Friend retrovirus infection induces the development of memory-like natural killer cells.

Abstract:

:Traditionally, NK cells belong to the innate immune system and eliminate virus-infected cells through their germline-encoded receptors. However, NK cells were recently reported to possess memory-like functions that were predominantly provided by hepatic NK cells. Memory properties were mainly documented in contact hypersensitivity models or during cytomegalovirus infections. However, the precise role and the physiologic importance of memory-like NK cells during retroviral infections are still under investigation. Here, we show that Friend retrovirus (FV) infection of mice induced a population of phenotypically memory-like NK cells at 28 days post infection. Upon secondary antigen encounter, these NK cells showed an increased production of the pro-inflammatory cytokines IFNγ and TNFα as well as the death ligand FasL in comparison to naïve NK cells. Furthermore, we found an augmented elimination of antigen-matched but not antigen-mismatched target cells by these memory-like NK cells. In adoptive cell transfer experiments, equal antiviral activities of splenic and hepatic memory-like NK cells during the late phase of acute FV infection were found. Our results strongly imply the existence and antiviral activity of spleen and liver memory-like NK cells in FV infection, which efficiently respond upon secondary exposure to retroviral antigens.

journal_name

Retrovirology

journal_title

Retrovirology

authors

Littwitz-Salomon E,Nguyen T,Schimmer S,Dittmer U

doi

10.1186/s12977-018-0450-1

subject

Has Abstract

pub_date

2018-10-06 00:00:00

pages

68

issue

1

issn

1742-4690

pii

10.1186/s12977-018-0450-1

journal_volume

15

pub_type

杂志文章
  • Inhibition of Tat activity by the HEXIM1 protein.

    abstract:BACKGROUND:The positive transcription elongation factor b (P-TEFb) composed by CDK9/CyclinT1 subunits is a dedicated co-factor of HIV transcriptional transactivator Tat protein. Transcription driven by the long terminal repeat (LTR) of HIV involves formation of a quaternary complex between P-TEFb, Tat and the TAR eleme...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-2-42

    authors: Fraldi A,Varrone F,Napolitano G,Michels AA,Majello B,Bensaude O,Lania L

    更新日期:2005-07-02 00:00:00

  • Reactivation of latent HIV-1 in central memory CD4⁺ T cells through TLR-1/2 stimulation.

    abstract:BACKGROUND:Toll-like receptors (TLRs) are crucial for recognition of pathogen-associated molecular patterns by cells of the innate immune system. TLRs are present and functional in CD4⁺ T cells. Memory CD4⁺ T cells, predominantly central memory cells (TCM), constitute the main reservoir of latent HIV-1. However, how TL...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-10-119

    authors: Novis CL,Archin NM,Buzon MJ,Verdin E,Round JL,Lichterfeld M,Margolis DM,Planelles V,Bosque A

    更新日期:2013-10-24 00:00:00

  • Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors.

    abstract:BACKGROUND:HIV-1 typically develops resistance to any single antiretroviral agent. Combined anti-retroviral therapy to reduce drug-resistance development is necessary to control HIV-1 infection. Here, to assess the utility of a combination of antibody and fusion inhibitor treatments, we investigated the potency of mono...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/s12977-016-0304-7

    authors: Alam M,Kuwata T,Shimura K,Yokoyama M,Ramirez Valdez KP,Tanaka K,Maruta Y,Oishi S,Fujii N,Sato H,Matsuoka M,Matsushita S

    更新日期:2016-09-27 00:00:00

  • Increased susceptibility of CD4+ T cells from elderly individuals to HIV-1 infection and apoptosis is associated with reduced CD4 and enhanced CXCR4 and FAS surface expression levels.

    abstract:BACKGROUND:Elderly HIV-1 infected individuals progress to AIDS more frequently and rapidly than people becoming infected at a young age. To identify possible reasons for these differences in clinical progression, we performed comprehensive phenotypic analyses of CD4+ T cells from uninfected young and elderly individual...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/s12977-015-0213-1

    authors: Heigele A,Joas S,Regensburger K,Kirchhoff F

    更新日期:2015-10-09 00:00:00

  • The XVI International Conference on AIDS: the place to be!

    abstract::This editorial represents a plea to retrovirologists to attend the XVI International Conference on AIDS that will take place in Toronto, Canada between August 13-18, 2006. In short, it is vital that politicians and opinion leaders understand that basic scientists are no less committed to the worldwide battle against H...

    journal_title:Retrovirology

    pub_type: 社论

    doi:10.1186/1742-4690-3-9

    authors: Wainberg MA

    更新日期:2006-02-03 00:00:00

  • Host proteins interacting with the Moloney murine leukemia virus integrase: multiple transcriptional regulators and chromatin binding factors.

    abstract:BACKGROUND:A critical step for retroviral replication is the stable integration of the provirus into the genome of its host. The viral integrase protein is key in this essential step of the retroviral life cycle. Although the basic mechanism of integration by mammalian retroviruses has been well characterized, the fact...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-5-48

    authors: Studamire B,Goff SP

    更新日期:2008-06-13 00:00:00

  • Digital PCR as a tool to measure HIV persistence.

    abstract::Although antiretroviral therapy is able to suppress HIV replication in infected patients, the virus persists and rebounds when treatment is stopped. In order to find a cure that can eradicate the latent reservoir, one must be able to quantify the persisting virus. Traditionally, HIV persistence studies have used real-...

    journal_title:Retrovirology

    pub_type: 杂志文章,评审

    doi:10.1186/s12977-018-0399-0

    authors: Rutsaert S,Bosman K,Trypsteen W,Nijhuis M,Vandekerckhove L

    更新日期:2018-01-30 00:00:00

  • Induction of p21(CIP1/WAF1) expression by human T-lymphotropic virus type 1 Tax requires transcriptional activation and mRNA stabilization.

    abstract::HTLV-1 Tax can induce senescence by up-regulating the levels of cyclin-dependent kinase inhibitors p21(CIP1/WAF1) and p27(KIP1). Tax increases p27(KIP1) protein stability by activating the anaphase promoting complex/cyclosome (APC/C) precociously, causing degradation of Skp2 and inactivation of SCF(Skp2), the E3 ligas...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-6-35

    authors: Zhang L,Zhi H,Liu M,Kuo YL,Giam CZ

    更新日期:2009-04-08 00:00:00

  • Interferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma.

    abstract:BACKGROUND:Adult T-cell leukemia lymphoma (ATLL) is a chemotherapy-resistant malignancy with a median survival of less than one year that will afflict between one hundred thousand and one million individuals worldwide who are currently infected with human T-cell leukemia virus type 1. Recurrent somatic mutations in hos...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/s12977-020-00535-z

    authors: Rauch DA,Olson SL,Harding JC,Sundaramoorthi H,Kim Y,Zhou T,MacLeod AR,Challen G,Ratner L

    更新日期:2020-08-28 00:00:00

  • HLA-B*35 as a new marker for susceptibility to human T-cell lymphotropic virus type 1 (HTLV-1) Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in patients living in Argentina.

    abstract:BACKGROUND:Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of HTLV associated myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) and Adult T cell leukemia/lymphoma (ATLL), in around 2-5% of the infected individuals. Host genetic background might play a role in disease progression. Several previ...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/s12977-020-00536-y

    authors: Benencio P,Fraile Gonzalez SA,Ducasa N,Page K,Berini CA,Biglione MM

    更新日期:2020-09-03 00:00:00

  • Detection, characterization and regulation of antisense transcripts in HIV-1.

    abstract:BACKGROUND:We and others have recently demonstrated that the human retrovirus HTLV-I was producing a spliced antisense transcript, which led to the synthesis of the HBZ protein. The objective of the present study was to demonstrate the existence of antisense transcription in HIV-1 and to provide a better characterizati...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-4-71

    authors: Landry S,Halin M,Lefort S,Audet B,Vaquero C,Mesnard JM,Barbeau B

    更新日期:2007-10-02 00:00:00

  • The S40 residue in HIV-1 Gag p6 impacts local and distal budding determinants, revealing additional late domain activities.

    abstract:BACKGROUND:HIV-1 budding is directed primarily by two motifs in Gag p6 designated as late domain-1 and -2 that recruit ESCRT machinery by binding Tsg101 and Alix, respectively, and by poorly characterized determinants in the capsid (CA) domain. Here, we report that a conserved Gag p6 residue, S40, impacts budding media...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-10-143

    authors: Watanabe SM,Chen MH,Khan M,Ehrlich L,Kemal KS,Weiser B,Shi B,Chen C,Powell M,Anastos K,Burger H,Carter CA

    更新日期:2013-11-21 00:00:00

  • The HIV-1 Rev/RRE system is required for HIV-1 5' UTR cis elements to augment encapsidation of heterologous RNA into HIV-1 viral particles.

    abstract:BACKGROUND:The process of HIV-1 genomic RNA (gRNA) encapsidation is governed by a number of viral encoded components, most notably the Gag protein and gRNA cis elements in the canonical packaging signal (ψ). Also implicated in encapsidation are cis determinants in the R, U5, and PBS (primer binding site) from the 5' un...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-8-51

    authors: Cockrell AS,van Praag H,Santistevan N,Ma H,Kafri T

    更新日期:2011-06-24 00:00:00

  • Human TRIM5alpha mediated restriction of different HIV-1 subtypes and Lv2 sensitive and insensitive HIV-2 variants.

    abstract::In order to characterize the antiviral activity of human TRIM5alpha in more detail human derived indicator cell lines over expressing wild type human TRIM5alpha were generated and challenged with HIV-1 and HIV-2 viruses pseudotyped with HIV envelope proteins in comparison to VSV-G pseudotyped particles. HIV envelope p...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-3-79

    authors: Kaumanns P,Hagmann I,Dittmar MT

    更新日期:2006-11-06 00:00:00

  • Evidence for preferential copackaging of Moloney murine leukemia virus genomic RNAs transcribed in the same chromosomal site.

    abstract:BACKGROUND:Retroviruses have a diploid genome and recombine at high frequency. Recombinant proviruses can be generated when two genetically different RNA genomes are packaged into the same retroviral particle. It was shown in several studies that recombinant proviruses could be generated in each round of HIV-1 replicat...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-2-3

    authors: Kharytonchyk SA,Kireyeva AI,Osipovich AB,Fomin IK

    更新日期:2005-01-18 00:00:00

  • Conference highlights of the 16th International Conference on Human Retrovirology: HTLV and related retroviruses, 26-30 June 2013, Montreal, Canada.

    abstract::The 16th International Conference on Human Retrovirology: HTLV and Related Retroviruses was held in Montreal, Québec from June 26th to June 30th, 2013 and was therefore hosted by a Canadian city for the first time. The major topic of the meeting was human T-lymphotropic viruses (HTLVs) and was covered through distinct...

    journal_title:Retrovirology

    pub_type:

    doi:10.1186/1742-4690-11-19

    authors: Barbeau B,Hiscott J,Bazarbachi A,Carvalho E,Jones K,Martin F,Matsuoka M,Murphy EL,Ratner L,Switzer WM,Watanabe T

    更新日期:2014-02-24 00:00:00

  • The co-receptor signaling model of HIV-1 pathogenesis in peripheral CD4 T cells.

    abstract::HIV-mediated CD4 depletion is the hallmark of AIDS and is the most reliable predictor of disease progression. While HIV replication is associated with CD4 depletion in general, plasma viremia by itself predicts the rate of CD4 loss only minimally in untreated patients. To resolve this paradox, I hypothesize the existe...

    journal_title:Retrovirology

    pub_type: 社论

    doi:10.1186/1742-4690-6-41

    authors: Wu Y

    更新日期:2009-05-01 00:00:00

  • Combination of nanoparticle-based therapeutic vaccination and transient ablation of regulatory T cells enhances anti-viral immunity during chronic retroviral infection.

    abstract:BACKGROUND:Regulatory T cells (Tregs) have been shown to limit anti-viral immunity during chronic retroviral infection and to restrict vaccine-induced T cell responses. The objective of the study was to assess whether a combinational therapy of nanoparticle-based therapeutic vaccination and concomitant transient ablati...

    journal_title:Retrovirology

    pub_type: 杂志文章,评审

    doi:10.1186/s12977-016-0258-9

    authors: Knuschke T,Rotan O,Bayer W,Sokolova V,Hansen W,Sparwasser T,Dittmer U,Epple M,Buer J,Westendorf AM

    更新日期:2016-04-14 00:00:00

  • Small non-coding RNAs, mammalian cells, and viruses: regulatory interactions?

    abstract::Recent findings suggest that mammalian cells can use small non-coding RNAs (ncRNA) to regulate physiological viral infections. Here, we comment on several lines of evidence that support this concept. We discuss how viruses may in turn protect, suppress, evade, modulate, or adapt to the host cell's ncRNA regulatory sch...

    journal_title:Retrovirology

    pub_type: 社论,评审

    doi:10.1186/1742-4690-4-74

    authors: Yeung ML,Benkirane M,Jeang KT

    更新日期:2007-10-15 00:00:00

  • Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal.

    abstract:BACKGROUND:We reported previously that while prolonged tenofovir monotherapy of macaques infected with virulent simian immunodeficiency virus (SIV) resulted invariably in the emergence of viral mutants with reduced in vitro drug susceptibility and a K65R mutation in reverse transcriptase, some animals controlled virus ...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-9-57

    authors: Van Rompay KK,Trott KA,Jayashankar K,Geng Y,LaBranche CC,Johnson JA,Landucci G,Lipscomb J,Tarara RP,Canfield DR,Heneine W,Forthal DN,Montefiori D,Abel K

    更新日期:2012-07-17 00:00:00

  • CD45 immunoaffinity depletion of vesicles from Jurkat T cells demonstrates that exosomes contain CD45: no evidence for a distinct exosome/HIV-1 budding pathway.

    abstract::The presence of relatively high levels of cellular protein contamination in density-purified virion preparations is a confounding factor in biochemical analyses of HIV and SIV produced from hematopoietic cells. A major source of this contamination is from vesicles, either microvesicles or exosomes, that have similar p...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-5-64

    authors: Coren LV,Shatzer T,Ott DE

    更新日期:2008-07-16 00:00:00

  • Utilization of HIV-1 envelope V3 to identify X4- and R5-specific Tat and LTR sequence signatures.

    abstract:BACKGROUND:HIV-1 entry is a receptor-mediated process directed by the interaction of the viral envelope with the host cell CD4 molecule and one of two co-receptors, CCR5 or CXCR4. The amino acid sequence of the third variable (V3) loop of the HIV-1 envelope is highly predictive of co-receptor utilization preference dur...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/s12977-016-0266-9

    authors: Antell GC,Dampier W,Aiamkitsumrit B,Nonnemacher MR,Jacobson JM,Pirrone V,Zhong W,Kercher K,Passic S,Williams JW,Schwartz G,Hershberg U,Krebs FC,Wigdahl B

    更新日期:2016-05-03 00:00:00

  • Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2.

    abstract:BACKGROUND:Platelets are associated with HIV in the blood of infected individuals and might modulate viral dissemination, particularly if the virus is directly transmitted into the bloodstream. The C-type lectin DC-SIGN and the novel HIV attachment factor CLEC-2 are expressed by platelets and facilitate HIV transmissio...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-7-47

    authors: Chaipan C,Steffen I,Tsegaye TS,Bertram S,Glowacka I,Kato Y,Schmökel J,Münch J,Simmons G,Gerardy-Schahn R,Pöhlmann S

    更新日期:2010-05-19 00:00:00

  • Contamination of clinical specimens with MLV-encoding nucleic acids: implications for XMRV and other candidate human retroviruses.

    abstract::Efforts to assess the prevalence of xenotropic murine leukemia virus-related virus (XMRV) in patients with prostate cancer and chronic fatigue syndrome have relied heavily on PCR-based testing of clinical samples and have yielded widely divergent findings. This week in Retrovirology, reports from four independent rese...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-7-112

    authors: Smith RA

    更新日期:2010-12-20 00:00:00

  • Are anti-HIV IgAs good guys or bad guys?

    abstract::An estimated 90% of all HIV transmissions occur mucosally. Immunoglobulin A (IgA) molecules are important components of mucosal fluids. In a vaccine efficacy study, in which virosomes displaying HIV gp41 antigens protected most rhesus monkeys (RMs) against simian-human immunodeficiency virus (SHIV), protection correla...

    journal_title:Retrovirology

    pub_type: 杂志文章,评审

    doi:10.1186/s12977-014-0109-5

    authors: Zhou M,Ruprecht RM

    更新日期:2014-12-14 00:00:00

  • HIV-1 Rev oligomerization is not obligatory in the presence of an extra basic domain.

    abstract:BACKGROUND:The HIV-1 Rev regulatory protein binds as an oligomeric complex to viral RNA mediating nuclear export of incompletely spliced and non-spliced viral mRNAs encoding the viral structural proteins. However, the biological significance of the obligatory complex formation of Rev upon the viral RNA is unclear. RES...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-2-39

    authors: Furnes C,Arnesen T,Askjaer P,Kjems J,Szilvay AM

    更新日期:2005-06-10 00:00:00

  • Proteasome inhibitors act as bifunctional antagonists of human immunodeficiency virus type 1 latency and replication.

    abstract:BACKGROUND:Existing highly active antiretroviral therapy (HAART) effectively controls viral replication in human immunodeficiency virus type 1 (HIV-1) infected individuals but cannot completely eradicate the infection, at least in part due to the persistence of latently infected cells. One strategy that is being active...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-10-120

    authors: Miller LK,Kobayashi Y,Chen CC,Russnak TA,Ron Y,Dougherty JP

    更新日期:2013-10-24 00:00:00

  • The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity.

    abstract:BACKGROUND:HIV-1 Integrase (IN) interacts with the cellular co-factor LEDGF/p75 and tethers the HIV preintegration complex to the host genome enabling integration. Recently a new class of IN inhibitors was described, the IN-LEDGF allosteric inhibitors (INLAIs). Designed to interfere with the IN-LEDGF interaction during...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/s12977-017-0373-2

    authors: Amadori C,van der Velden YU,Bonnard D,Orlov I,van Bel N,Le Rouzic E,Miralles L,Brias J,Chevreuil F,Spehner D,Chasset S,Ledoussal B,Mayr L,Moreau F,García F,Gatell J,Zamborlini A,Emiliani S,Ruff M,Klaholz BP,Moog C

    更新日期:2017-11-09 00:00:00

  • Modulation of HIV-1 Gag NC/p1 cleavage efficiency affects protease inhibitor resistance and viral replicative capacity.

    abstract:BACKGROUND:Mutations in the substrate of HIV-1 protease, especially changes in the NC/p1 cleavage site, can directly contribute to protease inhibitor (PI) resistance and also compensate for defects in viral replicative capacity (RC) due to a drug resistant protease. These NC/p1 changes are known to enhance processing o...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-9-29

    authors: van Maarseveen NM,Andersson D,Lepšík M,Fun A,Schipper PJ,de Jong D,Boucher CA,Nijhuis M

    更新日期:2012-04-01 00:00:00

  • Distinct roles of CD4+ T cell subpopulations in retroviral immunity: lessons from the Friend virus mouse model.

    abstract::It is well established that CD4(+) T cells play an important role in immunity to infections with retroviruses such as HIV. However, in recent years CD4(+) T cells have been subdivided into several distinct populations that are differentially regulated and perform widely varying functions. Thus, it is important to deli...

    journal_title:Retrovirology

    pub_type: 杂志文章,评审

    doi:10.1186/1742-4690-8-76

    authors: Nair S,Bayer W,Ploquin MJ,Kassiotis G,Hasenkrug KJ,Dittmer U

    更新日期:2011-09-26 00:00:00