解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
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放射学,核医学和医学成像
康复学
生殖生物学
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风湿病学
运动科学
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毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::As HIV has fueled a global resurgence of tuberculosis over the last several decades, there is a growing awareness that HIV-mediated impairments in both innate and adaptive immunity contribute to the heightened risk of tuberculosis in people with HIV. Since early immune responses to Mycobacterium tuberculosis (Mtb) set...
journal_title:Retrovirology
pub_type: 杂志文章,评审
doi:10.1186/s12977-020-00540-2
更新日期:2020-09-23 00:00:00
abstract:BACKGROUND:Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of HTLV associated myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) and Adult T cell leukemia/lymphoma (ATLL), in around 2-5% of the infected individuals. Host genetic background might play a role in disease progression. Several previ...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-020-00536-y
更新日期:2020-09-03 00:00:00
abstract:BACKGROUND:Adult T-cell leukemia lymphoma (ATLL) is a chemotherapy-resistant malignancy with a median survival of less than one year that will afflict between one hundred thousand and one million individuals worldwide who are currently infected with human T-cell leukemia virus type 1. Recurrent somatic mutations in hos...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-020-00535-z
更新日期:2020-08-28 00:00:00
abstract:BACKGROUND:The reliable diagnosis of human T-cell leukemia virus type 1 (HTLV-1) infection is important, particularly as it can be vertically transmitted by breast feeding mothers to their infants. However, current diagnosis in Japan requires a confirmatory western blot (WB) test after screening/primary testing for HTL...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-020-00534-0
更新日期:2020-08-24 00:00:00
abstract:BACKGROUND:HIV-1 infects a wide range of CD4+ T cells with different phenotypic properties and differing expression levels of entry coreceptors. We sought to determine the viral tropism of subtype C (C-HIV) Envelope (Env) clones for different CD4+ T cell subsets and whether tropism changes during acute to chronic disea...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-020-00532-2
更新日期:2020-08-06 00:00:00
abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:Retrovirology
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12977-020-00531-3
更新日期:2020-07-29 00:00:00
abstract:BACKGROUND:The continued persistence of HIV-1 as a public health concern due to the lack of a cure calls for the development of new tools for studying replication of the virus. Here, we used NanoLuc, a small and extremely bright luciferase protein, to develop an HIV-1 bioluminescent reporter virus that simplifies funct...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-020-00521-5
更新日期:2020-05-19 00:00:00
abstract::The development of safe and effective combination antiretroviral therapies for human immunodeficiency virus (HIV) infection over the past several decades has significantly reduced HIV-associated morbidity and mortality. Additionally, antiretroviral drugs have provided an effective means of protection against HIV trans...
journal_title:Retrovirology
pub_type: 杂志文章,评审
doi:10.1186/s12977-020-00515-3
更新日期:2020-04-10 00:00:00
abstract::HTLV-1 was the first described human retrovirus and was soon found to be associated with severe clinical diseases, including a devastating lymphoma/leukemia and other inflammatory diseases. Although HTLV-2 is not usually pathogenic, it is widely distributed among native Indian populations in Brazil, particularly in th...
journal_title:Retrovirology
pub_type: 杂志文章,评审
doi:10.1186/s12977-020-0512-z
更新日期:2020-02-14 00:00:00
abstract::Few years after HTLV-1 identification and isolation in humans, STLV-1, its simian counterpart, was discovered. It then became clear that STLV-1 is present almost in all simian species. Subsequent molecular epidemiology studies demonstrated that, apart from HTLV-1 subtype A, all human subtypes have a simian homolog. As...
journal_title:Retrovirology
pub_type: 杂志文章,评审
doi:10.1186/s12977-019-0503-0
更新日期:2019-12-16 00:00:00
abstract:BACKGROUND:HIV-1 integration results in genomic DNA gaps that are repaired by cellular DNA repair pathways. This step of the lentiviral life cycle remains poorly understood despite its crucial importance for successful replication. We and others reported that Ku70 protein of the non-homologous end joining pathway (NHEJ...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-019-0492-z
更新日期:2019-11-06 00:00:00
abstract:BACKGROUND:Reverse transcription (RT) of HIV and SIV is initiated by the binding of the acceptor stem of tRNALys3 to the primer binding site (PBS) of the viral RNA genome. Previous studies have suggested that this tRNALys3 is not the only molecule capable of priming reverse transcription, and that at least one other ly...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-019-0473-2
更新日期:2019-04-04 00:00:00
abstract:BACKGROUND:We previously showed that the gM of HSV-1 could restrict the release of infectious HIV-1 from cells. In this study, we analyzed if the four HSV-1 glycoproteins (gD, gB, and gH/gL), which are the minimum glycoproteins required for HSV-1 entry, restricted the release of infectious HIV-1. RESULTS:Of these four...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-019-0470-5
更新日期:2019-04-02 00:00:00
abstract:BACKGROUND:Mammalian cells harbour RNA quality control and degradative machineries such as nonsense-mediated mRNA decay that target cellular mRNAs for clearance from the cell to avoid aberrant gene expression. The role of the host mRNA decay pathways in macrophages in the context of human immunodeficiency virus type 1 ...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-019-0465-2
更新日期:2019-02-07 00:00:00
abstract:BACKGROUND:The APOBEC3 (A3) family of DNA cytosine deaminases provides an innate barrier to infection by retroviruses including HIV-1. A total of five enzymes, A3C, A3D, A3F, A3G and A3H, are degraded by the viral accessory protein Vif and expressed at high levels in CD4+ T cells, the primary reservoir for HIV-1 replic...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-018-0459-5
更新日期:2018-12-17 00:00:00
abstract:BACKGROUND:HIV infection and antiretroviral treatment are associated with changes in lipid levels, insulin resistance and risk of cardiovascular disease (CVD). We investigated these changes in the first 96 weeks of treatment with low-dose stavudine or tenofovir regimens. METHODS:This is a secondary analysis of a doubl...
journal_title:Retrovirology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12977-018-0460-z
更新日期:2018-12-14 00:00:00
abstract:BACKGROUND:Among human T cell leukemia virus type 1 (HTLV-1)-infected individuals, there is an association between HTLV-1 tax subgroups (subgroup-A or subgroup-B) and the risk of HAM/TSP in the Japanese population. To investigate the role of HTLV-1 subgroups in viral pathogenesis, we studied the functional difference i...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-018-0454-x
更新日期:2018-11-06 00:00:00
abstract::Integration of viral DNA into the host genome is a central event in the replication cycle and the pathogenesis of retroviruses, including HIV. Although most cells infected with HIV are rapidly eliminated in vivo, HIV also infects long-lived cells that persist during combination antiretroviral therapy (cART). Cells wit...
journal_title:Retrovirology
pub_type: 杂志文章,评审
doi:10.1186/s12977-018-0448-8
更新日期:2018-10-23 00:00:00
abstract::Traditionally, NK cells belong to the innate immune system and eliminate virus-infected cells through their germline-encoded receptors. However, NK cells were recently reported to possess memory-like functions that were predominantly provided by hepatic NK cells. Memory properties were mainly documented in contact hyp...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-018-0450-1
更新日期:2018-10-06 00:00:00
abstract::The identification of the most appropriate marker to measure reservoir size has been a great challenge for the HIV field. Quantitative viral outgrowth assay (QVOA), the reference standard to quantify the amount of replication-competent virus, has several limitations, as it is laborious, expensive, and unable to robust...
journal_title:Retrovirology
pub_type: 杂志文章,评审
doi:10.1186/s12977-018-0396-3
更新日期:2018-02-17 00:00:00
abstract::Although antiretroviral therapy is able to suppress HIV replication in infected patients, the virus persists and rebounds when treatment is stopped. In order to find a cure that can eradicate the latent reservoir, one must be able to quantify the persisting virus. Traditionally, HIV persistence studies have used real-...
journal_title:Retrovirology
pub_type: 杂志文章,评审
doi:10.1186/s12977-018-0399-0
更新日期:2018-01-30 00:00:00
abstract:BACKGROUND:HIV-1 Integrase (IN) interacts with the cellular co-factor LEDGF/p75 and tethers the HIV preintegration complex to the host genome enabling integration. Recently a new class of IN inhibitors was described, the IN-LEDGF allosteric inhibitors (INLAIs). Designed to interfere with the IN-LEDGF interaction during...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-017-0373-2
更新日期:2017-11-09 00:00:00
abstract:BACKGROUND:Human endogenous retroviruses (HERVs), the remnants of ancient retroviral infections, constitute approximately 8% of human genomic DNA. Since HERV-K Gag expression is induced by HIV-1 Tat in T cells, induced HERV-K proteins could affect HIV-1 replication. Indeed, previously we showed that HERV-K Gag and HIV-...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-017-0351-8
更新日期:2017-04-26 00:00:00
abstract:BACKGROUND:HIV-1 Vif interacts with the cellular core-binding factor β (CBFβ) and counteracts the protective roles of certain human APOBEC3 (A3) proteins by targeting them for proteasomal degradation. Previous studies have identified some amino acids important for Vif-CBFβ interactions, and recently a co-crystal struct...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-017-0346-5
更新日期:2017-03-17 00:00:00
abstract:BACKGROUND:The foamy viral genome encodes four central purine-rich elements localized in the integrase-coding region of pol. Previously, we have shown that the first two of these RNA elements (A and B) are required for protease dimerization and activation. The D element functions as internal polypurine tract during rev...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-017-0337-6
更新日期:2017-02-06 00:00:00
abstract:BACKGROUND:HIV-1 replication is critically dependent upon controlled processing of its RNA and the activities provided by its encoded regulatory factors Tat and Rev. A screen of small molecule modulators of RNA processing identified several which inhibited virus gene expression, affecting both relative abundance of spe...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-017-0330-0
更新日期:2017-01-26 00:00:00
abstract:BACKGROUND:Jaagsiekte sheep retrovirus (JSRV) causes a contagious lung cancer in sheep and goats that can be transmitted by aerosols produced by infected animals. Virus entry into cells is initiated by binding of the viral envelope (Env) protein to a specific cell-surface receptor, Hyal2. Unlike almost all other retrov...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-017-0329-6
更新日期:2017-01-20 00:00:00
abstract:BACKGROUND:The replication of HBV involves the production of covalently closed circular DNA (cccDNA) from the HBV genome through the repair of virion relaxed circular DNA (rcDNA) in the virion. As cccDNA is the transcription template for HBV genomes, it needs to be eliminated from hepatocytes if the eradication of chro...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-016-0318-1
更新日期:2016-12-20 00:00:00
abstract:BACKGROUND:HIV-1 typically develops resistance to any single antiretroviral agent. Combined anti-retroviral therapy to reduce drug-resistance development is necessary to control HIV-1 infection. Here, to assess the utility of a combination of antibody and fusion inhibitor treatments, we investigated the potency of mono...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-016-0304-7
更新日期:2016-09-27 00:00:00
abstract::The glycan supersite centered on N332 in the V3 base of the HIV-1 envelope (Env) is a target for broadly neutralizing antibodies (bnAbs) such as PGT121 and PGT128. In this study, we examined the basis of resistance of HIV-1 clade C Envs obtained from broadly cross neutralizing (BCN) plasma of an Indian donor with N332...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-016-0297-2
更新日期:2016-08-30 00:00:00
abstract:BACKGROUND:Eradication of HIV cannot be achieved with combination antiretroviral therapy (cART) because of the persistence of long-lived latently infected resting memory CD4(+) T cells. We previously reported that HIV latency could be established in resting CD4(+) T cells in the presence of the chemokine CCL19. To defi...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-016-0284-7
更新日期:2016-07-26 00:00:00
abstract:BACKGROUND:Accumulating data suggest that immune effector functions mediated through the Fc portion of HIV-1-specific immunoglobulin G (IgG) are a key component of HIV-1 protective immunity, affecting both disease progression and HIV-1 acquisition. Through studying Fc gamma receptor (FcγR) variants known to alter IgG F...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-016-0272-y
更新日期:2016-06-10 00:00:00
abstract:BACKGROUND:HIV-1 entry is a receptor-mediated process directed by the interaction of the viral envelope with the host cell CD4 molecule and one of two co-receptors, CCR5 or CXCR4. The amino acid sequence of the third variable (V3) loop of the HIV-1 envelope is highly predictive of co-receptor utilization preference dur...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-016-0266-9
更新日期:2016-05-03 00:00:00
abstract:BACKGROUND:HIV-1 capsid influences viral uncoating and nuclear import. Some capsid is detected in the nucleus but it is unclear if it has any function. We reported that the antibiotic Coumermycin-A1 (C-A1) inhibits HIV-1 integration and that a capsid mutation confers resistance to C-A1, suggesting that capsid might aff...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-016-0262-0
更新日期:2016-04-23 00:00:00
abstract:BACKGROUND:Regulatory T cells (Tregs) have been shown to limit anti-viral immunity during chronic retroviral infection and to restrict vaccine-induced T cell responses. The objective of the study was to assess whether a combinational therapy of nanoparticle-based therapeutic vaccination and concomitant transient ablati...
journal_title:Retrovirology
pub_type: 杂志文章,评审
doi:10.1186/s12977-016-0258-9
更新日期:2016-04-14 00:00:00
abstract:BACKGROUND:Long term infection with HIV-1, even in the context of therapy, leads to chronic health problems including an array of neurocognitive dysfunctions. The viral Tat protein has previously been implicated in neuropathogenesis through its effect on astrocytes. Tat has also been shown to inhibit the biogenesis of ...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-016-0256-y
更新日期:2016-04-08 00:00:00
abstract:BACKGROUND:LILRA3 is an immunostimulatory molecule which can conditionally induce the proliferation of cytotoxic cells. LILRA3 has a deletion genotype which is associated with multiple immune disorders. In this study, we wanted to analyze the regulation of LILRA3 and its significance in the context of HIV infection. R...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-016-0248-y
更新日期:2016-03-12 00:00:00
abstract:BACKGROUND:Elderly HIV-1 infected individuals progress to AIDS more frequently and rapidly than people becoming infected at a young age. To identify possible reasons for these differences in clinical progression, we performed comprehensive phenotypic analyses of CD4+ T cells from uninfected young and elderly individual...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-015-0213-1
更新日期:2015-10-09 00:00:00
abstract:BACKGROUND:Endogenous retroviruses (ERVs) are genetic elements with a retroviral origin that are integrated into vertebrate genomes. In felids (Mammalia, Carnivora, Felidae), ERVs have been described mostly in the domestic cat, and only rarely in wild species. To gain insight into the origins and evolutionary dynamics ...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-015-0152-x
更新日期:2015-03-15 00:00:00
abstract:BACKGROUND:Host SAM domain and HD domain-containing protein 1 (SAMHD1) suppresses reverse transcription kinetics of HIV-1 in nondividing cells such as macrophages by hydrolyzing and nearly depleting cellular dNTPs, which are the substrates of viral reverse transcriptase (RT). However, unlike HIV-1, HIV-2 and SIVsm enco...
journal_title:Retrovirology
pub_type: 杂志文章
doi:10.1186/s12977-014-0111-y
更新日期:2014-12-19 00:00:00