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Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients.

Abstract：

:B cells play an important role in the clearance of hepatitis B virus (HBV) and protection against reinfection. However, the functional characteristics of these cells that are associated with the outcome of chronic HBV infection remain unknown. We comprehensively investigated the frequency, phenotype, and function of peripheral B-cell subsets from CHB patients in different phases: immune tolerance (IT), immune activation (IA), immune clearance (IC), responders with HBsAg seroconversion (resolved patients, RP), and healthy controls (HC). IA patients displayed lower percentages of peripheral blood memory B cells compared with the other groups. Overall polyclonal activation of B cells, indicated by higher levels of activation markers and secretion of IgG and IgM, was observed in IA patients. This B-cell hyperactivation could be induced by increased IFN-α and soluble CD40 ligands in IA patients. Notably, the expression of the co-stimulator molecule CD80 and serum HBsAb and the frequency of HBsAg-specific B cells were significantly decreased in IT, IA, and IC patients compared with HC subjects. More importantly, the B-cell hyperactivation, co-stimulatory molecule downregulation and HBsAg-specific B-cell impairment were reversed in RP patients. The reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients.

journal_name

Cell Mol Immunol

journal_title

Cellular & molecular immunology

authors

Xu X,Shang Q,Chen X,Nie W,Zou Z,Huang A,Meng M,Jin L,Xu R,Zhang JY,Fu J,Wang L,Tang Z,Xie Y,Yang X,Zhang Z,Wang FS

doi

10.1038/cmi.2015.25

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

309-16

issue

3

eissn

1672-7681

issn

2042-0226

pii

cmi201525

journal_volume

12

pub_type

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