The roles of microglia in viral encephalitis: from sensome to therapeutic targeting.

Abstract:

:Viral encephalitis is a devastating disease with high mortality, and survivors often suffer from severe neurological complications. Microglia are innate immune cells of the central nervous system (CNS) parenchyma whose turnover is reliant on local proliferation. Microglia express a diverse range of proteins, which allows them to continuously sense the environment and quickly react to changes. Under inflammatory conditions such as CNS viral infection, microglia promote innate and adaptive immune responses to protect the host. However, during viral infection, a dysregulated microglia-T-cell interplay may result in altered phagocytosis of neuronal synapses by microglia that causes neurocognitive impairment. In this review, we summarize the current knowledge on the role of microglia in viral encephalitis, propose questions to be answered in the future and suggest possible therapeutic targets.

journal_name

Cell Mol Immunol

authors

Chhatbar C,Prinz M

doi

10.1038/s41423-020-00620-5

subject

Has Abstract

pub_date

2021-02-01 00:00:00

pages

250-258

issue

2

eissn

1672-7681

issn

2042-0226

pii

10.1038/s41423-020-00620-5

journal_volume

18

pub_type

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