Abstract：
:Acute morphine administration is known to alter the course of herpes simplex virus infection. In this study, the effect of acute morphine administration on the reactivation of latent herpes was investigated in a mouse model. Because of the important role of cytolytic T lymphocyte (CTL) activity in the inhibition of herpes simplex virus type 1 (HSV-1) reactivation, the effect of acute morphine administration on CTL responses was also evaluated. Furthermore, lymphocyte proliferation and IFN-gamma production were evaluated for their roles in the induction of the CTL response. The findings showed that acute morphine administration significantly reduced CTL responses, lymphocyte proliferation, and IFN-gamma production. Furthermore, acute morphine administration has been shown to reactivate latent HSV-1. Previous studies have shown that cellular immune responses have important roles in the inhibition of HSV reactivation. These findings suggest that suppression of a portion of the cellular immune response after acute morphine administration may constitute one part of the mechanism that induces HSV reactivation.
journal_name
Cell Mol Immunoljournal_title
Cellular & molecular immunologyauthors
Mojadadi S,Jamali A,Khansarinejad B,Soleimanjahi H,Bamdad Tdoi
10.1038/cmi.2009.15subject
Has Abstractpub_date
2009-04-01 00:00:00pages
111-6issue
2eissn
1672-7681issn
2042-0226journal_volume
6pub_type
杂志文章abstract：:Previous studies have shown that the CC chemokine receptor CCR5 is downregulated on monocyte/macrophage (MO/Mphi) surfaces in head and neck squamous cell carcinoma (HNSCC) patients (stage IIIB). Ligands (RANTES, MIP-1alpha and MIP-1beta) of this chemokine receptor were also secreted in lesser quantity from MO/Mphi of ...
journal_title：Cellular & molecular immunology
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abstract：:Transplantable experimental tumor models were constructed to study the activities of recombinant human interleukin-15 (rhIL-15) against tumor recurrence and metastasis. The results showed that tumor nodule formation was retarded and tumor growth was inhibited in the subcutaneous tumor model of LA795 lung adenocarcinom...
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journal_title：Cellular & molecular immunology
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abstract：:It is well-documented that alcohol drinking together with hepatitis viral infection accelerates liver injury; however the underlying mechanisms remain unknown. In this paper, we demonstrated that primary hepatocytes from transgenic mice overexpressing hepatitis B virus X protein (HBX) were more susceptible to ethanol-...
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pub_type： 杂志文章,评审
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abstract：:Neutrophil infiltration is a hallmark of alcoholic steatohepatitis; however, the underlying mechanisms remain unclear. We previously reported that chronic-plus-binge ethanol feeding synergistically induces hepatic recruitment of neutrophils, which contributes to liver injury. In this paper, we investigated the roles o...
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pub_type： 杂志文章,评审
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journal_title：Cellular & molecular immunology
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journal_title：Cellular & molecular immunology
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doi：
更新日期：2007-02-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章
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更新日期：2018-04-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：
更新日期：2007-10-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章,收录出版
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2014.102
更新日期：2015-07-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/cmi.2010.18
更新日期：2010-05-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
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更新日期：2014-09-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2014.113
更新日期：2016-01-01 00:00:00
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journal_title：Cellular & molecular immunology
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：
更新日期：2006-10-01 00:00:00
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journal_title：Cellular & molecular immunology
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/cmi.2008.2
更新日期：2008-02-01 00:00:00
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2009.56
更新日期：2009-12-01 00:00:00
abstract：:Innate lymphoid cells (ILCs), including natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer (LTi) cells, comprise the first line of innate immune defense against pathogens and tumors. Over the past decade, accumulating evidence has demonstrated immunological memory in ILC subsets: for example, ...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
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journal_title：Cellular & molecular immunology
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journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
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更新日期：2021-02-01 00:00:00
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journal_title：Cellular & molecular immunology
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doi：
更新日期：2007-08-01 00:00:00
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journal_title：Cellular & molecular immunology
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journal_title：Cellular & molecular immunology
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abstract：:It has recently been established that neutrophils, the most abundant leukocytes, are capable of changes in gene expression during inflammatory responses. However, changes in the transcriptome as the neutrophil leaves the bone marrow have yet to be described. We hypothesized that neutrophils are transcriptionally activ...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2014.37
更新日期：2015-01-01 00:00:00
