Abstract：
:Many monoclonal antibodies (mAbs) have been extensively used in the clinic, such as rituximab to treat lymphoma. However, resistance and non-responsiveness to mAb treatment have been challenging for this line of therapy. Complement is one of the main mediators of antibody-based cancer therapy via the complement-dependent cytolysis (CDC) effect. CD59 plays a critical role in resistance to mAbs through the CDC effect. In this paper, we attempted to investigate whether the novel CD59 inhibitor, recombinant ILYd4, was effective in enhancing the rituximab-mediated CDC effect on rituximab-sensitive RL-7 lymphoma cells and rituximab-induced resistant RR51.2 cells. Meanwhile, the CDC effects, which were mediated by rituximab and anti-CD24 mAb, on the refractory multiple myeloma (MM) cell line ARH-77 and the solid tumor osteosarcoma cell line Saos-2, were respectively investigated. We found that rILYd4 rendered the refractory cells sensitive to the mAb-mediated CDC effect and that rILYd4 exhibited a synergistic effect with the mAb that resulted in tumor cells lysis. This effect on tumor cell lysis was apparent on both hematological tumors and solid tumors. Therefore, rILYd4 may serve as an adjuvant for mAb mediated-tumor immunotherapy.
journal_name
Cell Mol Immunoljournal_title
Cellular & molecular immunologyauthors
You T,Hu W,Ge X,Shen J,Qin Xdoi
10.1038/cmi.2010.35subject
Has Abstractpub_date
2011-03-01 00:00:00pages
157-63issue
2eissn
1672-7681issn
2042-0226pii
cmi201035journal_volume
8pub_type
杂志文章abstract：:pR(ST98) is a large and conjugative resistant plasmid (R plasmid) of 98.6 mega-dalton from multi-drug resistant Salmonella typhi (S. typhi), which was classified to incompatibility group C (Inc C). It has been found that pRST98 made its host bacteria not only antibiotic resistant but also more virulent. In this study ...
journal_title：Cellular & molecular immunology
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更新日期：2005-04-01 00:00:00
abstract：:To elucidate the structures of SLA-DR (swine leukocyte antigen DR) genes of three Chinese pig strains (Gz, Bm and Yn), the SLA-DRA and SLA-DRB cDNA were amplified by RT-PCR and subjected to determine the sequences. The whole structures of SLA-DRA alleles are identical among three strains, consisting of 759 nucleotides...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：
更新日期：2004-06-01 00:00:00
abstract：:Apoptotic cell transfer has been found to be able to facilitate engraftment of allograft. However, the underlying mechanisms remain to be fully understood. Here we demonstrate that intravenous administration of donor apoptotic splenocytes can promote pancreatic islet engraftment by inducing generation of tolerogenic d...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2013.16
更新日期：2013-09-01 00:00:00
abstract：:In an attempt to isolate and characterize peptides mimicking epitopes of metalloprotease and explore their immunological protection against Schistosoma japonicum (S. japonicum), polyclonal anti-metalloprotease sera was prepared to screen a 12-mer random peptide library to isolate phages binding specially to antisera I...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：
更新日期：2005-06-01 00:00:00
abstract：:To evaluate the balance status of interleukin 18 (IL-18) and interleukin 18 binding protein (IL-18BP) in circulation in patients with lupus nephritis (LN) and primary nephrotic syndrome (PNS), plasma levels as well as mRNA expression in peripheral blood mononuclear cells (PBMCs) of IL-18 and IL-18BP were measured by E...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：
更新日期：2006-08-01 00:00:00
abstract：:Experimental autoimmune encephalomyelitis (EAE) is a good model for human multiple sclerosis (MS) research. However, there are some defects in the traditional models. Here, we improved the model by using the human myelin basic protein (MBP) as antigen. EAE was induced by immunization of female Wistar rats with human M...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：
更新日期：2004-10-01 00:00:00
abstract：:Vγ2Vδ2 T (also known as Vγ9Vδ2 T) cells exist only in primates, and in humans represent a major γδ T-cell sub-population in the total population of circulating γδ T cells. Results from recent studies suggest that while (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) phosphoantigen from Mycobacterium tuberculos...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/cmi.2012.46
更新日期：2013-01-01 00:00:00
abstract：:Acute morphine administration is known to alter the course of herpes simplex virus infection. In this study, the effect of acute morphine administration on the reactivation of latent herpes was investigated in a mouse model. Because of the important role of cytolytic T lymphocyte (CTL) activity in the inhibition of he...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2009.15
更新日期：2009-04-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：
更新日期：2005-08-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2009.105
更新日期：2010-01-01 00:00:00
abstract：:Psoriasis is a chronic inflammatory skin condition that has a fairly wide range of clinical presentations. Plaque psoriasis, which is the most common manifestation of psoriasis, is located on one end of the spectrum, dominated by adaptive immune responses, whereas the rarer pustular psoriasis lies on the opposite end,...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/s41423-020-0519-3
更新日期：2021-02-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/s41423-020-00620-5
更新日期：2021-02-01 00:00:00
abstract：:The nuclear receptor superfamily and the transcriptional factors associated with cytokines are inherently different families of signaling molecules and activate gene transcription by binding to their respective responsive element. However, it has become increasingly clear from our works and others that nuclear recepto...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：
更新日期：2004-12-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2014.37
更新日期：2015-01-01 00:00:00
abstract：:The concept of stem cells, their physiological existence, the intricate anatomical localization, the known and the unknown functions, and their exclusive utility for the purpose of regenerative medicine, are all now encompassed within an emergent question, 'how compatible these cells are immunologically?' Indeed, the ...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/cmi.2008.13
更新日期：2008-04-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2008.23
更新日期：2008-06-01 00:00:00
abstract：:Psoriasis is a chronic inflammatory skin disease with a strong genetic background and is triggered by environmental factors. Available evidence supports CD6, a lymphocyte surface receptor mostly expressed by T cells, as a putative target in autoimmunity. Accordingly, a humanized anti-CD6 antibody has been assayed for ...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2017.119
更新日期：2018-10-01 00:00:00
abstract：:Inflammasomes are important for maintaining intestinal homeostasis, and dysbiosis contributes to the pathology of inflammatory bowel disease (IBD) and increases the risk for colorectal cancer. Inflammasome defects contribute to chronic intestinal inflammation and increase the susceptibility to colitis in mice. However...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2016.35
更新日期：2017-01-01 00:00:00
abstract：:Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers, the majority of patients with solid tumors do not respond well, but the underlying reason remains unclear. Here, we studied ovarian cancer (OvCa), a tumor type generally resistant to current immunotherapies, to investigate PD-1-inde...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/s41423-019-0305-2
更新日期：2020-03-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/s41423-018-0041-z
更新日期：2019-06-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/s41423-020-00557-9
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2008.45
更新日期：2008-10-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/s41423-019-0210-8
更新日期：2019-03-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：
更新日期：2006-06-01 00:00:00
abstract：:The capacity of pluri-potent stem cells to repair the tissues in which stem cells reside holds great promise in development of novel cell replacement therapeutics for treating chronic and degenerative diseases. However, numerous reports show that stem cell therapy, even in an autologous setting, triggers lymphocyte in...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：
更新日期：2007-06-01 00:00:00
abstract：:The uterus in early pregnancy is a non-lymphoid organ that is enriched in natural killer (NK) cells. Studies to address the role of these abundant human NK cells at the maternal/fetal interface have focused on their response to the major histocompatibility complex (MHC) molecules on fetal trophoblast cells that they c...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/cmi.2014.53
更新日期：2014-09-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2011.10
更新日期：2011-07-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：
更新日期：2007-10-01 00:00:00
abstract：:A classical function of C1q is to bind immune complexes and initiate complement activation producing membrane lytic complexes, opsonins and anaphylatoxins. This classical pathway of complement activation is also elicited when C1q binds some other ligands. Besides complement activation, C1q also regulates cell differen...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/cmi.2008.2
更新日期：2008-02-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Cellular & molecular immunology
pub_type： 已发布勘误
doi：10.1038/s41423-019-0332-z
更新日期：2020-03-01 00:00:00
