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Evaluation of a rat model of experimental autoimmune encephalomyelitis with human MBP as antigen.

Abstract：

:Experimental autoimmune encephalomyelitis (EAE) is a good model for human multiple sclerosis (MS) research. However, there are some defects in the traditional models. Here, we improved the model by using the human myelin basic protein (MBP) as antigen. EAE was induced by immunization of female Wistar rats with human MBP. Compared with the traditional models, the new model was evaluated by clinical signs to pathological changes. The immune state of the model was assessed by the lymphocyte infiltrative response and levels of TNF-alpha, IFN-gamma, IL-10. It was found that most of rats exhibited tail tone loss and hind-limb paralysis, also there were demyelination, infiltrative lymphocyte foci, "neuronophagia" in the cortex of cerebra and the white matter of spinal cords. PBMCs and spleen lymphocytes were strongly responsive to the stimulation of MBP and PHA. The levels of TNF-alpha and IFN-gamma were altered with the severity of EAE. In the remitting phase, IL-10 was increased significantly. This study demonstrates that the animal model of EAE induced by human MBP bears resemblance to the features of human multiple sclerosis and promises to be a better model than ever before for the study of MS.

journal_name

Cell Mol Immunol

journal_title

Cellular & molecular immunology

authors

Guo L,Li Y,Lin H,Ji X,Li J,Que L,Zhang Y,Rong Y,Wang J

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

387-91

issue

5

eissn

1672-7681

issn

2042-0226

journal_volume

1

pub_type

杂志文章

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