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Regulatory B cells in autoimmune diseases.

Abstract：

:B cells are generally considered to be positive regulators of the immune response because of their capability to produce antibodies, including autoantibodies. The production of antibodies facilitates optimal CD4(+) T-cell activation because B cells serve as antigen-presenting cells and exert other modulatory functions in immune responses. However, certain B cells can also negatively regulate the immune response by producing regulatory cytokines and directly interacting with pathogenic T cells via cell-to-cell contact. These types of B cells are defined as regulatory B (Breg) cells. The regulatory function of Breg cells has been demonstrated in mouse models of inflammation, cancer, transplantation, and particularly in autoimmunity. In this review, we focus on the recent advances that lead to the understanding of the development and function of Breg cells and the implications of B cells in human autoimmune diseases.

journal_name

Cell Mol Immunol

journal_title

Cellular & molecular immunology

authors

Yang M,Rui K,Wang S,Lu L

doi

10.1038/cmi.2012.60

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

122-32

issue

2

eissn

1672-7681

issn

2042-0226

pii

cmi201260

journal_volume

10

pub_type

杂志文章,评审

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