The classical and regulatory functions of C1q in immunity and autoimmunity.

abstract：:Previous study showed that aerosolized signal transducer and activator of transcription-1 (STAT1) antisense oligodeoxynucleotide (ASON) inhibited the expression of STAT1 and ICAM-1 mRNA and protein in alveolar macrophages (AMs) and decreased the concentrations of TGF-beta, PDGF and TNF-alpha in bronchioalveolar lavage...

journal_title：Cellular & molecular immunology

authors： Wang WJ,Liao B,Zeng M,Zhu C,Fan XM

更新日期：2009-02-01 00:00:00

abstract：:Circulating monocyte subsets with distinct functions play important roles in hepatitis C virus (HCV) infection. However, the mechanisms have not been well studied. In this study, we analyzed the distributions and phenotypic characteristics of three circulating monocyte subsets-CD14(++)CD16(-), CD14(++)CD16(+) and CD14...

journal_title：Cellular & molecular immunology

authors： Zheng J,Liang H,Xu C,Xu Q,Zhang T,Shen T,Lu F

更新日期：2014-05-01 00:00:00

abstract：:Regulatory B cells (Bregs) are a functionally defined B cell subset, and IL-10 is crucial for the suppressive functions of Bregs. However, little is known regarding how IL-10 production is regulated in B cells. To explore the mechanisms by which IL-10 is regulated in B cells, we used mRNA microarrays to screen for mol...

journal_title：Cellular & molecular immunology

authors： Wei Y,Zhang F,Zhang Y,Wang X,Xing C,Guo J,Zhang H,Suo Z,Li Y,Wang J,Wang R,Cai Z

更新日期：2019-06-01 00:00:00

abstract：:Exercise at regular intervals is assumed to have a positive effect on immune functions. Conversely, after spaceflight and under simulated weightlessness (e.g., bed rest), immune functions can be suppressed. We aimed to assess the effects of simulated weightlessness (Second Berlin BedRest Study; BBR2-2) on immunologica...

journal_title：Cellular & molecular immunology

authors： Hoff P,Belavý DL,Huscher D,Lang A,Hahne M,Kuhlmey AK,Maschmeyer P,Armbrecht G,Fitzner R,Perschel FH,Gaber T,Burmester GR,Straub RH,Felsenberg D,Buttgereit F

更新日期：2015-07-01 00:00:00

abstract：:Recognition of viral dsRNA by Toll-like receptor 3 (TLR3) leads to the induction of downstream antiviral effectors and the innate antiviral immune response. Here, we identified the zinc-finger FYVE domain-containing protein ZFYVE1, a guanylate-binding protein (GBP), as a positive regulator of TLR3-mediated signaling. ...

journal_title：Cellular & molecular immunology

authors： Zhong X,Feng L,Xu WH,Wu X,Ding YD,Zhou Y,Lei CQ,Shu HB

更新日期：2020-07-01 00:00:00

abstract：:The uterus in early pregnancy is a non-lymphoid organ that is enriched in natural killer (NK) cells. Studies to address the role of these abundant human NK cells at the maternal/fetal interface have focused on their response to the major histocompatibility complex (MHC) molecules on fetal trophoblast cells that they c...

journal_title：Cellular & molecular immunology

authors： Rajagopalan S

更新日期：2014-09-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a good model for human multiple sclerosis (MS) research. However, there are some defects in the traditional models. Here, we improved the model by using the human myelin basic protein (MBP) as antigen. EAE was induced by immunization of female Wistar rats with human M...

journal_title：Cellular & molecular immunology

authors： Guo L,Li Y,Lin H,Ji X,Li J,Que L,Zhang Y,Rong Y,Wang J

更新日期：2004-10-01 00:00:00

abstract：:In previous research, chimerical BPI23-Fcgamma1 gene which consisted of human bactericidal/permeability increasing protein (BPI) gene of encoding the functional N terminus (amino acid residues 1 to 199) of human BPI and Fcgamma1 gene of encoding the Fc segment of human immunoglobulin G1 was successfully reconstructed ...

journal_title：Cellular & molecular immunology

authors： Li J,Kong Q,Lv Z,Guan Y,Qiu Y,Li C,Sun M,Liu Z,An Y

更新日期：2008-12-01 00:00:00

abstract：:Inflammasomes are important for maintaining intestinal homeostasis, and dysbiosis contributes to the pathology of inflammatory bowel disease (IBD) and increases the risk for colorectal cancer. Inflammasome defects contribute to chronic intestinal inflammation and increase the susceptibility to colitis in mice. However...

journal_title：Cellular & molecular immunology

authors： Ratsimandresy RA,Indramohan M,Dorfleutner A,Stehlik C

更新日期：2017-01-01 00:00:00

abstract：:The interactions of CD4+ T cells and B cells are fundamental for the generation of protective antibody responses, as well as for the development of harmful autoimmune diseases. Recent studies of human tissues and blood samples have established a new subset of CD4+ B helper T cells named peripheral helper T (Tph) cells...

journal_title：Cellular & molecular immunology

authors： Yoshitomi H,Ueno H

更新日期：2020-08-31 00:00:00

abstract：:The concept of stem cells, their physiological existence, the intricate anatomical localization, the known and the unknown functions, and their exclusive utility for the purpose of regenerative medicine, are all now encompassed within an emergent question, 'how compatible these cells are immunologically?' Indeed, the ...

journal_title：Cellular & molecular immunology

authors： Sujata L,Chaudhuri S

更新日期：2008-04-01 00:00:00

abstract：:Macroautophagy has been implicated in modulating the therapeutic function of mesenchymal stromal cells (MSCs). However, the biological function of chaperone-mediated autophagy (CMA) in MSCs remains elusive. Here, we found that CMA was inhibited in MSCs in response to the proinflammatory cytokines interferon-γ (IFN-γ) ...

journal_title：Cellular & molecular immunology

authors： Zhang J,Huang J,Gu Y,Xue M,Qian F,Wang B,Yang W,Yu H,Wang Q,Guo X,Ding X,Wang J,Jin M,Zhang Y

更新日期：2020-01-03 00:00:00

abstract：:Innate lymphoid cells (ILCs), as an important component of the innate immune system, arise from a common lymphoid progenitor and are located in mucosal barriers and various tissues, including the intestine, skin, lung, and adipose tissue. ILCs are heterogeneous subsets of lymphocytes that have emerging roles in orches...

journal_title：Cellular & molecular immunology

authors： Zhou S,Li Q,Wu H,Lu Q

更新日期：2020-04-01 00:00:00

abstract：:We evaluated the antitumor effect of combined therapy with tegafur/uracil (UFT) plus leucovorin (LV) (UFT/LV) and protein-bound polysaccharide, PSK, in three mouse models of transplantable tumors. UFT/LV showed antitumor effect against Meth A sarcoma, and the antitumor effect was enhanced when PSK given concomitantly....

journal_title：Cellular & molecular immunology

authors： Katoh R,Ooshiro M

更新日期：2007-08-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by B-cell hyperreactivity. The Toll-like receptor 7 (TLR7) signaling pathway is abnormally activated in SLE B cells. CyclinD3 (CCND3) plays an important role in B-cell proliferation, development, and differentiation. Although previous studies fo...

journal_title：Cellular & molecular immunology

authors： Ren D,Liu F,Dong G,You M,Ji J,Huang Y,Hou Y,Fan H

更新日期：2016-11-01 00:00:00

abstract：:CD8(+) natural killer T (NKT) cells from EBV-associated tumour patients are quantitatively and functionally impaired. EBV-induced CD8(+) NKT cells drive syngeneic T cells into a Th1-bias response to suppress EBV-associated malignancies. IL-4-biased CD4(+) NKT cells do not affect either syngeneic T cell cytotoxicity or...

journal_title：Cellular & molecular immunology

authors： Xiao W,Li L,Zhou R,Xiao R,Wang Y,Ji X,Wu M,Wang L,Huang W,Zheng X,Tan X,Chen L,Xiong T,Xiong J,Jin Y,Tan J,He Y

更新日期：2009-10-01 00:00:00

abstract：:Mesenchymal stem/stromal cells (MSCs) possess some characteristics of immune cells, including a pro-inflammatory phenotype, an immunosuppressive phenotype, antibacterial properties and the expression of Toll-like receptor proteins. Here we show that, similar to immune cells, MSCs retain information from danger signals...

journal_title：Cellular & molecular immunology

authors： Liu GY,Liu Y,Lu Y,Qin YR,Di GH,Lei YH,Liu HX,Li YQ,Wu C,Hu XW,Duan HF

更新日期：2016-05-01 00:00:00

abstract：:Activation of the TAK1 signalosome is crucial for mediating the innate immune response to pathogen invasion and is regulated by multiple layers of posttranslational modifications, including ubiquitination, SUMOylation, and phosphorylation; however, the underlying molecular mechanism is not fully understood. In this st...

journal_title：Cellular & molecular immunology

authors： Gu Z,Chen X,Yang W,Qi Y,Yu H,Wang X,Gong Y,Chen Q,Zhong B,Dai L,Qi S,Zhang Z,Zhang H,Hu H

更新日期：2020-11-12 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cellular & molecular immunology

authors： Alim MA,Grujic M,Ackermann PW,Kristiansson P,Blomgran P,Eliasson P,Peterson M,Pejler G

更新日期：2020-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of small non-coding regulatory RNAs, and changes in miRNAs are involved in tumor origin and progression. Studies have shown that miR-20a is overexpressed in human ovarian cancer tissues and that this miRNA enhances long-term cellular proliferation and invasion capabilities. In this study...

journal_title：Cellular & molecular immunology

authors： Xie J,Liu M,Li Y,Nie Y,Mi Q,Zhao S

更新日期：2014-09-01 00:00:00

abstract：:Complications arising from abnormal immune responses are the major causes of mortality and morbidity in diabetic patients. CD4+CD25+T regulatory cells (Tregs) play pivotal roles in controlling immune homeostasis, immunity and tolerance. The effect of hyperglycemia on CD4+CD25+Tregs has not yet been addressed. Here we ...

journal_title：Cellular & molecular immunology

authors： Zhen Y,Sun L,Liu H,Duan K,Zeng C,Zhang L,Jin D,Peng J,Ding W,Zhao Y

更新日期：2012-01-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cellular & molecular immunology

authors： Romanets-Korbut O,Kovalevska LM,Seya T,Sidorenko SP,Horvat B

更新日期：2020-03-01 00:00:00

abstract：:4-1BB (CD137) is a strong enhancer of the proliferation of CD8+ T cells. Since these cells require increased production of energy and biomass to support their proliferation, we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism. We found that treatment with agonistic anti-4-1BB mAb promoted ...

journal_title：Cellular & molecular immunology

authors： Choi BK,Lee DY,Lee DG,Kim YH,Kim SH,Oh HS,Han C,Kwon BS

更新日期：2017-09-01 00:00:00

abstract：:Decidual natural killer (dNK) cells express an array of activation receptors to regulate placental immunity and development during early pregnancy. We investigated the functional character of human dNK cells during the first and second trimester of gestation and the interaction between dNK and trophoblast cells. Altho...

journal_title：Cellular & molecular immunology

authors： Zhang J,Dunk CE,Kwan M,Jones RL,Harris LK,Keating S,Lye SJ

更新日期：2017-02-01 00:00:00

abstract：:A complex process including both the innate and acquired immune responses results in allograft rejection. Some chemokine receptors and their ligands play essential roles not only for leukocyte migration into the graft but also in facilitating dendritic and T cell trafficking between lymph nodes and the transplant in t...

journal_title：Cellular & molecular immunology

authors： Tan J,Zhou G

更新日期：2005-10-01 00:00:00

abstract：:Many monoclonal antibodies (mAbs) have been extensively used in the clinic, such as rituximab to treat lymphoma. However, resistance and non-responsiveness to mAb treatment have been challenging for this line of therapy. Complement is one of the main mediators of antibody-based cancer therapy via the complement-depend...

journal_title：Cellular & molecular immunology

authors： You T,Hu W,Ge X,Shen J,Qin X

更新日期：2011-03-01 00:00:00

abstract：:Recent studies suggest differential roles for CD103+ and CD11bhi lung dendritic cells (LDCs) in host defense against viral and bacterial infections. In this study, we examined the contribution of these LDC subsets in protective immunity to chlamydial lung infection using a Chlamydia muridarum mouse infection model. We...

journal_title：Cellular & molecular immunology

authors： Shekhar S,Peng Y,Wang S,Yang X

更新日期：2018-04-01 00:00:00

abstract：:Patients with primary ciliary dyskinesia (PCD) and cystic fibrosis (CF), two inherited disorders, suffer from recurrent airway infections characterized by persistent bacterial colonization and uncontrollable inflammation. Although present in high counts, neutrophils fail to clear infection in the airways. High levels ...

journal_title：Cellular & molecular immunology

authors： Cockx M,Gouwy M,Van Damme J,Struyf S

更新日期：2018-04-01 00:00:00

abstract：:Genetic mutations in the gene encoding DOCK8 cause an autosomal recessive form of hyper immunoglobulin E syndrome (AR-HIES), referred to as DOCK8 deficiency. DOCK8 deficiency in humans results in the onset of combined immunodeficiency disease (CID), clinically associated with chronic infections with diverse microbial ...

journal_title：Cellular & molecular immunology

authors： Kearney CJ,Randall KL,Oliaro J

更新日期：2017-05-01 00:00:00

abstract：:Neonates are at increased risk of viral encephalopathies that can result in neurological dysfunction, seizures, permanent disability and even death. The neurological damage results from the combined effect of the virus and the immune response it elicits, thus finding tools to facilitate viral clearance from central ne...

journal_title：Cellular & molecular immunology

authors： Ireland DD,Tami C,Pedras-Vasconcelos J,Verthelyi D

更新日期：2017-01-01 00:00:00