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How to engage Cofilin.

Abstract：

:In HIV-infected people, resting CD4+ T cells are the main reservoir of latent virus and the reason for the failure of drug therapy to cure HIV infection. Still, we do not have a complete understanding of the factors regulating HIV replication in these cells. A recent paper in Cell describes a new trick that the virus uses to infect resting T cells. Interaction between the viral gp120 and cellular HIV co-receptor, CXCR4, during viral entry initiates signaling that activates cofilin, the main regulator of actin polymerization. As a result of this activation, actin is depolymerized, thus destroying the natural barrier to HIV replication. I discuss implications of this study for our understanding of HIV biology and development of novel anti-HIV therapeutic approaches.

journal_name

Retrovirology

journal_title

Retrovirology

authors

Bukrinsky M

doi

10.1186/1742-4690-5-85

subject

Has Abstract

pub_date

2008-09-22 00:00:00

pages

85

issn

1742-4690

pii

1742-4690-5-85

journal_volume

5

pub_type

杂志文章,评审

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