The Infectious Diseases BioBank at King's College London: archiving samples from patients infected with HIV to facilitate translational research.

abstract：BACKGROUND:The process of HIV-1 genomic RNA (gRNA) encapsidation is governed by a number of viral encoded components, most notably the Gag protein and gRNA cis elements in the canonical packaging signal (ψ). Also implicated in encapsidation are cis determinants in the R, U5, and PBS (primer binding site) from the 5' un...

journal_title：Retrovirology

authors： Cockrell AS,van Praag H,Santistevan N,Ma H,Kafri T

更新日期：2011-06-24 00:00:00

abstract：BACKGROUND:HTLV-I associated adult T-cell leukemia/lymphoma (ATL) carries a dismal prognosis due to chemo-resistance and immuno-compromised micro-environment. The combination of zidovudine and interferon-alpha (IFN) significantly improved survival in ATL. Promising results were reported by adding arsenic trioxide to zi...

journal_title：Retrovirology

authors： Kchour G,Rezaee R,Farid R,Ghantous A,Rafatpanah H,Tarhini M,Kooshyar MM,El Hajj H,Berry F,Mortada M,Nasser R,Shirdel A,Dassouki Z,Ezzedine M,Rahimi H,Ghavamzadeh A,de Thé H,Hermine O,Mahmoudi M,Bazarbachi A

更新日期：2013-08-20 00:00:00

abstract：BACKGROUND:Several factors determine the risk of HIV mother-to-child transmission (MTCT), such as coinfections in placentas from HIV-1 positive mothers with other pathogens. Chagas' disease is one of the most endemic zoonoses in Latin America, caused by the protozoan Trypanosoma cruzi. The purpose of the study was to d...

journal_title：Retrovirology

authors： Dolcini GL,Solana ME,Andreani G,Celentano AM,Parodi LM,Donato AM,Elissondo N,González Cappa SM,Giavedoni LD,Martínez Peralta L

更新日期：2008-07-01 00:00:00

abstract：:Recent findings suggest that mammalian cells can use small non-coding RNAs (ncRNA) to regulate physiological viral infections. Here, we comment on several lines of evidence that support this concept. We discuss how viruses may in turn protect, suppress, evade, modulate, or adapt to the host cell's ncRNA regulatory sch...

journal_title：Retrovirology

authors： Yeung ML,Benkirane M,Jeang KT

更新日期：2007-10-15 00:00:00

abstract：BACKGROUND:Jaagsiekte sheep retrovirus (JSRV) causes a contagious lung cancer in sheep and goats that can be transmitted by aerosols produced by infected animals. Virus entry into cells is initiated by binding of the viral envelope (Env) protein to a specific cell-surface receptor, Hyal2. Unlike almost all other retrov...

journal_title：Retrovirology

authors： Miller AD,De Las Heras M,Yu J,Zhang F,Liu SL,Vaughan AE,Vaughan TL,Rosadio R,Rocca S,Palmieri G,Goedert JJ,Fujimoto J,Wistuba II

更新日期：2017-01-20 00:00:00

abstract：BACKGROUND:The widespread use of highly effective, combination antiretroviral therapy (cART) has led to a significant reduction in the incidence of HIV-associated dementia (HAD). Despite these advances, the prevalence of HIV-1 associated neurocognitive disorders (HANDs) has been estimated at approximately 40%-50%. In t...

journal_title：Retrovirology

authors： Evering TH,Kamau E,St Bernard L,Farmer CB,Kong XP,Markowitz M

更新日期：2014-08-15 00:00:00

abstract：BACKGROUND:Ankyrins are cellular mediators of a number of essential protein-protein interactions. Unlike intrabodies, ankyrins are composed of highly structured repeat modules characterized by disulfide bridge-independent folding. Artificial ankyrin molecules, designed to target viral components, might act as intracell...

journal_title：Retrovirology

authors： Nangola S,Urvoas A,Valerio-Lepiniec M,Khamaikawin W,Sakkhachornphop S,Hong SS,Boulanger P,Minard P,Tayapiwatana C

更新日期：2012-02-20 00:00:00

abstract：:Integration of the reverse transcribed viral genome into host chromatin is the hallmark of retroviral replication. Yet, during natural HIV infection, various unintegrated viral DNA forms exist in abundance. Though linear viral cDNA is the precursor to an integrated provirus, increasing evidence suggests that transcrip...

journal_title：Retrovirology

authors： Sloan RD,Wainberg MA

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Entry of human immunodeficiency virus type 1 (HIV-1) into the host cell involves interactions between the viral envelope glycoproteins (Env) and the cellular receptor CD4 as well as a coreceptor molecule (most importantly CCR5 or CXCR4). Viral preference for a specific coreceptor (tropism) is in particular d...

journal_title：Retrovirology

authors： Bozek K,Eckhardt M,Sierra S,Anders M,Kaiser R,Kräusslich HG,Müller B,Lengauer T

更新日期：2012-07-25 00:00:00

abstract：:The 16th International Conference on Human Retrovirology: HTLV and Related Retroviruses was held in Montreal, Québec from June 26th to June 30th, 2013 and was therefore hosted by a Canadian city for the first time. The major topic of the meeting was human T-lymphotropic viruses (HTLVs) and was covered through distinct...

journal_title：Retrovirology

authors： Barbeau B,Hiscott J,Bazarbachi A,Carvalho E,Jones K,Martin F,Matsuoka M,Murphy EL,Ratner L,Switzer WM,Watanabe T

更新日期：2014-02-24 00:00:00

abstract：BACKGROUND:LILRA3 is an immunostimulatory molecule which can conditionally induce the proliferation of cytotoxic cells. LILRA3 has a deletion genotype which is associated with multiple immune disorders. In this study, we wanted to analyze the regulation of LILRA3 and its significance in the context of HIV infection. R...

journal_title：Retrovirology

authors： Low HZ,Ahrenstorf G,Pommerenke C,Habermann N,Schughart K,Ordóñez D,Stripecke R,Wilk E,Witte T

更新日期：2016-03-12 00:00:00

abstract：BACKGROUND:SAMHD1 is an HIV-1 restriction factor in non-dividing monocytes, dendritic cells (DCs), macrophages, and resting CD4+ T-cells. Acting as a deoxynucleoside triphosphate (dNTP) triphosphohydrolase, SAMHD1 hydrolyzes dNTPs and restricts HIV-1 infection in macrophages and resting CD4+ T-cells by decreasing the i...

journal_title：Retrovirology

authors： St Gelais C,de Silva S,Amie SM,Coleman CM,Hoy H,Hollenbaugh JA,Kim B,Wu L

更新日期：2012-12-11 00:00:00

abstract：BACKGROUND:The N-heptad repeat region of the HIV-1 Transmembrane Envelope protein is a trimerization domain that forms part of a "six helix bundle" crucial to Envelope-mediated membrane fusion. N-heptad repeat peptides have been used as extracellular reagents to inhibit virus fusion. RESULTS:When expressed intracellul...

journal_title：Retrovirology

authors： Ou W,Silver J

更新日期：2005-08-10 00:00:00

abstract：BACKGROUND:A critical step for retroviral replication is the stable integration of the provirus into the genome of its host. The viral integrase protein is key in this essential step of the retroviral life cycle. Although the basic mechanism of integration by mammalian retroviruses has been well characterized, the fact...

journal_title：Retrovirology

authors： Studamire B,Goff SP

更新日期：2008-06-13 00:00:00

abstract：BACKGROUND:HIV-1 Nef is a viral accessory protein critical for AIDS progression. Nef lacks intrinsic catalytic activity and binds multiple host cell signaling proteins, including Hck and other Src-family tyrosine kinases. Nef binding induces constitutive Hck activation that may contribute to HIV pathogenesis by promoti...

journal_title：Retrovirology

authors： Trible RP,Narute P,Emert-Sedlak LA,Alvarado JJ,Atkins K,Thomas L,Kodama T,Yanamala N,Korotchenko V,Day BW,Thomas G,Smithgall TE

更新日期：2013-11-14 00:00:00

abstract：BACKGROUND:The reliable diagnosis of human T-cell leukemia virus type 1 (HTLV-1) infection is important, particularly as it can be vertically transmitted by breast feeding mothers to their infants. However, current diagnosis in Japan requires a confirmatory western blot (WB) test after screening/primary testing for HTL...

journal_title：Retrovirology

authors： Okuma K,Kuramitsu M,Niwa T,Taniguchi T,Masaki Y,Ueda G,Matsumoto C,Sobata R,Sagara Y,Nakamura H,Satake M,Miura K,Fuchi N,Masuzaki H,Okayama A,Umeki K,Yamano Y,Sato T,Iwanaga M,Uchimaru K,Nakashima M,Utsunomiya A

更新日期：2020-08-24 00:00:00

abstract：BACKGROUND:Combination anti-viral therapies have reduced treatment failure rates by requiring multiple specific mutations to be selected on the same viral genome to impart high-level drug resistance. To determine if the common protease inhibitor resistance mutation L90M is only selected once or repeatedly on different ...

journal_title：Retrovirology

authors： Kapoor A,Shapiro B,Shafer RW,Shulman N,Rhee SY,Delwart EL

更新日期：2008-01-25 00:00:00

abstract：BACKGROUND:HIV-1 typically develops resistance to any single antiretroviral agent. Combined anti-retroviral therapy to reduce drug-resistance development is necessary to control HIV-1 infection. Here, to assess the utility of a combination of antibody and fusion inhibitor treatments, we investigated the potency of mono...

journal_title：Retrovirology

authors： Alam M,Kuwata T,Shimura K,Yokoyama M,Ramirez Valdez KP,Tanaka K,Maruta Y,Oishi S,Fujii N,Sato H,Matsuoka M,Matsushita S

更新日期：2016-09-27 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Retrovirology

authors： Desimmie BA,Weydert C,Schrijvers R,Vets S,Demeulemeester J,Proost P,Paron I,De Rijck J,Mast J,Bannert N,Gijsbers R,Christ F,Debyser Z

更新日期：2020-07-29 00:00:00

abstract：:An estimated 90% of all HIV transmissions occur mucosally. Immunoglobulin A (IgA) molecules are important components of mucosal fluids. In a vaccine efficacy study, in which virosomes displaying HIV gp41 antigens protected most rhesus monkeys (RMs) against simian-human immunodeficiency virus (SHIV), protection correla...

journal_title：Retrovirology

authors： Zhou M,Ruprecht RM

更新日期：2014-12-14 00:00:00

abstract：BACKGROUND:HIV-1 replication is critically dependent upon controlled processing of its RNA and the activities provided by its encoded regulatory factors Tat and Rev. A screen of small molecule modulators of RNA processing identified several which inhibited virus gene expression, affecting both relative abundance of spe...

journal_title：Retrovirology

authors： Balachandran A,Wong R,Stoilov P,Pan S,Blencowe B,Cheung P,Harrigan PR,Cochrane A

更新日期：2017-01-26 00:00:00

abstract：BACKGROUND:Crocodilians are thought to be hosts to a diverse and divergent complement of endogenous retroviruses (ERVs) but a comprehensive investigation is yet to be performed. The recent sequencing of three crocodilian genomes provides an opportunity for a more detailed and accurate representation of the ERV diversit...

journal_title：Retrovirology

authors： Chong AY,Kojima KK,Jurka J,Ray DA,Smit AF,Isberg SR,Gongora J

更新日期：2014-12-12 00:00:00

abstract：:For many years, scientists and suppliers have refered to AMV-RT as the reverse transcriptase produced by the Avian Myelobalstosis Virus. This manuscript briefly reviews the molecular basis for biological dependence of AMV for the envelope and RT proteins that are produced by its natural helper the Myeloblastosis Assoc...

journal_title：Retrovirology

authors： Perbal B

更新日期：2008-06-16 00:00:00

abstract：:Integration of viral DNA into the host genome is a central event in the replication cycle and the pathogenesis of retroviruses, including HIV. Although most cells infected with HIV are rapidly eliminated in vivo, HIV also infects long-lived cells that persist during combination antiretroviral therapy (cART). Cells wit...

journal_title：Retrovirology

authors： Anderson EM,Maldarelli F

更新日期：2018-10-23 00:00:00

abstract：:HIV viruses encode a set of accessory proteins, which are important determinants of virulence due to their ability to manipulate the host cell physiology for the benefit of the virus. Although these viral proteins are dispensable for viral growth in many in vitro cell culture systems, they influence the efficiency of ...

journal_title：Retrovirology

authors： Ayinde D,Maudet C,Transy C,Margottin-Goguet F

更新日期：2010-04-09 00:00:00

abstract：BACKGROUND:Host SAM domain and HD domain-containing protein 1 (SAMHD1) suppresses reverse transcription kinetics of HIV-1 in nondividing cells such as macrophages by hydrolyzing and nearly depleting cellular dNTPs, which are the substrates of viral reverse transcriptase (RT). However, unlike HIV-1, HIV-2 and SIVsm enco...

journal_title：Retrovirology

authors： Lenzi GM,Domaoal RA,Kim DH,Schinazi RF,Kim B

更新日期：2014-12-19 00:00:00

abstract：BACKGROUND:We have previously reported that CD4 T cells from some exposed uninfected (EU) Vietnamese intravenous drug users are relatively resistant to HIV infection in vitro. Here, we further characterized the restriction of viral replication in CD4 T cells from five EUs and assessed its persistence in serial samples....

journal_title：Retrovirology

authors： Sáez-Cirión A,Versmisse P,Truong LX,Chakrabarti LA,Carpentier W,Barré-Sinoussi F,Scott-Algara D,Pancino G

更新日期：2006-11-08 00:00:00

abstract：BACKGROUND:The 18 residue tail abutting the SH3 fold that comprises the heart of the C-terminal domain is the only part of HIV-1 integrase yet to be visualized by structural biology. To ascertain the role of the tail region in integrase function and HIV-1 replication, a set of deletion mutants that successively lacked ...

journal_title：Retrovirology

authors： Dar MJ,Monel B,Krishnan L,Shun MC,Di Nunzio F,Helland DE,Engelman A

更新日期：2009-10-19 00:00:00

abstract：BACKGROUND:Interferon induced transmembrane proteins 1, 2 and 3 (IFITMs) belong to a family of highly related antiviral factors that have been shown to interfere with a large spectrum of viruses including Filoviruses, Coronaviruses, Influenza virus, Dengue virus and HIV-1. In all these cases, the reported mechanism of ...

journal_title：Retrovirology

authors： Tartour K,Appourchaux R,Gaillard J,Nguyen XN,Durand S,Turpin J,Beaumont E,Roch E,Berger G,Mahieux R,Brand D,Roingeard P,Cimarelli A

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:Efficient targeted gene transfer and cell type specific transgene expression are important for the safe and effective expression of transgenes in vivo. Enveloped viral vectors allow insertion of exogenous membrane proteins into their envelopes, which could potentially aid in the targeted transduction of spec...

journal_title：Retrovirology

authors： Ye Z,Harmison GG,Ragheb JA,Schubert M

更新日期：2005-12-21 00:00:00