Increased uterine NK-derived IFN-gamma and TNF-alpha in C57BL/6J mice during early gestation.

abstract：:MiR-122 is one of the non-coding RNAs which showed its effects on the lipo-metablism, virus infection and HCC forming through regulation of liver gene expression. Its eukaryotic expression vector was constructed by using pSuper which was widely applied in the siRNA expression. The precursor of human miR-122 gene was a...

journal_title：Cellular & molecular immunology

authors： Chen S,Ni M,Yu B,Lv T,Lu M,Gong F

更新日期：2007-12-01 00:00:00

abstract：:Trogocytosis is a process which involves the transfer of membrane fragments and cell surface proteins between cells. Various types of T cells have been shown to be able to acquire membrane-bound proteins from antigen-presenting cells and their functions can be modulated following trogocytosis. However, it is not known...

journal_title：Cellular & molecular immunology

authors： Gu P,Gao JF,D'Souza CA,Kowalczyk A,Chou KY,Zhang L

更新日期：2012-03-01 00:00:00

abstract：:It has recently been established that neutrophils, the most abundant leukocytes, are capable of changes in gene expression during inflammatory responses. However, changes in the transcriptome as the neutrophil leaves the bone marrow have yet to be described. We hypothesized that neutrophils are transcriptionally activ...

journal_title：Cellular & molecular immunology

authors： Lakschevitz FS,Visser MB,Sun C,Glogauer M

更新日期：2015-01-01 00:00:00

abstract：:Innate lymphoid cells (ILCs), as an important component of the innate immune system, arise from a common lymphoid progenitor and are located in mucosal barriers and various tissues, including the intestine, skin, lung, and adipose tissue. ILCs are heterogeneous subsets of lymphocytes that have emerging roles in orches...

journal_title：Cellular & molecular immunology

authors： Zhou S,Li Q,Wu H,Lu Q

更新日期：2020-04-01 00:00:00

abstract：:Induction of osteopontin (OPN), a well-known pro-inflammatory molecule, has been observed in acetaminophen (APAP)-induced hepatotoxicity. However, the precise cell source for OPN induction and its role during APAP-induced hepatotoxicity has not been fully explored. By employing a hepatotoxic mouse model induced by APA...

journal_title：Cellular & molecular immunology

authors： Wen Y,Wang C,Gu J,Yu C,Wang K,Sun X,Sun Y,Wu H,Tong Y,Xia Q,Kong X

更新日期：2019-05-01 00:00:00

abstract：:The unmethylated CpG DNA can prevent spontaneous apoptosis of B cells. However, the precise mechanisms by which CpG DNA blocks apoptosis remain unclear. In this study, we showed B cell apoptosis was significantly inhibited by addition of CpG DNA. Treatment of CpG DNA could reduce the expression of caspase 3, increase ...

journal_title：Cellular & molecular immunology

authors： Zhou Y,Zhen H,Mei Y,Wang Y,Feng J,Xu S,Fu X

更新日期：2009-06-01 00:00:00

abstract：:Inflammasomes are important for maintaining intestinal homeostasis, and dysbiosis contributes to the pathology of inflammatory bowel disease (IBD) and increases the risk for colorectal cancer. Inflammasome defects contribute to chronic intestinal inflammation and increase the susceptibility to colitis in mice. However...

journal_title：Cellular & molecular immunology

authors： Ratsimandresy RA,Indramohan M,Dorfleutner A,Stehlik C

更新日期：2017-01-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) has been recognized as an activator of nuclear factor kappaB (NF-kappaB), a factor implicated in the protection of many cell types from apoptosis. We and others have presented evidence to suggest that Fas-induced apoptosis may be an important aspect of the resolution of inflamma...

journal_title：Cellular & molecular immunology

authors： Qin Y,Auh S,Blokh L,Long C,Gagnon I,Hamann KJ

更新日期：2007-02-01 00:00:00

abstract：:While there is mounting evidence that interleukin (IL)-23-IL-17 axis plays a critical role in the pathogenesis of various autoimmune diseases, much remains to be elucidated on how IL-23 is induced in the pathological processes. IL-23 is a heterodimer composed of p19 and p40, the latter being shared with IL-12. We prev...

journal_title：Cellular & molecular immunology

authors： Ma X,Aoki T,Narumiya S

更新日期：2016-03-01 00:00:00

abstract：:Infection with human immunodeficiency virus (HIV) disrupts the balance among γδ T cell subsets, with increasing Vδ1+ cells and substantial depletion of circulating Vδ2+ cells. Depletion is an indirect effect of HIV in CD4-negative Vδ2 cells, but is specific for phosphoantigen-responsive subpopulations identified by th...

journal_title：Cellular & molecular immunology

authors： Li H,Chaudhry S,Poonia B,Shao Y,Pauza CD

更新日期：2013-01-01 00:00:00

abstract：:pR(ST98) is a large and conjugative resistant plasmid (R plasmid) of 98.6 mega-dalton from multi-drug resistant Salmonella typhi (S. typhi), which was classified to incompatibility group C (Inc C). It has been found that pRST98 made its host bacteria not only antibiotic resistant but also more virulent. In this study ...

journal_title：Cellular & molecular immunology

authors： Huang R,Wu S,Zhang X,Zhang Y

更新日期：2005-04-01 00:00:00

abstract：:Epigenetic modifications to histones dictate the differentiation of naïve CD4+ T cells into different subsets of effector T helper (TH) cells. The histone methyltransferase enhancer of zeste homolog 2 (EZH2) has been implicated in the mechanism regulating the differentiation of TH1, TH2 and regulatory T (Treg) cells. ...

journal_title：Cellular & molecular immunology

authors： Chen X,Cao G,Wu J,Wang X,Pan Z,Gao J,Tian Q,Xu L,Li Z,Hao Y,Huang Q,Wang P,Xiao M,Xie L,Tang S,Liu Z,Hu L,Tang J,He R,Wang L,Zhou X,Wu Y,Chen M,Sun B,Zhu B,Huang J,Ye L

更新日期：2020-03-01 00:00:00

abstract：:Using a newly generated monoclonal antibody (2E6) against human B7-H3, we explored the expression of the molecule on dendritic cells derived from monocytes (Mo-DCs). Its expression was examined by means of immunostaining and flow cytometric (FCM) analysis. The results showed that B7-H3 was expressed in the course of M...

journal_title：Cellular & molecular immunology

authors： Zhang G,Dong Q,Xu Y,Yu G,Zhang X

更新日期：2005-08-01 00:00:00

abstract：:Metagenomic approaches are currently being used to decipher the genome of the microbiota (microbiome), and, in parallel, functional studies are being performed to analyze the effects of the microbiota on the host. Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization...

journal_title：Cellular & molecular immunology

authors： Tlaskalová-Hogenová H,Stěpánková R,Kozáková H,Hudcovic T,Vannucci L,Tučková L,Rossmann P,Hrnčíř T,Kverka M,Zákostelská Z,Klimešová K,Přibylová J,Bártová J,Sanchez D,Fundová P,Borovská D,Srůtková D,Zídek Z,Schwarzer M

更新日期：2011-03-01 00:00:00

abstract：:Despite impressive results obtained in animal models, the clinical use of Fas ligand (FasL) as an anticancer drug is limited by severe toxicity. Systemic toxicity of death ligands may be prevented by using genes encoding membrane-bound death ligands and by targeted transgene expression through either targeted transduc...

journal_title：Cellular & molecular immunology

authors： Liu Z,Wang J,Yin P,Qiu J,Liu R,Li W,Fan X,Cheng X,Chen C,Zhang J,Zhuang G

更新日期：2009-08-01 00:00:00

abstract：:In previous research, chimerical BPI23-Fcgamma1 gene which consisted of human bactericidal/permeability increasing protein (BPI) gene of encoding the functional N terminus (amino acid residues 1 to 199) of human BPI and Fcgamma1 gene of encoding the Fc segment of human immunoglobulin G1 was successfully reconstructed ...

journal_title：Cellular & molecular immunology

authors： Li J,Kong Q,Lv Z,Guan Y,Qiu Y,Li C,Sun M,Liu Z,An Y

更新日期：2008-12-01 00:00:00

abstract：:In cancer, myeloid cells have tumor-supporting roles. We reported that the protein GPNMB (glycoprotein nonmetastatic B) was profoundly upregulated in macrophages interacting with tumor cells. Here, using mouse tumor models, we show that macrophage-derived soluble GPNMB increases tumor growth and metastasis in Gpnmb-mu...

journal_title：Cellular & molecular immunology

authors： Liguori M,Digifico E,Vacchini A,Avigni R,Colombo FS,Borroni EM,Farina FM,Milanesi S,Castagna A,Mannarino L,Craparotta I,Marchini S,Erba E,Panini N,Tamborini M,Rimoldi V,Allavena P,Belgiovine C

更新日期：2020-07-29 00:00:00

abstract：:In an attempt to isolate and characterize peptides mimicking epitopes of metalloprotease and explore their immunological protection against Schistosoma japonicum (S. japonicum), polyclonal anti-metalloprotease sera was prepared to screen a 12-mer random peptide library to isolate phages binding specially to antisera I...

journal_title：Cellular & molecular immunology

authors： Tang L,Chen Y,Wang L,Zhang S,Zeng X,Yi X

更新日期：2005-06-01 00:00:00

abstract：:Potential crosslinks between inflammation and leukaemia have been discussed for some time, but experimental evidence to support this dogma is scarce. In particular, it is important to understand the mechanisms responsible for potential upregulation of proto-oncogenic growth factor expressions by inflammatory mediators...

journal_title：Cellular & molecular immunology

authors： Wyszynski RW,Gibbs BF,Varani L,Iannotta D,Sumbayev VV

更新日期：2016-01-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is an important factor in the induction of colon cancer, but its mechanism is unclear. Colitis and colitis-associated colorectal cancer (CAC) models induced using both dextran sulfate sodium (DSS) and the azoxymethane/DSS protocol were established in wild-type (WT) and CTRP4 transgenic...

journal_title：Cellular & molecular immunology

authors： Luo Y,Wu X,Ma Z,Tan W,Wang L,Na D,Zhang G,Yin A,Huang H,Xia D,Zhang Y,Shi X,Wang L

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:Plasma phospholipid transfer protein (PLTP) is a key determinant of lipoprotein metabolism, and both animal and human studies converge to indicate that PLTP promotes atherogenesis and its thromboembolic complications. Moreover, it has recently been reported that PLTP modulates inflammation and immune response...

journal_title：Cellular & molecular immunology

authors： Desrumaux C,Lemaire-Ewing S,Ogier N,Yessoufou A,Hammann A,Sequeira-Le Grand A,Deckert V,Pais de Barros JP,Le Guern N,Guy J,Khan NA,Lagrost L

更新日期：2016-11-01 00:00:00

abstract：:The disturbance of maternal immune tolerance to a semiallogeneic fetus is recognized as one of the key pathologies of preeclampsia (PE), in which an imbalance between the inflammation-limiting regulatory T cells (Tregs) and the inflammation-mediating Th17 cells plays an essential role. Previously, we reported that the...

journal_title：Cellular & molecular immunology

authors： Ding H,Dai Y,Lei Y,Wang Z,Liu D,Li R,Shen L,Gu N,Zheng M,Zhu X,Zhao G,Hu Y

更新日期：2019-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a heterogeneous disease with a poor prognosis and limited markers for predicting patient survival. Because chemokines and chemokine receptors play numerous and integral roles in HCC disease progression, the CXCR4-CXCL12-CXCR7 axis was studied in HCC patients. CXCR4 and CXCR7 expressio...

journal_title：Cellular & molecular immunology

authors： Neve Polimeno M,Ierano C,D'Alterio C,Simona Losito N,Napolitano M,Portella L,Scognamiglio G,Tatangelo F,Maria Trotta A,Curley S,Costantini S,Liuzzi R,Izzo F,Scala S

更新日期：2015-07-01 00:00:00

abstract：:The concept of stem cells, their physiological existence, the intricate anatomical localization, the known and the unknown functions, and their exclusive utility for the purpose of regenerative medicine, are all now encompassed within an emergent question, 'how compatible these cells are immunologically?' Indeed, the ...

journal_title：Cellular & molecular immunology

authors： Sujata L,Chaudhuri S

更新日期：2008-04-01 00:00:00

abstract：:Genetic mutations in the gene encoding DOCK8 cause an autosomal recessive form of hyper immunoglobulin E syndrome (AR-HIES), referred to as DOCK8 deficiency. DOCK8 deficiency in humans results in the onset of combined immunodeficiency disease (CID), clinically associated with chronic infections with diverse microbial ...

journal_title：Cellular & molecular immunology

authors： Kearney CJ,Randall KL,Oliaro J

更新日期：2017-05-01 00:00:00

abstract：:The human immunodeficiency virus-1 (HIV-1) envelope protein gp120 is the major contributor to the pathogenesis of HIV-associated neurocognitive disorder (HAND). Neuroinflammation plays a pivotal role in gp120-induced neuropathology, but how gp120 triggers neuroinflammatory processes and subsequent neuronal death remai...

journal_title：Cellular & molecular immunology

authors： He X,Yang W,Zeng Z,Wei Y,Gao J,Zhang B,Li L,Liu L,Wan Y,Zeng Q,Gong Z,Liu L,Zhang H,Li Y,Yang S,Hu T,Wu L,Masliah E,Huang S,Cao H

更新日期：2020-03-01 00:00:00

abstract：:Hypoxia is a major characteristic of the tumor microenvironment, and its effects on immune cells are proposed to be important factors for the process of tumor immune escape. It has been reported that hypoxia affects the function of dendritic cells and the antitumor function of T cells. Here we discuss the effects of h...

journal_title：Cellular & molecular immunology

authors： Sun J,Zhang Y,Yang M,Zhang Y,Xie Q,Li Z,Dong Z,Yang Y,Deng B,Feng A,Hu W,Mao H,Qu X

更新日期：2010-01-01 00:00:00

abstract：:The relationship between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and host immunity is poorly understood. We performed an extensive analysis of immune responses in 32 patients with severe COVID-19, some of whom succumbed. A control population of healthy subjects was included. Patients with COVID-19...

journal_title：Cellular & molecular immunology

authors： Varchetta S,Mele D,Oliviero B,Mantovani S,Ludovisi S,Cerino A,Bruno R,Castelli A,Mosconi M,Vecchia M,Roda S,Sachs M,Klersy C,Mondelli MU

更新日期：2020-10-15 00:00:00

abstract：:Apoptotic cell transfer has been found to be able to facilitate engraftment of allograft. However, the underlying mechanisms remain to be fully understood. Here we demonstrate that intravenous administration of donor apoptotic splenocytes can promote pancreatic islet engraftment by inducing generation of tolerogenic d...

journal_title：Cellular & molecular immunology

authors： Wu C,Zhang Y,Jiang Y,Wang Q,Long Y,Wang C,Cao X,Chen G

更新日期：2013-09-01 00:00:00

abstract：:Interleukin-22 (IL-22) is a recently identified T cell-derived cytokine whose biological significance remains obscure. Previously, we have shown that IL-22 plays a protective role in T cell-mediated hepatitis induced by Concanavalin A (Con A), acting as a survival factor for hepatocytes. In the present paper, we demon...

journal_title：Cellular & molecular immunology

authors： Pan H,Hong F,Radaeva S,Gao B

更新日期：2004-02-01 00:00:00