The aryl hydrocarbon receptor and the gut-brain axis.

Abstract:

:The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified as the receptor for dioxin. Almost half a century after its discovery, AHR is now recognized as a receptor for multiple physiological ligands, with important roles in health and disease. In this review, we discuss the role of AHR in the gut-brain axis and its potential value as a therapeutic target for immune-mediated diseases.

journal_name

Cell Mol Immunol

authors

Barroso A,Mahler JV,Fonseca-Castro PH,Quintana FJ

doi

10.1038/s41423-020-00585-5

subject

Has Abstract

pub_date

2021-02-01 00:00:00

pages

259-268

issue

2

eissn

1672-7681

issn

2042-0226

pii

10.1038/s41423-020-00585-5

journal_volume

18

pub_type

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