： Tlaskalová-Hogenová H,Stěpánková R,Kozáková H,Hudcovic T,Vannucci L,Tučková L,Rossmann P,Hrnčíř T,Kverka M,Zákostelská Z,Klimešová K,Přibylová J,Bártová J,Sanchez D,Fundová P,Borovská D,Srůtková D,Zídek Z,Schwarzer M

更新日期：2011-03-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (GM-CSF), produced by CD4+ T cells, has recently been implicated in the pathogenesis of inflammatory diseases, such as multiple sclerosis and juvenile arthritis. However, the role of GM-CSF-producing CD4+ T cells in sepsis remains unknown. This study reports peripheral changes in ...

journal_title：Cellular & molecular immunology

authors： Huang H,Wang S,Jiang T,Fan R,Zhang Z,Mu J,Li K,Wang Y,Jin L,Lin F,Xia J,Sun L,Xu B,Ji C,Chen J,Chang J,Tu B,Song B,Zhang C,Wang FS,Xu R

更新日期：2019-06-01 00:00:00

abstract：:In an attempt to isolate and characterize peptides mimicking epitopes of metalloprotease and explore their immunological protection against Schistosoma japonicum (S. japonicum), polyclonal anti-metalloprotease sera was prepared to screen a 12-mer random peptide library to isolate phages binding specially to antisera I...

journal_title：Cellular & molecular immunology

authors： Tang L,Chen Y,Wang L,Zhang S,Zeng X,Yi X

更新日期：2005-06-01 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19), caused by the novel human coronavirus SARS-CoV-2, is currently a major threat to public health worldwide. The viral spike protein binds the host receptor angiotensin-converting enzyme 2 (ACE2) via the receptor-binding domain (RBD), and thus is believed to be a major target to block...

journal_title：Cellular & molecular immunology

authors： Yi C,Sun X,Ye J,Ding L,Liu M,Yang Z,Lu X,Zhang Y,Ma L,Gu W,Qu A,Xu J,Shi Z,Ling Z,Sun B

更新日期：2020-06-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cellular & molecular immunology

authors： Romanets-Korbut O,Kovalevska LM,Seya T,Sidorenko SP,Horvat B

更新日期：2020-03-01 00:00:00

abstract：:A classical function of C1q is to bind immune complexes and initiate complement activation producing membrane lytic complexes, opsonins and anaphylatoxins. This classical pathway of complement activation is also elicited when C1q binds some other ligands. Besides complement activation, C1q also regulates cell differen...

journal_title：Cellular & molecular immunology

authors： Lu JH,Teh BK,Wang Ld,Wang YN,Tan YS,Lai MC,Reid KB

更新日期：2008-02-01 00:00:00

abstract：:Dendritic cells (DCs) are the most potent professional antigen-presenting cells, and capable of stimulating naïve T cells and driving primary immune responses. DCs are poised to capture antigen, migrate to draining lymphoid organs, and after a process of maturation, select antigen-specific lymphocytes to which they pr...

journal_title：Cellular & molecular immunology

authors： Sun K,Wang L,Zhang Y

更新日期：2006-06-01 00:00:00

abstract：:Radiofrequency ablation (RFA) is the most common approach to thermal ablation for cancer therapy. Unfortunately, its efficacy is limited by incomplete ablation, and further optimization of RFA is required. Here, we demonstrate that incubation at 65 °C triggers more EG7 tumor cell death by necrosis than treatment at 45...

journal_title：Cellular & molecular immunology

authors： Xu A,Zhang L,Yuan J,Babikr F,Freywald A,Chibbar R,Moser M,Zhang W,Zhang B,Fu Z,Xiang J

更新日期：2019-10-01 00:00:00

abstract：:Circulating monocyte subsets with distinct functions play important roles in hepatitis C virus (HCV) infection. However, the mechanisms have not been well studied. In this study, we analyzed the distributions and phenotypic characteristics of three circulating monocyte subsets-CD14(++)CD16(-), CD14(++)CD16(+) and CD14...

journal_title：Cellular & molecular immunology

authors： Zheng J,Liang H,Xu C,Xu Q,Zhang T,Shen T,Lu F

更新日期：2014-05-01 00:00:00

abstract：:To evaluate the balance status of interleukin 18 (IL-18) and interleukin 18 binding protein (IL-18BP) in circulation in patients with lupus nephritis (LN) and primary nephrotic syndrome (PNS), plasma levels as well as mRNA expression in peripheral blood mononuclear cells (PBMCs) of IL-18 and IL-18BP were measured by E...

journal_title：Cellular & molecular immunology

authors： Liang D,Ma W,Yao C,Liu H,Chen X

更新日期：2006-08-01 00:00:00

abstract：:Natural killer (NK) cells are bone marrow-derived lymphocytes. They produce cytokines that regulate the development of acquired immunity. In view of their accumulation at the maternal-fetal interface, uterine natural killer (uNK) cells are also thought to play essential roles during pregnancy. Our results compared the...

journal_title：Cellular & molecular immunology

authors： Wu X,Wei H,Zhang J,Tian Z

更新日期：2006-04-01 00:00:00

abstract：:Neutrophil infiltration is a hallmark of alcoholic steatohepatitis; however, the underlying mechanisms remain unclear. We previously reported that chronic-plus-binge ethanol feeding synergistically induces hepatic recruitment of neutrophils, which contributes to liver injury. In this paper, we investigated the roles o...

journal_title：Cellular & molecular immunology

authors： Mathews S,Feng D,Maricic I,Ju C,Kumar V,Gao B

更新日期：2016-03-01 00:00:00

abstract：:Programmed death one homolog (PD-1H) is a cell surface molecule of the B7/CD28 immune modulatory gene family. Although PD-1H has been shown to function as a coinhibitory receptor on T cells to limit naive T-cell activation and proliferation, its role in the regulation of the T-cell response to allergens is unknown. We...

journal_title：Cellular & molecular immunology

authors： Liu H,Li X,Hu L,Zhu M,He B,Luo L,Chen L

更新日期：2018-09-01 00:00:00

abstract：:Despite impressive results obtained in animal models, the clinical use of Fas ligand (FasL) as an anticancer drug is limited by severe toxicity. Systemic toxicity of death ligands may be prevented by using genes encoding membrane-bound death ligands and by targeted transgene expression through either targeted transduc...

journal_title：Cellular & molecular immunology

authors： Liu Z,Wang J,Yin P,Qiu J,Liu R,Li W,Fan X,Cheng X,Chen C,Zhang J,Zhuang G

更新日期：2009-08-01 00:00:00

abstract：:T follicular helper (Tfh) cells were discovered just over a decade ago as germinal centre T cells that help B cells make antibodies. Included in this role is affinity maturation and isotype switching. It is here that their functions become less clear. Tfh cells principally produce IL-21 which inhibits class switching ...

journal_title：Cellular & molecular immunology

authors： Kemeny DM

更新日期：2012-09-01 00:00:00

abstract：:The nuclear receptor superfamily and the transcriptional factors associated with cytokines are inherently different families of signaling molecules and activate gene transcription by binding to their respective responsive element. However, it has become increasingly clear from our works and others that nuclear recepto...

journal_title：Cellular & molecular immunology

authors： Wang L,Zhang X,Farrar WL,Yang X

更新日期：2004-12-01 00:00:00

abstract：:Epigenetic regulation of gene expression in cancer cells has been extensively studied in recent decades, resulting in the FDA approval of multiple epigenetic agents for treating different cancer types. Recent studies have revealed novel roles of epigenetic dysregulation in altering the phenotypes of immune cells and t...

journal_title：Cellular & molecular immunology

authors： Pan X,Zheng L

更新日期：2020-09-01 00:00:00

abstract：:The uterus in early pregnancy is a non-lymphoid organ that is enriched in natural killer (NK) cells. Studies to address the role of these abundant human NK cells at the maternal/fetal interface have focused on their response to the major histocompatibility complex (MHC) molecules on fetal trophoblast cells that they c...

journal_title：Cellular & molecular immunology

authors： Rajagopalan S

更新日期：2014-09-01 00:00:00

abstract：:Transplantable experimental tumor models were constructed to study the activities of recombinant human interleukin-15 (rhIL-15) against tumor recurrence and metastasis. The results showed that tumor nodule formation was retarded and tumor growth was inhibited in the subcutaneous tumor model of LA795 lung adenocarcinom...

journal_title：Cellular & molecular immunology

authors： Tang F,Zhao LT,Jiang Y,Ba de N,Cui LX,He W

更新日期：2008-06-01 00:00:00

abstract：:Inflammasomes are important for maintaining intestinal homeostasis, and dysbiosis contributes to the pathology of inflammatory bowel disease (IBD) and increases the risk for colorectal cancer. Inflammasome defects contribute to chronic intestinal inflammation and increase the susceptibility to colitis in mice. However...

journal_title：Cellular & molecular immunology

authors： Ratsimandresy RA,Indramohan M,Dorfleutner A,Stehlik C

更新日期：2017-01-01 00:00:00