当前位置： SCI文献检索 > Cellular & Molecular Immunology期刊下所有文献 > The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway.

The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway.

Abstract：

:Inflammasomes are important for maintaining intestinal homeostasis, and dysbiosis contributes to the pathology of inflammatory bowel disease (IBD) and increases the risk for colorectal cancer. Inflammasome defects contribute to chronic intestinal inflammation and increase the susceptibility to colitis in mice. However, the inflammasome sensor absent in melanoma 2 (AIM2) protects against colorectal cancer in an inflammasome-independent manner through DNA-dependent protein kinase and Akt pathways. Yet, the roles of the AIM2 inflammasome in IBD and the early phases of colorectal cancer remain ill-defined. Here we show that the AIM2 inflammasome has a protective role in the intestine. During steady state, Aim2 deletion results in the loss of IL-18 secretion, suppression of the IL-22 binding protein (IL-22BP) in intestinal epithelial cells and consequent loss of the STAT3-dependent antimicrobial peptides (AMPs) Reg3β and Reg3γ, which promotes dysbiosis-linked colitis. During dextran sulfate sodium-induced colitis, a dysfunctional IL-18/IL-22BP pathway in Aim2-/- mice promotes excessive IL-22 production and elevated STAT3 activation. Aim2-/- mice further exhibit sustained STAT3 and Akt activation during the resolution of colitis fueled by enhanced Reg3b and Reg3g expression. This self-perpetuating mechanism promotes proliferation of intestinal crypt cells and likely contributes to the recently described increase in susceptibility of Aim2-/- mice to colorectal cancer. Collectively, our results demonstrate a central role for the AIM2 inflammasome in preventing dysbiosis and intestinal inflammation through regulation of the IL-18/IL-22BP/IL-22 and STAT3 pathway and expression of select AMPs.

journal_name

Cell Mol Immunol

journal_title

Cellular & molecular immunology

authors

Ratsimandresy RA,Indramohan M,Dorfleutner A,Stehlik C

doi

10.1038/cmi.2016.35

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

127-142

issue

1

eissn

1672-7681

issn

2042-0226

pii

cmi201635

journal_volume

14

pub_type

杂志文章

相关文献

Cellular & Molecular Immunology文献大全
  • Novel SLA-DR alleles of three Chinese pig strains and the related function in human T cell response.

    abstract：:To elucidate the structures of SLA-DR (swine leukocyte antigen DR) genes of three Chinese pig strains (Gz, Bm and Yn), the SLA-DRA and SLA-DRB cDNA were amplified by RT-PCR and subjected to determine the sequences. The whole structures of SLA-DRA alleles are identical among three strains, consisting of 759 nucleotides...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：

    authors： Chen F,Xie J,Zhou Y,Li N,Chou KY

    更新日期：2004-06-01 00:00:00

  • Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies.

    abstract：:Coronavirus disease 2019 (COVID-19), caused by the novel human coronavirus SARS-CoV-2, is currently a major threat to public health worldwide. The viral spike protein binds the host receptor angiotensin-converting enzyme 2 (ACE2) via the receptor-binding domain (RBD), and thus is believed to be a major target to block...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/s41423-020-0458-z

    authors： Yi C,Sun X,Ye J,Ding L,Liu M,Yang Z,Lu X,Zhang Y,Ma L,Gu W,Qu A,Xu J,Shi Z,Ling Z,Sun B

    更新日期：2020-06-01 00:00:00

  • T cell vaccination as an immunotherapy for autoimmune diseases.

    abstract：:Immunization with inactivated autoreactive T cells (T cell vaccination) selected from individual's own T cell repertoire provides a unique in vivo setting for testing immune regulation that is known to involve interactions of a variety of related surface molecules (1). It induces regulatory immune responses that close...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,评审

    doi：

    authors： Zhang J

    更新日期：2004-10-01 00:00:00

  • TLR9 agonist enhances radiofrequency ablation-induced CTL responses, leading to the potent inhibition of primary tumor growth and lung metastasis.

    abstract：:Radiofrequency ablation (RFA) is the most common approach to thermal ablation for cancer therapy. Unfortunately, its efficacy is limited by incomplete ablation, and further optimization of RFA is required. Here, we demonstrate that incubation at 65 °C triggers more EG7 tumor cell death by necrosis than treatment at 45...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/s41423-018-0184-y

    authors： Xu A,Zhang L,Yuan J,Babikr F,Freywald A,Chibbar R,Moser M,Zhang W,Zhang B,Fu Z,Xiang J

    更新日期：2019-10-01 00:00:00

  • The soluble glycoprotein NMB (GPNMB) produced by macrophages induces cancer stemness and metastasis via CD44 and IL-33.

    abstract：:In cancer, myeloid cells have tumor-supporting roles. We reported that the protein GPNMB (glycoprotein nonmetastatic B) was profoundly upregulated in macrophages interacting with tumor cells. Here, using mouse tumor models, we show that macrophage-derived soluble GPNMB increases tumor growth and metastasis in Gpnmb-mu...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/s41423-020-0501-0

    authors： Liguori M,Digifico E,Vacchini A,Avigni R,Colombo FS,Borroni EM,Farina FM,Milanesi S,Castagna A,Mannarino L,Craparotta I,Marchini S,Erba E,Panini N,Tamborini M,Rimoldi V,Allavena P,Belgiovine C

    更新日期：2020-07-29 00:00:00

  • Activation of the Ig Iα1 promoter by the transcription factor Ets-1 triggers Ig Iα1-Cα1 germline transcription in epithelial cancer cells.

    abstract：:Immunoglobulins (Igs) are known to be synthesized and secreted only by B lymphocytes. Class switch recombination (CSR) is a key event that enables B cells to express Igs, and one of the crucial steps for CSR initiation is the germline transcription of Ig genes. Surprisingly, recent studies have demonstrated that the I...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/cmi.2013.52

    authors： Duan Z,Zheng H,Xu S,Jiang Y,Liu H,Li M,Hu D,Li W,Bode AM,Dong Z,Cao Y

    更新日期：2014-03-01 00:00:00

  • Hypoxia induces T-cell apoptosis by inhibiting chemokine C receptor 7 expression: the role of adenosine receptor A(2).

    abstract：:Hypoxia is a major characteristic of the tumor microenvironment, and its effects on immune cells are proposed to be important factors for the process of tumor immune escape. It has been reported that hypoxia affects the function of dendritic cells and the antitumor function of T cells. Here we discuss the effects of h...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/cmi.2009.105

    authors： Sun J,Zhang Y,Yang M,Zhang Y,Xie Q,Li Z,Dong Z,Yang Y,Deng B,Feng A,Hu W,Mao H,Qu X

    更新日期：2010-01-01 00:00:00

  • Neutrophil transcriptional profile changes during transit from bone marrow to sites of inflammation.

    abstract：:It has recently been established that neutrophils, the most abundant leukocytes, are capable of changes in gene expression during inflammatory responses. However, changes in the transcriptome as the neutrophil leaves the bone marrow have yet to be described. We hypothesized that neutrophils are transcriptionally activ...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/cmi.2014.37

    authors： Lakschevitz FS,Visser MB,Sun C,Glogauer M

    更新日期：2015-01-01 00:00:00

  • Upregulation of CD81 in trophoblasts induces an imbalance of Treg/Th17 cells by promoting IL-6 expression in preeclampsia.

    abstract：:The disturbance of maternal immune tolerance to a semiallogeneic fetus is recognized as one of the key pathologies of preeclampsia (PE), in which an imbalance between the inflammation-limiting regulatory T cells (Tregs) and the inflammation-mediating Th17 cells plays an essential role. Previously, we reported that the...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/s41423-018-0186-9

    authors： Ding H,Dai Y,Lei Y,Wang Z,Liu D,Li R,Shen L,Gu N,Zheng M,Zhu X,Zhao G,Hu Y

    更新日期：2019-01-01 00:00:00

  • Antigen presentation, autoantibody production, and therapeutic targets in autoimmune liver disease.

    abstract：:The liver is an important immunological organ that controls systemic tolerance. The liver harbors professional and unconventional antigen-presenting cells that are crucial for tolerance induction and maintenance. Orchestrating the immune response in homeostasis depends on a healthy and well-toned immunological liver m...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1038/s41423-020-00568-6

    authors： Horst AK,Kumashie KG,Neumann K,Diehl L,Tiegs G

    更新日期：2021-01-01 00:00:00

  • The roles of microglia in viral encephalitis: from sensome to therapeutic targeting.

    abstract：:Viral encephalitis is a devastating disease with high mortality, and survivors often suffer from severe neurological complications. Microglia are innate immune cells of the central nervous system (CNS) parenchyma whose turnover is reliant on local proliferation. Microglia express a diverse range of proteins, which all...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1038/s41423-020-00620-5

    authors： Chhatbar C,Prinz M

    更新日期：2021-02-01 00:00:00

  • Shared and distinct roles of T peripheral helper and T follicular helper cells in human diseases.

    abstract：:The interactions of CD4+ T cells and B cells are fundamental for the generation of protective antibody responses, as well as for the development of harmful autoimmune diseases. Recent studies of human tissues and blood samples have established a new subset of CD4+ B helper T cells named peripheral helper T (Tph) cells...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1038/s41423-020-00529-z

    authors： Yoshitomi H,Ueno H

    更新日期：2020-08-31 00:00:00

  • Increased uterine NK-derived IFN-gamma and TNF-alpha in C57BL/6J mice during early gestation.

    abstract：:Natural killer (NK) cells are bone marrow-derived lymphocytes. They produce cytokines that regulate the development of acquired immunity. In view of their accumulation at the maternal-fetal interface, uterine natural killer (uNK) cells are also thought to play essential roles during pregnancy. Our results compared the...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：

    authors： Wu X,Wei H,Zhang J,Tian Z

    更新日期：2006-04-01 00:00:00

  • MicroRNA-99a mimics inhibit M1 macrophage phenotype and adipose tissue inflammation by targeting TNFα.

    abstract：:In human adipose tissue and obesity, miR-99a expression is negatively correlated with inflammation. Therefore, the present study investigated the role of miR-99a in macrophage phenotype activation and adipose tissue inflammation. M2 BMDMs showed a significant increase in miR-99a expression when compared to the M0 and ...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/s41423-018-0038-7

    authors： Jaiswal A,Reddy SS,Maurya M,Maurya P,Barthwal MK

    更新日期：2019-05-01 00:00:00

  • Invariant natural killer T cells contribute to chronic-plus-binge ethanol-mediated liver injury by promoting hepatic neutrophil infiltration.

    abstract：:Neutrophil infiltration is a hallmark of alcoholic steatohepatitis; however, the underlying mechanisms remain unclear. We previously reported that chronic-plus-binge ethanol feeding synergistically induces hepatic recruitment of neutrophils, which contributes to liver injury. In this paper, we investigated the roles o...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/cmi.2015.06

    authors： Mathews S,Feng D,Maricic I,Ju C,Kumar V,Gao B

    更新日期：2016-03-01 00:00:00

  • Tissue-resident lymphocytes: from adaptive to innate immunity.

    abstract：:Efficient immune responses against invading pathogens often involve coordination between cells from both the innate and adaptive immune systems. For multiple decades, it has been believed that CD8+ memory T cells and natural killer (NK) cells constantly and uniformly recirculate. Only recently was the existence of non...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1038/s41423-018-0192-y

    authors： Sun H,Sun C,Xiao W,Sun R

    更新日期：2019-03-01 00:00:00

  • Post-transcriptional regulator Rbm47 elevates IL-10 production and promotes the immunosuppression of B cells.

    abstract：:Regulatory B cells (Bregs) are a functionally defined B cell subset, and IL-10 is crucial for the suppressive functions of Bregs. However, little is known regarding how IL-10 production is regulated in B cells. To explore the mechanisms by which IL-10 is regulated in B cells, we used mRNA microarrays to screen for mol...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/s41423-018-0041-z

    authors： Wei Y,Zhang F,Zhang Y,Wang X,Xing C,Guo J,Zhang H,Suo Z,Li Y,Wang J,Wang R,Cai Z

    更新日期：2019-06-01 00:00:00

  • The rLrp of Mycobacterium tuberculosis inhibits proinflammatory cytokine production and downregulates APC function in mouse macrophages via a TLR2-mediated PI3K/Akt pathway activation-dependent mechanism.

    abstract：:We demonstrate that Mycobacterium tuberculosis recombinant leucine-responsive regulatory protein (rLrp) inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-α), interleukin-6, and interleukin-12 production and blocks the nuclear translocation of subunits of the nuclear-receptor transcription fact...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/cmi.2015.58

    authors： Liu Y,Li JY,Chen ST,Huang HR,Cai H

    更新日期：2016-11-01 00:00:00

  • Transcriptional crosstalk between nuclear receptors and cytokine signal transduction pathways in immunity.

    abstract：:The nuclear receptor superfamily and the transcriptional factors associated with cytokines are inherently different families of signaling molecules and activate gene transcription by binding to their respective responsive element. However, it has become increasingly clear from our works and others that nuclear recepto...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,评审

    doi：

    authors： Wang L,Zhang X,Farrar WL,Yang X

    更新日期：2004-12-01 00:00:00

  • The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases.

    abstract：:Metagenomic approaches are currently being used to decipher the genome of the microbiota (microbiome), and, in parallel, functional studies are being performed to analyze the effects of the microbiota on the host. Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1038/cmi.2010.67

    authors： Tlaskalová-Hogenová H,Stěpánková R,Kozáková H,Hudcovic T,Vannucci L,Tučková L,Rossmann P,Hrnčíř T,Kverka M,Zákostelská Z,Klimešová K,Přibylová J,Bártová J,Sanchez D,Fundová P,Borovská D,Srůtková D,Zídek Z,Schwarzer M

    更新日期：2011-03-01 00:00:00

  • Chemokine receptors and transplantation.

    abstract：:A complex process including both the innate and acquired immune responses results in allograft rejection. Some chemokine receptors and their ligands play essential roles not only for leukocyte migration into the graft but also in facilitating dendritic and T cell trafficking between lymph nodes and the transplant in t...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,评审

    doi：

    authors： Tan J,Zhou G

    更新日期：2005-10-01 00:00:00

  • Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties.

    abstract：:Diabetes-associated periodontitis (DP) aggravates diabetic complications and increases mortality from diabetes. DP is caused by diabetes-enhanced host immune-inflammatory responses to bacterial insult. In this study, we found that persistently elevated CCL2 levels in combination with proinflammatory monocyte infiltrat...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/s41423-020-0500-1

    authors： Shen Z,Kuang S,Zhang M,Huang X,Chen J,Guan M,Qin W,Xu HHK,Lin Z

    更新日期：2020-07-16 00:00:00

  • Chemoattractants and cytokines in primary ciliary dyskinesia and cystic fibrosis: key players in chronic respiratory diseases.

    abstract：:Patients with primary ciliary dyskinesia (PCD) and cystic fibrosis (CF), two inherited disorders, suffer from recurrent airway infections characterized by persistent bacterial colonization and uncontrollable inflammation. Although present in high counts, neutrophils fail to clear infection in the airways. High levels ...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1038/cmi.2017.118

    authors： Cockx M,Gouwy M,Van Damme J,Struyf S

    更新日期：2018-04-01 00:00:00

  • The effects of aerosolized STAT1 antisense oligodeoxynucleotides on rat pulmonary fibrosis.

    abstract：:Previous study showed that aerosolized signal transducer and activator of transcription-1 (STAT1) antisense oligodeoxynucleotide (ASON) inhibited the expression of STAT1 and ICAM-1 mRNA and protein in alveolar macrophages (AMs) and decreased the concentrations of TGF-beta, PDGF and TNF-alpha in bronchioalveolar lavage...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/cmi.2009.7

    authors： Wang WJ,Liao B,Zeng M,Zhu C,Fan XM

    更新日期：2009-02-01 00:00:00

  • The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection.

    abstract：:Epigenetic modifications to histones dictate the differentiation of naïve CD4+ T cells into different subsets of effector T helper (TH) cells. The histone methyltransferase enhancer of zeste homolog 2 (EZH2) has been implicated in the mechanism regulating the differentiation of TH1, TH2 and regulatory T (Treg) cells. ...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/s41423-019-0219-z

    authors： Chen X,Cao G,Wu J,Wang X,Pan Z,Gao J,Tian Q,Xu L,Li Z,Hao Y,Huang Q,Wang P,Xiao M,Xie L,Tang S,Liu Z,Hu L,Tang J,He R,Wang L,Zhou X,Wu Y,Chen M,Sun B,Zhu B,Huang J,Ye L

    更新日期：2020-03-01 00:00:00

  • Plasmacytoid dendritic cells act as the most competent cell type in linking antiviral innate and adaptive immune responses.

    abstract：:Appropriate in vivo control of plasmacytoid dendritic cell (pDC) recruitment and activation is a fundamental requirement for defense against viral infection. During this process, a pivotal event that influences the outcome of viral infection is the production of high levels of type I interferon by pDCs. In particular,...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,评审

    doi：

    authors： Zhang Z,Wang FS

    更新日期：2005-12-01 00:00:00

  • Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy.

    abstract：:Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers, the majority of patients with solid tumors do not respond well, but the underlying reason remains unclear. Here, we studied ovarian cancer (OvCa), a tumor type generally resistant to current immunotherapies, to investigate PD-1-inde...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/s41423-019-0305-2

    authors： Cai D,Li J,Liu D,Hong S,Qiao Q,Sun Q,Li P,Lyu N,Sun T,Xie S,Guo L,Ni L,Jin L,Dong C

    更新日期：2020-03-01 00:00:00

  • The role of the T follicular helper cells in allergic disease.

    abstract：:T follicular helper (Tfh) cells were discovered just over a decade ago as germinal centre T cells that help B cells make antibodies. Included in this role is affinity maturation and isotype switching. It is here that their functions become less clear. Tfh cells principally produce IL-21 which inhibits class switching ...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1038/cmi.2012.31

    authors： Kemeny DM

    更新日期：2012-09-01 00:00:00

  • Regulatory B cells in autoimmune diseases.

    abstract：:B cells are generally considered to be positive regulators of the immune response because of their capability to produce antibodies, including autoantibodies. The production of antibodies facilitates optimal CD4(+) T-cell activation because B cells serve as antigen-presenting cells and exert other modulatory functions...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1038/cmi.2012.60

    authors： Yang M,Rui K,Wang S,Lu L

    更新日期：2013-03-01 00:00:00

  • Protection of immuno-compromised mice from lethal infection of Klebsiella pneumonia by rAAV2-BPI23-Fcgamma1 gene transfer.

    abstract：:In previous research, chimerical BPI23-Fcgamma1 gene which consisted of human bactericidal/permeability increasing protein (BPI) gene of encoding the functional N terminus (amino acid residues 1 to 199) of human BPI and Fcgamma1 gene of encoding the Fc segment of human immunoglobulin G1 was successfully reconstructed ...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/cmi.2008.55

    authors： Li J,Kong Q,Lv Z,Guan Y,Qiu Y,Li C,Sun M,Liu Z,An Y

    更新日期：2008-12-01 00:00:00