Multifunctional immune responses of HMBPP-specific Vγ2Vδ2 T cells in M. tuberculosis and other infections.

abstract：:Innate lymphoid cells (ILCs), including natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer (LTi) cells, comprise the first line of innate immune defense against pathogens and tumors. Over the past decade, accumulating evidence has demonstrated immunological memory in ILC subsets: for example, ...

journal_title：Cellular & molecular immunology

authors： Wang X,Peng H,Tian Z

更新日期：2019-05-01 00:00:00

abstract：:Previously, we demonstrated that macrophages from thrombospondin 1 (TSP1)-deficient mice have a reduced inflammatory phenotype, suggesting that TSP1 plays a role in macrophage activation. In this study, we determined how TSP1 regulates macrophage function. We found that recombinant or purified platelet human TSP1 trea...

journal_title：Cellular & molecular immunology

authors： Li Y,Qi X,Tong X,Wang S

更新日期：2013-11-01 00:00:00

abstract：:CD8(+) natural killer T (NKT) cells from EBV-associated tumour patients are quantitatively and functionally impaired. EBV-induced CD8(+) NKT cells drive syngeneic T cells into a Th1-bias response to suppress EBV-associated malignancies. IL-4-biased CD4(+) NKT cells do not affect either syngeneic T cell cytotoxicity or...

journal_title：Cellular & molecular immunology

authors： Xiao W,Li L,Zhou R,Xiao R,Wang Y,Ji X,Wu M,Wang L,Huang W,Zheng X,Tan X,Chen L,Xiong T,Xiong J,Jin Y,Tan J,He Y

更新日期：2009-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of small non-coding regulatory RNAs, and changes in miRNAs are involved in tumor origin and progression. Studies have shown that miR-20a is overexpressed in human ovarian cancer tissues and that this miRNA enhances long-term cellular proliferation and invasion capabilities. In this study...

journal_title：Cellular & molecular immunology

authors： Xie J,Liu M,Li Y,Nie Y,Mi Q,Zhao S

更新日期：2014-09-01 00:00:00

abstract：:Activation of the TAK1 signalosome is crucial for mediating the innate immune response to pathogen invasion and is regulated by multiple layers of posttranslational modifications, including ubiquitination, SUMOylation, and phosphorylation; however, the underlying molecular mechanism is not fully understood. In this st...

journal_title：Cellular & molecular immunology

authors： Gu Z,Chen X,Yang W,Qi Y,Yu H,Wang X,Gong Y,Chen Q,Zhong B,Dai L,Qi S,Zhang Z,Zhang H,Hu H

更新日期：2020-11-12 00:00:00

abstract：:To construct cDNA library of nasopharyngeal carcinoma (NPC) and obtain the NPC associated or specific antigens from it, we used a powerful new method to identify the antigens eliciting humoral immune response, which is SEREX (serological identification of antigen by recombinant cDNA expression library). Autologous ser...

journal_title：Cellular & molecular immunology

authors： Shu J,He XJ,Li GC

更新日期：2006-02-01 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19), caused by the novel human coronavirus SARS-CoV-2, is currently a major threat to public health worldwide. The viral spike protein binds the host receptor angiotensin-converting enzyme 2 (ACE2) via the receptor-binding domain (RBD), and thus is believed to be a major target to block...

journal_title：Cellular & molecular immunology

authors： Yi C,Sun X,Ye J,Ding L,Liu M,Yang Z,Lu X,Zhang Y,Ma L,Gu W,Qu A,Xu J,Shi Z,Ling Z,Sun B

更新日期：2020-06-01 00:00:00

abstract：:The type 2 immune response is critical for host defense against large parasites such as helminths. On the other hand, dysregulation of the type 2 immune response may cause immunopathological conditions, including asthma, atopic dermatitis, rhinitis, and anaphylaxis. Thus, a balanced type 2 immune response must be achi...

journal_title：Cellular & molecular immunology

authors： Gurram RK,Zhu J

更新日期：2019-03-01 00:00:00

abstract：:Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules for naive T cell activation and expansion, dendritic cells are thought to also provide signals for the differentiation of CD4+ T ce...

journal_title：Cellular & molecular immunology

authors： Hilligan KL,Ronchese F

更新日期：2020-06-01 00:00:00

abstract：:Recognition of viral dsRNA by Toll-like receptor 3 (TLR3) leads to the induction of downstream antiviral effectors and the innate antiviral immune response. Here, we identified the zinc-finger FYVE domain-containing protein ZFYVE1, a guanylate-binding protein (GBP), as a positive regulator of TLR3-mediated signaling. ...

journal_title：Cellular & molecular immunology

authors： Zhong X,Feng L,Xu WH,Wu X,Ding YD,Zhou Y,Lei CQ,Shu HB

更新日期：2020-07-01 00:00:00

abstract：:In contrast to the previous belief that autoreactive B cells are eliminated from the normal repertoire of B cells, many autoreactive B cells actually escape clonal deletion and develop into mature B cells. These autoreactive B cells in healthy individuals perform some beneficial functions in the host and are homeostat...

journal_title：Cellular & molecular immunology

authors： Lee S,Ko Y,Kim TJ

更新日期：2020-06-01 00:00:00

abstract：:The outcome of hepatitis B viral (HBV) infection is determined by the complex interactions between replicating HBV and the immune system. While the role of the adaptive immune system in the resolution of HBV infection has been studied extensively, the contribution of innate immune mechanisms remains to be defined. Her...

journal_title：Cellular & molecular immunology

authors： Ma Z,Liu J,Wu W,Zhang E,Zhang X,Li Q,Zelinskyy G,Buer J,Dittmer U,Kirschning CJ,Lu M

更新日期：2017-12-01 00:00:00

abstract：:Many monoclonal antibodies (mAbs) have been extensively used in the clinic, such as rituximab to treat lymphoma. However, resistance and non-responsiveness to mAb treatment have been challenging for this line of therapy. Complement is one of the main mediators of antibody-based cancer therapy via the complement-depend...

journal_title：Cellular & molecular immunology

authors： You T,Hu W,Ge X,Shen J,Qin X

更新日期：2011-03-01 00:00:00

abstract：:Mesenchymal stem/stromal cells (MSCs) possess some characteristics of immune cells, including a pro-inflammatory phenotype, an immunosuppressive phenotype, antibacterial properties and the expression of Toll-like receptor proteins. Here we show that, similar to immune cells, MSCs retain information from danger signals...

journal_title：Cellular & molecular immunology

authors： Liu GY,Liu Y,Lu Y,Qin YR,Di GH,Lei YH,Liu HX,Li YQ,Wu C,Hu XW,Duan HF

更新日期：2016-05-01 00:00:00

abstract：:The T-cell-mediated immune response is implicated in many clinical hepatic injuries, such as autoimmune hepatitis and acute virus hepatitis. CD24 is widely expressed by different immune cells and plays an important role in the pathogenesis of many autoimmune diseases. However, the role of CD24 in T-cell-mediated liver...

journal_title：Cellular & molecular immunology

authors： Zheng C,Yin S,Yang Y,Yu Y,Xie X

更新日期：2018-03-01 00:00:00

abstract：:Intestinal stem cells may have important roles in the maintenance of epithelial integrity during tissue repair. Alemtuzumab is a humanized anti-CD52 lymphocytic antibody that is increasingly being used to induce immunosuppression; intestinal barrier function is impaired during treatment with alemtuzumab. We investigat...

journal_title：Cellular & molecular immunology

authors： Li Q,Zhang Q,Wang C,Jiang S,Li N,Li J

更新日期：2011-07-01 00:00:00

abstract：:Inflammasomes are multi-protein signaling complexes that trigger the activation of inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome complexes, the NLRP3 inflammasome is best characterized and has been linked with various human autoinflammatory and autoimmune diseases. Thus, the NL...

journal_title：Cellular & molecular immunology

authors： Jo EK,Kim JK,Shin DM,Sasakawa C

更新日期：2016-03-01 00:00:00

abstract：:Kupffer cells (KCs), the liver resident macrophages accounting for 80-90% of the total population of fixed tissue macrophages in the body, not only play a key role in host defense via removing particulate materials from the portal circulation, but may also contribute to the pathogenesis of various liver diseases. We h...

journal_title：Cellular & molecular immunology

authors： Miller AM,Zhang JX

更新日期：2009-12-01 00:00:00

abstract：:It is well-documented that alcohol drinking together with hepatitis viral infection accelerates liver injury; however the underlying mechanisms remain unknown. In this paper, we demonstrated that primary hepatocytes from transgenic mice overexpressing hepatitis B virus X protein (HBX) were more susceptible to ethanol-...

journal_title：Cellular & molecular immunology

authors： Kim WH,Hong F,Jaruga B,Zhang ZS,Fan SJ,Liang TJ,Gao B

更新日期：2005-02-01 00:00:00

abstract：:Infection with human immunodeficiency virus (HIV) disrupts the balance among γδ T cell subsets, with increasing Vδ1+ cells and substantial depletion of circulating Vδ2+ cells. Depletion is an indirect effect of HIV in CD4-negative Vδ2 cells, but is specific for phosphoantigen-responsive subpopulations identified by th...

journal_title：Cellular & molecular immunology

authors： Li H,Chaudhry S,Poonia B,Shao Y,Pauza CD

更新日期：2013-01-01 00:00:00

abstract：:Previous studies have shown that the CC chemokine receptor CCR5 is downregulated on monocyte/macrophage (MO/Mphi) surfaces in head and neck squamous cell carcinoma (HNSCC) patients (stage IIIB). Ligands (RANTES, MIP-1alpha and MIP-1beta) of this chemokine receptor were also secreted in lesser quantity from MO/Mphi of ...

journal_title：Cellular & molecular immunology

authors： Chakraborty K,Bose A,Chakraborty T,Sarkar K,Goswami S,Pal S,Baral R

更新日期：2010-09-01 00:00:00

abstract：:Dendritic cells (DCs) are the most potent professional antigen-presenting cells, and capable of stimulating naïve T cells and driving primary immune responses. DCs are poised to capture antigen, migrate to draining lymphoid organs, and after a process of maturation, select antigen-specific lymphocytes to which they pr...

journal_title：Cellular & molecular immunology

authors： Sun K,Wang L,Zhang Y

更新日期：2006-06-01 00:00:00

abstract：:We generated a human dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN) transgenic mouse in which renal tubular epithelial cells expressed DC-SIGN. The transgenic mice were infected with Candida albicans intravenously to study how DC-SIGN expression affected the pathogenesis of systemic candidiasis. We dis...

journal_title：Cellular & molecular immunology

authors： Chen WY,Wu SY,Lin TC,Lin SL,Wu-Hsieh BA

更新日期：2019-03-01 00:00:00

abstract：:Organ transplantation is an effective therapeutic tool for treating many terminal diseases. However, one of the biggest challenges of transplantation is determining how to achieve the long-term survival of the allogeneic or xenogeneic transplant by, for example, preventing transplant rejection. In the current study, C...

journal_title：Cellular & molecular immunology

authors： Zhao X,Zhang K,Daniel P,Wisbrun N,Fuchs H,Fan H

更新日期：2019-06-01 00:00:00

abstract：:MiR-122 is one of the non-coding RNAs which showed its effects on the lipo-metablism, virus infection and HCC forming through regulation of liver gene expression. Its eukaryotic expression vector was constructed by using pSuper which was widely applied in the siRNA expression. The precursor of human miR-122 gene was a...

journal_title：Cellular & molecular immunology

authors： Chen S,Ni M,Yu B,Lv T,Lu M,Gong F

更新日期：2007-12-01 00:00:00

abstract：:Bispecific antibodies (bsAbs) refer to a large family of molecules that recognize two different epitopes or antigens. Although a series of challenges, especially immunogenicity and chain mispairing issues, once hindered the development of bsAbs, they have been gradually overcome with the help of rapidly developing tec...

journal_title：Cellular & molecular immunology

authors： Li H,Er Saw P,Song E

更新日期：2020-05-01 00:00:00

abstract：:The Hippo signaling pathway has been established as a key regulator of organ size control, tumor suppression, and tissue regeneration in multiple organisms. Recently, emerging evidence has indicated that Hippo signaling might play an important role in regulating the immune system in both Drosophila and mammals. In par...

journal_title：Cellular & molecular immunology

authors： Hong L,Li X,Zhou D,Geng J,Chen L

更新日期：2018-12-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is an important factor in the induction of colon cancer, but its mechanism is unclear. Colitis and colitis-associated colorectal cancer (CAC) models induced using both dextran sulfate sodium (DSS) and the azoxymethane/DSS protocol were established in wild-type (WT) and CTRP4 transgenic...

journal_title：Cellular & molecular immunology

authors： Luo Y,Wu X,Ma Z,Tan W,Wang L,Na D,Zhang G,Yin A,Huang H,Xia D,Zhang Y,Shi X,Wang L

更新日期：2016-09-01 00:00:00

abstract：:Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers, the majority of patients with solid tumors do not respond well, but the underlying reason remains unclear. Here, we studied ovarian cancer (OvCa), a tumor type generally resistant to current immunotherapies, to investigate PD-1-inde...

journal_title：Cellular & molecular immunology

authors： Cai D,Li J,Liu D,Hong S,Qiao Q,Sun Q,Li P,Lyu N,Sun T,Xie S,Guo L,Ni L,Jin L,Dong C

更新日期：2020-03-01 00:00:00

abstract：:Regulatory B cells (Bregs) are a functionally defined B cell subset, and IL-10 is crucial for the suppressive functions of Bregs. However, little is known regarding how IL-10 production is regulated in B cells. To explore the mechanisms by which IL-10 is regulated in B cells, we used mRNA microarrays to screen for mol...

journal_title：Cellular & molecular immunology

authors： Wei Y,Zhang F,Zhang Y,Wang X,Xing C,Guo J,Zhang H,Suo Z,Li Y,Wang J,Wang R,Cai Z

更新日期：2019-06-01 00:00:00