An unbalanced PD-L1/CD86 ratio in CD14(++)CD16(+) monocytes is correlated with HCV viremia during chronic HCV infection.

abstract：:While there is mounting evidence that interleukin (IL)-23-IL-17 axis plays a critical role in the pathogenesis of various autoimmune diseases, much remains to be elucidated on how IL-23 is induced in the pathological processes. IL-23 is a heterodimer composed of p19 and p40, the latter being shared with IL-12. We prev...

journal_title：Cellular & molecular immunology

authors： Ma X,Aoki T,Narumiya S

更新日期：2016-03-01 00:00:00

abstract：:In an attempt to isolate and characterize peptides mimicking epitopes of metalloprotease and explore their immunological protection against Schistosoma japonicum (S. japonicum), polyclonal anti-metalloprotease sera was prepared to screen a 12-mer random peptide library to isolate phages binding specially to antisera I...

journal_title：Cellular & molecular immunology

authors： Tang L,Chen Y,Wang L,Zhang S,Zeng X,Yi X

更新日期：2005-06-01 00:00:00

abstract：:Epstein-Barr virus (EBV), a potential oncogenic herpesvirus, has been found to be associated with several malignancies. It's critical to elicit cellular immunity of the body to fight against EBV-associated tumor development. Using dendritic cells (DCs) loaded with latent membrane protein 2A (LMP2A) to elicit T cell re...

journal_title：Cellular & molecular immunology

authors： Chen Y,Yao K,Wang B,Qing J,Liu G

更新日期：2008-10-01 00:00:00

abstract：:Many monoclonal antibodies (mAbs) have been extensively used in the clinic, such as rituximab to treat lymphoma. However, resistance and non-responsiveness to mAb treatment have been challenging for this line of therapy. Complement is one of the main mediators of antibody-based cancer therapy via the complement-depend...

journal_title：Cellular & molecular immunology

authors： You T,Hu W,Ge X,Shen J,Qin X

更新日期：2011-03-01 00:00:00

abstract：:Programmed death one homolog (PD-1H) is a cell surface molecule of the B7/CD28 immune modulatory gene family. Although PD-1H has been shown to function as a coinhibitory receptor on T cells to limit naive T-cell activation and proliferation, its role in the regulation of the T-cell response to allergens is unknown. We...

journal_title：Cellular & molecular immunology

authors： Liu H,Li X,Hu L,Zhu M,He B,Luo L,Chen L

更新日期：2018-09-01 00:00:00

abstract：:Allergen-specific immunotherapy (allergen-SIT) is a highly effective treatment for children with allergic asthma (AA), an immune-mediated chronic disease leading to bronchial muscle hypertrophy and airway obstruction in response to specific allergens. T helper cells and secreted cytokines play important roles in the p...

journal_title：Cellular & molecular immunology

authors： Wang CM,Chang CB,Chan MW,Wen ZH,Wu SF

更新日期：2018-11-01 00:00:00

abstract：:The outcome of hepatitis B viral (HBV) infection is determined by the complex interactions between replicating HBV and the immune system. While the role of the adaptive immune system in the resolution of HBV infection has been studied extensively, the contribution of innate immune mechanisms remains to be defined. Her...

journal_title：Cellular & molecular immunology

authors： Ma Z,Liu J,Wu W,Zhang E,Zhang X,Li Q,Zelinskyy G,Buer J,Dittmer U,Kirschning CJ,Lu M

更新日期：2017-12-01 00:00:00

abstract：:It is well-documented that alcohol drinking together with hepatitis viral infection accelerates liver injury; however the underlying mechanisms remain unknown. In this paper, we demonstrated that primary hepatocytes from transgenic mice overexpressing hepatitis B virus X protein (HBX) were more susceptible to ethanol-...

journal_title：Cellular & molecular immunology

authors： Kim WH,Hong F,Jaruga B,Zhang ZS,Fan SJ,Liang TJ,Gao B

更新日期：2005-02-01 00:00:00

abstract：:We evaluated the antitumor effect of combined therapy with tegafur/uracil (UFT) plus leucovorin (LV) (UFT/LV) and protein-bound polysaccharide, PSK, in three mouse models of transplantable tumors. UFT/LV showed antitumor effect against Meth A sarcoma, and the antitumor effect was enhanced when PSK given concomitantly....

journal_title：Cellular & molecular immunology

authors： Katoh R,Ooshiro M

更新日期：2007-08-01 00:00:00

abstract：:Dendritic cells (DCs) are the most potent professional antigen-presenting cells, and capable of stimulating naïve T cells and driving primary immune responses. DCs are poised to capture antigen, migrate to draining lymphoid organs, and after a process of maturation, select antigen-specific lymphocytes to which they pr...

journal_title：Cellular & molecular immunology

authors： Sun K,Wang L,Zhang Y

更新日期：2006-06-01 00:00:00

abstract：:Genetic mutations in the gene encoding DOCK8 cause an autosomal recessive form of hyper immunoglobulin E syndrome (AR-HIES), referred to as DOCK8 deficiency. DOCK8 deficiency in humans results in the onset of combined immunodeficiency disease (CID), clinically associated with chronic infections with diverse microbial ...

journal_title：Cellular & molecular immunology

authors： Kearney CJ,Randall KL,Oliaro J

更新日期：2017-05-01 00:00:00

abstract：:T follicular helper (Tfh) cells were discovered just over a decade ago as germinal centre T cells that help B cells make antibodies. Included in this role is affinity maturation and isotype switching. It is here that their functions become less clear. Tfh cells principally produce IL-21 which inhibits class switching ...

journal_title：Cellular & molecular immunology

authors： Kemeny DM

更新日期：2012-09-01 00:00:00

abstract：:Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers, the majority of patients with solid tumors do not respond well, but the underlying reason remains unclear. Here, we studied ovarian cancer (OvCa), a tumor type generally resistant to current immunotherapies, to investigate PD-1-inde...

journal_title：Cellular & molecular immunology

authors： Cai D,Li J,Liu D,Hong S,Qiao Q,Sun Q,Li P,Lyu N,Sun T,Xie S,Guo L,Ni L,Jin L,Dong C

更新日期：2020-03-01 00:00:00

abstract：:Previously, we demonstrated that macrophages from thrombospondin 1 (TSP1)-deficient mice have a reduced inflammatory phenotype, suggesting that TSP1 plays a role in macrophage activation. In this study, we determined how TSP1 regulates macrophage function. We found that recombinant or purified platelet human TSP1 trea...

journal_title：Cellular & molecular immunology

authors： Li Y,Qi X,Tong X,Wang S

更新日期：2013-11-01 00:00:00

abstract：:Transplantation of mesenchymal stem cells (MSCs) has been recently studied in animal models, and in clinical trials of patients with fulminant hepatic failure, end-stage liver diseases and inherited metabolic disorders. Modulatory cytokines produced by MSCs can inhibit immunocyte proliferation and migration to the liv...

journal_title：Cellular & molecular immunology

authors： Lin H,Xu R,Zhang Z,Chen L,Shi M,Wang FS

更新日期：2011-01-01 00:00:00

abstract：:In contrast to the previous belief that autoreactive B cells are eliminated from the normal repertoire of B cells, many autoreactive B cells actually escape clonal deletion and develop into mature B cells. These autoreactive B cells in healthy individuals perform some beneficial functions in the host and are homeostat...

journal_title：Cellular & molecular immunology

authors： Lee S,Ko Y,Kim TJ

更新日期：2020-06-01 00:00:00

abstract：:Decidual natural killer (dNK) cells express an array of activation receptors to regulate placental immunity and development during early pregnancy. We investigated the functional character of human dNK cells during the first and second trimester of gestation and the interaction between dNK and trophoblast cells. Altho...

journal_title：Cellular & molecular immunology

authors： Zhang J,Dunk CE,Kwan M,Jones RL,Harris LK,Keating S,Lye SJ

更新日期：2017-02-01 00:00:00

abstract：:Low-dose total body irradiation (LTBI) is used in the treatment of some cancers mainly for immune enhancement rather than cell killing. However, the mechanism underlying LTBI remains unknown. In this study, by analyzing the immune patterns of lymphocytes, we found that the percentage and absolute number of CD4(+)CD25(...

journal_title：Cellular & molecular immunology

authors： Liu R,Xiong S,Zhang L,Chu Y

更新日期：2010-03-01 00:00:00

abstract：:Immunization with inactivated autoreactive T cells (T cell vaccination) selected from individual's own T cell repertoire provides a unique in vivo setting for testing immune regulation that is known to involve interactions of a variety of related surface molecules (1). It induces regulatory immune responses that close...

journal_title：Cellular & molecular immunology

authors： Zhang J

更新日期：2004-10-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (GM-CSF), produced by CD4+ T cells, has recently been implicated in the pathogenesis of inflammatory diseases, such as multiple sclerosis and juvenile arthritis. However, the role of GM-CSF-producing CD4+ T cells in sepsis remains unknown. This study reports peripheral changes in ...

journal_title：Cellular & molecular immunology

authors： Huang H,Wang S,Jiang T,Fan R,Zhang Z,Mu J,Li K,Wang Y,Jin L,Lin F,Xia J,Sun L,Xu B,Ji C,Chen J,Chang J,Tu B,Song B,Zhang C,Wang FS,Xu R

更新日期：2019-06-01 00:00:00

abstract：:The failure of a massive influx of tumor-infiltrating T lymphocytes to eradicate tumor cells in the tumor microenvironment is mainly due to the dysfunction of T cells hyporesponsive to tumors. T-cell exhaustion and senescence induced by malignant tumors are two important dysfunctional states that coexist in cancer pat...

journal_title：Cellular & molecular immunology

authors： Zhao Y,Shao Q,Peng G

更新日期：2020-01-01 00:00:00

abstract：:We generated a human dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN) transgenic mouse in which renal tubular epithelial cells expressed DC-SIGN. The transgenic mice were infected with Candida albicans intravenously to study how DC-SIGN expression affected the pathogenesis of systemic candidiasis. We dis...

journal_title：Cellular & molecular immunology

authors： Chen WY,Wu SY,Lin TC,Lin SL,Wu-Hsieh BA

更新日期：2019-03-01 00:00:00

abstract：:Recognition of viral dsRNA by Toll-like receptor 3 (TLR3) leads to the induction of downstream antiviral effectors and the innate antiviral immune response. Here, we identified the zinc-finger FYVE domain-containing protein ZFYVE1, a guanylate-binding protein (GBP), as a positive regulator of TLR3-mediated signaling. ...

journal_title：Cellular & molecular immunology

authors： Zhong X,Feng L,Xu WH,Wu X,Ding YD,Zhou Y,Lei CQ,Shu HB

更新日期：2020-07-01 00:00:00

abstract：:The liver is an important immunological organ that controls systemic tolerance. The liver harbors professional and unconventional antigen-presenting cells that are crucial for tolerance induction and maintenance. Orchestrating the immune response in homeostasis depends on a healthy and well-toned immunological liver m...

journal_title：Cellular & molecular immunology

authors： Horst AK,Kumashie KG,Neumann K,Diehl L,Tiegs G

更新日期：2021-01-01 00:00:00

abstract：:Innate lymphoid cells (ILCs), including natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer (LTi) cells, comprise the first line of innate immune defense against pathogens and tumors. Over the past decade, accumulating evidence has demonstrated immunological memory in ILC subsets: for example, ...

journal_title：Cellular & molecular immunology

authors： Wang X,Peng H,Tian Z

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:Plasma phospholipid transfer protein (PLTP) is a key determinant of lipoprotein metabolism, and both animal and human studies converge to indicate that PLTP promotes atherogenesis and its thromboembolic complications. Moreover, it has recently been reported that PLTP modulates inflammation and immune response...

journal_title：Cellular & molecular immunology

authors： Desrumaux C,Lemaire-Ewing S,Ogier N,Yessoufou A,Hammann A,Sequeira-Le Grand A,Deckert V,Pais de Barros JP,Le Guern N,Guy J,Khan NA,Lagrost L

更新日期：2016-11-01 00:00:00

abstract：:Using a newly generated monoclonal antibody (2E6) against human B7-H3, we explored the expression of the molecule on dendritic cells derived from monocytes (Mo-DCs). Its expression was examined by means of immunostaining and flow cytometric (FCM) analysis. The results showed that B7-H3 was expressed in the course of M...

journal_title：Cellular & molecular immunology

authors： Zhang G,Dong Q,Xu Y,Yu G,Zhang X

更新日期：2005-08-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a heterogeneous disease with a poor prognosis and limited markers for predicting patient survival. Because chemokines and chemokine receptors play numerous and integral roles in HCC disease progression, the CXCR4-CXCL12-CXCR7 axis was studied in HCC patients. CXCR4 and CXCR7 expressio...

journal_title：Cellular & molecular immunology

authors： Neve Polimeno M,Ierano C,D'Alterio C,Simona Losito N,Napolitano M,Portella L,Scognamiglio G,Tatangelo F,Maria Trotta A,Curley S,Costantini S,Liuzzi R,Izzo F,Scala S

更新日期：2015-07-01 00:00:00

abstract：:Cytomegaloviruses (CMVs), members of the herpesvirus family, have evolved a variety of mechanisms to evade the immune response to survive in infected hosts and to establish latent infection. They effectively hide infected cells from the effector mechanisms of adaptive immunity by eliminating cellular proteins (major h...

journal_title：Cellular & molecular immunology

authors： Lučin P,Mahmutefendić H,Blagojević Zagorac G,Ilić Tomaš M

更新日期：2015-03-01 00:00:00

abstract：:Kupffer cells (KCs), the liver resident macrophages accounting for 80-90% of the total population of fixed tissue macrophages in the body, not only play a key role in host defense via removing particulate materials from the portal circulation, but may also contribute to the pathogenesis of various liver diseases. We h...

journal_title：Cellular & molecular immunology

authors： Miller AM,Zhang JX

更新日期：2009-12-01 00:00:00