当前位置： SCI文献检索 > Retrovirology期刊下所有文献 > HLA-B*35 as a new marker for susceptibility to human T-cell lymphotropic virus type 1 (HTLV-1) Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in patients living in Argentina.

HLA-B*35 as a new marker for susceptibility to human T-cell lymphotropic virus type 1 (HTLV-1) Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in patients living in Argentina.

Abstract：

BACKGROUND:Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of HTLV associated myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) and Adult T cell leukemia/lymphoma (ATLL), in around 2-5% of the infected individuals. Host genetic background might play a role in disease progression. Several previous studies across many countries report HLA haplotype to be one such factor. Here, we sequenced HLA-A, -B and -C of 66 individuals by Sequence-Based Typing (SBT), and compared the frequency of different alleles among ATLL patients, HAM/TSP patients, asymptomatic carriers and non-infected individuals living in Argentina. RESULTS:The frequency of HLA-A, -B and -C alleles largely matched that of the general population in Argentina. We identified HLA-A*02, HLA-B*35 and HLA-C*07 as associated to protection from ATLL (p = 0.031), susceptibility to HAM/TSP (p < 0.001) and susceptibility to ATLL (p = 0.017), respectively. We also found a strong correlation between high proviral load (PVL) and disease (p = 0.008), but were unable to identify any particular allele associated with high or low PVL. CONCLUSIONS:We have found HLA-A*02, HLA-B*35 and HLA-C*07 to be associated to protection from ATLL (HLA-A*02) and susceptibility to HAM/TSP (HLA-B*35) or to ATLL (HLA-C*07), respectively. Whereas HLA-A*02 protection from ATLL has already been extensively described in other regions of the world, this is the first report that links HLA-B*35 and an increased susceptibility to HAM/TSP. As for HLA-C*07 it has previously been associated to susceptibility to HAM/TSP in other countries but in our population it has been linked to ATLL.

journal_name

Retrovirology

journal_title

Retrovirology

authors

Benencio P,Fraile Gonzalez SA,Ducasa N,Page K,Berini CA,Biglione MM

doi

10.1186/s12977-020-00536-y

subject

Has Abstract

pub_date

2020-09-03 00:00:00

pages

29

issue

1

issn

1742-4690

pii

10.1186/s12977-020-00536-y

journal_volume

17

pub_type

杂志文章

相关文献

Retrovirology文献大全
  • Feline immunodeficiency virus (FIV) env recombinants are common in natural infections.

    abstract：BACKGROUND:Recombination is a common feature of retroviral biology and one of the most important factors responsible for generating viral diversity at both the intra-host and the population levels. However, relatively little is known about rates and molecular processes of recombination for retroviruses other than HIV, ...

    journal_title：Retrovirology

    pub_type： 杂志文章

    doi：10.1186/s12977-014-0080-1

    authors： Bęczkowski PM,Hughes J,Biek R,Litster A,Willett BJ,Hosie MJ

    更新日期：2014-09-17 00:00:00

  • TLR2 and TLR4 triggering exerts contrasting effects with regard to HIV-1 infection of human dendritic cells and subsequent virus transfer to CD4+ T cells.

    abstract：BACKGROUND:Recognition of microbial products through Toll-like receptors (TLRs) initiates inflammatory responses orchestrated by innate immune cells such as dendritic cells (DCs). As these cells are patrolling mucosal surfaces, a portal of entry for various pathogens including human immunodeficiency virus type-1 (HIV-1...

    journal_title：Retrovirology

    pub_type： 杂志文章

    doi：10.1186/1742-4690-6-42

    authors： Thibault S,Fromentin R,Tardif MR,Tremblay MJ

    更新日期：2009-05-06 00:00:00

  • STLV-1 as a model for studying HTLV-1 infection.

    abstract：:Few years after HTLV-1 identification and isolation in humans, STLV-1, its simian counterpart, was discovered. It then became clear that STLV-1 is present almost in all simian species. Subsequent molecular epidemiology studies demonstrated that, apart from HTLV-1 subtype A, all human subtypes have a simian homolog. As...

    journal_title：Retrovirology

    pub_type： 杂志文章,评审

    doi：10.1186/s12977-019-0503-0

    authors： Jégado B,Kashanchi F,Dutartre H,Mahieux R

    更新日期：2019-12-16 00:00:00

  • Ubiquitination and sumoylation of the HTLV-2 Tax-2B protein regulate its NF-κB activity: a comparative study with the HTLV-1 Tax-1 protein.

    abstract：BACKGROUND:Retroviruses HTLV-1 and HTLV-2 have homologous genomic structures but differ significantly in pathogenicity. HTLV-1 is associated with Adult T cell Leukemia (ATL), whereas infection by HTLV-2 has no association with neoplasia. Transformation of T lymphocytes by HTLV-1 is linked to the capacity of its oncopro...

    journal_title：Retrovirology

    pub_type： 杂志文章

    doi：10.1186/1742-4690-9-102

    authors： Turci M,Lodewick J,Di Gennaro G,Rinaldi AS,Marin O,Diani E,Sampaio C,Bex F,Bertazzoni U,Romanelli MG

    更新日期：2012-12-07 00:00:00

  • Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2.

    abstract：BACKGROUND:Platelets are associated with HIV in the blood of infected individuals and might modulate viral dissemination, particularly if the virus is directly transmitted into the bloodstream. The C-type lectin DC-SIGN and the novel HIV attachment factor CLEC-2 are expressed by platelets and facilitate HIV transmissio...

    journal_title：Retrovirology

    pub_type： 杂志文章

    doi：10.1186/1742-4690-7-47

    authors： Chaipan C,Steffen I,Tsegaye TS,Bertram S,Glowacka I,Kato Y,Schmökel J,Münch J,Simmons G,Gerardy-Schahn R,Pöhlmann S

    更新日期：2010-05-19 00:00:00

  • Longitudinal analysis of subtype C envelope tropism for memory CD4+ T cell subsets over the first 3 years of untreated HIV-1 infection.

    abstract：BACKGROUND:HIV-1 infects a wide range of CD4+ T cells with different phenotypic properties and differing expression levels of entry coreceptors. We sought to determine the viral tropism of subtype C (C-HIV) Envelope (Env) clones for different CD4+ T cell subsets and whether tropism changes during acute to chronic disea...

    journal_title：Retrovirology

    pub_type： 杂志文章

    doi：10.1186/s12977-020-00532-2

    authors： Gartner MJ,Gorry PR,Tumpach C,Zhou J,Dantanarayana A,Chang JJ,Angelovich TA,Ellenberg P,Laumaea AE,Nonyane M,Moore PL,Lewin SR,Churchill MJ,Flynn JK,Roche M

    更新日期：2020-08-06 00:00:00

  • Evolution and gene capture in ancient endogenous retroviruses - insights from the crocodilian genomes.

    abstract：BACKGROUND:Crocodilians are thought to be hosts to a diverse and divergent complement of endogenous retroviruses (ERVs) but a comprehensive investigation is yet to be performed. The recent sequencing of three crocodilian genomes provides an opportunity for a more detailed and accurate representation of the ERV diversit...

    journal_title：Retrovirology

    pub_type： 杂志文章

    doi：10.1186/s12977-014-0071-2

    authors： Chong AY,Kojima KK,Jurka J,Ray DA,Smit AF,Isberg SR,Gongora J

    更新日期：2014-12-12 00:00:00

  • Microbial exposure alters HIV-1-induced mucosal CD4+ T cell death pathways Ex vivo.

    abstract：BACKGROUND:Early HIV-1 infection causes massive CD4+ T cell death in the gut and translocation of bacteria into the circulation. However, the programmed cell death (PCD) pathways used by HIV-1 to kill CD4+ T cells in the gut, and the impact of microbial exposure on T cell loss, remain unclear. Understanding mucosal HIV...

    journal_title：Retrovirology

    pub_type： 杂志文章

    doi：10.1186/1742-4690-11-14

    authors： Steele AK,Lee EJ,Manuzak JA,Dillon SM,Beckham JD,McCarter MD,Santiago ML,Wilson CC

    更新日期：2014-02-04 00:00:00

  • Identification of novel subgroup A variants with enhanced receptor binding and replicative capacity in primary isolates of anaemogenic strains of feline leukaemia virus.

    abstract：BACKGROUND:The development of anaemia in feline leukaemia virus (FeLV)-infected cats is associated with the emergence of a novel viral subgroup, FeLV-C. FeLV-C arises from the subgroup that is transmitted, FeLV-A, through alterations in the amino acid sequence of the receptor binding domain (RBD) of the envelope glycop...

    journal_title：Retrovirology

    pub_type： 杂志文章

    doi：10.1186/1742-4690-9-48

    authors： Stewart H,Adema KW,McMonagle EL,Hosie MJ,Willett BJ

    更新日期：2012-05-31 00:00:00

  • Conference highlights of the 16th International Conference on Human Retrovirology: HTLV and related retroviruses, 26-30 June 2013, Montreal, Canada.

    abstract：:The 16th International Conference on Human Retrovirology: HTLV and Related Retroviruses was held in Montreal, Québec from June 26th to June 30th, 2013 and was therefore hosted by a Canadian city for the first time. The major topic of the meeting was human T-lymphotropic viruses (HTLVs) and was covered through distinct...

    journal_title：Retrovirology

    pub_type：

    doi：10.1186/1742-4690-11-19

    authors： Barbeau B,Hiscott J,Bazarbachi A,Carvalho E,Jones K,Martin F,Matsuoka M,Murphy EL,Ratner L,Switzer WM,Watanabe T

    更新日期：2014-02-24 00:00:00

  • The expanding role of Tax in transcription.

    abstract：:The viral transactivator of HTLV-I, Tax, has long been shown to target the earliest steps of transcription by forming quaternary complexes with sequence specific transcription factors and histone-modifying enzymes in the LTR of HTLV-I. However, a new study suggests that Tax preferentially transactivates the 21-bp repe...

    journal_title：Retrovirology

    pub_type： 杂志文章

    doi：10.1186/1742-4690-1-19

    authors： de la Fuente C,Kashanchi F

    更新日期：2004-07-30 00:00:00

  • HIV and the tuberculosis "set point": how HIV impairs alveolar macrophage responses to tuberculosis and sets the stage for progressive disease.

    abstract：:As HIV has fueled a global resurgence of tuberculosis over the last several decades, there is a growing awareness that HIV-mediated impairments in both innate and adaptive immunity contribute to the heightened risk of tuberculosis in people with HIV. Since early immune responses to Mycobacterium tuberculosis (Mtb) set...

    journal_title：Retrovirology

    pub_type： 杂志文章,评审

    doi：10.1186/s12977-020-00540-2

    authors： Auld SC,Staitieh BS

    更新日期：2020-09-23 00:00:00

  • SIVdrl detection in captive mandrills: are mandrills infected with a third strain of simian immunodeficiency virus?

    abstract：:A pol-fragment of simian immunodeficiency virus (SIV) that is highly related to SIVdrl-pol from drill monkeys (Mandrillus leucophaeus) was detected in two mandrills (Mandrillus sphinx) from Amsterdam Zoo. These captivity-born mandrills had never been in contact with drill monkeys, and were unlikely to be hybrids. Thei...

    journal_title：Retrovirology

    pub_type： 杂志文章

    doi：10.1186/1742-4690-1-36

    authors： van der Kuyl AC,van den Burg R,Hoyer MJ,Gruters RA,Osterhaus AD,Berkhout B

    更新日期：2004-11-01 00:00:00

  • Human Immunodeficiency Virus-Type 1 LTR DNA contains an intrinsic gene producing antisense RNA and protein products.

    abstract：BACKGROUND:While viruses have long been shown to capitalize on their limited genomic size by utilizing both strands of DNA or complementary DNA/RNA intermediates to code for viral proteins, it has been assumed that human retroviruses have all their major proteins translated only from the plus or sense strand of RNA, de...

    journal_title：Retrovirology

    pub_type： 杂志文章

    doi：10.1186/1742-4690-3-80

    authors： Ludwig LB,Ambrus JL Jr,Krawczyk KA,Sharma S,Brooks S,Hsiao CB,Schwartz SA

    更新日期：2006-11-08 00:00:00

  • Reservoir cells no longer detectable after a heterologous SHIV challenge with the synthetic HIV-1 Tat Oyi vaccine.

    abstract：BACKGROUND:Extra-cellular roles of Tat might be the main cause of maintenance of HIV-1 infected CD4 T cells or reservoir cells. We developed a synthetic vaccine based on a Tat variant of 101 residues called Tat Oyi, which was identified in HIV infected patients in Africa who did not progress to AIDS. We compared, using...

    journal_title：Retrovirology

    pub_type： 杂志文章

    doi：10.1186/1742-4690-3-8

    authors： Watkins JD,Lancelot S,Campbell GR,Esquieu D,de Mareuil J,Opi S,Annappa S,Salles JP,Loret EP

    更新日期：2006-01-27 00:00:00

  • The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells.

    abstract：BACKGROUND:The human T-cell leukemia virus type 1 (HTLV-1) Tax protein indirectly influences transcriptional activation, signal transduction, cell cycle control, and apoptosis. The function of Tax primarily relies on protein-protein interactions. We have previously shown that Tax upregulates the cell cycle checkpoint p...

    journal_title：Retrovirology

    pub_type： 杂志文章

    doi：10.1186/1742-4690-1-6

    authors： Kehn K,Deng L,de la Fuente C,Strouss K,Wu K,Maddukuri A,Baylor S,Rufner R,Pumfery A,Bottazzi ME,Kashanchi F

    更新日期：2004-04-13 00:00:00

  • Low-level alternative tRNA priming of reverse transcription of HIV-1 and SIV in vivo.

    abstract：BACKGROUND:Reverse transcription (RT) of HIV and SIV is initiated by the binding of the acceptor stem of tRNALys3 to the primer binding site (PBS) of the viral RNA genome. Previous studies have suggested that this tRNALys3 is not the only molecule capable of priming reverse transcription, and that at least one other ly...

    journal_title：Retrovirology

    pub_type： 杂志文章

    doi：10.1186/s12977-019-0473-2

    authors： Fennessey CM,Camus C,Immonen TT,Reid C,Maldarelli F,Lifson JD,Keele BF

    更新日期：2019-04-04 00:00:00

  • Natural APOBEC3C variants can elicit differential HIV-1 restriction activity.

    abstract：BACKGROUND:The APOBEC3 (A3) family of DNA cytosine deaminases provides an innate barrier to infection by retroviruses including HIV-1. A total of five enzymes, A3C, A3D, A3F, A3G and A3H, are degraded by the viral accessory protein Vif and expressed at high levels in CD4+ T cells, the primary reservoir for HIV-1 replic...

    journal_title：Retrovirology

    pub_type： 杂志文章

    doi：10.1186/s12977-018-0459-5

    authors： Anderson BD,Ikeda T,Moghadasi SA,Martin AS,Brown WL,Harris RS

    更新日期：2018-12-17 00:00:00

  • Modulation of HIV-1-host interaction: role of the Vpu accessory protein.

    abstract：:Viral protein U (Vpu) is a type 1 membrane-associated accessory protein that is unique to human immunodeficiency virus type 1 (HIV-1) and a subset of related simian immunodeficiency virus (SIV). The Vpu protein encoded by HIV-1 is associated with two primary functions during the viral life cycle. First, it contributes...

    journal_title：Retrovirology

    pub_type： 杂志文章,评审

    doi：10.1186/1742-4690-7-114

    authors： Dubé M,Bego MG,Paquay C,Cohen ÉA

    更新日期：2010-12-22 00:00:00

  • Moving beyond the mousetrap: current and emerging humanized mouse and rat models for investigating prevention and cure strategies against HIV infection and associated pathologies.

    abstract：:The development of safe and effective combination antiretroviral therapies for human immunodeficiency virus (HIV) infection over the past several decades has significantly reduced HIV-associated morbidity and mortality. Additionally, antiretroviral drugs have provided an effective means of protection against HIV trans...

    journal_title：Retrovirology

    pub_type： 杂志文章,评审

    doi：10.1186/s12977-020-00515-3

    authors： Agarwal Y,Beatty C,Biradar S,Castronova I,Ho S,Melody K,Bility MT

    更新日期：2020-04-10 00:00:00

  • A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants.

    abstract：BACKGROUND:The recently approved anti-AIDS drug rilpivirine (TMC278, Edurant) is a nonnucleoside inhibitor (NNRTI) that binds to reverse transcriptase (RT) and allosterically blocks the chemical step of DNA synthesis. In contrast to earlier NNRTIs, rilpivirine retains potency against well-characterized, clinically rele...

    journal_title：Retrovirology

    pub_type： 杂志文章

    doi：10.1186/1742-4690-9-99

    authors： Johnson BC,Pauly GT,Rai G,Patel D,Bauman JD,Baker HL,Das K,Schneider JP,Maloney DJ,Arnold E,Thomas CJ,Hughes SH

    更新日期：2012-12-05 00:00:00

  • Virus-producing cells determine the host protein profiles of HIV-1 virion cores.

    abstract：BACKGROUND:Upon HIV entry into target cells, viral cores are released and rearranged into reverse transcription complexes (RTCs), which support reverse transcription and also protect and transport viral cDNA to the site of integration. RTCs are composed of viral and cellular proteins that originate from both target and...

    journal_title：Retrovirology

    pub_type： 杂志文章

    doi：10.1186/1742-4690-9-65

    authors： Santos S,Obukhov Y,Nekhai S,Bukrinsky M,Iordanskiy S

    更新日期：2012-08-13 00:00:00

  • Efficient trapping of HIV-1 envelope protein by hetero-oligomerization with an N-helix chimera.

    abstract：BACKGROUND:The N-heptad repeat region of the HIV-1 Transmembrane Envelope protein is a trimerization domain that forms part of a "six helix bundle" crucial to Envelope-mediated membrane fusion. N-heptad repeat peptides have been used as extracellular reagents to inhibit virus fusion. RESULTS:When expressed intracellul...

    journal_title：Retrovirology

    pub_type： 杂志文章

    doi：10.1186/1742-4690-2-51

    authors： Ou W,Silver J

    更新日期：2005-08-10 00:00:00

  • Interferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma.

    abstract：BACKGROUND:Adult T-cell leukemia lymphoma (ATLL) is a chemotherapy-resistant malignancy with a median survival of less than one year that will afflict between one hundred thousand and one million individuals worldwide who are currently infected with human T-cell leukemia virus type 1. Recurrent somatic mutations in hos...

    journal_title：Retrovirology

    pub_type： 杂志文章

    doi：10.1186/s12977-020-00535-z

    authors： Rauch DA,Olson SL,Harding JC,Sundaramoorthi H,Kim Y,Zhou T,MacLeod AR,Challen G,Ratner L

    更新日期：2020-08-28 00:00:00

  • Limelight on two HIV/SIV accessory proteins in macrophage infection: is Vpx overshadowing Vpr?

    abstract：:HIV viruses encode a set of accessory proteins, which are important determinants of virulence due to their ability to manipulate the host cell physiology for the benefit of the virus. Although these viral proteins are dispensable for viral growth in many in vitro cell culture systems, they influence the efficiency of ...

    journal_title：Retrovirology

    pub_type： 杂志文章,评审

    doi：10.1186/1742-4690-7-35

    authors： Ayinde D,Maudet C,Transy C,Margottin-Goguet F

    更新日期：2010-04-09 00:00:00

  • CD45 immunoaffinity depletion of vesicles from Jurkat T cells demonstrates that exosomes contain CD45: no evidence for a distinct exosome/HIV-1 budding pathway.

    abstract：:The presence of relatively high levels of cellular protein contamination in density-purified virion preparations is a confounding factor in biochemical analyses of HIV and SIV produced from hematopoietic cells. A major source of this contamination is from vesicles, either microvesicles or exosomes, that have similar p...

    journal_title：Retrovirology

    pub_type： 杂志文章

    doi：10.1186/1742-4690-5-64

    authors： Coren LV,Shatzer T,Ott DE

    更新日期：2008-07-16 00:00:00

  • WIP1 deficiency inhibits HTLV-1 Tax oncogenesis: novel therapeutic prospects for treatment of ATL?

    abstract：:Attenuation of p53 activity appears to be a major step in Human T-lymphotropic virus type 1 (HTLV-1) Tax transformation. However, p53 genomic mutations are late and rather infrequent events in HTLV-1 induced Adult T cell leukemia (ATL). The paper by Zane et al. shows that a mediator of p53 activity, Wild-type p53-indu...

    journal_title：Retrovirology

    pub_type： 评论,杂志文章

    doi：10.1186/1742-4690-9-115

    authors： Gillet N,Carpentier A,Barez PY,Willems L

    更新日期：2012-12-21 00:00:00

  • Distinct roles of CD4+ T cell subpopulations in retroviral immunity: lessons from the Friend virus mouse model.

    abstract：:It is well established that CD4(+) T cells play an important role in immunity to infections with retroviruses such as HIV. However, in recent years CD4(+) T cells have been subdivided into several distinct populations that are differentially regulated and perform widely varying functions. Thus, it is important to deli...

    journal_title：Retrovirology

    pub_type： 杂志文章,评审

    doi：10.1186/1742-4690-8-76

    authors： Nair S,Bayer W,Ploquin MJ,Kassiotis G,Hasenkrug KJ,Dittmer U

    更新日期：2011-09-26 00:00:00

  • Memories of John N. Brady: scientist, mentor and friend.

    abstract：:Friends and colleagues remember John N. Brady, Ph.D., Chief of the Virus Tumor Biology Section of the Laboratory of Cellular Oncology, who died much too young at the age of 57 on April 27, 2009 of colon cancer. John grew up in Illinois and received his Ph.D. with Dr. Richard Consigli at Kansas State University studyin...

    journal_title：Retrovirology

    pub_type： 传,社论,历史文章

    doi：10.1186/1742-4690-6-48

    authors： Pise-Masison CA,Marriott SJ

    更新日期：2009-05-19 00:00:00

  • Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3.

    abstract：:We have obtained the 1.7 A crystal structure of FIV protease (PR) in which 12 critical residues around the active site have been substituted with the structurally equivalent residues of HIV PR (12X FIV PR). The chimeric PR was crystallized in complex with the broad-based inhibitor TL-3, which inhibits wild type FIV an...

    journal_title：Retrovirology

    pub_type： 杂志文章

    doi：10.1186/1742-4690-4-1

    authors： Heaslet H,Lin YC,Tam K,Torbett BE,Elder JH,Stout CD

    更新日期：2007-01-09 00:00:00