The silent defense: micro-RNA directed defense against HIV-1 replication.

Abstract:

:MicroRNAs play critical role in regulating gene expression. MicroRNA profile of particular cell type bears the signature of cell type specific gene expression. Given that viral pathogens replicate by evading host defenses, research is now focused on the miRNA-regulated genes that critically regulate HIV-1 propagation in human host cells.

journal_name

Retrovirology

journal_title

Retrovirology

authors

Kumar A

doi

10.1186/1742-4690-4-26

subject

Has Abstract

pub_date

2007-04-12 00:00:00

pages

26

issn

1742-4690

pii

1742-4690-4-26

journal_volume

4

pub_type

杂志文章
  • Kinetic variations between reverse transcriptases of viral protein X coding and noncoding lentiviruses.

    abstract:BACKGROUND:Host SAM domain and HD domain-containing protein 1 (SAMHD1) suppresses reverse transcription kinetics of HIV-1 in nondividing cells such as macrophages by hydrolyzing and nearly depleting cellular dNTPs, which are the substrates of viral reverse transcriptase (RT). However, unlike HIV-1, HIV-2 and SIVsm enco...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/s12977-014-0111-y

    authors: Lenzi GM,Domaoal RA,Kim DH,Schinazi RF,Kim B

    更新日期:2014-12-19 00:00:00

  • MDM2 is a novel E3 ligase for HIV-1 Vif.

    abstract::The human immunodeficiency virus type 1 (HIV-1) Vif plays a crucial role in the viral life cycle by antagonizing a host restriction factor APOBEC3G (A3G). Vif interacts with A3G and induces its polyubiquitination and subsequent degradation via the formation of active ubiquitin ligase (E3) complex with Cullin5-ElonginB...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-6-1

    authors: Izumi T,Takaori-Kondo A,Shirakawa K,Higashitsuji H,Itoh K,Io K,Matsui M,Iwai K,Kondoh H,Sato T,Tomonaga M,Ikeda S,Akari H,Koyanagi Y,Fujita J,Uchiyama T

    更新日期:2009-01-07 00:00:00

  • Identification of novel subgroup A variants with enhanced receptor binding and replicative capacity in primary isolates of anaemogenic strains of feline leukaemia virus.

    abstract:BACKGROUND:The development of anaemia in feline leukaemia virus (FeLV)-infected cats is associated with the emergence of a novel viral subgroup, FeLV-C. FeLV-C arises from the subgroup that is transmitted, FeLV-A, through alterations in the amino acid sequence of the receptor binding domain (RBD) of the envelope glycop...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-9-48

    authors: Stewart H,Adema KW,McMonagle EL,Hosie MJ,Willett BJ

    更新日期:2012-05-31 00:00:00

  • Measuring integrated HIV DNA ex vivo and in vitro provides insights about how reservoirs are formed and maintained.

    abstract::The identification of the most appropriate marker to measure reservoir size has been a great challenge for the HIV field. Quantitative viral outgrowth assay (QVOA), the reference standard to quantify the amount of replication-competent virus, has several limitations, as it is laborious, expensive, and unable to robust...

    journal_title:Retrovirology

    pub_type: 杂志文章,评审

    doi:10.1186/s12977-018-0396-3

    authors: Pinzone MR,O'Doherty U

    更新日期:2018-02-17 00:00:00

  • Gene expression profiling of microglia infected by a highly neurovirulent murine leukemia virus: implications for neuropathogenesis.

    abstract:BACKGROUND:Certain murine leukemia viruses (MLVs) are capable of inducing progressive spongiform motor neuron disease in susceptible mice upon infection of the central nervous system (CNS). The major CNS parenchymal target of these neurovirulent retroviruses (NVs) are the microglia, whose infection is largely coinciden...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-3-26

    authors: Dimcheff DE,Volkert LG,Li Y,DeLucia AL,Lynch WP

    更新日期:2006-05-12 00:00:00

  • Increased susceptibility of CD4+ T cells from elderly individuals to HIV-1 infection and apoptosis is associated with reduced CD4 and enhanced CXCR4 and FAS surface expression levels.

    abstract:BACKGROUND:Elderly HIV-1 infected individuals progress to AIDS more frequently and rapidly than people becoming infected at a young age. To identify possible reasons for these differences in clinical progression, we performed comprehensive phenotypic analyses of CD4+ T cells from uninfected young and elderly individual...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/s12977-015-0213-1

    authors: Heigele A,Joas S,Regensburger K,Kirchhoff F

    更新日期:2015-10-09 00:00:00

  • Evidence for preferential copackaging of Moloney murine leukemia virus genomic RNAs transcribed in the same chromosomal site.

    abstract:BACKGROUND:Retroviruses have a diploid genome and recombine at high frequency. Recombinant proviruses can be generated when two genetically different RNA genomes are packaged into the same retroviral particle. It was shown in several studies that recombinant proviruses could be generated in each round of HIV-1 replicat...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-2-3

    authors: Kharytonchyk SA,Kireyeva AI,Osipovich AB,Fomin IK

    更新日期:2005-01-18 00:00:00

  • Human Immunodeficiency Virus-Type 1 LTR DNA contains an intrinsic gene producing antisense RNA and protein products.

    abstract:BACKGROUND:While viruses have long been shown to capitalize on their limited genomic size by utilizing both strands of DNA or complementary DNA/RNA intermediates to code for viral proteins, it has been assumed that human retroviruses have all their major proteins translated only from the plus or sense strand of RNA, de...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-3-80

    authors: Ludwig LB,Ambrus JL Jr,Krawczyk KA,Sharma S,Brooks S,Hsiao CB,Schwartz SA

    更新日期:2006-11-08 00:00:00

  • The role of unintegrated DNA in HIV infection.

    abstract::Integration of the reverse transcribed viral genome into host chromatin is the hallmark of retroviral replication. Yet, during natural HIV infection, various unintegrated viral DNA forms exist in abundance. Though linear viral cDNA is the precursor to an integrated provirus, increasing evidence suggests that transcrip...

    journal_title:Retrovirology

    pub_type: 杂志文章,评审

    doi:10.1186/1742-4690-8-52

    authors: Sloan RD,Wainberg MA

    更新日期:2011-07-01 00:00:00

  • HIV-1 capsid is involved in post-nuclear entry steps.

    abstract:BACKGROUND:HIV-1 capsid influences viral uncoating and nuclear import. Some capsid is detected in the nucleus but it is unclear if it has any function. We reported that the antibiotic Coumermycin-A1 (C-A1) inhibits HIV-1 integration and that a capsid mutation confers resistance to C-A1, suggesting that capsid might aff...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/s12977-016-0262-0

    authors: Chen NY,Zhou L,Gane PJ,Opp S,Ball NJ,Nicastro G,Zufferey M,Buffone C,Luban J,Selwood D,Diaz-Griffero F,Taylor I,Fassati A

    更新日期:2016-04-23 00:00:00

  • Molecular mechanisms by which HERV-K Gag interferes with HIV-1 Gag assembly and particle infectivity.

    abstract:BACKGROUND:Human endogenous retroviruses (HERVs), the remnants of ancient retroviral infections, constitute approximately 8% of human genomic DNA. Since HERV-K Gag expression is induced by HIV-1 Tat in T cells, induced HERV-K proteins could affect HIV-1 replication. Indeed, previously we showed that HERV-K Gag and HIV-...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/s12977-017-0351-8

    authors: Monde K,Terasawa H,Nakano Y,Soheilian F,Nagashima K,Maeda Y,Ono A

    更新日期:2017-04-26 00:00:00

  • Microbial exposure alters HIV-1-induced mucosal CD4+ T cell death pathways Ex vivo.

    abstract:BACKGROUND:Early HIV-1 infection causes massive CD4+ T cell death in the gut and translocation of bacteria into the circulation. However, the programmed cell death (PCD) pathways used by HIV-1 to kill CD4+ T cells in the gut, and the impact of microbial exposure on T cell loss, remain unclear. Understanding mucosal HIV...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-11-14

    authors: Steele AK,Lee EJ,Manuzak JA,Dillon SM,Beckham JD,McCarter MD,Santiago ML,Wilson CC

    更新日期:2014-02-04 00:00:00

  • How to engage Cofilin.

    abstract::In HIV-infected people, resting CD4+ T cells are the main reservoir of latent virus and the reason for the failure of drug therapy to cure HIV infection. Still, we do not have a complete understanding of the factors regulating HIV replication in these cells. A recent paper in Cell describes a new trick that the virus ...

    journal_title:Retrovirology

    pub_type: 杂志文章,评审

    doi:10.1186/1742-4690-5-85

    authors: Bukrinsky M

    更新日期:2008-09-22 00:00:00

  • Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3.

    abstract::We have obtained the 1.7 A crystal structure of FIV protease (PR) in which 12 critical residues around the active site have been substituted with the structurally equivalent residues of HIV PR (12X FIV PR). The chimeric PR was crystallized in complex with the broad-based inhibitor TL-3, which inhibits wild type FIV an...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-4-1

    authors: Heaslet H,Lin YC,Tam K,Torbett BE,Elder JH,Stout CD

    更新日期:2007-01-09 00:00:00

  • The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells.

    abstract:BACKGROUND:The human T-cell leukemia virus type 1 (HTLV-1) Tax protein indirectly influences transcriptional activation, signal transduction, cell cycle control, and apoptosis. The function of Tax primarily relies on protein-protein interactions. We have previously shown that Tax upregulates the cell cycle checkpoint p...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-1-6

    authors: Kehn K,Deng L,de la Fuente C,Strouss K,Wu K,Maddukuri A,Baylor S,Rufner R,Pumfery A,Bottazzi ME,Kashanchi F

    更新日期:2004-04-13 00:00:00

  • In vitro nuclear interactome of the HIV-1 Tat protein.

    abstract:BACKGROUND:One facet of the complexity underlying the biology of HIV-1 resides not only in its limited number of viral proteins, but in the extensive repertoire of cellular proteins they interact with and their higher-order assembly. HIV-1 encodes the regulatory protein Tat (86-101aa), which is essential for HIV-1 repl...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-6-47

    authors: Gautier VW,Gu L,O'Donoghue N,Pennington S,Sheehy N,Hall WW

    更新日期:2009-05-19 00:00:00

  • Correction to: HIV-1 IN/Pol recruits LEDGF/p75 into viral particles.

    abstract::An amendment to this paper has been published and can be accessed via the original article. ...

    journal_title:Retrovirology

    pub_type: 杂志文章,已发布勘误

    doi:10.1186/s12977-020-00531-3

    authors: Desimmie BA,Weydert C,Schrijvers R,Vets S,Demeulemeester J,Proost P,Paron I,De Rijck J,Mast J,Bannert N,Gijsbers R,Christ F,Debyser Z

    更新日期:2020-07-29 00:00:00

  • The S40 residue in HIV-1 Gag p6 impacts local and distal budding determinants, revealing additional late domain activities.

    abstract:BACKGROUND:HIV-1 budding is directed primarily by two motifs in Gag p6 designated as late domain-1 and -2 that recruit ESCRT machinery by binding Tsg101 and Alix, respectively, and by poorly characterized determinants in the capsid (CA) domain. Here, we report that a conserved Gag p6 residue, S40, impacts budding media...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-10-143

    authors: Watanabe SM,Chen MH,Khan M,Ehrlich L,Kemal KS,Weiser B,Shi B,Chen C,Powell M,Anastos K,Burger H,Carter CA

    更新日期:2013-11-21 00:00:00

  • SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons.

    abstract:BACKGROUND:SAMHD1 is an HIV-1 restriction factor in non-dividing monocytes, dendritic cells (DCs), macrophages, and resting CD4+ T-cells. Acting as a deoxynucleoside triphosphate (dNTP) triphosphohydrolase, SAMHD1 hydrolyzes dNTPs and restricts HIV-1 infection in macrophages and resting CD4+ T-cells by decreasing the i...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-9-105

    authors: St Gelais C,de Silva S,Amie SM,Coleman CM,Hoy H,Hollenbaugh JA,Kim B,Wu L

    更新日期:2012-12-11 00:00:00

  • Identification of the feline foamy virus Bet domain essential for APOBEC3 counteraction.

    abstract:BACKGROUND:APOBEC3 (A3) proteins restrict viral replication by cytidine deamination of viral DNA genomes and impairing reverse transcription and integration. To escape this restriction, lentiviruses have evolved the viral infectivity factor (Vif), which binds A3 proteins and targets them for proteolytic degradation. In...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-10-76

    authors: Lukic DS,Hotz-Wagenblatt A,Lei J,Räthe AM,Mühle M,Denner J,Münk C,Löchelt M

    更新日期:2013-07-24 00:00:00

  • Transcriptional profiling reveals molecular signatures associated with HIV permissiveness in Th1Th17 cells and identifies peroxisome proliferator-activated receptor gamma as an intrinsic negative regulator of viral replication.

    abstract:BACKGROUND:We previously demonstrated that primary Th1Th17 cells are highly permissive to HIV-1, whereas Th1 cells are relatively resistant. Molecular mechanisms underlying these differences remain unknown. RESULTS:Exposure to replication competent and single-round VSV-G pseudotyped HIV strains provide evidence that s...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-10-160

    authors: Bernier A,Cleret-Buhot A,Zhang Y,Goulet JP,Monteiro P,Gosselin A,DaFonseca S,Wacleche VS,Jenabian MA,Routy JP,Tremblay C,Ancuta P

    更新日期:2013-12-21 00:00:00

  • The HIV-1 Rev/RRE system is required for HIV-1 5' UTR cis elements to augment encapsidation of heterologous RNA into HIV-1 viral particles.

    abstract:BACKGROUND:The process of HIV-1 genomic RNA (gRNA) encapsidation is governed by a number of viral encoded components, most notably the Gag protein and gRNA cis elements in the canonical packaging signal (ψ). Also implicated in encapsidation are cis determinants in the R, U5, and PBS (primer binding site) from the 5' un...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-8-51

    authors: Cockrell AS,van Praag H,Santistevan N,Ma H,Kafri T

    更新日期:2011-06-24 00:00:00

  • Distinct gene expression signatures induced by viral transactivators of different HTLV-1 subgroups that confer a different risk of HAM/TSP.

    abstract:BACKGROUND:Among human T cell leukemia virus type 1 (HTLV-1)-infected individuals, there is an association between HTLV-1 tax subgroups (subgroup-A or subgroup-B) and the risk of HAM/TSP in the Japanese population. To investigate the role of HTLV-1 subgroups in viral pathogenesis, we studied the functional difference i...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/s12977-018-0454-x

    authors: Naito T,Yasunaga JI,Mitobe Y,Shirai K,Sejima H,Ushirogawa H,Tanaka Y,Nakamura T,Hanada K,Fujii M,Matsuoka M,Saito M

    更新日期:2018-11-06 00:00:00

  • No evidence of XMRV in prostate cancer cohorts in the Midwestern United States.

    abstract:BACKGROUND:Xenotropic murine leukemia virus (MLV)-related virus (XMRV) was initially identified in prostate cancer (PCa) tissue, particularly in the prostatic stromal fibroblasts, of patients homozygous for the RNASEL R462Q mutation. A subsequent study reported XMRV antigens in malignant prostatic epithelium and associ...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-8-23

    authors: Sakuma T,Hué S,Squillace KA,Tonne JM,Blackburn PR,Ohmine S,Thatava T,Towers GJ,Ikeda Y

    更新日期:2011-03-29 00:00:00

  • Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix.

    abstract:BACKGROUND:HIV-1 Nef is a multifunctional protein required for full pathogenicity of the virus. As Nef has no known enzymatic activity, it necessarily functions through protein-protein interaction interfaces. A critical Nef protein interaction interface is centered on its polyproline segment (P69VRPQVPLRP78) which cont...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-9-47

    authors: Kuo LS,Baugh LL,Denial SJ,Watkins RL,Liu M,Garcia JV,Foster JL

    更新日期:2012-05-31 00:00:00

  • The pathogenesis of HIV infection: stupid may not be so dumb after all.

    abstract::In the mid-1990's, researchers hypothesized, based on new viral load data, that HIV-1 causes CD4+ T-cell depletion by direct cytopathic effect. New data from non-human primate studies has raised doubts about this model of HIV-1 pathogenesis. Despite having high levels of viremia, most SIV infections are well tolerated...

    journal_title:Retrovirology

    pub_type: 社论

    doi:10.1186/1742-4690-3-60

    authors: Smith SM

    更新日期:2006-09-08 00:00:00

  • H-index, mentoring-index, highly-cited and highly-accessed: how to evaluate scientists?

    abstract::How best to evaluate scientists within a peer group is a difficult task. This editorial discusses the use of the H-index and total citations. It also raises the consideration of a mentoring-index and the value of understanding the frequency that a published paper is accessed by readers. ...

    journal_title:Retrovirology

    pub_type: 社论

    doi:10.1186/1742-4690-5-106

    authors: Jeang KT

    更新日期:2008-11-25 00:00:00

  • An expanded model of HIV cell entry phenotype based on multi-parameter single-cell data.

    abstract:BACKGROUND:Entry of human immunodeficiency virus type 1 (HIV-1) into the host cell involves interactions between the viral envelope glycoproteins (Env) and the cellular receptor CD4 as well as a coreceptor molecule (most importantly CCR5 or CXCR4). Viral preference for a specific coreceptor (tropism) is in particular d...

    journal_title:Retrovirology

    pub_type: 杂志文章

    doi:10.1186/1742-4690-9-60

    authors: Bozek K,Eckhardt M,Sierra S,Anders M,Kaiser R,Kräusslich HG,Müller B,Lengauer T

    更新日期:2012-07-25 00:00:00

  • The XVI International Conference on AIDS: the place to be!

    abstract::This editorial represents a plea to retrovirologists to attend the XVI International Conference on AIDS that will take place in Toronto, Canada between August 13-18, 2006. In short, it is vital that politicians and opinion leaders understand that basic scientists are no less committed to the worldwide battle against H...

    journal_title:Retrovirology

    pub_type: 社论

    doi:10.1186/1742-4690-3-9

    authors: Wainberg MA

    更新日期:2006-02-03 00:00:00

  • Combination of nanoparticle-based therapeutic vaccination and transient ablation of regulatory T cells enhances anti-viral immunity during chronic retroviral infection.

    abstract:BACKGROUND:Regulatory T cells (Tregs) have been shown to limit anti-viral immunity during chronic retroviral infection and to restrict vaccine-induced T cell responses. The objective of the study was to assess whether a combinational therapy of nanoparticle-based therapeutic vaccination and concomitant transient ablati...

    journal_title:Retrovirology

    pub_type: 杂志文章,评审

    doi:10.1186/s12977-016-0258-9

    authors: Knuschke T,Rotan O,Bayer W,Sokolova V,Hansen W,Sparwasser T,Dittmer U,Epple M,Buer J,Westendorf AM

    更新日期:2016-04-14 00:00:00