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Neutrophil transcriptional profile changes during transit from bone marrow to sites of inflammation.

Abstract：

:It has recently been established that neutrophils, the most abundant leukocytes, are capable of changes in gene expression during inflammatory responses. However, changes in the transcriptome as the neutrophil leaves the bone marrow have yet to be described. We hypothesized that neutrophils are transcriptionally active cells that alter their gene expression profiles as they migrate into the vasculature and then into inflamed tissues. Our goal was to provide an overview of how the neutrophil's transcriptome changes as they migrate through different compartments using microarray and bio-informatic approaches. Our study demonstrates that neutrophils are highly plastic cells where normal environmental cues result in a site-specific neutrophil transcriptome. We demonstrate that neutrophil genes undergo one of four distinct expression change patterns as they move from bone marrow through the circulation to sites of inflammation: (i) continuously increasing; (ii) continuously decreasing; (iii) a down-up-down; and (iv) an up-down-up pattern. Additionally, we demonstrate that the neutrophil migration signaling network and the balance between anti-apoptotic and pro-apoptotic signaling are two of the main regulatory mechanisms that change as the neutrophil transits through compartments.

journal_name

Cell Mol Immunol

journal_title

Cellular & molecular immunology

authors

Lakschevitz FS,Visser MB,Sun C,Glogauer M

doi

10.1038/cmi.2014.37

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

53-65

issue

1

eissn

1672-7681

issn

2042-0226

pii

cmi201437

journal_volume

12

pub_type

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