• HIV and the tuberculosis "set point": how HIV impairs alveolar macrophage responses to tuberculosis and sets the stage for progressive disease.

    abstract::As HIV has fueled a global resurgence of tuberculosis over the last several decades, there is a growing awareness that HIV-mediated impairments in both innate and adaptive immunity contribute to the heightened risk of tuberculosis in people with HIV. Since early immune responses to Mycobacterium tuberculosis (Mtb) set...


    pub_type: 杂志文章,评审


    authors: Auld SC,Staitieh BS

    更新日期:2020-09-23 00:00:00

  • HLA-B*35 as a new marker for susceptibility to human T-cell lymphotropic virus type 1 (HTLV-1) Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in patients living in Argentina.

    abstract:BACKGROUND:Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of HTLV associated myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) and Adult T cell leukemia/lymphoma (ATLL), in around 2-5% of the infected individuals. Host genetic background might play a role in disease progression. Several previ...


    pub_type: 杂志文章


    authors: Benencio P,Fraile Gonzalez SA,Ducasa N,Page K,Berini CA,Biglione MM

    更新日期:2020-09-03 00:00:00

  • Interferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma.

    abstract:BACKGROUND:Adult T-cell leukemia lymphoma (ATLL) is a chemotherapy-resistant malignancy with a median survival of less than one year that will afflict between one hundred thousand and one million individuals worldwide who are currently infected with human T-cell leukemia virus type 1. Recurrent somatic mutations in hos...


    pub_type: 杂志文章


    authors: Rauch DA,Olson SL,Harding JC,Sundaramoorthi H,Kim Y,Zhou T,MacLeod AR,Challen G,Ratner L

    更新日期:2020-08-28 00:00:00

  • Establishment of a novel diagnostic test algorithm for human T-cell leukemia virus type 1 infection with line immunoassay replacement of western blotting: a collaborative study for performance evaluation of diagnostic assays in Japan.

    abstract:BACKGROUND:The reliable diagnosis of human T-cell leukemia virus type 1 (HTLV-1) infection is important, particularly as it can be vertically transmitted by breast feeding mothers to their infants. However, current diagnosis in Japan requires a confirmatory western blot (WB) test after screening/primary testing for HTL...


    pub_type: 杂志文章


    authors: Okuma K,Kuramitsu M,Niwa T,Taniguchi T,Masaki Y,Ueda G,Matsumoto C,Sobata R,Sagara Y,Nakamura H,Satake M,Miura K,Fuchi N,Masuzaki H,Okayama A,Umeki K,Yamano Y,Sato T,Iwanaga M,Uchimaru K,Nakashima M,Utsunomiya A

    更新日期:2020-08-24 00:00:00

  • Longitudinal analysis of subtype C envelope tropism for memory CD4+ T cell subsets over the first 3 years of untreated HIV-1 infection.

    abstract:BACKGROUND:HIV-1 infects a wide range of CD4+ T cells with different phenotypic properties and differing expression levels of entry coreceptors. We sought to determine the viral tropism of subtype C (C-HIV) Envelope (Env) clones for different CD4+ T cell subsets and whether tropism changes during acute to chronic disea...


    pub_type: 杂志文章


    authors: Gartner MJ,Gorry PR,Tumpach C,Zhou J,Dantanarayana A,Chang JJ,Angelovich TA,Ellenberg P,Laumaea AE,Nonyane M,Moore PL,Lewin SR,Churchill MJ,Flynn JK,Roche M

    更新日期:2020-08-06 00:00:00

  • Correction to: HIV-1 IN/Pol recruits LEDGF/p75 into viral particles.

    abstract::An amendment to this paper has been published and can be accessed via the original article. ...


    pub_type: 杂志文章,已发布勘误


    authors: Desimmie BA,Weydert C,Schrijvers R,Vets S,Demeulemeester J,Proost P,Paron I,De Rijck J,Mast J,Bannert N,Gijsbers R,Christ F,Debyser Z

    更新日期:2020-07-29 00:00:00

  • Generation and validation of a highly sensitive bioluminescent HIV-1 reporter vector that simplifies measurement of virus release.

    abstract:BACKGROUND:The continued persistence of HIV-1 as a public health concern due to the lack of a cure calls for the development of new tools for studying replication of the virus. Here, we used NanoLuc, a small and extremely bright luciferase protein, to develop an HIV-1 bioluminescent reporter virus that simplifies funct...


    pub_type: 杂志文章


    authors: Kirui J,Freed EO

    更新日期:2020-05-19 00:00:00

  • Moving beyond the mousetrap: current and emerging humanized mouse and rat models for investigating prevention and cure strategies against HIV infection and associated pathologies.

    abstract::The development of safe and effective combination antiretroviral therapies for human immunodeficiency virus (HIV) infection over the past several decades has significantly reduced HIV-associated morbidity and mortality. Additionally, antiretroviral drugs have provided an effective means of protection against HIV trans...


    pub_type: 杂志文章,评审


    authors: Agarwal Y,Beatty C,Biradar S,Castronova I,Ho S,Melody K,Bility MT

    更新日期:2020-04-10 00:00:00

  • The challenge of describing the epidemiology of HTLV in the Amazon region of Brazil.

    abstract::HTLV-1 was the first described human retrovirus and was soon found to be associated with severe clinical diseases, including a devastating lymphoma/leukemia and other inflammatory diseases. Although HTLV-2 is not usually pathogenic, it is widely distributed among native Indian populations in Brazil, particularly in th...


    pub_type: 杂志文章,评审


    authors: Ishak R,de Oliveira Guimarães Ishak M,Vallinoto ACR

    更新日期:2020-02-14 00:00:00

  • STLV-1 as a model for studying HTLV-1 infection.

    abstract::Few years after HTLV-1 identification and isolation in humans, STLV-1, its simian counterpart, was discovered. It then became clear that STLV-1 is present almost in all simian species. Subsequent molecular epidemiology studies demonstrated that, apart from HTLV-1 subtype A, all human subtypes have a simian homolog. As...


    pub_type: 杂志文章,评审


    authors: Jégado B,Kashanchi F,Dutartre H,Mahieux R

    更新日期:2019-12-16 00:00:00

  • NHEJ pathway is involved in post-integrational DNA repair due to Ku70 binding to HIV-1 integrase.

    abstract:BACKGROUND:HIV-1 integration results in genomic DNA gaps that are repaired by cellular DNA repair pathways. This step of the lentiviral life cycle remains poorly understood despite its crucial importance for successful replication. We and others reported that Ku70 protein of the non-homologous end joining pathway (NHEJ...


    pub_type: 杂志文章


    authors: Knyazhanskaya E,Anisenko A,Shadrina O,Kalinina A,Zatsepin T,Zalevsky A,Mazurov D,Gottikh M

    更新日期:2019-11-06 00:00:00

  • Low-level alternative tRNA priming of reverse transcription of HIV-1 and SIV in vivo.

    abstract:BACKGROUND:Reverse transcription (RT) of HIV and SIV is initiated by the binding of the acceptor stem of tRNALys3 to the primer binding site (PBS) of the viral RNA genome. Previous studies have suggested that this tRNALys3 is not the only molecule capable of priming reverse transcription, and that at least one other ly...


    pub_type: 杂志文章


    authors: Fennessey CM,Camus C,Immonen TT,Reid C,Maldarelli F,Lifson JD,Keele BF

    更新日期:2019-04-04 00:00:00

  • Analysis of herpes simplex type 1 gB, gD, and gH/gL on production of infectious HIV-1: HSV-1 gD restricts HIV-1 by exclusion of HIV-1 Env from maturing viral particles.

    abstract:BACKGROUND:We previously showed that the gM of HSV-1 could restrict the release of infectious HIV-1 from cells. In this study, we analyzed if the four HSV-1 glycoproteins (gD, gB, and gH/gL), which are the minimum glycoproteins required for HSV-1 entry, restricted the release of infectious HIV-1. RESULTS:Of these four...


    pub_type: 杂志文章


    authors: Polpitiya Arachchige S,Henke W,Kalamvoki M,Stephens EB

    更新日期:2019-04-02 00:00:00

  • Host mRNA decay proteins influence HIV-1 replication and viral gene expression in primary monocyte-derived macrophages.

    abstract:BACKGROUND:Mammalian cells harbour RNA quality control and degradative machineries such as nonsense-mediated mRNA decay that target cellular mRNAs for clearance from the cell to avoid aberrant gene expression. The role of the host mRNA decay pathways in macrophages in the context of human immunodeficiency virus type 1 ...


    pub_type: 杂志文章


    authors: Rao S,Amorim R,Niu M,Breton Y,Tremblay MJ,Mouland AJ

    更新日期:2019-02-07 00:00:00

  • Natural APOBEC3C variants can elicit differential HIV-1 restriction activity.

    abstract:BACKGROUND:The APOBEC3 (A3) family of DNA cytosine deaminases provides an innate barrier to infection by retroviruses including HIV-1. A total of five enzymes, A3C, A3D, A3F, A3G and A3H, are degraded by the viral accessory protein Vif and expressed at high levels in CD4+ T cells, the primary reservoir for HIV-1 replic...


    pub_type: 杂志文章


    authors: Anderson BD,Ikeda T,Moghadasi SA,Martin AS,Brown WL,Harris RS

    更新日期:2018-12-17 00:00:00

  • Lipid levels, insulin resistance and cardiovascular risk over 96 weeks of antiretroviral therapy: a randomised controlled trial comparing low-dose stavudine and tenofovir.

    abstract:BACKGROUND:HIV infection and antiretroviral treatment are associated with changes in lipid levels, insulin resistance and risk of cardiovascular disease (CVD). We investigated these changes in the first 96 weeks of treatment with low-dose stavudine or tenofovir regimens. METHODS:This is a secondary analysis of a doubl...


    pub_type: 杂志文章,随机对照试验


    authors: Vos AG,Chersich MF,Klipstein-Grobusch K,Zuithoff P,Moorhouse MA,Lalla-Edward ST,Kambugu A,Kumarasamy N,Grobbee DE,Barth RE,Venter WD

    更新日期:2018-12-14 00:00:00

  • Distinct gene expression signatures induced by viral transactivators of different HTLV-1 subgroups that confer a different risk of HAM/TSP.

    abstract:BACKGROUND:Among human T cell leukemia virus type 1 (HTLV-1)-infected individuals, there is an association between HTLV-1 tax subgroups (subgroup-A or subgroup-B) and the risk of HAM/TSP in the Japanese population. To investigate the role of HTLV-1 subgroups in viral pathogenesis, we studied the functional difference i...


    pub_type: 杂志文章


    authors: Naito T,Yasunaga JI,Mitobe Y,Shirai K,Sejima H,Ushirogawa H,Tanaka Y,Nakamura T,Hanada K,Fujii M,Matsuoka M,Saito M

    更新日期:2018-11-06 00:00:00

  • The role of integration and clonal expansion in HIV infection: live long and prosper.

    abstract::Integration of viral DNA into the host genome is a central event in the replication cycle and the pathogenesis of retroviruses, including HIV. Although most cells infected with HIV are rapidly eliminated in vivo, HIV also infects long-lived cells that persist during combination antiretroviral therapy (cART). Cells wit...


    pub_type: 杂志文章,评审


    authors: Anderson EM,Maldarelli F

    更新日期:2018-10-23 00:00:00

  • Friend retrovirus infection induces the development of memory-like natural killer cells.

    abstract::Traditionally, NK cells belong to the innate immune system and eliminate virus-infected cells through their germline-encoded receptors. However, NK cells were recently reported to possess memory-like functions that were predominantly provided by hepatic NK cells. Memory properties were mainly documented in contact hyp...


    pub_type: 杂志文章


    authors: Littwitz-Salomon E,Nguyen T,Schimmer S,Dittmer U

    更新日期:2018-10-06 00:00:00

  • Measuring integrated HIV DNA ex vivo and in vitro provides insights about how reservoirs are formed and maintained.

    abstract::The identification of the most appropriate marker to measure reservoir size has been a great challenge for the HIV field. Quantitative viral outgrowth assay (QVOA), the reference standard to quantify the amount of replication-competent virus, has several limitations, as it is laborious, expensive, and unable to robust...


    pub_type: 杂志文章,评审


    authors: Pinzone MR,O'Doherty U

    更新日期:2018-02-17 00:00:00

  • Digital PCR as a tool to measure HIV persistence.

    abstract::Although antiretroviral therapy is able to suppress HIV replication in infected patients, the virus persists and rebounds when treatment is stopped. In order to find a cure that can eradicate the latent reservoir, one must be able to quantify the persisting virus. Traditionally, HIV persistence studies have used real-...


    pub_type: 杂志文章,评审


    authors: Rutsaert S,Bosman K,Trypsteen W,Nijhuis M,Vandekerckhove L

    更新日期:2018-01-30 00:00:00

  • The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity.

    abstract:BACKGROUND:HIV-1 Integrase (IN) interacts with the cellular co-factor LEDGF/p75 and tethers the HIV preintegration complex to the host genome enabling integration. Recently a new class of IN inhibitors was described, the IN-LEDGF allosteric inhibitors (INLAIs). Designed to interfere with the IN-LEDGF interaction during...


    pub_type: 杂志文章


    authors: Amadori C,van der Velden YU,Bonnard D,Orlov I,van Bel N,Le Rouzic E,Miralles L,Brias J,Chevreuil F,Spehner D,Chasset S,Ledoussal B,Mayr L,Moreau F,García F,Gatell J,Zamborlini A,Emiliani S,Ruff M,Klaholz BP,Moog C

    更新日期:2017-11-09 00:00:00

  • Molecular mechanisms by which HERV-K Gag interferes with HIV-1 Gag assembly and particle infectivity.

    abstract:BACKGROUND:Human endogenous retroviruses (HERVs), the remnants of ancient retroviral infections, constitute approximately 8% of human genomic DNA. Since HERV-K Gag expression is induced by HIV-1 Tat in T cells, induced HERV-K proteins could affect HIV-1 replication. Indeed, previously we showed that HERV-K Gag and HIV-...


    pub_type: 杂志文章


    authors: Monde K,Terasawa H,Nakano Y,Soheilian F,Nagashima K,Maeda Y,Ono A

    更新日期:2017-04-26 00:00:00

  • Identification of a tripartite interaction between the N-terminus of HIV-1 Vif and CBFβ that is critical for Vif function.

    abstract:BACKGROUND:HIV-1 Vif interacts with the cellular core-binding factor β (CBFβ) and counteracts the protective roles of certain human APOBEC3 (A3) proteins by targeting them for proteasomal degradation. Previous studies have identified some amino acids important for Vif-CBFβ interactions, and recently a co-crystal struct...


    pub_type: 杂志文章


    authors: Desimmie BA,Smith JL,Matsuo H,Hu WS,Pathak VK

    更新日期:2017-03-17 00:00:00

  • A purine-rich element in foamy virus pol regulates env splicing and gag/pol expression.

    abstract:BACKGROUND:The foamy viral genome encodes four central purine-rich elements localized in the integrase-coding region of pol. Previously, we have shown that the first two of these RNA elements (A and B) are required for protease dimerization and activation. The D element functions as internal polypurine tract during rev...


    pub_type: 杂志文章


    authors: Moschall R,Denk S,Erkelenz S,Schenk C,Schaal H,Bodem J

    更新日期:2017-02-06 00:00:00

  • Identification of small molecule modulators of HIV-1 Tat and Rev protein accumulation.

    abstract:BACKGROUND:HIV-1 replication is critically dependent upon controlled processing of its RNA and the activities provided by its encoded regulatory factors Tat and Rev. A screen of small molecule modulators of RNA processing identified several which inhibited virus gene expression, affecting both relative abundance of spe...


    pub_type: 杂志文章


    authors: Balachandran A,Wong R,Stoilov P,Pan S,Blencowe B,Cheung P,Harrigan PR,Cochrane A

    更新日期:2017-01-26 00:00:00

  • Evidence against a role for jaagsiekte sheep retrovirus in human lung cancer.

    abstract:BACKGROUND:Jaagsiekte sheep retrovirus (JSRV) causes a contagious lung cancer in sheep and goats that can be transmitted by aerosols produced by infected animals. Virus entry into cells is initiated by binding of the viral envelope (Env) protein to a specific cell-surface receptor, Hyal2. Unlike almost all other retrov...


    pub_type: 杂志文章


    authors: Miller AD,De Las Heras M,Yu J,Zhang F,Liu SL,Vaughan AE,Vaughan TL,Rosadio R,Rocca S,Palmieri G,Goedert JJ,Fujimoto J,Wistuba II

    更新日期:2017-01-20 00:00:00

  • PCR mediated recombination impacts the analysis of hepatitis B Virus covalently closed circular DNA.

    abstract:BACKGROUND:The replication of HBV involves the production of covalently closed circular DNA (cccDNA) from the HBV genome through the repair of virion relaxed circular DNA (rcDNA) in the virion. As cccDNA is the transcription template for HBV genomes, it needs to be eliminated from hepatocytes if the eradication of chro...


    pub_type: 杂志文章


    authors: Suspène R,Thiers V,Vartanian JP,Wain-Hobson S

    更新日期:2016-12-20 00:00:00

  • Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors.

    abstract:BACKGROUND:HIV-1 typically develops resistance to any single antiretroviral agent. Combined anti-retroviral therapy to reduce drug-resistance development is necessary to control HIV-1 infection. Here, to assess the utility of a combination of antibody and fusion inhibitor treatments, we investigated the potency of mono...


    pub_type: 杂志文章


    authors: Alam M,Kuwata T,Shimura K,Yokoyama M,Ramirez Valdez KP,Tanaka K,Maruta Y,Oishi S,Fujii N,Sato H,Matsuoka M,Matsushita S

    更新日期:2016-09-27 00:00:00

  • HIV-1 clade C escapes broadly neutralizing autologous antibodies with N332 glycan specificity by distinct mechanisms.

    abstract::The glycan supersite centered on N332 in the V3 base of the HIV-1 envelope (Env) is a target for broadly neutralizing antibodies (bnAbs) such as PGT121 and PGT128. In this study, we examined the basis of resistance of HIV-1 clade C Envs obtained from broadly cross neutralizing (BCN) plasma of an Indian donor with N332...


    pub_type: 杂志文章


    authors: Deshpande S,Patil S,Kumar R,Hermanus T,Murugavel KG,Srikrishnan AK,Solomon S,Morris L,Bhattacharya J

    更新日期:2016-08-30 00:00:00

  • HIV integration and the establishment of latency in CCL19-treated resting CD4(+) T cells require activation of NF-κB.

    abstract:BACKGROUND:Eradication of HIV cannot be achieved with combination antiretroviral therapy (cART) because of the persistence of long-lived latently infected resting memory CD4(+) T cells. We previously reported that HIV latency could be established in resting CD4(+) T cells in the presence of the chemokine CCL19. To defi...


    pub_type: 杂志文章


    authors: Saleh S,Lu HK,Evans V,Harisson D,Zhou J,Jaworowski A,Sallmann G,Cheong KY,Mota TM,Tennakoon S,Angelovich TA,Anderson J,Harman A,Cunningham A,Gray L,Churchill M,Mak J,Drummer H,Vatakis DN,Lewin SR,Cameron PU

    更新日期:2016-07-26 00:00:00

  • Perinatal HIV-1 transmission: Fc gamma receptor variability associates with maternal infectiousness and infant susceptibility.

    abstract:BACKGROUND:Accumulating data suggest that immune effector functions mediated through the Fc portion of HIV-1-specific immunoglobulin G (IgG) are a key component of HIV-1 protective immunity, affecting both disease progression and HIV-1 acquisition. Through studying Fc gamma receptor (FcγR) variants known to alter IgG F...


    pub_type: 杂志文章


    authors: Lassaunière R,Musekiwa A,Gray GE,Kuhn L,Tiemessen CT

    更新日期:2016-06-10 00:00:00

  • Utilization of HIV-1 envelope V3 to identify X4- and R5-specific Tat and LTR sequence signatures.

    abstract:BACKGROUND:HIV-1 entry is a receptor-mediated process directed by the interaction of the viral envelope with the host cell CD4 molecule and one of two co-receptors, CCR5 or CXCR4. The amino acid sequence of the third variable (V3) loop of the HIV-1 envelope is highly predictive of co-receptor utilization preference dur...


    pub_type: 杂志文章


    authors: Antell GC,Dampier W,Aiamkitsumrit B,Nonnemacher MR,Jacobson JM,Pirrone V,Zhong W,Kercher K,Passic S,Williams JW,Schwartz G,Hershberg U,Krebs FC,Wigdahl B

    更新日期:2016-05-03 00:00:00

  • HIV-1 capsid is involved in post-nuclear entry steps.

    abstract:BACKGROUND:HIV-1 capsid influences viral uncoating and nuclear import. Some capsid is detected in the nucleus but it is unclear if it has any function. We reported that the antibiotic Coumermycin-A1 (C-A1) inhibits HIV-1 integration and that a capsid mutation confers resistance to C-A1, suggesting that capsid might aff...


    pub_type: 杂志文章


    authors: Chen NY,Zhou L,Gane PJ,Opp S,Ball NJ,Nicastro G,Zufferey M,Buffone C,Luban J,Selwood D,Diaz-Griffero F,Taylor I,Fassati A

    更新日期:2016-04-23 00:00:00

  • Combination of nanoparticle-based therapeutic vaccination and transient ablation of regulatory T cells enhances anti-viral immunity during chronic retroviral infection.

    abstract:BACKGROUND:Regulatory T cells (Tregs) have been shown to limit anti-viral immunity during chronic retroviral infection and to restrict vaccine-induced T cell responses. The objective of the study was to assess whether a combinational therapy of nanoparticle-based therapeutic vaccination and concomitant transient ablati...


    pub_type: 杂志文章,评审


    authors: Knuschke T,Rotan O,Bayer W,Sokolova V,Hansen W,Sparwasser T,Dittmer U,Epple M,Buer J,Westendorf AM

    更新日期:2016-04-14 00:00:00

  • The inhibition of microRNAs by HIV-1 Tat suppresses beta catenin activity in astrocytes.

    abstract:BACKGROUND:Long term infection with HIV-1, even in the context of therapy, leads to chronic health problems including an array of neurocognitive dysfunctions. The viral Tat protein has previously been implicated in neuropathogenesis through its effect on astrocytes. Tat has also been shown to inhibit the biogenesis of ...


    pub_type: 杂志文章


    authors: Sardo L,Vakil PR,Elbezanti W,El-Sayed A,Klase Z

    更新日期:2016-04-08 00:00:00

  • TLR8 regulation of LILRA3 in monocytes is abrogated in human immunodeficiency virus infection and correlates to CD4 counts and virus loads.

    abstract:BACKGROUND:LILRA3 is an immunostimulatory molecule which can conditionally induce the proliferation of cytotoxic cells. LILRA3 has a deletion genotype which is associated with multiple immune disorders. In this study, we wanted to analyze the regulation of LILRA3 and its significance in the context of HIV infection. R...


    pub_type: 杂志文章


    authors: Low HZ,Ahrenstorf G,Pommerenke C,Habermann N,Schughart K,Ordóñez D,Stripecke R,Wilk E,Witte T

    更新日期:2016-03-12 00:00:00

  • Increased susceptibility of CD4+ T cells from elderly individuals to HIV-1 infection and apoptosis is associated with reduced CD4 and enhanced CXCR4 and FAS surface expression levels.

    abstract:BACKGROUND:Elderly HIV-1 infected individuals progress to AIDS more frequently and rapidly than people becoming infected at a young age. To identify possible reasons for these differences in clinical progression, we performed comprehensive phenotypic analyses of CD4+ T cells from uninfected young and elderly individual...


    pub_type: 杂志文章


    authors: Heigele A,Joas S,Regensburger K,Kirchhoff F

    更新日期:2015-10-09 00:00:00

  • Identification and characterization of diverse groups of endogenous retroviruses in felids.

    abstract:BACKGROUND:Endogenous retroviruses (ERVs) are genetic elements with a retroviral origin that are integrated into vertebrate genomes. In felids (Mammalia, Carnivora, Felidae), ERVs have been described mostly in the domestic cat, and only rarely in wild species. To gain insight into the origins and evolutionary dynamics ...


    pub_type: 杂志文章


    authors: Mata H,Gongora J,Eizirik E,Alves BM,Soares MA,Ravazzolo AP

    更新日期:2015-03-15 00:00:00

  • Kinetic variations between reverse transcriptases of viral protein X coding and noncoding lentiviruses.

    abstract:BACKGROUND:Host SAM domain and HD domain-containing protein 1 (SAMHD1) suppresses reverse transcription kinetics of HIV-1 in nondividing cells such as macrophages by hydrolyzing and nearly depleting cellular dNTPs, which are the substrates of viral reverse transcriptase (RT). However, unlike HIV-1, HIV-2 and SIVsm enco...


    pub_type: 杂志文章


    authors: Lenzi GM,Domaoal RA,Kim DH,Schinazi RF,Kim B

    更新日期:2014-12-19 00:00:00

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