Abstract:
:Organ transplantation is an effective therapeutic tool for treating many terminal diseases. However, one of the biggest challenges of transplantation is determining how to achieve the long-term survival of the allogeneic or xenogeneic transplant by, for example, preventing transplant rejection. In the current study, CD26 gene-knockout mice were used to investigate the potential role of CD26/dipeptidyl peptidase-4 (DPPIV) in allogeneic skin graft rejection by tail-skin transplantation. Compared with wild-type (CD26+/+) counterparts, CD26-/- mice showed reduced necrosis of grafts and delayed graft rejection after skin transplantation. Concentrations of serum IgG, including its subclasses IgG1 and IgG2a, were significantly reduced in CD26-/- mice during graft rejection. Moreover, after allogeneic skin transplantation, the secretion levels of the cytokines IFN-γ, IL-2, IL-6, IL-4, and IL-13 were significantly reduced, whereas the level of the cytokine IL-10 was increased in the serum of CD26-/- mice compared with that in the serum of CD26+/+ mice. Additionally, the concentration of IL-17 in serum and the percentage of cells secreting IL-17 in mouse peripheral blood lymphocytes (MPBLs) were both significantly lower, while the percentage of regulatory T cells (Tregs) was significantly higher in MPBLs of CD26-/- mice than in those of CD26+/+ mice. Furthermore, a lower percentage of CD8+ T cells in MPBLs and fewer infiltrated macrophages and T cells in graft tissues of CD26-/- mice were detected during graft rejection. These results indicate that CD26 is involved in allogeneic skin graft rejection and provides another hint that CD26 deficiency leads to less rejection due to lower activation and proliferation of host immune cells.
journal_name
Cell Mol Immunoljournal_title
Cellular & molecular immunologyauthors
Zhao X,Zhang K,Daniel P,Wisbrun N,Fuchs H,Fan Hdoi
10.1038/s41423-018-0009-zsubject
Has Abstractpub_date
2019-06-01 00:00:00pages
557-567issue
6eissn
1672-7681issn
2042-0226pii
10.1038/s41423-018-0009-zjournal_volume
16pub_type
杂志文章abstract::CD8(+) natural killer T (NKT) cells from EBV-associated tumour patients are quantitatively and functionally impaired. EBV-induced CD8(+) NKT cells drive syngeneic T cells into a Th1-bias response to suppress EBV-associated malignancies. IL-4-biased CD4(+) NKT cells do not affect either syngeneic T cell cytotoxicity or...
journal_title:Cellular & molecular immunology
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journal_title:Cellular & molecular immunology
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journal_title:Cellular & molecular immunology
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journal_title:Cellular & molecular immunology
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journal_title:Cellular & molecular immunology
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/cmi.2010.18
更新日期:2010-05-01 00:00:00
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journal_title:Cellular & molecular immunology
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2009.114
更新日期:2010-03-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/cmi.2012.46
更新日期:2013-01-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:
更新日期:2006-08-01 00:00:00
abstract::In human adipose tissue and obesity, miR-99a expression is negatively correlated with inflammation. Therefore, the present study investigated the role of miR-99a in macrophage phenotype activation and adipose tissue inflammation. M2 BMDMs showed a significant increase in miR-99a expression when compared to the M0 and ...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/s41423-018-0038-7
更新日期:2019-05-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:
更新日期:2004-10-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/cmi.2017.9
更新日期:2017-05-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/s41423-020-00529-z
更新日期:2020-08-31 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2013.16
更新日期:2013-09-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2009.7
更新日期:2009-02-01 00:00:00
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doi:
更新日期:2004-12-01 00:00:00
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journal_title:Cellular & molecular immunology
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doi:10.1038/s41423-018-0161-5
更新日期:2019-03-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,收录出版
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更新日期:2009-08-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2015.75
更新日期:2016-11-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/s41423-020-00557-9
更新日期:2020-10-15 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2008.55
更新日期:2008-12-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/s41423-020-0501-0
更新日期:2020-07-29 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2009.15
更新日期:2009-04-01 00:00:00
abstract::Recent study has suggested that innate immune system might play an important role in pregnancy progression. In this study, to investigate whether NK cells and NKT cells, instead of T cells, are the dominant populations of peripheral blood in early pregnancy, flow cytometry was used to detect the percentage and intrace...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:
更新日期:2007-10-01 00:00:00
abstract::The type 2 immune response is critical for host defense against large parasites such as helminths. On the other hand, dysregulation of the type 2 immune response may cause immunopathological conditions, including asthma, atopic dermatitis, rhinitis, and anaphylaxis. Thus, a balanced type 2 immune response must be achi...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/s41423-019-0210-8
更新日期:2019-03-01 00:00:00