Molecular mechanisms regulating NLRP3 inflammasome activation.

Abstract:

:Inflammasomes are multi-protein signaling complexes that trigger the activation of inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome complexes, the NLRP3 inflammasome is best characterized and has been linked with various human autoinflammatory and autoimmune diseases. Thus, the NLRP3 inflammasome may be a promising target for anti-inflammatory therapies. In this review, we summarize the current understanding of the mechanisms by which the NLRP3 inflammasome is activated in the cytosol. We also describe the binding partners of NLRP3 inflammasome complexes activating or inhibiting the inflammasome assembly. Our knowledge of the mechanisms regulating NLRP3 inflammasome signaling and how these influence inflammatory responses offers further insight into potential therapeutic strategies to treat inflammatory diseases associated with dysregulation of the NLRP3 inflammasome.

journal_name

Cell Mol Immunol

authors

Jo EK,Kim JK,Shin DM,Sasakawa C

doi

10.1038/cmi.2015.95

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

148-59

issue

2

eissn

1672-7681

issn

2042-0226

pii

cmi201595

journal_volume

13

pub_type

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