Abstract:
:HIV-mediated CD4 depletion is the hallmark of AIDS and is the most reliable predictor of disease progression. While HIV replication is associated with CD4 depletion in general, plasma viremia by itself predicts the rate of CD4 loss only minimally in untreated patients. To resolve this paradox, I hypothesize the existence of a subpopulation of R5X4-signaling viruses. I also suggest that the gradual evolution and emergence of this subpopulation are largely responsible for the slow depletion of peripheral CD4 T cells.
journal_name
Retrovirologyjournal_title
Retrovirologyauthors
Wu Ydoi
10.1186/1742-4690-6-41subject
Has Abstractpub_date
2009-05-01 00:00:00pages
41issn
1742-4690pii
1742-4690-6-41journal_volume
6pub_type
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