Human TRIM5alpha mediated restriction of different HIV-1 subtypes and Lv2 sensitive and insensitive HIV-2 variants.

abstract：BACKGROUND:The widespread use of highly effective, combination antiretroviral therapy (cART) has led to a significant reduction in the incidence of HIV-associated dementia (HAD). Despite these advances, the prevalence of HIV-1 associated neurocognitive disorders (HANDs) has been estimated at approximately 40%-50%. In t...

journal_title：Retrovirology

authors： Evering TH,Kamau E,St Bernard L,Farmer CB,Kong XP,Markowitz M

更新日期：2014-08-15 00:00:00

abstract：BACKGROUND:Accumulating data suggest that immune effector functions mediated through the Fc portion of HIV-1-specific immunoglobulin G (IgG) are a key component of HIV-1 protective immunity, affecting both disease progression and HIV-1 acquisition. Through studying Fc gamma receptor (FcγR) variants known to alter IgG F...

journal_title：Retrovirology

authors： Lassaunière R,Musekiwa A,Gray GE,Kuhn L,Tiemessen CT

更新日期：2016-06-10 00:00:00

abstract：:How best to evaluate scientists within a peer group is a difficult task. This editorial discusses the use of the H-index and total citations. It also raises the consideration of a mentoring-index and the value of understanding the frequency that a published paper is accessed by readers. ...

journal_title：Retrovirology

authors： Jeang KT

更新日期：2008-11-25 00:00:00

abstract：BACKGROUND:It has been accepted that HIV buds from the cell surface in T lymphocytes, whereas in macrophages it buds into intracellular endosomes. Recent studies, on the other hand, suggest that HIV preferentially buds from the cell surface even in monocytic cells. However, most studies are based on observations in acu...

journal_title：Retrovirology

authors： Suyama M,Daikoku E,Goto T,Sano K,Morikawa Y

更新日期：2009-07-13 00:00:00

abstract：BACKGROUND:Among human T cell leukemia virus type 1 (HTLV-1)-infected individuals, there is an association between HTLV-1 tax subgroups (subgroup-A or subgroup-B) and the risk of HAM/TSP in the Japanese population. To investigate the role of HTLV-1 subgroups in viral pathogenesis, we studied the functional difference i...

journal_title：Retrovirology

authors： Naito T,Yasunaga JI,Mitobe Y,Shirai K,Sejima H,Ushirogawa H,Tanaka Y,Nakamura T,Hanada K,Fujii M,Matsuoka M,Saito M

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:Emergence of drug-resistant strains of human immunodeficiency virus type 1 (HIV-1) is a major obstacle to successful antiretroviral therapy (ART) in HIV-infected patients. Whether antiviral immunity can augment ART by suppressing replication of drug-resistant HIV-1 in humans is not well understood, but can b...

journal_title：Retrovirology

authors： Metzner KJ,Binley JM,Gettie A,Marx P,Nixon DF,Connor RI

更新日期：2006-12-21 00:00:00

abstract：BACKGROUND:Cellular infection with human immunodeficiency virus (HIV) both in vitro and in vivo requires a member of the chemokine receptor family to act as a co-receptor for viral entry. However, it is presently unclear to what extent the interaction of HIV proteins with chemokine receptors generates intracellular sig...

journal_title：Retrovirology

authors： Grainger DJ,Lever AM

更新日期：2005-04-04 00:00:00

abstract：:The King's College London (KCL) Infectious Diseases BioBank opened in 2007 and collects peripheral venous blood (PVB) from individuals infected with pathogens including human immunodeficiency virus (HIV). PVBs are fractionated into plasmas, lymphocytes and DNA and are then frozen. All donations are from subjects who h...

journal_title：Retrovirology

authors： Williams R,Mant C,Cason J

更新日期：2009-11-03 00:00:00

abstract：BACKGROUND:HIV-1 Nef is a viral accessory protein critical for AIDS progression. Nef lacks intrinsic catalytic activity and binds multiple host cell signaling proteins, including Hck and other Src-family tyrosine kinases. Nef binding induces constitutive Hck activation that may contribute to HIV pathogenesis by promoti...

journal_title：Retrovirology

authors： Trible RP,Narute P,Emert-Sedlak LA,Alvarado JJ,Atkins K,Thomas L,Kodama T,Yanamala N,Korotchenko V,Day BW,Thomas G,Smithgall TE

更新日期：2013-11-14 00:00:00

abstract：BACKGROUND:MicroRNA (miRNA)-mediated RNA silencing is integral to virtually every cellular process including cell cycle progression and response to virus infection. The interplay between RNA silencing and HIV-1 is multifaceted, and accumulating evidence posits a strike-counterstrike interface that alters the cellular e...

journal_title：Retrovirology

authors： Hayes AM,Qian S,Yu L,Boris-Lawrie K

更新日期：2011-05-13 00:00:00

abstract：:Friends and colleagues remember John N. Brady, Ph.D., Chief of the Virus Tumor Biology Section of the Laboratory of Cellular Oncology, who died much too young at the age of 57 on April 27, 2009 of colon cancer. John grew up in Illinois and received his Ph.D. with Dr. Richard Consigli at Kansas State University studyin...

journal_title：Retrovirology

authors： Pise-Masison CA,Marriott SJ

更新日期：2009-05-19 00:00:00

abstract：BACKGROUND:Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of HTLV associated myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) and Adult T cell leukemia/lymphoma (ATLL), in around 2-5% of the infected individuals. Host genetic background might play a role in disease progression. Several previ...

journal_title：Retrovirology

authors： Benencio P,Fraile Gonzalez SA,Ducasa N,Page K,Berini CA,Biglione MM

更新日期：2020-09-03 00:00:00

abstract：:Previous studies have reported that various inbred SAM mouse strains differ markedly with regard to a variety of parameters, such as capacity for learning and memory, life spans and brain histopathology. A potential cause of differences seen in these strains may be based on the fact that some strains have a high conce...

journal_title：Retrovirology

authors： Kim BH,Meeker HC,Shin HY,Kim JI,Jeong BH,Choi EK,Carp RI,Kim YS

更新日期：2008-11-25 00:00:00

abstract：:HTLV-1 was the first described human retrovirus and was soon found to be associated with severe clinical diseases, including a devastating lymphoma/leukemia and other inflammatory diseases. Although HTLV-2 is not usually pathogenic, it is widely distributed among native Indian populations in Brazil, particularly in th...

journal_title：Retrovirology

authors： Ishak R,de Oliveira Guimarães Ishak M,Vallinoto ACR

更新日期：2020-02-14 00:00:00

abstract：:In HIV-infected people, resting CD4+ T cells are the main reservoir of latent virus and the reason for the failure of drug therapy to cure HIV infection. Still, we do not have a complete understanding of the factors regulating HIV replication in these cells. A recent paper in Cell describes a new trick that the virus ...

journal_title：Retrovirology

authors： Bukrinsky M

更新日期：2008-09-22 00:00:00

abstract：BACKGROUND:The gut-associated lymphoid tissue (GALT) is the largest lymphoid organ infected by human immunodeficiency virus type 1 (HIV-1). It serves as a viral reservoir and host-pathogen interface in infection. This study examined whether different parts of the gut and peripheral blood lymphocytes (PBL) contain diffe...

journal_title：Retrovirology

authors： van Marle G,Church DL,Nunweiler KD,Cannon K,Wainberg MA,Gill MJ

更新日期：2010-09-13 00:00:00

abstract：BACKGROUND:The development of anaemia in feline leukaemia virus (FeLV)-infected cats is associated with the emergence of a novel viral subgroup, FeLV-C. FeLV-C arises from the subgroup that is transmitted, FeLV-A, through alterations in the amino acid sequence of the receptor binding domain (RBD) of the envelope glycop...

journal_title：Retrovirology

authors： Stewart H,Adema KW,McMonagle EL,Hosie MJ,Willett BJ

更新日期：2012-05-31 00:00:00

abstract：BACKGROUND:Unlike CD4+ T cells, HIV-1 infected macrophages exhibit extended life span even upon stress, consistent with their in vivo role as long-lived HIV-1 reservoirs. RESULTS:Here, we demonstrate that PI3K/Akt inhibitors, including clinically available Miltefosine, dramatically reduced HIV-1 production from long-l...

journal_title：Retrovirology

authors： Chugh P,Bradel-Tretheway B,Monteiro-Filho CM,Planelles V,Maggirwar SB,Dewhurst S,Kim B

更新日期：2008-01-31 00:00:00

abstract：BACKGROUND:Reducing transmission of HIV-1 through breast milk is needed to help decrease the burden of pediatric HIV/AIDS in society. We have previously reported that alkyl sulfates (i.e., sodium dodecyl sulfate, SDS) are microbicidal against HIV-1 at low concentrations, are biodegradable, have little/no toxicity and a...

journal_title：Retrovirology

authors： Urdaneta S,Wigdahl B,Neely EB,Berlin CM Jr,Schengrund CL,Lin HM,Howett MK

更新日期：2005-04-29 00:00:00

abstract：:The presence of relatively high levels of cellular protein contamination in density-purified virion preparations is a confounding factor in biochemical analyses of HIV and SIV produced from hematopoietic cells. A major source of this contamination is from vesicles, either microvesicles or exosomes, that have similar p...

journal_title：Retrovirology

authors： Coren LV,Shatzer T,Ott DE

更新日期：2008-07-16 00:00:00

abstract：BACKGROUND:Retroviruses have a diploid genome and recombine at high frequency. Recombinant proviruses can be generated when two genetically different RNA genomes are packaged into the same retroviral particle. It was shown in several studies that recombinant proviruses could be generated in each round of HIV-1 replicat...

journal_title：Retrovirology

authors： Kharytonchyk SA,Kireyeva AI,Osipovich AB,Fomin IK

更新日期：2005-01-18 00:00:00

abstract：:For many years, scientists and suppliers have refered to AMV-RT as the reverse transcriptase produced by the Avian Myelobalstosis Virus. This manuscript briefly reviews the molecular basis for biological dependence of AMV for the envelope and RT proteins that are produced by its natural helper the Myeloblastosis Assoc...

journal_title：Retrovirology

authors： Perbal B

更新日期：2008-06-16 00:00:00

abstract：:HIV-mediated CD4 depletion is the hallmark of AIDS and is the most reliable predictor of disease progression. While HIV replication is associated with CD4 depletion in general, plasma viremia by itself predicts the rate of CD4 loss only minimally in untreated patients. To resolve this paradox, I hypothesize the existe...

journal_title：Retrovirology

authors： Wu Y

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Interferon induced transmembrane proteins 1, 2 and 3 (IFITMs) belong to a family of highly related antiviral factors that have been shown to interfere with a large spectrum of viruses including Filoviruses, Coronaviruses, Influenza virus, Dengue virus and HIV-1. In all these cases, the reported mechanism of ...

journal_title：Retrovirology

authors： Tartour K,Appourchaux R,Gaillard J,Nguyen XN,Durand S,Turpin J,Beaumont E,Roch E,Berger G,Mahieux R,Brand D,Roingeard P,Cimarelli A

更新日期：2014-11-25 00:00:00

abstract：:HTLV-1 Tax can induce senescence by up-regulating the levels of cyclin-dependent kinase inhibitors p21(CIP1/WAF1) and p27(KIP1). Tax increases p27(KIP1) protein stability by activating the anaphase promoting complex/cyclosome (APC/C) precociously, causing degradation of Skp2 and inactivation of SCF(Skp2), the E3 ligas...

journal_title：Retrovirology

authors： Zhang L,Zhi H,Liu M,Kuo YL,Giam CZ

更新日期：2009-04-08 00:00:00

abstract：OBJECTIVES:It has been shown that socioeconomic status (SES) is associated with adherence to treatment of patients with several chronic diseases. However, there is a controversy regarding the impact of SES on adherence among patients with the human immunodeficiency virus (HIV) infection or acquired immunodeficiency syn...

journal_title：Retrovirology

authors： Falagas ME,Zarkadoulia EA,Pliatsika PA,Panos G

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Existing highly active antiretroviral therapy (HAART) effectively controls viral replication in human immunodeficiency virus type 1 (HIV-1) infected individuals but cannot completely eradicate the infection, at least in part due to the persistence of latently infected cells. One strategy that is being active...

journal_title：Retrovirology

authors： Miller LK,Kobayashi Y,Chen CC,Russnak TA,Ron Y,Dougherty JP

更新日期：2013-10-24 00:00:00

abstract：BACKGROUND:HIV-1 and all retroviruses are related to retroelements of simpler organisms such as the yeast Ty elements. Recent work has suggested that the yeast retroelement Ty1 replicates via an unexpected RNA lariat intermediate in cDNA synthesis. The putative genomic RNA lariat intermediate is formed by a 2'-5' phosp...

journal_title：Retrovirology

authors： Ye Y,De Leon J,Yokoyama N,Naidu Y,Camerini D

更新日期：2005-10-18 00:00:00

abstract：BACKGROUND:Binding of the viral envelope protein (Env), and particularly of its gp120 subunit, to the cellular CD4 receptor is the first essential step of the HIV-1 entry process. The CD4 binding site (CD4bs) of gp120, and especially a recessed cavity occupied by the CD4 Phe43 residue, are known to be highly conserved ...

journal_title：Retrovirology

authors： Grupping K,Selhorst P,Michiels J,Vereecken K,Heyndrickx L,Kessler P,Vanham G,Martin L,Ariën KK

更新日期：2012-05-02 00:00:00

abstract：:Members of the APOBEC family of cellular cytidine deaminases represent a recently identified group of proteins that provide immunity to infection by retroviruses and protect the cell from endogenous mobile retroelements. Yet, HIV-1 is largely immune to the intrinsic antiviral effects of APOBEC proteins because it enco...

journal_title：Retrovirology

authors： Goila-Gaur R,Strebel K

更新日期：2008-06-24 00:00:00