Abstract:
:T follicular helper (Tfh) cells were discovered just over a decade ago as germinal centre T cells that help B cells make antibodies. Included in this role is affinity maturation and isotype switching. It is here that their functions become less clear. Tfh cells principally produce IL-21 which inhibits class switching to IgE. Recent studies have questioned whether the germinal centre is the main site of IgE class switching or IgE affinity maturation. In this review, I will examine the evidence that these cells are responsible for regulating IgE class switching and the relationship between Tfh cells and T helper 2 (Th2) effector cells.
journal_name
Cell Mol Immunoljournal_title
Cellular & molecular immunologyauthors
Kemeny DMdoi
10.1038/cmi.2012.31subject
Has Abstractpub_date
2012-09-01 00:00:00pages
386-9issue
5eissn
1672-7681issn
2042-0226pii
cmi201231journal_volume
9pub_type
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