Comparative immunization in BALB/c mice with recombinant replication-defective adenovirus vector and DNA plasmid expressing a SARS-CoV nucleocapsid protein gene.

abstract：:Exercise at regular intervals is assumed to have a positive effect on immune functions. Conversely, after spaceflight and under simulated weightlessness (e.g., bed rest), immune functions can be suppressed. We aimed to assess the effects of simulated weightlessness (Second Berlin BedRest Study; BBR2-2) on immunologica...

journal_title：Cellular & molecular immunology

authors： Hoff P,Belavý DL,Huscher D,Lang A,Hahne M,Kuhlmey AK,Maschmeyer P,Armbrecht G,Fitzner R,Perschel FH,Gaber T,Burmester GR,Straub RH,Felsenberg D,Buttgereit F

更新日期：2015-07-01 00:00:00

abstract：:Regulatory B cells (Bregs) are a functionally defined B cell subset, and IL-10 is crucial for the suppressive functions of Bregs. However, little is known regarding how IL-10 production is regulated in B cells. To explore the mechanisms by which IL-10 is regulated in B cells, we used mRNA microarrays to screen for mol...

journal_title：Cellular & molecular immunology

authors： Wei Y,Zhang F,Zhang Y,Wang X,Xing C,Guo J,Zhang H,Suo Z,Li Y,Wang J,Wang R,Cai Z

更新日期：2019-06-01 00:00:00

abstract：:The nuclear receptor superfamily and the transcriptional factors associated with cytokines are inherently different families of signaling molecules and activate gene transcription by binding to their respective responsive element. However, it has become increasingly clear from our works and others that nuclear recepto...

journal_title：Cellular & molecular immunology

authors： Wang L,Zhang X,Farrar WL,Yang X

更新日期：2004-12-01 00:00:00

abstract：:Metagenomic approaches are currently being used to decipher the genome of the microbiota (microbiome), and, in parallel, functional studies are being performed to analyze the effects of the microbiota on the host. Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization...

journal_title：Cellular & molecular immunology

authors： Tlaskalová-Hogenová H,Stěpánková R,Kozáková H,Hudcovic T,Vannucci L,Tučková L,Rossmann P,Hrnčíř T,Kverka M,Zákostelská Z,Klimešová K,Přibylová J,Bártová J,Sanchez D,Fundová P,Borovská D,Srůtková D,Zídek Z,Schwarzer M

更新日期：2011-03-01 00:00:00

abstract：:4-1BB (CD137) is a strong enhancer of the proliferation of CD8+ T cells. Since these cells require increased production of energy and biomass to support their proliferation, we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism. We found that treatment with agonistic anti-4-1BB mAb promoted ...

journal_title：Cellular & molecular immunology

authors： Choi BK,Lee DY,Lee DG,Kim YH,Kim SH,Oh HS,Han C,Kwon BS

更新日期：2017-09-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is an important factor in the induction of colon cancer, but its mechanism is unclear. Colitis and colitis-associated colorectal cancer (CAC) models induced using both dextran sulfate sodium (DSS) and the azoxymethane/DSS protocol were established in wild-type (WT) and CTRP4 transgenic...

journal_title：Cellular & molecular immunology

authors： Luo Y,Wu X,Ma Z,Tan W,Wang L,Na D,Zhang G,Yin A,Huang H,Xia D,Zhang Y,Shi X,Wang L

更新日期：2016-09-01 00:00:00

abstract：:Decidual natural killer (dNK) cells express an array of activation receptors to regulate placental immunity and development during early pregnancy. We investigated the functional character of human dNK cells during the first and second trimester of gestation and the interaction between dNK and trophoblast cells. Altho...

journal_title：Cellular & molecular immunology

authors： Zhang J,Dunk CE,Kwan M,Jones RL,Harris LK,Keating S,Lye SJ

更新日期：2017-02-01 00:00:00

abstract：:Inflammasomes are multi-protein signaling complexes that trigger the activation of inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome complexes, the NLRP3 inflammasome is best characterized and has been linked with various human autoinflammatory and autoimmune diseases. Thus, the NL...

journal_title：Cellular & molecular immunology

authors： Jo EK,Kim JK,Shin DM,Sasakawa C

更新日期：2016-03-01 00:00:00

abstract：:Efficient immune responses against invading pathogens often involve coordination between cells from both the innate and adaptive immune systems. For multiple decades, it has been believed that CD8+ memory T cells and natural killer (NK) cells constantly and uniformly recirculate. Only recently was the existence of non...

journal_title：Cellular & molecular immunology

authors： Sun H,Sun C,Xiao W,Sun R

更新日期：2019-03-01 00:00:00

abstract：:Age-related thymic involution causes a decreased output of thymocytes from the thymus, thereby resulting in impairment of T cell-mediated immunity. While alterations in the T cell and non-haematopoietic stromal compartments have been described, the effects of thymic involution on thymic dendritic cells (DC) are not cl...

journal_title：Cellular & molecular immunology

authors： van Dommelen SL,Rizzitelli A,Chidgey A,Boyd R,Shortman K,Wu L

更新日期：2010-03-01 00:00:00

abstract：:Viral encephalitis is a devastating disease with high mortality, and survivors often suffer from severe neurological complications. Microglia are innate immune cells of the central nervous system (CNS) parenchyma whose turnover is reliant on local proliferation. Microglia express a diverse range of proteins, which all...

journal_title：Cellular & molecular immunology

authors： Chhatbar C,Prinz M

更新日期：2021-02-01 00:00:00

abstract：:Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules for naive T cell activation and expansion, dendritic cells are thought to also provide signals for the differentiation of CD4+ T ce...

journal_title：Cellular & molecular immunology

authors： Hilligan KL,Ronchese F

更新日期：2020-06-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified as the receptor for dioxin. Almost half a century after its discovery, AHR is now recognized as a receptor for multiple physiological ligands, with important roles in health and disease. In this review, we discuss the r...

journal_title：Cellular & molecular immunology

authors： Barroso A,Mahler JV,Fonseca-Castro PH,Quintana FJ

更新日期：2021-02-01 00:00:00

abstract：:It is well-documented that alcohol drinking together with hepatitis viral infection accelerates liver injury; however the underlying mechanisms remain unknown. In this paper, we demonstrated that primary hepatocytes from transgenic mice overexpressing hepatitis B virus X protein (HBX) were more susceptible to ethanol-...

journal_title：Cellular & molecular immunology

authors： Kim WH,Hong F,Jaruga B,Zhang ZS,Fan SJ,Liang TJ,Gao B

更新日期：2005-02-01 00:00:00

abstract：:We demonstrate that Mycobacterium tuberculosis recombinant leucine-responsive regulatory protein (rLrp) inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-α), interleukin-6, and interleukin-12 production and blocks the nuclear translocation of subunits of the nuclear-receptor transcription fact...

journal_title：Cellular & molecular immunology

authors： Liu Y,Li JY,Chen ST,Huang HR,Cai H

更新日期：2016-11-01 00:00:00

abstract：:In addition to serving as molecular chaperones, heat shock proteins (HSPs) have been implicated in autoimmune diseases, antigen presentation and tumor immunity. Extensive work in the last 10 years has also suggested that HSPs such as Hsp60, Hsp70, Hsp90 and gp96, may be potent activators of the innate immune system ca...

journal_title：Cellular & molecular immunology

authors： Tsan MF,Gao B

更新日期：2004-08-01 00:00:00

abstract：:Follicular helper T (Tfh) cells select mutated B cells in germinal centres, which can then differentiate into long-lived high affinity memory B cells and plasma cells. Tfh cells are regulated by a unique molecular programme orchestrated by the transcriptional repressor Bcl6. This transcription factor turns down expres...

journal_title：Cellular & molecular immunology

authors： Yu D,Vinuesa CG

更新日期：2010-05-01 00:00:00

abstract：:Genetic mutations in the gene encoding DOCK8 cause an autosomal recessive form of hyper immunoglobulin E syndrome (AR-HIES), referred to as DOCK8 deficiency. DOCK8 deficiency in humans results in the onset of combined immunodeficiency disease (CID), clinically associated with chronic infections with diverse microbial ...

journal_title：Cellular & molecular immunology

authors： Kearney CJ,Randall KL,Oliaro J

更新日期：2017-05-01 00:00:00

abstract：:Epigenetic modifications to histones dictate the differentiation of naïve CD4+ T cells into different subsets of effector T helper (TH) cells. The histone methyltransferase enhancer of zeste homolog 2 (EZH2) has been implicated in the mechanism regulating the differentiation of TH1, TH2 and regulatory T (Treg) cells. ...

journal_title：Cellular & molecular immunology

authors： Chen X,Cao G,Wu J,Wang X,Pan Z,Gao J,Tian Q,Xu L,Li Z,Hao Y,Huang Q,Wang P,Xiao M,Xie L,Tang S,Liu Z,Hu L,Tang J,He R,Wang L,Zhou X,Wu Y,Chen M,Sun B,Zhu B,Huang J,Ye L

更新日期：2020-03-01 00:00:00

abstract：:Diabetes-associated periodontitis (DP) aggravates diabetic complications and increases mortality from diabetes. DP is caused by diabetes-enhanced host immune-inflammatory responses to bacterial insult. In this study, we found that persistently elevated CCL2 levels in combination with proinflammatory monocyte infiltrat...

journal_title：Cellular & molecular immunology

authors： Shen Z,Kuang S,Zhang M,Huang X,Chen J,Guan M,Qin W,Xu HHK,Lin Z

更新日期：2020-07-16 00:00:00

abstract：:Vγ2Vδ2 T (also known as Vγ9Vδ2 T) cells exist only in primates, and in humans represent a major γδ T-cell sub-population in the total population of circulating γδ T cells. Results from recent studies suggest that while (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) phosphoantigen from Mycobacterium tuberculos...

journal_title：Cellular & molecular immunology

authors： Chen ZW

更新日期：2013-01-01 00:00:00

abstract：:In an attempt to isolate and characterize peptides mimicking epitopes of metalloprotease and explore their immunological protection against Schistosoma japonicum (S. japonicum), polyclonal anti-metalloprotease sera was prepared to screen a 12-mer random peptide library to isolate phages binding specially to antisera I...

journal_title：Cellular & molecular immunology

authors： Tang L,Chen Y,Wang L,Zhang S,Zeng X,Yi X

更新日期：2005-06-01 00:00:00

abstract：:It has recently been established that neutrophils, the most abundant leukocytes, are capable of changes in gene expression during inflammatory responses. However, changes in the transcriptome as the neutrophil leaves the bone marrow have yet to be described. We hypothesized that neutrophils are transcriptionally activ...

journal_title：Cellular & molecular immunology

authors： Lakschevitz FS,Visser MB,Sun C,Glogauer M

更新日期：2015-01-01 00:00:00

abstract：:Infection with human immunodeficiency virus (HIV) disrupts the balance among γδ T cell subsets, with increasing Vδ1+ cells and substantial depletion of circulating Vδ2+ cells. Depletion is an indirect effect of HIV in CD4-negative Vδ2 cells, but is specific for phosphoantigen-responsive subpopulations identified by th...

journal_title：Cellular & molecular immunology

authors： Li H,Chaudhry S,Poonia B,Shao Y,Pauza CD

更新日期：2013-01-01 00:00:00

abstract：:Neonates are at increased risk of viral encephalopathies that can result in neurological dysfunction, seizures, permanent disability and even death. The neurological damage results from the combined effect of the virus and the immune response it elicits, thus finding tools to facilitate viral clearance from central ne...

journal_title：Cellular & molecular immunology

authors： Ireland DD,Tami C,Pedras-Vasconcelos J,Verthelyi D

更新日期：2017-01-01 00:00:00

abstract：:Potential crosslinks between inflammation and leukaemia have been discussed for some time, but experimental evidence to support this dogma is scarce. In particular, it is important to understand the mechanisms responsible for potential upregulation of proto-oncogenic growth factor expressions by inflammatory mediators...

journal_title：Cellular & molecular immunology

authors： Wyszynski RW,Gibbs BF,Varani L,Iannotta D,Sumbayev VV

更新日期：2016-01-01 00:00:00

abstract：:Activation of the TAK1 signalosome is crucial for mediating the innate immune response to pathogen invasion and is regulated by multiple layers of posttranslational modifications, including ubiquitination, SUMOylation, and phosphorylation; however, the underlying molecular mechanism is not fully understood. In this st...

journal_title：Cellular & molecular immunology

authors： Gu Z,Chen X,Yang W,Qi Y,Yu H,Wang X,Gong Y,Chen Q,Zhong B,Dai L,Qi S,Zhang Z,Zhang H,Hu H

更新日期：2020-11-12 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by B-cell hyperreactivity. The Toll-like receptor 7 (TLR7) signaling pathway is abnormally activated in SLE B cells. CyclinD3 (CCND3) plays an important role in B-cell proliferation, development, and differentiation. Although previous studies fo...

journal_title：Cellular & molecular immunology

authors： Ren D,Liu F,Dong G,You M,Ji J,Huang Y,Hou Y,Fan H

更新日期：2016-11-01 00:00:00

abstract：:Psoriasis is a chronic inflammatory skin disease with a strong genetic background and is triggered by environmental factors. Available evidence supports CD6, a lymphocyte surface receptor mostly expressed by T cells, as a putative target in autoimmunity. Accordingly, a humanized anti-CD6 antibody has been assayed for ...

journal_title：Cellular & molecular immunology

authors： Consuegra-Fernández M,Julià M,Martínez-Florensa M,Aranda F,Català C,Armiger-Borràs N,Arias MT,Santiago F,Guilabert A,Esteve A,Muñoz C,Ferrándiz C,Carrascosa JM,Pedrosa E,Romaní J,Alsina M,Mascaró-Galy JM,Lozano F

更新日期：2018-10-01 00:00:00

abstract：:Dendritic cells (DCs) are the most potent professional antigen-presenting cells, and capable of stimulating naïve T cells and driving primary immune responses. DCs are poised to capture antigen, migrate to draining lymphoid organs, and after a process of maturation, select antigen-specific lymphocytes to which they pr...

journal_title：Cellular & molecular immunology

authors： Sun K,Wang L,Zhang Y

更新日期：2006-06-01 00:00:00