Abstract:
:MicroRNAs are a recently discovered class of small noncoding functional RNAs. These molecules mediate post-transcriptional regulation of gene expression in a sequence specific manner. MicroRNAs are now known to be key players in a variety of biological processes and have been shown to be deregulated in a number of cancers. The discovery of viral encoded microRNAs, especially from a family of oncogenic viruses, has attracted immense attention towards the possibility of microRNAs as critical modulators of viral oncogenesis. The host-virus crosstalk mediated by microRNAs, messenger RNAs and proteins, is complex and involves the different cellular regulatory layers. In this commentary, we describe models of microRNA mediated viral oncogenesis.
journal_name
Retrovirologyjournal_title
Retrovirologyauthors
Scaria V,Jadhav Vdoi
10.1186/1742-4690-4-82subject
Has Abstractpub_date
2007-11-24 00:00:00pages
82issn
1742-4690pii
1742-4690-4-82journal_volume
4pub_type
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