Abstract：
:To construct cDNA library of nasopharyngeal carcinoma (NPC) and obtain the NPC associated or specific antigens from it, we used a powerful new method to identify the antigens eliciting humoral immune response, which is SEREX (serological identification of antigen by recombinant cDNA expression library). Autologous serum of NPC patient was used to screen the reactive clones in the human NPC tissue cDNA library consisted of 3.64 million recombinants. The 23 exact positive clones were subcloned to monoclonality and the size of cDNA inserts was identified by PCR. Then the nucleotide sequence of cDNA inserts was determined, and the sequence alignments were performed with BLAST software on GenBank database. They represented 16 different antigens. A detailed sequence analysis showed that 10 of 16 genes were high homologous to genes known in GenBank, such as RPL31, S100 A2, MT2A, etc. However, there were also 6 genes with low homology to genes in GenBank. Furthermore, 3 of 6 genes may be novel genes. The associations of these genes to NPC and the roles that they played in the occurrence and development of NPC should be further revealed.
journal_name
Cell Mol Immunoljournal_title
Cellular & molecular immunologyauthors
Shu J,He XJ,Li GCsubject
Has Abstractpub_date
2006-02-01 00:00:00pages
53-7issue
1eissn
1672-7681issn
2042-0226journal_volume
3pub_type
杂志文章abstract：:The nuclear receptor superfamily and the transcriptional factors associated with cytokines are inherently different families of signaling molecules and activate gene transcription by binding to their respective responsive element. However, it has become increasingly clear from our works and others that nuclear recepto...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：
更新日期：2004-12-01 00:00:00
abstract：:Tumor necrosis factor alpha (TNF-alpha) has been recognized as an activator of nuclear factor kappaB (NF-kappaB), a factor implicated in the protection of many cell types from apoptosis. We and others have presented evidence to suggest that Fas-induced apoptosis may be an important aspect of the resolution of inflamma...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：
更新日期：2007-02-01 00:00:00
abstract：:The disturbance of maternal immune tolerance to a semiallogeneic fetus is recognized as one of the key pathologies of preeclampsia (PE), in which an imbalance between the inflammation-limiting regulatory T cells (Tregs) and the inflammation-mediating Th17 cells plays an essential role. Previously, we reported that the...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/s41423-018-0186-9
更新日期：2019-01-01 00:00:00
abstract：:Vγ2Vδ2 T (also known as Vγ9Vδ2 T) cells exist only in primates, and in humans represent a major γδ T-cell sub-population in the total population of circulating γδ T cells. Results from recent studies suggest that while (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) phosphoantigen from Mycobacterium tuberculos...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/cmi.2012.46
更新日期：2013-01-01 00:00:00
abstract：:In previous research, chimerical BPI23-Fcgamma1 gene which consisted of human bactericidal/permeability increasing protein (BPI) gene of encoding the functional N terminus (amino acid residues 1 to 199) of human BPI and Fcgamma1 gene of encoding the Fc segment of human immunoglobulin G1 was successfully reconstructed ...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2008.55
更新日期：2008-12-01 00:00:00
abstract：:The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified as the receptor for dioxin. Almost half a century after its discovery, AHR is now recognized as a receptor for multiple physiological ligands, with important roles in health and disease. In this review, we discuss the r...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/s41423-020-00585-5
更新日期：2021-02-01 00:00:00
abstract：:The major limitation for the maturation of dendritic cells (DCs) using Toll-like receptor (TLR) agonists is their decreased ability to migrate into lymph nodes compared with conventional DCs. CD38 can be used as a multifunctional marker to modulate migration, survival and Th1 responses of DCs. CD74 has been shown to n...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2011.7
更新日期：2011-07-01 00:00:00
abstract：:Immunoglobulins (Igs) are known to be synthesized and secreted only by B lymphocytes. Class switch recombination (CSR) is a key event that enables B cells to express Igs, and one of the crucial steps for CSR initiation is the germline transcription of Ig genes. Surprisingly, recent studies have demonstrated that the I...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2013.52
更新日期：2014-03-01 00:00:00
abstract：:Organ transplantation is an effective therapeutic tool for treating many terminal diseases. However, one of the biggest challenges of transplantation is determining how to achieve the long-term survival of the allogeneic or xenogeneic transplant by, for example, preventing transplant rejection. In the current study, C...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/s41423-018-0009-z
更新日期：2019-06-01 00:00:00
abstract：:To elucidate the structures of SLA-DR (swine leukocyte antigen DR) genes of three Chinese pig strains (Gz, Bm and Yn), the SLA-DRA and SLA-DRB cDNA were amplified by RT-PCR and subjected to determine the sequences. The whole structures of SLA-DRA alleles are identical among three strains, consisting of 759 nucleotides...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：
更新日期：2004-06-01 00:00:00
abstract：:Age-related thymic involution causes a decreased output of thymocytes from the thymus, thereby resulting in impairment of T cell-mediated immunity. While alterations in the T cell and non-haematopoietic stromal compartments have been described, the effects of thymic involution on thymic dendritic cells (DC) are not cl...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2009.114
更新日期：2010-03-01 00:00:00
abstract：:Viral encephalitis is a devastating disease with high mortality, and survivors often suffer from severe neurological complications. Microglia are innate immune cells of the central nervous system (CNS) parenchyma whose turnover is reliant on local proliferation. Microglia express a diverse range of proteins, which all...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/s41423-020-00620-5
更新日期：2021-02-01 00:00:00
abstract：:Epigenetic modifications to histones dictate the differentiation of naïve CD4+ T cells into different subsets of effector T helper (TH) cells. The histone methyltransferase enhancer of zeste homolog 2 (EZH2) has been implicated in the mechanism regulating the differentiation of TH1, TH2 and regulatory T (Treg) cells. ...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/s41423-019-0219-z
更新日期：2020-03-01 00:00:00
abstract：:A classical function of C1q is to bind immune complexes and initiate complement activation producing membrane lytic complexes, opsonins and anaphylatoxins. This classical pathway of complement activation is also elicited when C1q binds some other ligands. Besides complement activation, C1q also regulates cell differen...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/cmi.2008.2
更新日期：2008-02-01 00:00:00
abstract：:It is well-documented that alcohol drinking together with hepatitis viral infection accelerates liver injury; however the underlying mechanisms remain unknown. In this paper, we demonstrated that primary hepatocytes from transgenic mice overexpressing hepatitis B virus X protein (HBX) were more susceptible to ethanol-...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：
更新日期：2005-02-01 00:00:00
abstract：:Previous studies have shown that the CC chemokine receptor CCR5 is downregulated on monocyte/macrophage (MO/Mphi) surfaces in head and neck squamous cell carcinoma (HNSCC) patients (stage IIIB). Ligands (RANTES, MIP-1alpha and MIP-1beta) of this chemokine receptor were also secreted in lesser quantity from MO/Mphi of ...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2010.29
更新日期：2010-09-01 00:00:00
abstract：:Transplantable experimental tumor models were constructed to study the activities of recombinant human interleukin-15 (rhIL-15) against tumor recurrence and metastasis. The results showed that tumor nodule formation was retarded and tumor growth was inhibited in the subcutaneous tumor model of LA795 lung adenocarcinom...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2008.23
更新日期：2008-06-01 00:00:00
abstract：:Immunization with inactivated autoreactive T cells (T cell vaccination) selected from individual's own T cell repertoire provides a unique in vivo setting for testing immune regulation that is known to involve interactions of a variety of related surface molecules (1). It induces regulatory immune responses that close...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：
更新日期：2004-10-01 00:00:00
abstract：:Mesenchymal stem/stromal cells (MSCs) possess some characteristics of immune cells, including a pro-inflammatory phenotype, an immunosuppressive phenotype, antibacterial properties and the expression of Toll-like receptor proteins. Here we show that, similar to immune cells, MSCs retain information from danger signals...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2015.11
更新日期：2016-05-01 00:00:00
abstract：:Decidual natural killer (dNK) cells express an array of activation receptors to regulate placental immunity and development during early pregnancy. We investigated the functional character of human dNK cells during the first and second trimester of gestation and the interaction between dNK and trophoblast cells. Altho...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2015.66
更新日期：2017-02-01 00:00:00
abstract：:The combination of immunotherapy and chemotherapy is regarded as a promising approach for the treatment of certain types of cancer. However, the underlying mechanisms need to be fully investigated to guide the design of more efficient protocols for cancer chemoimmunotherapy. It is well known that danger-associated mol...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2013.59
更新日期：2014-03-01 00:00:00
abstract：:Follicular helper T (Tfh) cells select mutated B cells in germinal centres, which can then differentiate into long-lived high affinity memory B cells and plasma cells. Tfh cells are regulated by a unique molecular programme orchestrated by the transcriptional repressor Bcl6. This transcription factor turns down expres...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/cmi.2010.18
更新日期：2010-05-01 00:00:00
abstract：:Macroautophagy has been implicated in modulating the therapeutic function of mesenchymal stromal cells (MSCs). However, the biological function of chaperone-mediated autophagy (CMA) in MSCs remains elusive. Here, we found that CMA was inhibited in MSCs in response to the proinflammatory cytokines interferon-γ (IFN-γ) ...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/s41423-019-0345-7
更新日期：2020-01-03 00:00:00
abstract：:Acute morphine administration is known to alter the course of herpes simplex virus infection. In this study, the effect of acute morphine administration on the reactivation of latent herpes was investigated in a mouse model. Because of the important role of cytolytic T lymphocyte (CTL) activity in the inhibition of he...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2009.15
更新日期：2009-04-01 00:00:00
abstract：:Among various immunoregulatory molecules, the B7 family of immune-checkpoint receptors consists of highly valuable targets for cancer immunotherapy. Antibodies targeting two B7 family co-inhibitory receptors, CTLA-4 and PD-1, have elicited long-term clinical outcomes in previously refractory cancer types and are consi...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/cmi.2017.148
更新日期：2018-05-01 00:00:00
abstract：:Complications arising from abnormal immune responses are the major causes of mortality and morbidity in diabetic patients. CD4+CD25+T regulatory cells (Tregs) play pivotal roles in controlling immune homeostasis, immunity and tolerance. The effect of hyperglycemia on CD4+CD25+Tregs has not yet been addressed. Here we ...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2011.37
更新日期：2012-01-01 00:00:00
abstract：:The capacity of pluri-potent stem cells to repair the tissues in which stem cells reside holds great promise in development of novel cell replacement therapeutics for treating chronic and degenerative diseases. However, numerous reports show that stem cell therapy, even in an autologous setting, triggers lymphocyte in...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：
更新日期：2007-06-01 00:00:00
abstract：:Psoriasis is a chronic inflammatory skin disease with a strong genetic background and is triggered by environmental factors. Available evidence supports CD6, a lymphocyte surface receptor mostly expressed by T cells, as a putative target in autoimmunity. Accordingly, a humanized anti-CD6 antibody has been assayed for ...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2017.119
更新日期：2018-10-01 00:00:00
abstract：:It has recently been established that neutrophils, the most abundant leukocytes, are capable of changes in gene expression during inflammatory responses. However, changes in the transcriptome as the neutrophil leaves the bone marrow have yet to be described. We hypothesized that neutrophils are transcriptionally activ...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2014.37
更新日期：2015-01-01 00:00:00
abstract：:The liver is an important immunological organ that controls systemic tolerance. The liver harbors professional and unconventional antigen-presenting cells that are crucial for tolerance induction and maintenance. Orchestrating the immune response in homeostasis depends on a healthy and well-toned immunological liver m...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/s41423-020-00568-6
更新日期：2021-01-01 00:00:00
