Thrombospondin 1 activates the macrophage Toll-like receptor 4 pathway.


:Previously, we demonstrated that macrophages from thrombospondin 1 (TSP1)-deficient mice have a reduced inflammatory phenotype, suggesting that TSP1 plays a role in macrophage activation. In this study, we determined how TSP1 regulates macrophage function. We found that recombinant or purified platelet human TSP1 treatment stimulated tumor-necrosis factor (TNF)-α expression in bone marrow-derived macrophages in a time- and dose-dependent manner. Toll-like receptor 4 (TLR4) expression (at the mRNA and protein levels) and nuclear factor-kappaB (NF-κB) activity were also stimulated by TSP1 treatment. The TSP1-mediated increase in TNF-α production was abolished in TLR4-deficient macrophages, suggesting that TSP1 activates macrophages through a TLR4-dependent pathway. TSP1 also stimulated TLR4 activation in macrophages in vivo. Furthermore, TSP1-mediated macrophage activation was attenuated by using a peptide or an antibody to block the association between TSP1 and CD36. Taken together, these data suggest that the stimulation of the macrophage TLR4 pathway by TSP1 is partially mediated by the interaction of TSP1 with its receptor, CD36.


Cell Mol Immunol


Li Y,Qi X,Tong X,Wang S




Has Abstract


2013-11-01 00:00:00














  • HLA-G-mediated NK cell senescence promotes vascular remodeling: implications for reproduction.

    abstract::The uterus in early pregnancy is a non-lymphoid organ that is enriched in natural killer (NK) cells. Studies to address the role of these abundant human NK cells at the maternal/fetal interface have focused on their response to the major histocompatibility complex (MHC) molecules on fetal trophoblast cells that they c...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审


    authors: Rajagopalan S

    更新日期:2014-09-01 00:00:00

  • Hepatitis B virus X protein sensitizes primary mouse hepatocytes to ethanol- and TNF-alpha-induced apoptosis by a caspase-3-dependent mechanism.

    abstract::It is well-documented that alcohol drinking together with hepatitis viral infection accelerates liver injury; however the underlying mechanisms remain unknown. In this paper, we demonstrated that primary hepatocytes from transgenic mice overexpressing hepatitis B virus X protein (HBX) were more susceptible to ethanol-...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章


    authors: Kim WH,Hong F,Jaruga B,Zhang ZS,Fan SJ,Liang TJ,Gao B

    更新日期:2005-02-01 00:00:00

  • TNF-alpha induces transient resistance to Fas-induced apoptosis in eosinophilic acute myeloid leukemia cells.

    abstract::Tumor necrosis factor alpha (TNF-alpha) has been recognized as an activator of nuclear factor kappaB (NF-kappaB), a factor implicated in the protection of many cell types from apoptosis. We and others have presented evidence to suggest that Fas-induced apoptosis may be an important aspect of the resolution of inflamma...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章


    authors: Qin Y,Auh S,Blokh L,Long C,Gagnon I,Hamann KJ

    更新日期:2007-02-01 00:00:00

  • A MyD88-JAK1-STAT1 complex directly induces SOCS-1 expression in macrophages infected with Group A Streptococcus.

    abstract::Some pathogens can use host suppressor of cytokine signaling 1 (SOCS-1), an important negative-feedback molecule, as the main mode of immune evasion. Here we found that group A Streptococcus (GAS) is capable of inducing SOCS-1 expression in RAW264.7 and BMDM macrophages. IFN-β plays a role in GAS-induced SOCS-1 expres...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章


    authors: Wu J,Ma C,Wang H,Wu S,Xue G,Shi X,Song Z,Wei L

    更新日期:2015-05-01 00:00:00

  • Human prolactin improves engraftment and reconstitution of human peripheral blood lymphocytes in SCID mice.

    abstract::Recombinant human prolactin (rhPRL) was administered to huPBL-SCID mice to determine its effects on human immunologic reconstitution and function. The huPBL-SCID mice were given 10 microg i.p. injection of rhPRL every other day for a total of 10 injections after huPBL were transferred. The results demonstrated that rh...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章


    authors: Sun R,Zhang J,Zhang C,Zhang J,Liang S,Sun A,Wang J,Tian Z

    更新日期:2004-04-01 00:00:00

  • Post-transcriptional regulator Rbm47 elevates IL-10 production and promotes the immunosuppression of B cells.

    abstract::Regulatory B cells (Bregs) are a functionally defined B cell subset, and IL-10 is crucial for the suppressive functions of Bregs. However, little is known regarding how IL-10 production is regulated in B cells. To explore the mechanisms by which IL-10 is regulated in B cells, we used mRNA microarrays to screen for mol...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章


    authors: Wei Y,Zhang F,Zhang Y,Wang X,Xing C,Guo J,Zhang H,Suo Z,Li Y,Wang J,Wang R,Cai Z

    更新日期:2019-06-01 00:00:00

  • Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy.

    abstract::Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers, the majority of patients with solid tumors do not respond well, but the underlying reason remains unclear. Here, we studied ovarian cancer (OvCa), a tumor type generally resistant to current immunotherapies, to investigate PD-1-inde...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章


    authors: Cai D,Li J,Liu D,Hong S,Qiao Q,Sun Q,Li P,Lyu N,Sun T,Xie S,Guo L,Ni L,Jin L,Dong C

    更新日期:2020-03-01 00:00:00

  • DOCK8 regulates signal transduction events to control immunity.

    abstract::Genetic mutations in the gene encoding DOCK8 cause an autosomal recessive form of hyper immunoglobulin E syndrome (AR-HIES), referred to as DOCK8 deficiency. DOCK8 deficiency in humans results in the onset of combined immunodeficiency disease (CID), clinically associated with chronic infections with diverse microbial ...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审


    authors: Kearney CJ,Randall KL,Oliaro J

    更新日期:2017-05-01 00:00:00

  • Cytomegalovirus immune evasion by perturbation of endosomal trafficking.

    abstract::Cytomegaloviruses (CMVs), members of the herpesvirus family, have evolved a variety of mechanisms to evade the immune response to survive in infected hosts and to establish latent infection. They effectively hide infected cells from the effector mechanisms of adaptive immunity by eliminating cellular proteins (major h...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审


    authors: Lučin P,Mahmutefendić H,Blagojević Zagorac G,Ilić Tomaš M

    更新日期:2015-03-01 00:00:00

  • Apoptotic cell administration enhances pancreatic islet engraftment by induction of regulatory T cells and tolerogenic dendritic cells.

    abstract::Apoptotic cell transfer has been found to be able to facilitate engraftment of allograft. However, the underlying mechanisms remain to be fully understood. Here we demonstrate that intravenous administration of donor apoptotic splenocytes can promote pancreatic islet engraftment by inducing generation of tolerogenic d...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章


    authors: Wu C,Zhang Y,Jiang Y,Wang Q,Long Y,Wang C,Cao X,Chen G

    更新日期:2013-09-01 00:00:00

  • An unbalanced PD-L1/CD86 ratio in CD14(++)CD16(+) monocytes is correlated with HCV viremia during chronic HCV infection.

    abstract::Circulating monocyte subsets with distinct functions play important roles in hepatitis C virus (HCV) infection. However, the mechanisms have not been well studied. In this study, we analyzed the distributions and phenotypic characteristics of three circulating monocyte subsets-CD14(++)CD16(-), CD14(++)CD16(+) and CD14...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章


    authors: Zheng J,Liang H,Xu C,Xu Q,Zhang T,Shen T,Lu F

    更新日期:2014-05-01 00:00:00

  • RGD-FasL induces apoptosis in hepatocellular carcinoma.

    abstract::Despite impressive results obtained in animal models, the clinical use of Fas ligand (FasL) as an anticancer drug is limited by severe toxicity. Systemic toxicity of death ligands may be prevented by using genes encoding membrane-bound death ligands and by targeted transgene expression through either targeted transduc...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,收录出版


    authors: Liu Z,Wang J,Yin P,Qiu J,Liu R,Li W,Fan X,Cheng X,Chen C,Zhang J,Zhuang G

    更新日期:2009-08-01 00:00:00

  • CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not.

    abstract::Hepatocellular carcinoma (HCC) is a heterogeneous disease with a poor prognosis and limited markers for predicting patient survival. Because chemokines and chemokine receptors play numerous and integral roles in HCC disease progression, the CXCR4-CXCL12-CXCR7 axis was studied in HCC patients. CXCR4 and CXCR7 expressio...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章


    authors: Neve Polimeno M,Ierano C,D'Alterio C,Simona Losito N,Napolitano M,Portella L,Scognamiglio G,Tatangelo F,Maria Trotta A,Curley S,Costantini S,Liuzzi R,Izzo F,Scala S

    更新日期:2015-07-01 00:00:00

  • Interleukin-1 beta induces the expression and production of stem cell factor by epithelial cells: crucial involvement of the PI-3K/mTOR pathway and HIF-1 transcription complex.

    abstract::Potential crosslinks between inflammation and leukaemia have been discussed for some time, but experimental evidence to support this dogma is scarce. In particular, it is important to understand the mechanisms responsible for potential upregulation of proto-oncogenic growth factor expressions by inflammatory mediators...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章


    authors: Wyszynski RW,Gibbs BF,Varani L,Iannotta D,Sumbayev VV

    更新日期:2016-01-01 00:00:00

  • Homeostasis and regulation of autoreactive B cells.

    abstract::In contrast to the previous belief that autoreactive B cells are eliminated from the normal repertoire of B cells, many autoreactive B cells actually escape clonal deletion and develop into mature B cells. These autoreactive B cells in healthy individuals perform some beneficial functions in the host and are homeostat...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审


    authors: Lee S,Ko Y,Kim TJ

    更新日期:2020-06-01 00:00:00

  • Role of Hippo signaling in regulating immunity.

    abstract::The Hippo signaling pathway has been established as a key regulator of organ size control, tumor suppression, and tissue regeneration in multiple organisms. Recently, emerging evidence has indicated that Hippo signaling might play an important role in regulating the immune system in both Drosophila and mammals. In par...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审


    authors: Hong L,Li X,Zhou D,Geng J,Chen L

    更新日期:2018-12-01 00:00:00

  • Restoration of dysregulated CC chemokine signaling for monocyte/macrophage chemotaxis in head and neck squamous cell carcinoma patients by neem leaf glycoprotein maximizes tumor cell cytotoxicity.

    abstract::Previous studies have shown that the CC chemokine receptor CCR5 is downregulated on monocyte/macrophage (MO/Mphi) surfaces in head and neck squamous cell carcinoma (HNSCC) patients (stage IIIB). Ligands (RANTES, MIP-1alpha and MIP-1beta) of this chemokine receptor were also secreted in lesser quantity from MO/Mphi of ...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章


    authors: Chakraborty K,Bose A,Chakraborty T,Sarkar K,Goswami S,Pal S,Baral R

    更新日期:2010-09-01 00:00:00

  • Epigenetics in modulating immune functions of stromal and immune cells in the tumor microenvironment.

    abstract::Epigenetic regulation of gene expression in cancer cells has been extensively studied in recent decades, resulting in the FDA approval of multiple epigenetic agents for treating different cancer types. Recent studies have revealed novel roles of epigenetic dysregulation in altering the phenotypes of immune cells and t...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审


    authors: Pan X,Zheng L

    更新日期:2020-09-01 00:00:00

  • 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8+ T cell proliferation.

    abstract::4-1BB (CD137) is a strong enhancer of the proliferation of CD8+ T cells. Since these cells require increased production of energy and biomass to support their proliferation, we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism. We found that treatment with agonistic anti-4-1BB mAb promoted ...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章


    authors: Choi BK,Lee DY,Lee DG,Kim YH,Kim SH,Oh HS,Han C,Kwon BS

    更新日期:2017-09-01 00:00:00

  • T cell vaccination as an immunotherapy for autoimmune diseases.

    abstract::Immunization with inactivated autoreactive T cells (T cell vaccination) selected from individual's own T cell repertoire provides a unique in vivo setting for testing immune regulation that is known to involve interactions of a variety of related surface molecules (1). It induces regulatory immune responses that close...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审


    authors: Zhang J

    更新日期:2004-10-01 00:00:00

  • Dust mite allergen-specific immunotherapy increases IL4 DNA methylation and induces Der p-specific T cell tolerance in children with allergic asthma.

    abstract::Allergen-specific immunotherapy (allergen-SIT) is a highly effective treatment for children with allergic asthma (AA), an immune-mediated chronic disease leading to bronchial muscle hypertrophy and airway obstruction in response to specific allergens. T helper cells and secreted cytokines play important roles in the p...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章


    authors: Wang CM,Chang CB,Chan MW,Wen ZH,Wu SF

    更新日期:2018-11-01 00:00:00

  • The complement system in liver diseases.

    abstract::The complement system plays an important role in mediating both acquired and innate responses to defend against microbial infection, and in disposing immunoglobins and apoptotic cells. The liver (mainly hepatocytes) is responsible for biosynthesis of about 80-90% of plasma complement components and expresses a variety...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审


    authors: Qin X,Gao B

    更新日期:2006-10-01 00:00:00

  • A compromised specific humoral immune response against the SARS-CoV-2 receptor-binding domain is related to viral persistence and periodic shedding in the gastrointestinal tract.

    abstract::Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been redetected after discharge in some coronavirus disease 2019 (COVID-19) patients. The reason for the recurrent positivity of the test and the potential public health concern due to this occurrence are still unknown. Here, we analyzed the viral data a...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章


    authors: Hu F,Chen F,Ou Z,Fan Q,Tan X,Wang Y,Pan Y,Ke B,Li L,Guan Y,Mo X,Wang J,Wang J,Luo C,Wen X,Li M,Ren P,Ke C,Li J,Lei C,Tang X,Li F

    更新日期:2020-11-01 00:00:00

  • Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties.

    abstract::Diabetes-associated periodontitis (DP) aggravates diabetic complications and increases mortality from diabetes. DP is caused by diabetes-enhanced host immune-inflammatory responses to bacterial insult. In this study, we found that persistently elevated CCL2 levels in combination with proinflammatory monocyte infiltrat...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章


    authors: Shen Z,Kuang S,Zhang M,Huang X,Chen J,Guan M,Qin W,Xu HHK,Lin Z

    更新日期:2020-07-16 00:00:00

  • Depletion and dysfunction of Vγ2Vδ2 T cells in HIV disease: mechanisms, impacts and therapeutic implications.

    abstract::Infection with human immunodeficiency virus (HIV) disrupts the balance among γδ T cell subsets, with increasing Vδ1+ cells and substantial depletion of circulating Vδ2+ cells. Depletion is an indirect effect of HIV in CD4-negative Vδ2 cells, but is specific for phosphoantigen-responsive subpopulations identified by th...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审


    authors: Li H,Chaudhry S,Poonia B,Shao Y,Pauza CD

    更新日期:2013-01-01 00:00:00

  • Identification and characterization of peptides mimicking the epitopes of metalloprotease of Schistosoma japonicum.

    abstract::In an attempt to isolate and characterize peptides mimicking epitopes of metalloprotease and explore their immunological protection against Schistosoma japonicum (S. japonicum), polyclonal anti-metalloprotease sera was prepared to screen a 12-mer random peptide library to isolate phages binding specially to antisera I...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章


    authors: Tang L,Chen Y,Wang L,Zhang S,Zeng X,Yi X

    更新日期:2005-06-01 00:00:00

  • The soluble glycoprotein NMB (GPNMB) produced by macrophages induces cancer stemness and metastasis via CD44 and IL-33.

    abstract::In cancer, myeloid cells have tumor-supporting roles. We reported that the protein GPNMB (glycoprotein nonmetastatic B) was profoundly upregulated in macrophages interacting with tumor cells. Here, using mouse tumor models, we show that macrophage-derived soluble GPNMB increases tumor growth and metastasis in Gpnmb-mu...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章


    authors: Liguori M,Digifico E,Vacchini A,Avigni R,Colombo FS,Borroni EM,Farina FM,Milanesi S,Castagna A,Mannarino L,Craparotta I,Marchini S,Erba E,Panini N,Tamborini M,Rimoldi V,Allavena P,Belgiovine C

    更新日期:2020-07-29 00:00:00

  • EBV-induced human CD8(+) NKT cells synergise CD4(+) NKT cells suppressing EBV-associated tumours upon induction of Th1-bias.

    abstract::CD8(+) natural killer T (NKT) cells from EBV-associated tumour patients are quantitatively and functionally impaired. EBV-induced CD8(+) NKT cells drive syngeneic T cells into a Th1-bias response to suppress EBV-associated malignancies. IL-4-biased CD4(+) NKT cells do not affect either syngeneic T cell cytotoxicity or...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章


    authors: Xiao W,Li L,Zhou R,Xiao R,Wang Y,Ji X,Wu M,Wang L,Huang W,Zheng X,Tan X,Chen L,Xiong T,Xiong J,Jin Y,Tan J,He Y

    更新日期:2009-10-01 00:00:00

  • The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway.

    abstract::Inflammasomes are important for maintaining intestinal homeostasis, and dysbiosis contributes to the pathology of inflammatory bowel disease (IBD) and increases the risk for colorectal cancer. Inflammasome defects contribute to chronic intestinal inflammation and increase the susceptibility to colitis in mice. However...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章


    authors: Ratsimandresy RA,Indramohan M,Dorfleutner A,Stehlik C

    更新日期:2017-01-01 00:00:00

  • Transcriptional crosstalk between nuclear receptors and cytokine signal transduction pathways in immunity.

    abstract::The nuclear receptor superfamily and the transcriptional factors associated with cytokines are inherently different families of signaling molecules and activate gene transcription by binding to their respective responsive element. However, it has become increasingly clear from our works and others that nuclear recepto...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审


    authors: Wang L,Zhang X,Farrar WL,Yang X

    更新日期:2004-12-01 00:00:00