Abstract:
:Innate lymphoid cells (ILCs), as an important component of the innate immune system, arise from a common lymphoid progenitor and are located in mucosal barriers and various tissues, including the intestine, skin, lung, and adipose tissue. ILCs are heterogeneous subsets of lymphocytes that have emerging roles in orchestrating immune response and contribute to maintain metabolic homeostasis and regulate tissue inflammation. Currently, more details about the pathways for the development and differentiation of ILCs have largely been elucidated, and cytokine secretion and downstream immune cell responses in disease pathogenesis have been reported. Recent research has identified that several distinct subsets of ILCs at skin barriers are involved in the complex regulatory network in local immunity, potentiating adaptive immunity and the inflammatory response. Of note, additional studies that assess the effects of ILCs are required to better define how ILCs regulate their development and functions and how they interact with other immune cells in autoimmune-related and inflammatory skin disorders. In this review, we will distill recent research progress in ILC biology, abnormal functions and potential pathogenic mechanisms in autoimmune-related skin diseases, including systemic lupus erythematosus (SLE), scleroderma and inflammatory diseases, as well as psoriasis and atopic dermatitis (AD), thereby giving a comprehensive review of the diversity and plasticity of ILCs and their unique functions in disease conditions with the aim to provide new insights into molecular diagnosis and suggest potential value in immunotherapy.
journal_name
Cell Mol Immunoljournal_title
Cellular & molecular immunologyauthors
Zhou S,Li Q,Wu H,Lu Qdoi
10.1038/s41423-020-0399-6subject
Has Abstractpub_date
2020-04-01 00:00:00pages
335-346issue
4eissn
1672-7681issn
2042-0226pii
10.1038/s41423-020-0399-6journal_volume
17pub_type
杂志文章abstract::In addition to serving as molecular chaperones, heat shock proteins (HSPs) have been implicated in autoimmune diseases, antigen presentation and tumor immunity. Extensive work in the last 10 years has also suggested that HSPs such as Hsp60, Hsp70, Hsp90 and gp96, may be potent activators of the innate immune system ca...
journal_title:Cellular & molecular immunology
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doi:
更新日期:2004-08-01 00:00:00
abstract::pR(ST98) is a large and conjugative resistant plasmid (R plasmid) of 98.6 mega-dalton from multi-drug resistant Salmonella typhi (S. typhi), which was classified to incompatibility group C (Inc C). It has been found that pRST98 made its host bacteria not only antibiotic resistant but also more virulent. In this study ...
journal_title:Cellular & molecular immunology
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doi:
更新日期:2005-04-01 00:00:00
abstract::Recombinant human prolactin (rhPRL) was administered to huPBL-SCID mice to determine its effects on human immunologic reconstitution and function. The huPBL-SCID mice were given 10 microg i.p. injection of rhPRL every other day for a total of 10 injections after huPBL were transferred. The results demonstrated that rh...
journal_title:Cellular & molecular immunology
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更新日期:2004-04-01 00:00:00
abstract::The unmethylated CpG DNA can prevent spontaneous apoptosis of B cells. However, the precise mechanisms by which CpG DNA blocks apoptosis remain unclear. In this study, we showed B cell apoptosis was significantly inhibited by addition of CpG DNA. Treatment of CpG DNA could reduce the expression of caspase 3, increase ...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2009.24
更新日期:2009-06-01 00:00:00
abstract::Transplantable experimental tumor models were constructed to study the activities of recombinant human interleukin-15 (rhIL-15) against tumor recurrence and metastasis. The results showed that tumor nodule formation was retarded and tumor growth was inhibited in the subcutaneous tumor model of LA795 lung adenocarcinom...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2008.23
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abstract::Hypoxia is a major characteristic of the tumor microenvironment, and its effects on immune cells are proposed to be important factors for the process of tumor immune escape. It has been reported that hypoxia affects the function of dendritic cells and the antitumor function of T cells. Here we discuss the effects of h...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2009.105
更新日期:2010-01-01 00:00:00
abstract::Interleukin-22 (IL-22) is a recently identified T cell-derived cytokine whose biological significance remains obscure. Previously, we have shown that IL-22 plays a protective role in T cell-mediated hepatitis induced by Concanavalin A (Con A), acting as a survival factor for hepatocytes. In the present paper, we demon...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:
更新日期:2004-02-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/s41423-019-0212-6
更新日期:2019-05-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/cmi.2008.2
更新日期:2008-02-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/s41423-019-0260-y
更新日期:2020-03-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/s41423-020-00550-2
更新日期:2020-11-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2017.26
更新日期:2018-11-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 已发布勘误
doi:10.1038/s41423-019-0332-z
更新日期:2020-03-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2011.7
更新日期:2011-07-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2015.75
更新日期:2016-11-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/cmi.2012.46
更新日期:2013-01-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2008.45
更新日期:2008-10-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/s41423-020-00529-z
更新日期:2020-08-31 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2011.10
更新日期:2011-07-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/cmi.2010.67
更新日期:2011-03-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,收录出版
doi:10.1038/cmi.2009.38
更新日期:2009-08-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/cmi.2010.18
更新日期:2010-05-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:
更新日期:2005-12-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a heterogeneous disease with a poor prognosis and limited markers for predicting patient survival. Because chemokines and chemokine receptors play numerous and integral roles in HCC disease progression, the CXCR4-CXCL12-CXCR7 axis was studied in HCC patients. CXCR4 and CXCR7 expressio...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2014.102
更新日期:2015-07-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2011.37
更新日期:2012-01-01 00:00:00
abstract::To evaluate the balance status of interleukin 18 (IL-18) and interleukin 18 binding protein (IL-18BP) in circulation in patients with lupus nephritis (LN) and primary nephrotic syndrome (PNS), plasma levels as well as mRNA expression in peripheral blood mononuclear cells (PBMCs) of IL-18 and IL-18BP were measured by E...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:
更新日期:2006-08-01 00:00:00
abstract::The Hippo signaling pathway has been established as a key regulator of organ size control, tumor suppression, and tissue regeneration in multiple organisms. Recently, emerging evidence has indicated that Hippo signaling might play an important role in regulating the immune system in both Drosophila and mammals. In par...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/s41423-018-0007-1
更新日期:2018-12-01 00:00:00
abstract::In contrast to the previous belief that autoreactive B cells are eliminated from the normal repertoire of B cells, many autoreactive B cells actually escape clonal deletion and develop into mature B cells. These autoreactive B cells in healthy individuals perform some beneficial functions in the host and are homeostat...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/s41423-020-0445-4
更新日期:2020-06-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2015.58
更新日期:2016-11-01 00:00:00
abstract::Neonates are at increased risk of viral encephalopathies that can result in neurological dysfunction, seizures, permanent disability and even death. The neurological damage results from the combined effect of the virus and the immune response it elicits, thus finding tools to facilitate viral clearance from central ne...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2016.41
更新日期:2017-01-01 00:00:00