Abstract:
:Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules for naive T cell activation and expansion, dendritic cells are thought to also provide signals for the differentiation of CD4+ T cells into effector T cell populations. The mechanisms by which dendritic cells are able to adapt and respond to the great variety of infectious stimuli they are confronted with, and prime an appropriate CD4+ T cell response, are only partly understood. It is known that in the steady-state dendritic cells are highly heterogenous both in phenotype and transcriptional profile, and that this variability is dependent on developmental lineage, maturation stage, and the tissue environment in which dendritic cells are located. Exposure to infectious agents interfaces with this pre-existing heterogeneity by providing ligands for pattern-recognition and toll-like receptors that are variably expressed on different dendritic cell subsets, and elicit production of cytokines and chemokines to support innate cell activation and drive T cell differentiation. Here we review current information on dendritic cell biology, their heterogeneity, and the properties of different dendritic cell subsets. We then consider the signals required for the development of different types of Th immune responses, and the cellular and molecular evidence implicating different subsets of dendritic cells in providing such signals. We outline how dendritic cell subsets tailor their response according to the infectious agent, and how such transcriptional plasticity enables them to drive different types of immune responses.
journal_name
Cell Mol Immunoljournal_title
Cellular & molecular immunologyauthors
Hilligan KL,Ronchese Fdoi
10.1038/s41423-020-0465-0subject
Has Abstractpub_date
2020-06-01 00:00:00pages
587-599issue
6eissn
1672-7681issn
2042-0226pii
10.1038/s41423-020-0465-0journal_volume
17pub_type
杂志文章,评审abstract::In previous research, chimerical BPI23-Fcgamma1 gene which consisted of human bactericidal/permeability increasing protein (BPI) gene of encoding the functional N terminus (amino acid residues 1 to 199) of human BPI and Fcgamma1 gene of encoding the Fc segment of human immunoglobulin G1 was successfully reconstructed ...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2008.55
更新日期:2008-12-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Cellular & molecular immunology
pub_type: 已发布勘误
doi:10.1038/s41423-019-0332-z
更新日期:2020-03-01 00:00:00
abstract::Age-related thymic involution causes a decreased output of thymocytes from the thymus, thereby resulting in impairment of T cell-mediated immunity. While alterations in the T cell and non-haematopoietic stromal compartments have been described, the effects of thymic involution on thymic dendritic cells (DC) are not cl...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2009.114
更新日期:2010-03-01 00:00:00
abstract::The disturbance of maternal immune tolerance to a semiallogeneic fetus is recognized as one of the key pathologies of preeclampsia (PE), in which an imbalance between the inflammation-limiting regulatory T cells (Tregs) and the inflammation-mediating Th17 cells plays an essential role. Previously, we reported that the...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/s41423-018-0186-9
更新日期:2019-01-01 00:00:00
abstract::Mesenchymal stem/stromal cells (MSCs) possess some characteristics of immune cells, including a pro-inflammatory phenotype, an immunosuppressive phenotype, antibacterial properties and the expression of Toll-like receptor proteins. Here we show that, similar to immune cells, MSCs retain information from danger signals...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2015.11
更新日期:2016-05-01 00:00:00
abstract::Viral RNAs produced during viral infection are recognized by the cytoplasmic RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5). A central adapter protein downstream of RIG-I and MDA5 is the mitochondrial membrane protein virus-induced signaling adaptor (VISA), w...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2010.36
更新日期:2010-09-01 00:00:00
abstract::Patients with primary ciliary dyskinesia (PCD) and cystic fibrosis (CF), two inherited disorders, suffer from recurrent airway infections characterized by persistent bacterial colonization and uncontrollable inflammation. Although present in high counts, neutrophils fail to clear infection in the airways. High levels ...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/cmi.2017.118
更新日期:2018-04-01 00:00:00
abstract::A complex process including both the innate and acquired immune responses results in allograft rejection. Some chemokine receptors and their ligands play essential roles not only for leukocyte migration into the graft but also in facilitating dendritic and T cell trafficking between lymph nodes and the transplant in t...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:
更新日期:2005-10-01 00:00:00
abstract::The interactions of CD4+ T cells and B cells are fundamental for the generation of protective antibody responses, as well as for the development of harmful autoimmune diseases. Recent studies of human tissues and blood samples have established a new subset of CD4+ B helper T cells named peripheral helper T (Tph) cells...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/s41423-020-00529-z
更新日期:2020-08-31 00:00:00
abstract::Inflammasomes are important for maintaining intestinal homeostasis, and dysbiosis contributes to the pathology of inflammatory bowel disease (IBD) and increases the risk for colorectal cancer. Inflammasome defects contribute to chronic intestinal inflammation and increase the susceptibility to colitis in mice. However...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2016.35
更新日期:2017-01-01 00:00:00
abstract::Inflammatory bowel disease (IBD) is an important factor in the induction of colon cancer, but its mechanism is unclear. Colitis and colitis-associated colorectal cancer (CAC) models induced using both dextran sulfate sodium (DSS) and the azoxymethane/DSS protocol were established in wild-type (WT) and CTRP4 transgenic...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2016.16
更新日期:2016-09-01 00:00:00
abstract::Neonates are at increased risk of viral encephalopathies that can result in neurological dysfunction, seizures, permanent disability and even death. The neurological damage results from the combined effect of the virus and the immune response it elicits, thus finding tools to facilitate viral clearance from central ne...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2016.41
更新日期:2017-01-01 00:00:00
abstract::Innate lymphoid cells (ILCs), including natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer (LTi) cells, comprise the first line of innate immune defense against pathogens and tumors. Over the past decade, accumulating evidence has demonstrated immunological memory in ILC subsets: for example, ...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/s41423-019-0212-6
更新日期:2019-05-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a heterogeneous disease with a poor prognosis and limited markers for predicting patient survival. Because chemokines and chemokine receptors play numerous and integral roles in HCC disease progression, the CXCR4-CXCL12-CXCR7 axis was studied in HCC patients. CXCR4 and CXCR7 expressio...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2014.102
更新日期:2015-07-01 00:00:00
abstract::The liver is an important immunological organ that controls systemic tolerance. The liver harbors professional and unconventional antigen-presenting cells that are crucial for tolerance induction and maintenance. Orchestrating the immune response in homeostasis depends on a healthy and well-toned immunological liver m...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/s41423-020-00568-6
更新日期:2021-01-01 00:00:00
abstract::Cytomegaloviruses (CMVs), members of the herpesvirus family, have evolved a variety of mechanisms to evade the immune response to survive in infected hosts and to establish latent infection. They effectively hide infected cells from the effector mechanisms of adaptive immunity by eliminating cellular proteins (major h...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/cmi.2014.85
更新日期:2015-03-01 00:00:00
abstract::The relationship between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and host immunity is poorly understood. We performed an extensive analysis of immune responses in 32 patients with severe COVID-19, some of whom succumbed. A control population of healthy subjects was included. Patients with COVID-19...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/s41423-020-00557-9
更新日期:2020-10-15 00:00:00
abstract::Kupffer cells (KCs), the liver resident macrophages accounting for 80-90% of the total population of fixed tissue macrophages in the body, not only play a key role in host defense via removing particulate materials from the portal circulation, but may also contribute to the pathogenesis of various liver diseases. We h...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2009.56
更新日期:2009-12-01 00:00:00
abstract::To construct cDNA library of nasopharyngeal carcinoma (NPC) and obtain the NPC associated or specific antigens from it, we used a powerful new method to identify the antigens eliciting humoral immune response, which is SEREX (serological identification of antigen by recombinant cDNA expression library). Autologous ser...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:
更新日期:2006-02-01 00:00:00
abstract::Efficient immune responses against invading pathogens often involve coordination between cells from both the innate and adaptive immune systems. For multiple decades, it has been believed that CD8+ memory T cells and natural killer (NK) cells constantly and uniformly recirculate. Only recently was the existence of non...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/s41423-018-0192-y
更新日期:2019-03-01 00:00:00
abstract::Despite impressive results obtained in animal models, the clinical use of Fas ligand (FasL) as an anticancer drug is limited by severe toxicity. Systemic toxicity of death ligands may be prevented by using genes encoding membrane-bound death ligands and by targeted transgene expression through either targeted transduc...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章,收录出版
doi:10.1038/cmi.2009.38
更新日期:2009-08-01 00:00:00
abstract::Activation of the TAK1 signalosome is crucial for mediating the innate immune response to pathogen invasion and is regulated by multiple layers of posttranslational modifications, including ubiquitination, SUMOylation, and phosphorylation; however, the underlying molecular mechanism is not fully understood. In this st...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/s41423-020-00564-w
更新日期:2020-11-12 00:00:00
abstract::Exercise at regular intervals is assumed to have a positive effect on immune functions. Conversely, after spaceflight and under simulated weightlessness (e.g., bed rest), immune functions can be suppressed. We aimed to assess the effects of simulated weightlessness (Second Berlin BedRest Study; BBR2-2) on immunologica...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章,随机对照试验
doi:10.1038/cmi.2014.106
更新日期:2015-07-01 00:00:00
abstract::The concept of stem cells, their physiological existence, the intricate anatomical localization, the known and the unknown functions, and their exclusive utility for the purpose of regenerative medicine, are all now encompassed within an emergent question, 'how compatible these cells are immunologically?' Indeed, the ...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/cmi.2008.13
更新日期:2008-04-01 00:00:00
abstract::4-1BB (CD137) is a strong enhancer of the proliferation of CD8+ T cells. Since these cells require increased production of energy and biomass to support their proliferation, we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism. We found that treatment with agonistic anti-4-1BB mAb promoted ...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2016.02
更新日期:2017-09-01 00:00:00
abstract::In contrast to the previous belief that autoreactive B cells are eliminated from the normal repertoire of B cells, many autoreactive B cells actually escape clonal deletion and develop into mature B cells. These autoreactive B cells in healthy individuals perform some beneficial functions in the host and are homeostat...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/s41423-020-0445-4
更新日期:2020-06-01 00:00:00
abstract::Trogocytosis is a process which involves the transfer of membrane fragments and cell surface proteins between cells. Various types of T cells have been shown to be able to acquire membrane-bound proteins from antigen-presenting cells and their functions can be modulated following trogocytosis. However, it is not known...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2011.62
更新日期:2012-03-01 00:00:00
abstract::The combination of immunotherapy and chemotherapy is regarded as a promising approach for the treatment of certain types of cancer. However, the underlying mechanisms need to be fully investigated to guide the design of more efficient protocols for cancer chemoimmunotherapy. It is well known that danger-associated mol...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2013.59
更新日期:2014-03-01 00:00:00
abstract::Some pathogens can use host suppressor of cytokine signaling 1 (SOCS-1), an important negative-feedback molecule, as the main mode of immune evasion. Here we found that group A Streptococcus (GAS) is capable of inducing SOCS-1 expression in RAW264.7 and BMDM macrophages. IFN-β plays a role in GAS-induced SOCS-1 expres...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2014.107
更新日期:2015-05-01 00:00:00
abstract::Genetic mutations in the gene encoding DOCK8 cause an autosomal recessive form of hyper immunoglobulin E syndrome (AR-HIES), referred to as DOCK8 deficiency. DOCK8 deficiency in humans results in the onset of combined immunodeficiency disease (CID), clinically associated with chronic infections with diverse microbial ...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/cmi.2017.9
更新日期:2017-05-01 00:00:00