Role of Hippo signaling in regulating immunity.

Abstract:

:The Hippo signaling pathway has been established as a key regulator of organ size control, tumor suppression, and tissue regeneration in multiple organisms. Recently, emerging evidence has indicated that Hippo signaling might play an important role in regulating the immune system in both Drosophila and mammals. In particular, patients bearing a loss-of-function mutation of MST1 are reported to have an autosomal recessive primary immunodeficiency syndrome. MST1/2 kinases, the mammalian orthologs of Drosophila Hippo, may activate the non-canonical Hippo signaling pathway via MOB1A/B and/or NDR1/2 or cross-talk with other essential signaling pathways to regulate both innate and adaptive immunity. In this review, we present and discuss recent findings of cellular mechanisms/functions of Hippo signaling in the innate immunity in Drosophila and in mammals, T cell immunity, as well as the implications of Hippo signaling for tumor immunity.

journal_name

Cell Mol Immunol

authors

Hong L,Li X,Zhou D,Geng J,Chen L

doi

10.1038/s41423-018-0007-1

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

1003-1009

issue

12

eissn

1672-7681

issn

2042-0226

pii

10.1038/s41423-018-0007-1

journal_volume

15

pub_type

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