Distinct roles of CD4+ T cell subpopulations in retroviral immunity: lessons from the Friend virus mouse model.

abstract：BACKGROUND:HIV-1 Integrase (IN) interacts with the cellular co-factor LEDGF/p75 and tethers the HIV preintegration complex to the host genome enabling integration. Recently a new class of IN inhibitors was described, the IN-LEDGF allosteric inhibitors (INLAIs). Designed to interfere with the IN-LEDGF interaction during...

journal_title：Retrovirology

authors： Amadori C,van der Velden YU,Bonnard D,Orlov I,van Bel N,Le Rouzic E,Miralles L,Brias J,Chevreuil F,Spehner D,Chasset S,Ledoussal B,Mayr L,Moreau F,García F,Gatell J,Zamborlini A,Emiliani S,Ruff M,Klaholz BP,Moog C

更新日期：2017-11-09 00:00:00

abstract：BACKGROUND:The development of anaemia in feline leukaemia virus (FeLV)-infected cats is associated with the emergence of a novel viral subgroup, FeLV-C. FeLV-C arises from the subgroup that is transmitted, FeLV-A, through alterations in the amino acid sequence of the receptor binding domain (RBD) of the envelope glycop...

journal_title：Retrovirology

authors： Stewart H,Adema KW,McMonagle EL,Hosie MJ,Willett BJ

更新日期：2012-05-31 00:00:00

abstract：BACKGROUND:We have previously reported that CD4 T cells from some exposed uninfected (EU) Vietnamese intravenous drug users are relatively resistant to HIV infection in vitro. Here, we further characterized the restriction of viral replication in CD4 T cells from five EUs and assessed its persistence in serial samples....

journal_title：Retrovirology

authors： Sáez-Cirión A,Versmisse P,Truong LX,Chakrabarti LA,Carpentier W,Barré-Sinoussi F,Scott-Algara D,Pancino G

更新日期：2006-11-08 00:00:00

abstract：BACKGROUND:The 18 residue tail abutting the SH3 fold that comprises the heart of the C-terminal domain is the only part of HIV-1 integrase yet to be visualized by structural biology. To ascertain the role of the tail region in integrase function and HIV-1 replication, a set of deletion mutants that successively lacked ...

journal_title：Retrovirology

authors： Dar MJ,Monel B,Krishnan L,Shun MC,Di Nunzio F,Helland DE,Engelman A

更新日期：2009-10-19 00:00:00

abstract：:An estimated 90% of all HIV transmissions occur mucosally. Immunoglobulin A (IgA) molecules are important components of mucosal fluids. In a vaccine efficacy study, in which virosomes displaying HIV gp41 antigens protected most rhesus monkeys (RMs) against simian-human immunodeficiency virus (SHIV), protection correla...

journal_title：Retrovirology

authors： Zhou M,Ruprecht RM

更新日期：2014-12-14 00:00:00

abstract：BACKGROUND:Jaagsiekte sheep retrovirus (JSRV) causes a contagious lung cancer in sheep and goats that can be transmitted by aerosols produced by infected animals. Virus entry into cells is initiated by binding of the viral envelope (Env) protein to a specific cell-surface receptor, Hyal2. Unlike almost all other retrov...

journal_title：Retrovirology

authors： Miller AD,De Las Heras M,Yu J,Zhang F,Liu SL,Vaughan AE,Vaughan TL,Rosadio R,Rocca S,Palmieri G,Goedert JJ,Fujimoto J,Wistuba II

更新日期：2017-01-20 00:00:00

abstract：:Attenuation of p53 activity appears to be a major step in Human T-lymphotropic virus type 1 (HTLV-1) Tax transformation. However, p53 genomic mutations are late and rather infrequent events in HTLV-1 induced Adult T cell leukemia (ATL). The paper by Zane et al. shows that a mediator of p53 activity, Wild-type p53-indu...

journal_title：Retrovirology

authors： Gillet N,Carpentier A,Barez PY,Willems L

更新日期：2012-12-21 00:00:00

abstract：:Cells of the monocyte-macrophage lineage play multiple roles during the infection of primate lentiviruses serving as reservoirs for viral production or as vectors for viral spread to other cells and tissues. The human immunodeficiency type I virus is not only capable of establishing such complex and dynamic relations ...

journal_title：Retrovirology

authors： Cimarelli A

更新日期：2010-04-07 00:00:00

abstract：BACKGROUND:Recombination is a common feature of retroviral biology and one of the most important factors responsible for generating viral diversity at both the intra-host and the population levels. However, relatively little is known about rates and molecular processes of recombination for retroviruses other than HIV, ...

journal_title：Retrovirology

authors： Bęczkowski PM,Hughes J,Biek R,Litster A,Willett BJ,Hosie MJ

更新日期：2014-09-17 00:00:00

abstract：BACKGROUND:MicroRNA (miRNA)-mediated RNA silencing is integral to virtually every cellular process including cell cycle progression and response to virus infection. The interplay between RNA silencing and HIV-1 is multifaceted, and accumulating evidence posits a strike-counterstrike interface that alters the cellular e...

journal_title：Retrovirology

authors： Hayes AM,Qian S,Yu L,Boris-Lawrie K

更新日期：2011-05-13 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Retrovirology

authors： Desimmie BA,Weydert C,Schrijvers R,Vets S,Demeulemeester J,Proost P,Paron I,De Rijck J,Mast J,Bannert N,Gijsbers R,Christ F,Debyser Z

更新日期：2020-07-29 00:00:00

abstract：:The identification of the most appropriate marker to measure reservoir size has been a great challenge for the HIV field. Quantitative viral outgrowth assay (QVOA), the reference standard to quantify the amount of replication-competent virus, has several limitations, as it is laborious, expensive, and unable to robust...

journal_title：Retrovirology

authors： Pinzone MR,O'Doherty U

更新日期：2018-02-17 00:00:00

abstract：BACKGROUND:Combination anti-viral therapies have reduced treatment failure rates by requiring multiple specific mutations to be selected on the same viral genome to impart high-level drug resistance. To determine if the common protease inhibitor resistance mutation L90M is only selected once or repeatedly on different ...

journal_title：Retrovirology

authors： Kapoor A,Shapiro B,Shafer RW,Shulman N,Rhee SY,Delwart EL

更新日期：2008-01-25 00:00:00

abstract：:MicroRNAs are a recently discovered class of small noncoding functional RNAs. These molecules mediate post-transcriptional regulation of gene expression in a sequence specific manner. MicroRNAs are now known to be key players in a variety of biological processes and have been shown to be deregulated in a number of can...

journal_title：Retrovirology

authors： Scaria V,Jadhav V

更新日期：2007-11-24 00:00:00

abstract：BACKGROUND:Accumulating data suggest that immune effector functions mediated through the Fc portion of HIV-1-specific immunoglobulin G (IgG) are a key component of HIV-1 protective immunity, affecting both disease progression and HIV-1 acquisition. Through studying Fc gamma receptor (FcγR) variants known to alter IgG F...

journal_title：Retrovirology

authors： Lassaunière R,Musekiwa A,Gray GE,Kuhn L,Tiemessen CT

更新日期：2016-06-10 00:00:00

abstract：:Members of the APOBEC family of cellular cytidine deaminases represent a recently identified group of proteins that provide immunity to infection by retroviruses and protect the cell from endogenous mobile retroelements. Yet, HIV-1 is largely immune to the intrinsic antiviral effects of APOBEC proteins because it enco...

journal_title：Retrovirology

authors： Goila-Gaur R,Strebel K

更新日期：2008-06-24 00:00:00

abstract：:Susceptibility to HIV-1 and the clinical course after infection show a substantial heterogeneity between individuals. Part of this variability can be attributed to host genetic variation. Initial candidate gene studies have revealed interesting host factors that influence HIV infection, replication and pathogenesis. R...

journal_title：Retrovirology

authors： van Manen D,van 't Wout AB,Schuitemaker H

更新日期：2012-08-24 00:00:00

abstract：:Viral protein U (Vpu) is a type 1 membrane-associated accessory protein that is unique to human immunodeficiency virus type 1 (HIV-1) and a subset of related simian immunodeficiency virus (SIV). The Vpu protein encoded by HIV-1 is associated with two primary functions during the viral life cycle. First, it contributes...

journal_title：Retrovirology

authors： Dubé M,Bego MG,Paquay C,Cohen ÉA

更新日期：2010-12-22 00:00:00

abstract：:This editorial comments on selected progress made in combating the acquired immune deficiency syndrome (AIDS) after 26 years and some of the remaining challenges. ...

journal_title：Retrovirology

authors： Jeang KT

更新日期：2007-12-01 00:00:00

abstract：:The glycan supersite centered on N332 in the V3 base of the HIV-1 envelope (Env) is a target for broadly neutralizing antibodies (bnAbs) such as PGT121 and PGT128. In this study, we examined the basis of resistance of HIV-1 clade C Envs obtained from broadly cross neutralizing (BCN) plasma of an Indian donor with N332...

journal_title：Retrovirology

authors： Deshpande S,Patil S,Kumar R,Hermanus T,Murugavel KG,Srikrishnan AK,Solomon S,Morris L,Bhattacharya J

更新日期：2016-08-30 00:00:00

abstract：:Recent findings suggest that mammalian cells can use small non-coding RNAs (ncRNA) to regulate physiological viral infections. Here, we comment on several lines of evidence that support this concept. We discuss how viruses may in turn protect, suppress, evade, modulate, or adapt to the host cell's ncRNA regulatory sch...

journal_title：Retrovirology

authors： Yeung ML,Benkirane M,Jeang KT

更新日期：2007-10-15 00:00:00

abstract：BACKGROUND:We previously showed that the gM of HSV-1 could restrict the release of infectious HIV-1 from cells. In this study, we analyzed if the four HSV-1 glycoproteins (gD, gB, and gH/gL), which are the minimum glycoproteins required for HSV-1 entry, restricted the release of infectious HIV-1. RESULTS:Of these four...

journal_title：Retrovirology

authors： Polpitiya Arachchige S,Henke W,Kalamvoki M,Stephens EB

更新日期：2019-04-02 00:00:00

abstract：BACKGROUND:Despite intensive investigation the mechanism by which HIV-1 reaches the host cell nucleus is unknown. TNPO3, a karyopherin mediating nuclear entry of SR-proteins, was shown to be required for HIV-1 infectivity. Some investigators have reported that TNPO3 promotes HIV-1 nuclear import, as would be expected f...

journal_title：Retrovirology

authors： De Iaco A,Santoni F,Vannier A,Guipponi M,Antonarakis S,Luban J

更新日期：2013-02-15 00:00:00

abstract：BACKGROUND:We and others have recently demonstrated that the human retrovirus HTLV-I was producing a spliced antisense transcript, which led to the synthesis of the HBZ protein. The objective of the present study was to demonstrate the existence of antisense transcription in HIV-1 and to provide a better characterizati...

journal_title：Retrovirology

authors： Landry S,Halin M,Lefort S,Audet B,Vaquero C,Mesnard JM,Barbeau B

更新日期：2007-10-02 00:00:00

abstract：:How best to evaluate scientists within a peer group is a difficult task. This editorial discusses the use of the H-index and total citations. It also raises the consideration of a mentoring-index and the value of understanding the frequency that a published paper is accessed by readers. ...

journal_title：Retrovirology

authors： Jeang KT

更新日期：2008-11-25 00:00:00

abstract：BACKGROUND:HIV-1 replication is critically dependent upon controlled processing of its RNA and the activities provided by its encoded regulatory factors Tat and Rev. A screen of small molecule modulators of RNA processing identified several which inhibited virus gene expression, affecting both relative abundance of spe...

journal_title：Retrovirology

authors： Balachandran A,Wong R,Stoilov P,Pan S,Blencowe B,Cheung P,Harrigan PR,Cochrane A

更新日期：2017-01-26 00:00:00

abstract：BACKGROUND:Entry of human immunodeficiency virus type 1 (HIV-1) into the host cell involves interactions between the viral envelope glycoproteins (Env) and the cellular receptor CD4 as well as a coreceptor molecule (most importantly CCR5 or CXCR4). Viral preference for a specific coreceptor (tropism) is in particular d...

journal_title：Retrovirology

authors： Bozek K,Eckhardt M,Sierra S,Anders M,Kaiser R,Kräusslich HG,Müller B,Lengauer T

更新日期：2012-07-25 00:00:00

abstract：BACKGROUND:HIV-1 infects a wide range of CD4+ T cells with different phenotypic properties and differing expression levels of entry coreceptors. We sought to determine the viral tropism of subtype C (C-HIV) Envelope (Env) clones for different CD4+ T cell subsets and whether tropism changes during acute to chronic disea...

journal_title：Retrovirology

authors： Gartner MJ,Gorry PR,Tumpach C,Zhou J,Dantanarayana A,Chang JJ,Angelovich TA,Ellenberg P,Laumaea AE,Nonyane M,Moore PL,Lewin SR,Churchill MJ,Flynn JK,Roche M

更新日期：2020-08-06 00:00:00

abstract：BACKGROUND:The APOBEC3 (A3) family of DNA cytosine deaminases provides an innate barrier to infection by retroviruses including HIV-1. A total of five enzymes, A3C, A3D, A3F, A3G and A3H, are degraded by the viral accessory protein Vif and expressed at high levels in CD4+ T cells, the primary reservoir for HIV-1 replic...

journal_title：Retrovirology

authors： Anderson BD,Ikeda T,Moghadasi SA,Martin AS,Brown WL,Harris RS

更新日期：2018-12-17 00:00:00

abstract：BACKGROUND:Among human T cell leukemia virus type 1 (HTLV-1)-infected individuals, there is an association between HTLV-1 tax subgroups (subgroup-A or subgroup-B) and the risk of HAM/TSP in the Japanese population. To investigate the role of HTLV-1 subgroups in viral pathogenesis, we studied the functional difference i...

journal_title：Retrovirology

authors： Naito T,Yasunaga JI,Mitobe Y,Shirai K,Sejima H,Ushirogawa H,Tanaka Y,Nakamura T,Hanada K,Fujii M,Matsuoka M,Saito M

更新日期：2018-11-06 00:00:00