Hepatitis B virus X protein sensitizes primary mouse hepatocytes to ethanol- and TNF-alpha-induced apoptosis by a caspase-3-dependent mechanism.

abstract：:The liver is an important immunological organ that controls systemic tolerance. The liver harbors professional and unconventional antigen-presenting cells that are crucial for tolerance induction and maintenance. Orchestrating the immune response in homeostasis depends on a healthy and well-toned immunological liver m...

journal_title：Cellular & molecular immunology

authors： Horst AK,Kumashie KG,Neumann K,Diehl L,Tiegs G

更新日期：2021-01-01 00:00:00

abstract：:Previously, we demonstrated that macrophages from thrombospondin 1 (TSP1)-deficient mice have a reduced inflammatory phenotype, suggesting that TSP1 plays a role in macrophage activation. In this study, we determined how TSP1 regulates macrophage function. We found that recombinant or purified platelet human TSP1 trea...

journal_title：Cellular & molecular immunology

authors： Li Y,Qi X,Tong X,Wang S

更新日期：2013-11-01 00:00:00

abstract：:Using a newly generated monoclonal antibody (2E6) against human B7-H3, we explored the expression of the molecule on dendritic cells derived from monocytes (Mo-DCs). Its expression was examined by means of immunostaining and flow cytometric (FCM) analysis. The results showed that B7-H3 was expressed in the course of M...

journal_title：Cellular & molecular immunology

authors： Zhang G,Dong Q,Xu Y,Yu G,Zhang X

更新日期：2005-08-01 00:00:00

abstract：:The failure of a massive influx of tumor-infiltrating T lymphocytes to eradicate tumor cells in the tumor microenvironment is mainly due to the dysfunction of T cells hyporesponsive to tumors. T-cell exhaustion and senescence induced by malignant tumors are two important dysfunctional states that coexist in cancer pat...

journal_title：Cellular & molecular immunology

authors： Zhao Y,Shao Q,Peng G

更新日期：2020-01-01 00:00:00

abstract：:Despite impressive results obtained in animal models, the clinical use of Fas ligand (FasL) as an anticancer drug is limited by severe toxicity. Systemic toxicity of death ligands may be prevented by using genes encoding membrane-bound death ligands and by targeted transgene expression through either targeted transduc...

journal_title：Cellular & molecular immunology

authors： Liu Z,Wang J,Yin P,Qiu J,Liu R,Li W,Fan X,Cheng X,Chen C,Zhang J,Zhuang G

更新日期：2009-08-01 00:00:00

abstract：:Among various immunoregulatory molecules, the B7 family of immune-checkpoint receptors consists of highly valuable targets for cancer immunotherapy. Antibodies targeting two B7 family co-inhibitory receptors, CTLA-4 and PD-1, have elicited long-term clinical outcomes in previously refractory cancer types and are consi...

journal_title：Cellular & molecular immunology

authors： Xu W,Hiếu T,Malarkannan S,Wang L

更新日期：2018-05-01 00:00:00

abstract：:The unmethylated CpG DNA can prevent spontaneous apoptosis of B cells. However, the precise mechanisms by which CpG DNA blocks apoptosis remain unclear. In this study, we showed B cell apoptosis was significantly inhibited by addition of CpG DNA. Treatment of CpG DNA could reduce the expression of caspase 3, increase ...

journal_title：Cellular & molecular immunology

authors： Zhou Y,Zhen H,Mei Y,Wang Y,Feng J,Xu S,Fu X

更新日期：2009-06-01 00:00:00

abstract：:T follicular helper (Tfh) cells were discovered just over a decade ago as germinal centre T cells that help B cells make antibodies. Included in this role is affinity maturation and isotype switching. It is here that their functions become less clear. Tfh cells principally produce IL-21 which inhibits class switching ...

journal_title：Cellular & molecular immunology

authors： Kemeny DM

更新日期：2012-09-01 00:00:00

abstract：:Exercise at regular intervals is assumed to have a positive effect on immune functions. Conversely, after spaceflight and under simulated weightlessness (e.g., bed rest), immune functions can be suppressed. We aimed to assess the effects of simulated weightlessness (Second Berlin BedRest Study; BBR2-2) on immunologica...

journal_title：Cellular & molecular immunology

authors： Hoff P,Belavý DL,Huscher D,Lang A,Hahne M,Kuhlmey AK,Maschmeyer P,Armbrecht G,Fitzner R,Perschel FH,Gaber T,Burmester GR,Straub RH,Felsenberg D,Buttgereit F

更新日期：2015-07-01 00:00:00

abstract：:Patients with primary ciliary dyskinesia (PCD) and cystic fibrosis (CF), two inherited disorders, suffer from recurrent airway infections characterized by persistent bacterial colonization and uncontrollable inflammation. Although present in high counts, neutrophils fail to clear infection in the airways. High levels ...

journal_title：Cellular & molecular immunology

authors： Cockx M,Gouwy M,Van Damme J,Struyf S

更新日期：2018-04-01 00:00:00

abstract：:We demonstrate that Mycobacterium tuberculosis recombinant leucine-responsive regulatory protein (rLrp) inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-α), interleukin-6, and interleukin-12 production and blocks the nuclear translocation of subunits of the nuclear-receptor transcription fact...

journal_title：Cellular & molecular immunology

authors： Liu Y,Li JY,Chen ST,Huang HR,Cai H

更新日期：2016-11-01 00:00:00

abstract：:Inflammasomes are multi-protein signaling complexes that trigger the activation of inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome complexes, the NLRP3 inflammasome is best characterized and has been linked with various human autoinflammatory and autoimmune diseases. Thus, the NL...

journal_title：Cellular & molecular immunology

authors： Jo EK,Kim JK,Shin DM,Sasakawa C

更新日期：2016-03-01 00:00:00

abstract：:Mesenchymal stem/stromal cells (MSCs) possess some characteristics of immune cells, including a pro-inflammatory phenotype, an immunosuppressive phenotype, antibacterial properties and the expression of Toll-like receptor proteins. Here we show that, similar to immune cells, MSCs retain information from danger signals...

journal_title：Cellular & molecular immunology

authors： Liu GY,Liu Y,Lu Y,Qin YR,Di GH,Lei YH,Liu HX,Li YQ,Wu C,Hu XW,Duan HF

更新日期：2016-05-01 00:00:00

abstract：:Acute morphine administration is known to alter the course of herpes simplex virus infection. In this study, the effect of acute morphine administration on the reactivation of latent herpes was investigated in a mouse model. Because of the important role of cytolytic T lymphocyte (CTL) activity in the inhibition of he...

journal_title：Cellular & molecular immunology

authors： Mojadadi S,Jamali A,Khansarinejad B,Soleimanjahi H,Bamdad T

更新日期：2009-04-01 00:00:00

abstract：:In contrast to the previous belief that autoreactive B cells are eliminated from the normal repertoire of B cells, many autoreactive B cells actually escape clonal deletion and develop into mature B cells. These autoreactive B cells in healthy individuals perform some beneficial functions in the host and are homeostat...

journal_title：Cellular & molecular immunology

authors： Lee S,Ko Y,Kim TJ

更新日期：2020-06-01 00:00:00

abstract：:The relationship between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and host immunity is poorly understood. We performed an extensive analysis of immune responses in 32 patients with severe COVID-19, some of whom succumbed. A control population of healthy subjects was included. Patients with COVID-19...

journal_title：Cellular & molecular immunology

authors： Varchetta S,Mele D,Oliviero B,Mantovani S,Ludovisi S,Cerino A,Bruno R,Castelli A,Mosconi M,Vecchia M,Roda S,Sachs M,Klersy C,Mondelli MU

更新日期：2020-10-15 00:00:00

abstract：:Induction of osteopontin (OPN), a well-known pro-inflammatory molecule, has been observed in acetaminophen (APAP)-induced hepatotoxicity. However, the precise cell source for OPN induction and its role during APAP-induced hepatotoxicity has not been fully explored. By employing a hepatotoxic mouse model induced by APA...

journal_title：Cellular & molecular immunology

authors： Wen Y,Wang C,Gu J,Yu C,Wang K,Sun X,Sun Y,Wu H,Tong Y,Xia Q,Kong X

更新日期：2019-05-01 00:00:00

abstract：:Follicular helper T (Tfh) cells select mutated B cells in germinal centres, which can then differentiate into long-lived high affinity memory B cells and plasma cells. Tfh cells are regulated by a unique molecular programme orchestrated by the transcriptional repressor Bcl6. This transcription factor turns down expres...

journal_title：Cellular & molecular immunology

authors： Yu D,Vinuesa CG

更新日期：2010-05-01 00:00:00

abstract：:A complex process including both the innate and acquired immune responses results in allograft rejection. Some chemokine receptors and their ligands play essential roles not only for leukocyte migration into the graft but also in facilitating dendritic and T cell trafficking between lymph nodes and the transplant in t...

journal_title：Cellular & molecular immunology

authors： Tan J,Zhou G

更新日期：2005-10-01 00:00:00

abstract：:Neutrophil infiltration is a hallmark of alcoholic steatohepatitis; however, the underlying mechanisms remain unclear. We previously reported that chronic-plus-binge ethanol feeding synergistically induces hepatic recruitment of neutrophils, which contributes to liver injury. In this paper, we investigated the roles o...

journal_title：Cellular & molecular immunology

authors： Mathews S,Feng D,Maricic I,Ju C,Kumar V,Gao B

更新日期：2016-03-01 00:00:00

abstract：:Allergen-specific immunotherapy (allergen-SIT) is a highly effective treatment for children with allergic asthma (AA), an immune-mediated chronic disease leading to bronchial muscle hypertrophy and airway obstruction in response to specific allergens. T helper cells and secreted cytokines play important roles in the p...

journal_title：Cellular & molecular immunology

authors： Wang CM,Chang CB,Chan MW,Wen ZH,Wu SF

更新日期：2018-11-01 00:00:00

abstract：:The type 2 immune response is critical for host defense against large parasites such as helminths. On the other hand, dysregulation of the type 2 immune response may cause immunopathological conditions, including asthma, atopic dermatitis, rhinitis, and anaphylaxis. Thus, a balanced type 2 immune response must be achi...

journal_title：Cellular & molecular immunology

authors： Gurram RK,Zhu J

更新日期：2019-03-01 00:00:00

abstract：:Neonates are at increased risk of viral encephalopathies that can result in neurological dysfunction, seizures, permanent disability and even death. The neurological damage results from the combined effect of the virus and the immune response it elicits, thus finding tools to facilitate viral clearance from central ne...

journal_title：Cellular & molecular immunology

authors： Ireland DD,Tami C,Pedras-Vasconcelos J,Verthelyi D

更新日期：2017-01-01 00:00:00

abstract：:Some pathogens can use host suppressor of cytokine signaling 1 (SOCS-1), an important negative-feedback molecule, as the main mode of immune evasion. Here we found that group A Streptococcus (GAS) is capable of inducing SOCS-1 expression in RAW264.7 and BMDM macrophages. IFN-β plays a role in GAS-induced SOCS-1 expres...

journal_title：Cellular & molecular immunology

authors： Wu J,Ma C,Wang H,Wu S,Xue G,Shi X,Song Z,Wei L

更新日期：2015-05-01 00:00:00

abstract：:Immunoglobulins (Igs) are known to be synthesized and secreted only by B lymphocytes. Class switch recombination (CSR) is a key event that enables B cells to express Igs, and one of the crucial steps for CSR initiation is the germline transcription of Ig genes. Surprisingly, recent studies have demonstrated that the I...

journal_title：Cellular & molecular immunology

authors： Duan Z,Zheng H,Xu S,Jiang Y,Liu H,Li M,Hu D,Li W,Bode AM,Dong Z,Cao Y

更新日期：2014-03-01 00:00:00

abstract：:Immunization with inactivated autoreactive T cells (T cell vaccination) selected from individual's own T cell repertoire provides a unique in vivo setting for testing immune regulation that is known to involve interactions of a variety of related surface molecules (1). It induces regulatory immune responses that close...

journal_title：Cellular & molecular immunology

authors： Zhang J

更新日期：2004-10-01 00:00:00

abstract：:Genetic mutations in the gene encoding DOCK8 cause an autosomal recessive form of hyper immunoglobulin E syndrome (AR-HIES), referred to as DOCK8 deficiency. DOCK8 deficiency in humans results in the onset of combined immunodeficiency disease (CID), clinically associated with chronic infections with diverse microbial ...

journal_title：Cellular & molecular immunology

authors： Kearney CJ,Randall KL,Oliaro J

更新日期：2017-05-01 00:00:00

abstract：:Cytomegaloviruses (CMVs), members of the herpesvirus family, have evolved a variety of mechanisms to evade the immune response to survive in infected hosts and to establish latent infection. They effectively hide infected cells from the effector mechanisms of adaptive immunity by eliminating cellular proteins (major h...

journal_title：Cellular & molecular immunology

authors： Lučin P,Mahmutefendić H,Blagojević Zagorac G,Ilić Tomaš M

更新日期：2015-03-01 00:00:00

abstract：:Transplantation of mesenchymal stem cells (MSCs) has been recently studied in animal models, and in clinical trials of patients with fulminant hepatic failure, end-stage liver diseases and inherited metabolic disorders. Modulatory cytokines produced by MSCs can inhibit immunocyte proliferation and migration to the liv...

journal_title：Cellular & molecular immunology

authors： Lin H,Xu R,Zhang Z,Chen L,Shi M,Wang FS

更新日期：2011-01-01 00:00:00

abstract：:The human immunodeficiency virus-1 (HIV-1) envelope protein gp120 is the major contributor to the pathogenesis of HIV-associated neurocognitive disorder (HAND). Neuroinflammation plays a pivotal role in gp120-induced neuropathology, but how gp120 triggers neuroinflammatory processes and subsequent neuronal death remai...

journal_title：Cellular & molecular immunology

authors： He X,Yang W,Zeng Z,Wei Y,Gao J,Zhang B,Li L,Liu L,Wan Y,Zeng Q,Gong Z,Liu L,Zhang H,Li Y,Yang S,Hu T,Wu L,Masliah E,Huang S,Cao H

更新日期：2020-03-01 00:00:00