Interferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma.

abstract：BACKGROUND:Efficient targeted gene transfer and cell type specific transgene expression are important for the safe and effective expression of transgenes in vivo. Enveloped viral vectors allow insertion of exogenous membrane proteins into their envelopes, which could potentially aid in the targeted transduction of spec...

journal_title：Retrovirology

authors： Ye Z,Harmison GG,Ragheb JA,Schubert M

更新日期：2005-12-21 00:00:00

abstract：BACKGROUND:Thymidine analogue resistance mutations (TAMs) selected under treatment with nucleoside analogues generate two distinct genotypic profiles in the HIV-1 reverse transcriptase (RT): (i) TAM1: M41L, L210W and T215Y, and (ii) TAM2: D67N, K70R and K219E/Q, and sometimes T215F. Secondary mutations, including thumb...

journal_title：Retrovirology

authors： Betancor G,Garriga C,Puertas MC,Nevot M,Anta L,Blanco JL,Pérez-Elías MJ,de Mendoza C,Martínez MA,Martinez-Picado J,Menéndez-Arias L,Resistance Platform of the Spanish AIDS Research Network (ResRIS).,Iribarren JA,Caballero E,R

更新日期：2012-08-13 00:00:00

abstract：BACKGROUND:We previously showed that the gM of HSV-1 could restrict the release of infectious HIV-1 from cells. In this study, we analyzed if the four HSV-1 glycoproteins (gD, gB, and gH/gL), which are the minimum glycoproteins required for HSV-1 entry, restricted the release of infectious HIV-1. RESULTS:Of these four...

journal_title：Retrovirology

authors： Polpitiya Arachchige S,Henke W,Kalamvoki M,Stephens EB

更新日期：2019-04-02 00:00:00

abstract：BACKGROUND:HIV-1 Integrase (IN) interacts with the cellular co-factor LEDGF/p75 and tethers the HIV preintegration complex to the host genome enabling integration. Recently a new class of IN inhibitors was described, the IN-LEDGF allosteric inhibitors (INLAIs). Designed to interfere with the IN-LEDGF interaction during...

journal_title：Retrovirology

authors： Amadori C,van der Velden YU,Bonnard D,Orlov I,van Bel N,Le Rouzic E,Miralles L,Brias J,Chevreuil F,Spehner D,Chasset S,Ledoussal B,Mayr L,Moreau F,García F,Gatell J,Zamborlini A,Emiliani S,Ruff M,Klaholz BP,Moog C

更新日期：2017-11-09 00:00:00

abstract：:The development of safe and effective combination antiretroviral therapies for human immunodeficiency virus (HIV) infection over the past several decades has significantly reduced HIV-associated morbidity and mortality. Additionally, antiretroviral drugs have provided an effective means of protection against HIV trans...

journal_title：Retrovirology

authors： Agarwal Y,Beatty C,Biradar S,Castronova I,Ho S,Melody K,Bility MT

更新日期：2020-04-10 00:00:00

abstract：BACKGROUND:Retroviruses have a diploid genome and recombine at high frequency. Recombinant proviruses can be generated when two genetically different RNA genomes are packaged into the same retroviral particle. It was shown in several studies that recombinant proviruses could be generated in each round of HIV-1 replicat...

journal_title：Retrovirology

authors： Kharytonchyk SA,Kireyeva AI,Osipovich AB,Fomin IK

更新日期：2005-01-18 00:00:00

abstract：BACKGROUND:HIV-1 typically develops resistance to any single antiretroviral agent. Combined anti-retroviral therapy to reduce drug-resistance development is necessary to control HIV-1 infection. Here, to assess the utility of a combination of antibody and fusion inhibitor treatments, we investigated the potency of mono...

journal_title：Retrovirology

authors： Alam M,Kuwata T,Shimura K,Yokoyama M,Ramirez Valdez KP,Tanaka K,Maruta Y,Oishi S,Fujii N,Sato H,Matsuoka M,Matsushita S

更新日期：2016-09-27 00:00:00

abstract：BACKGROUND:We reported previously that while prolonged tenofovir monotherapy of macaques infected with virulent simian immunodeficiency virus (SIV) resulted invariably in the emergence of viral mutants with reduced in vitro drug susceptibility and a K65R mutation in reverse transcriptase, some animals controlled virus ...

journal_title：Retrovirology

authors： Van Rompay KK,Trott KA,Jayashankar K,Geng Y,LaBranche CC,Johnson JA,Landucci G,Lipscomb J,Tarara RP,Canfield DR,Heneine W,Forthal DN,Montefiori D,Abel K

更新日期：2012-07-17 00:00:00

abstract：:We have obtained the 1.7 A crystal structure of FIV protease (PR) in which 12 critical residues around the active site have been substituted with the structurally equivalent residues of HIV PR (12X FIV PR). The chimeric PR was crystallized in complex with the broad-based inhibitor TL-3, which inhibits wild type FIV an...

journal_title：Retrovirology

authors： Heaslet H,Lin YC,Tam K,Torbett BE,Elder JH,Stout CD

更新日期：2007-01-09 00:00:00

abstract：:HIV viruses encode a set of accessory proteins, which are important determinants of virulence due to their ability to manipulate the host cell physiology for the benefit of the virus. Although these viral proteins are dispensable for viral growth in many in vitro cell culture systems, they influence the efficiency of ...

journal_title：Retrovirology

authors： Ayinde D,Maudet C,Transy C,Margottin-Goguet F

更新日期：2010-04-09 00:00:00

abstract：BACKGROUND:Early HIV-1 infection causes massive CD4+ T cell death in the gut and translocation of bacteria into the circulation. However, the programmed cell death (PCD) pathways used by HIV-1 to kill CD4+ T cells in the gut, and the impact of microbial exposure on T cell loss, remain unclear. Understanding mucosal HIV...

journal_title：Retrovirology

authors： Steele AK,Lee EJ,Manuzak JA,Dillon SM,Beckham JD,McCarter MD,Santiago ML,Wilson CC

更新日期：2014-02-04 00:00:00

abstract：BACKGROUND:Long term infection with HIV-1, even in the context of therapy, leads to chronic health problems including an array of neurocognitive dysfunctions. The viral Tat protein has previously been implicated in neuropathogenesis through its effect on astrocytes. Tat has also been shown to inhibit the biogenesis of ...

journal_title：Retrovirology

authors： Sardo L,Vakil PR,Elbezanti W,El-Sayed A,Klase Z

更新日期：2016-04-08 00:00:00

abstract：BACKGROUND:Entry of human immunodeficiency virus type 1 (HIV-1) into the host cell involves interactions between the viral envelope glycoproteins (Env) and the cellular receptor CD4 as well as a coreceptor molecule (most importantly CCR5 or CXCR4). Viral preference for a specific coreceptor (tropism) is in particular d...

journal_title：Retrovirology

authors： Bozek K,Eckhardt M,Sierra S,Anders M,Kaiser R,Kräusslich HG,Müller B,Lengauer T

更新日期：2012-07-25 00:00:00

abstract：:With the proliferation of sequence data, great challenges are posed in the correct annotation of endogenous retroviruses, which together comprise up to ten per cent of the genomes of many organisms. It is therefore essential that all sources of information are carefully considered before drawing conclusions concerning...

journal_title：Retrovirology

authors： Young GR,Kassiotis G,Stoye JP

更新日期：2012-03-22 00:00:00

abstract：:Previous studies have reported that various inbred SAM mouse strains differ markedly with regard to a variety of parameters, such as capacity for learning and memory, life spans and brain histopathology. A potential cause of differences seen in these strains may be based on the fact that some strains have a high conce...

journal_title：Retrovirology

authors： Kim BH,Meeker HC,Shin HY,Kim JI,Jeong BH,Choi EK,Carp RI,Kim YS

更新日期：2008-11-25 00:00:00

abstract：:In HIV-infected people, resting CD4+ T cells are the main reservoir of latent virus and the reason for the failure of drug therapy to cure HIV infection. Still, we do not have a complete understanding of the factors regulating HIV replication in these cells. A recent paper in Cell describes a new trick that the virus ...

journal_title：Retrovirology

authors： Bukrinsky M

更新日期：2008-09-22 00:00:00

abstract：BACKGROUND:Several factors determine the risk of HIV mother-to-child transmission (MTCT), such as coinfections in placentas from HIV-1 positive mothers with other pathogens. Chagas' disease is one of the most endemic zoonoses in Latin America, caused by the protozoan Trypanosoma cruzi. The purpose of the study was to d...

journal_title：Retrovirology

authors： Dolcini GL,Solana ME,Andreani G,Celentano AM,Parodi LM,Donato AM,Elissondo N,González Cappa SM,Giavedoni LD,Martínez Peralta L

更新日期：2008-07-01 00:00:00

abstract：:An estimated 90% of all HIV transmissions occur mucosally. Immunoglobulin A (IgA) molecules are important components of mucosal fluids. In a vaccine efficacy study, in which virosomes displaying HIV gp41 antigens protected most rhesus monkeys (RMs) against simian-human immunodeficiency virus (SHIV), protection correla...

journal_title：Retrovirology

authors： Zhou M,Ruprecht RM

更新日期：2014-12-14 00:00:00

abstract：:How best to evaluate scientists within a peer group is a difficult task. This editorial discusses the use of the H-index and total citations. It also raises the consideration of a mentoring-index and the value of understanding the frequency that a published paper is accessed by readers. ...

journal_title：Retrovirology

authors： Jeang KT

更新日期：2008-11-25 00:00:00

abstract：BACKGROUND:HIV infection and antiretroviral treatment are associated with changes in lipid levels, insulin resistance and risk of cardiovascular disease (CVD). We investigated these changes in the first 96 weeks of treatment with low-dose stavudine or tenofovir regimens. METHODS:This is a secondary analysis of a doubl...

journal_title：Retrovirology

authors： Vos AG,Chersich MF,Klipstein-Grobusch K,Zuithoff P,Moorhouse MA,Lalla-Edward ST,Kambugu A,Kumarasamy N,Grobbee DE,Barth RE,Venter WD

更新日期：2018-12-14 00:00:00

abstract：BACKGROUND:The APOBEC3 (A3) family of DNA cytosine deaminases provides an innate barrier to infection by retroviruses including HIV-1. A total of five enzymes, A3C, A3D, A3F, A3G and A3H, are degraded by the viral accessory protein Vif and expressed at high levels in CD4+ T cells, the primary reservoir for HIV-1 replic...

journal_title：Retrovirology

authors： Anderson BD,Ikeda T,Moghadasi SA,Martin AS,Brown WL,Harris RS

更新日期：2018-12-17 00:00:00

abstract：BACKGROUND:The foamy viral genome encodes four central purine-rich elements localized in the integrase-coding region of pol. Previously, we have shown that the first two of these RNA elements (A and B) are required for protease dimerization and activation. The D element functions as internal polypurine tract during rev...

journal_title：Retrovirology

authors： Moschall R,Denk S,Erkelenz S,Schenk C,Schaal H,Bodem J

更新日期：2017-02-06 00:00:00

abstract：:Integration of the reverse transcribed viral genome into host chromatin is the hallmark of retroviral replication. Yet, during natural HIV infection, various unintegrated viral DNA forms exist in abundance. Though linear viral cDNA is the precursor to an integrated provirus, increasing evidence suggests that transcrip...

journal_title：Retrovirology

authors： Sloan RD,Wainberg MA

更新日期：2011-07-01 00:00:00

abstract：:It is well established that CD4(+) T cells play an important role in immunity to infections with retroviruses such as HIV. However, in recent years CD4(+) T cells have been subdivided into several distinct populations that are differentially regulated and perform widely varying functions. Thus, it is important to deli...

journal_title：Retrovirology

authors： Nair S,Bayer W,Ploquin MJ,Kassiotis G,Hasenkrug KJ,Dittmer U

更新日期：2011-09-26 00:00:00

abstract：BACKGROUND:We and others have recently demonstrated that the human retrovirus HTLV-I was producing a spliced antisense transcript, which led to the synthesis of the HBZ protein. The objective of the present study was to demonstrate the existence of antisense transcription in HIV-1 and to provide a better characterizati...

journal_title：Retrovirology

authors： Landry S,Halin M,Lefort S,Audet B,Vaquero C,Mesnard JM,Barbeau B

更新日期：2007-10-02 00:00:00

abstract：BACKGROUND:Among human T cell leukemia virus type 1 (HTLV-1)-infected individuals, there is an association between HTLV-1 tax subgroups (subgroup-A or subgroup-B) and the risk of HAM/TSP in the Japanese population. To investigate the role of HTLV-1 subgroups in viral pathogenesis, we studied the functional difference i...

journal_title：Retrovirology

authors： Naito T,Yasunaga JI,Mitobe Y,Shirai K,Sejima H,Ushirogawa H,Tanaka Y,Nakamura T,Hanada K,Fujii M,Matsuoka M,Saito M

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:Upon HIV entry into target cells, viral cores are released and rearranged into reverse transcription complexes (RTCs), which support reverse transcription and also protect and transport viral cDNA to the site of integration. RTCs are composed of viral and cellular proteins that originate from both target and...

journal_title：Retrovirology

authors： Santos S,Obukhov Y,Nekhai S,Bukrinsky M,Iordanskiy S

更新日期：2012-08-13 00:00:00

abstract：BACKGROUND:One facet of the complexity underlying the biology of HIV-1 resides not only in its limited number of viral proteins, but in the extensive repertoire of cellular proteins they interact with and their higher-order assembly. HIV-1 encodes the regulatory protein Tat (86-101aa), which is essential for HIV-1 repl...

journal_title：Retrovirology

authors： Gautier VW,Gu L,O'Donoghue N,Pennington S,Sheehy N,Hall WW

更新日期：2009-05-19 00:00:00

abstract：BACKGROUND:HIV-1 Vif interacts with the cellular core-binding factor β (CBFβ) and counteracts the protective roles of certain human APOBEC3 (A3) proteins by targeting them for proteasomal degradation. Previous studies have identified some amino acids important for Vif-CBFβ interactions, and recently a co-crystal struct...

journal_title：Retrovirology

authors： Desimmie BA,Smith JL,Matsuo H,Hu WS,Pathak VK

更新日期：2017-03-17 00:00:00

abstract：BACKGROUND:Reverse transcription (RT) of HIV and SIV is initiated by the binding of the acceptor stem of tRNALys3 to the primer binding site (PBS) of the viral RNA genome. Previous studies have suggested that this tRNALys3 is not the only molecule capable of priming reverse transcription, and that at least one other ly...

journal_title：Retrovirology

authors： Fennessey CM,Camus C,Immonen TT,Reid C,Maldarelli F,Lifson JD,Keele BF

更新日期：2019-04-04 00:00:00