Abstract:
:Inflammasomes are multi-protein signaling complexes that trigger the activation of inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome complexes, the NLRP3 inflammasome is best characterized and has been linked with various human autoinflammatory and autoimmune diseases. Thus, the NLRP3 inflammasome may be a promising target for anti-inflammatory therapies. In this review, we summarize the current understanding of the mechanisms by which the NLRP3 inflammasome is activated in the cytosol. We also describe the binding partners of NLRP3 inflammasome complexes activating or inhibiting the inflammasome assembly. Our knowledge of the mechanisms regulating NLRP3 inflammasome signaling and how these influence inflammatory responses offers further insight into potential therapeutic strategies to treat inflammatory diseases associated with dysregulation of the NLRP3 inflammasome.
journal_name
Cell Mol Immunoljournal_title
Cellular & molecular immunologyauthors
Jo EK,Kim JK,Shin DM,Sasakawa Cdoi
10.1038/cmi.2015.95subject
Has Abstractpub_date
2016-03-01 00:00:00pages
148-59issue
2eissn
1672-7681issn
2042-0226pii
cmi201595journal_volume
13pub_type
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