Abstract:
:The Hippo signaling pathway has been established as a key regulator of organ size control, tumor suppression, and tissue regeneration in multiple organisms. Recently, emerging evidence has indicated that Hippo signaling might play an important role in regulating the immune system in both Drosophila and mammals. In particular, patients bearing a loss-of-function mutation of MST1 are reported to have an autosomal recessive primary immunodeficiency syndrome. MST1/2 kinases, the mammalian orthologs of Drosophila Hippo, may activate the non-canonical Hippo signaling pathway via MOB1A/B and/or NDR1/2 or cross-talk with other essential signaling pathways to regulate both innate and adaptive immunity. In this review, we present and discuss recent findings of cellular mechanisms/functions of Hippo signaling in the innate immunity in Drosophila and in mammals, T cell immunity, as well as the implications of Hippo signaling for tumor immunity.
journal_name
Cell Mol Immunoljournal_title
Cellular & molecular immunologyauthors
Hong L,Li X,Zhou D,Geng J,Chen Ldoi
10.1038/s41423-018-0007-1subject
Has Abstractpub_date
2018-12-01 00:00:00pages
1003-1009issue
12eissn
1672-7681issn
2042-0226pii
10.1038/s41423-018-0007-1journal_volume
15pub_type
杂志文章,评审abstract::Induction of osteopontin (OPN), a well-known pro-inflammatory molecule, has been observed in acetaminophen (APAP)-induced hepatotoxicity. However, the precise cell source for OPN induction and its role during APAP-induced hepatotoxicity has not been fully explored. By employing a hepatotoxic mouse model induced by APA...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/s41423-018-0033-z
更新日期:2019-05-01 00:00:00
abstract::The liver is an important immunological organ that controls systemic tolerance. The liver harbors professional and unconventional antigen-presenting cells that are crucial for tolerance induction and maintenance. Orchestrating the immune response in homeostasis depends on a healthy and well-toned immunological liver m...
journal_title:Cellular & molecular immunology
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doi:10.1038/s41423-020-00568-6
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abstract::Decidual natural killer (dNK) cells express an array of activation receptors to regulate placental immunity and development during early pregnancy. We investigated the functional character of human dNK cells during the first and second trimester of gestation and the interaction between dNK and trophoblast cells. Altho...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/cmi.2017.118
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2013.16
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abstract::The T-cell-mediated immune response is implicated in many clinical hepatic injuries, such as autoimmune hepatitis and acute virus hepatitis. CD24 is widely expressed by different immune cells and plays an important role in the pathogenesis of many autoimmune diseases. However, the role of CD24 in T-cell-mediated liver...
journal_title:Cellular & molecular immunology
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doi:10.1038/cmi.2016.57
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journal_title:Cellular & molecular immunology
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doi:10.1038/s41423-018-0161-5
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2013.70
更新日期:2014-05-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
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journal_title:Cellular & molecular immunology
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/cmi.2010.67
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/s41423-020-00557-9
更新日期:2020-10-15 00:00:00
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journal_title:Cellular & molecular immunology
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doi:
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2017.26
更新日期:2018-11-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/s41423-018-0192-y
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/s41423-020-0465-0
更新日期:2020-06-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/s41423-018-0184-y
更新日期:2019-10-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Cellular & molecular immunology
pub_type: 已发布勘误
doi:10.1038/s41423-020-00543-1
更新日期:2020-10-01 00:00:00
abstract::Coronavirus disease 2019 (COVID-19), caused by the novel human coronavirus SARS-CoV-2, is currently a major threat to public health worldwide. The viral spike protein binds the host receptor angiotensin-converting enzyme 2 (ACE2) via the receptor-binding domain (RBD), and thus is believed to be a major target to block...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2009.117
更新日期:2010-03-01 00:00:00
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journal_title:Cellular & molecular immunology
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doi:10.1038/cmi.2014.102
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:
更新日期:2005-12-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
abstract::The human immunodeficiency virus-1 (HIV-1) envelope protein gp120 is the major contributor to the pathogenesis of HIV-associated neurocognitive disorder (HAND). Neuroinflammation plays a pivotal role in gp120-induced neuropathology, but how gp120 triggers neuroinflammatory processes and subsequent neuronal death remai...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/s41423-019-0260-y
更新日期:2020-03-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2008.55
更新日期:2008-12-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2015.70
更新日期:2016-03-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/cmi.2008.13
更新日期:2008-04-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2009.114
更新日期:2010-03-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/s41423-018-0041-z
更新日期:2019-06-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:
更新日期:2006-04-01 00:00:00