听力与言语-语言病理学

行为科学

医学伦理学

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  • Diagnostic Challenges of Acute Kidney Injury in Asia.

    abstract::Early diagnosis of acute kidney injury (AKI) is an important step to improve AKI outcome. In Asia, several distinct conditions of this region such as environment (tropical climate), socioeconomic status (high-resource and low-resource settings), process of care (shortage of nephrologists), exposure factors (specific t...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2020.08.003

    authors: Srisawat N,Lumlertgul N,Kulvichit W,Thamrongsat N,Peerapornratana S,Eiam-Ong S,Tungsanga K

    更新日期:2020-09-01 00:00:00

  • Role of the International and National Renal Organizations in Natural Disasters: Strategies for Renal Rescue.

    abstract::Besides loss of life and property, natural disasters result in a number of renal challenges, either by the creation of rhabdomyolysis and crush-induced acute kidney injury or by the destruction of existing dialysis facilities, leaving chronic dialysis patients and kidney transplanted patients without access to their r...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2020.06.007

    authors: Lameire N,Sever MS,Van Biesen W,Vanholder R

    更新日期:2020-07-01 00:00:00

  • Use of Semiprivate Smartphone Communication Applications in Nephrology Education.

    abstract::Advances in information technology have changed human interactions. These changes have had considerable implications for nonmedical and medical educational practices. The use of semi-private applications such as WhatsApp (Mountain View, CA), Slack (Canada), Viber (Israel), and Google Hangouts (Mountain View, CA) has n...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2020.04.010

    authors: Pandya A,Elrggal ME,Jhaveri KD

    更新日期:2020-05-01 00:00:00

  • Perioperative Clinical Trials in AKI.

    abstract::To characterize current evidence and current foci of perioperative clinical trials, we systematically reviewed Medline and identified perioperative trials involving 100 or more adult patients undergoing surgery and reporting renal end points that were published in high-impact journals since 2004. We categorized the 10...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2020.01.008

    authors: McIlroy DR,Lopez MG,Billings FT 4th

    更新日期:2020-03-01 00:00:00

  • Potential New Therapeutic Approaches for Renal Cell Carcinoma.

    abstract::Renal cell carcinoma (RCC) is increasing in incidence and one third of newly diagnosed cases already are metastatic. The metastatic spread of solid tumors renders RCC incurable by surgical resection and consequently more difficult to treat. New molecular-targeted therapies have played a pivotal role in RCC treatment. ...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2019.12.010

    authors: Yang DC,Chen CH

    更新日期:2020-01-01 00:00:00

  • Pathophysiological Role of Organelle Stress/Crosstalk in AKI-to-CKD Transition.

    abstract::Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected syndromes that represent a global public health challenge. Organelles play essential roles in a vast range of cell functions, and their damage is related to several kidney diseases. Organelles launch the stress signal or trigger the stress r...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2019.10.007

    authors: Maekawa H,Inagi R

    更新日期:2019-11-01 00:00:00

  • Vasopressor Therapy and Blood Pressure Management in the Setting of Acute Kidney Injury.

    abstract::Acute kidney injury (AKI) is common in the setting of shock. Hemodynamic instability is a risk factor for the development of AKI, and pathophysiological mechanisms include loss of renal perfusion pressure and impaired microcirculation. Although restoration of mean arterial pressure (MAP) may mitigate the risk of AKI t...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2019.06.006

    authors: Busse LW,Ostermann M

    更新日期:2019-09-01 00:00:00

  • Molecular Pathophysiology of Acid-Base Disorders.

    abstract::Acid-base balance is critical for normal life. Acute and chronic disturbances impact cellular energy metabolism, endocrine signaling, ion channel activity, neuronal activity, and cardiovascular functions such as cardiac contractility and vascular blood flow. Maintenance and adaptation of acid-base homeostasis are most...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2019.04.004

    authors: Wagner CA,Imenez Silva PH,Bourgeois S

    更新日期:2019-07-01 00:00:00

  • Other Potential CKD Hotspots in the World: The Cases of Mexico and the United States.

    abstract::Hotspots of chronic kidney disease of unknown etiology (CKDu) have been identified throughout the globe, of which the Mesoamerican nephropathy in Central America is the most conspicuous example. It affects mainly agricultural workers, heat exposure during extenuating shifts leading to sudden dehydration and subsequent...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2019.02.008

    authors: Aguilar DJ,Madero M

    更新日期:2019-05-01 00:00:00

  • Modeling Exposure to Understand and Predict Kidney Injury.

    abstract::Exposure is a critically important aspect to consider in the study and management of drug-induced kidney injury. Although blood concentrations of kidney toxicants often may provide a valid surrogate measure of kidney exposure, the kidney has several unique physiological and biochemical properties that lend themselves ...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2018.12.006

    authors: Li Z,Fisher C,Gardner I,Ghosh A,Litchfield J,Maurer TS

    更新日期:2019-03-01 00:00:00

  • AKI and the Neuroimmune Axis.

    abstract::Neuroimmune interaction is an emerging concept, wherein the nervous system modulates the immune system and vice versa. This concept is gaining attention as a novel therapeutic target in various inflammatory diseases including acute kidney injury (AKI). Vagus nerve stimulation or treatment with pulsed ultrasound activa...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2018.10.008

    authors: Tanaka S,Okusa MD

    更新日期:2019-01-01 00:00:00

  • Update on Chronic Kidney Disease Mineral and Bone Disorder in Cardiovascular Disease.

    abstract::Chronic kidney disease mineral and bone disorder (MBD) encompasses changes in mineral ion and vitamin D metabolism that are widespread in the setting of chronic kidney disease and end-stage renal disease. MBD components associate with cardiovascular disease in many epidemiologic studies. Through impacts on hypertensio...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2018.08.001

    authors: Lunyera J,Scialla JJ

    更新日期:2018-11-01 00:00:00

  • Role of Mesangial-Podocytic-Tubular Cross-Talk in IgA Nephropathy.

    abstract::IgA nephropathy (IgAN), a common primary glomerulonephritis worldwide, is associated with a substantial risk of progression to end-stage renal failure. The disease runs a highly variable clinical course with frequent involvement of tubulointerstitial damage. A subgroup of IgAN with proximal tubular epithelial cells (P...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2018.05.018

    authors: Leung JCK,Lai KN,Tang SCW

    更新日期:2018-09-01 00:00:00

  • Personalized Anemia Management and Precision Medicine in ESA and Iron Pharmacology in End-Stage Kidney Disease.

    abstract::Substantial progress has been made in the application of computer-driven methods to provide erythropoietic dosing information for patients with anemia resulting from chronic kidney disease. Initial solutions were simply computerized versions of traditional paper-based anemia management protocols. True personalization ...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2018.05.010

    authors: Brier ME,Gaweda AE,Aronoff GR

    更新日期:2018-07-01 00:00:00

  • Updates on the Mechanisms and the Care of Cardiovascular Calcification in Chronic Kidney Disease.

    abstract::In chronic kidney disease (CKD), the progressive decrease in renal function leads to disturbances of mineral metabolism that generally cause secondary hyperparathyroidism. The increase in serum parathyroid hormone is associated with reduced serum calcium and calcitriol levels and/or increased serum fibroblast growth f...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2018.02.004

    authors: Hénaut L,Chillon JM,Kamel S,Massy ZA

    更新日期:2018-05-01 00:00:00

  • Targeting Glucosylceramide Synthesis in the Treatment of Rare and Common Renal Disease.

    abstract::Sphingolipids, including ceramides, glycosphingolipids, sphingomyelin, and sphingosine-1-phosphate, have been recognized as important molecules that regulate critical cellular functions. Although originally studied in the context of lysosomal storage diseases, the roles of these compounds in more common disorders invo...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2018.01.007

    authors: Shayman JA

    更新日期:2018-03-01 00:00:00

  • Bringing Renal Biopsy Interpretation Into the Molecular Age With Single-Cell RNA Sequencing.

    abstract::The renal biopsy provides critical diagnostic and prognostic information to clinicians including cases of acute kidney injury, chronic kidney disease, and allograft dysfunction. Today, biopsy specimens are read using a combination of light microscopy, electron microscopy, and indirect immunofluorescence, with a limite...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2017.09.005

    authors: Malone AF,Wu H,Humphreys BD

    更新日期:2018-01-01 00:00:00

  • Apolipoprotein L1 Gene Effects on Kidney Transplantation.

    abstract::The pathogenesis of many common etiologies of nephropathy has been informed by recent molecular genetic breakthroughs. It now is apparent that the ethnic disparity in the risk for nondiabetic chronic kidney disease between African Americans and European Americans is explained largely by variation in the apolipoprotein...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2017.07.006

    authors: Freedman BI,Locke JE,Reeves-Daniel AM,Julian BA

    更新日期:2017-11-01 00:00:00

  • ANCA-Associated Vasculitis: Pathogenesis, Models, and Preclinical Testing.

    abstract::Our understanding of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis has developed greatly since the discovery of ANCA, directed against neutrophil components, in 1982. Observations in human disease, and increasingly sophisticated studies in vitro and in rodent models in vivo, have allowed a nuanced u...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2017.05.016

    authors: Hutton HL,Holdsworth SR,Kitching AR

    更新日期:2017-09-01 00:00:00

  • Female Adolescents with Chronic or End-Stage Kidney Disease and Strategies for their Care.

    abstract::The prevalence of chronic or end-stage kidney disease in pediatric girls is lower than in boys, however, girls have unique morbidities that can have great effect on their quality of life. For female adolescents, creatinine excretion peaks at approximately 14 years of age and is significantly less than males, owing to ...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2017.05.003

    authors: Diaz-Gonzalez De Ferris ME,Alvarez-Elías AC,Ferris MT,Medeiros M

    更新日期:2017-07-01 00:00:00

  • Menopause and Chronic Kidney Disease.

    abstract::Premature menopause defined as secondary amenorrhea is common in women with kidney disease. Moreover, the aging population has resulted in increasing numbers of postmenopausal women with kidney disease. Though the pathophysiology is poorly understood, kidney transplantation and more frequent hemodialysis can restore m...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2017.05.013

    authors: Ahmed SB

    更新日期:2017-07-01 00:00:00

  • Prehabilitation for the Frail Patient Approaching ESRD.

    abstract::Frailty is a distinct phenotype that is highly prevalent in chronic kidney disease (CKD) and appears to be more prevalent with decreasing glomerular filtration rate. Exercise training or intervention to increase physical activity may ameliorate poor physical functioning and frailty, and even may improve survival in pa...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2016.12.006

    authors: Sheshadri A,Johansen KL

    更新日期:2017-03-01 00:00:00

  • Acute PD: Evidence, Guidelines, and Controversies☆.

    abstract::Peritoneal dialysis (PD) may be a feasible, safe, and complementary alternative to hemodialysis not only in the chronic setting, but also in the acute setting. It previously was widely accepted for acute kidney injury (AKI) treatment, but its practice decreased in favor of other types of extracorporeal therapies. The ...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2016.10.011

    authors: Ponce D,Balbi A,Cullis B

    更新日期:2017-01-01 00:00:00

  • Cytomegalovirus and Other β-Herpesviruses.

    abstract::Cytomegalovirus (CMV), human herpes virus (HHV)-6, and HHV-7 are ubiquitous β-herpesviruses that can cause opportunistic infection and disease in kidney transplant recipients. Active CMV infection and disease are associated with acute allograft failure and death, and HHV-6 and HHV-7 replication are associated with CMV...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2016.05.012

    authors: Santos CA

    更新日期:2016-09-01 00:00:00

  • Cardiovascular Disease Consequences of CKD.

    abstract::Chronic kidney disease, defined as reduced glomerular filtration rate (estimated using serum creatinine- and/or serum cystatin C-based equations) or excess urinary protein excretion, affects approximately 13% of adult Americans and is linked to a variety of clinical complications. Although persons with end-stage renal...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2016.05.006

    authors: Go AS

    更新日期:2016-07-01 00:00:00

  • An Overview of Pathways of Regulated Necrosis in Acute Kidney Injury.

    abstract::Necrosis is the predominant form of regulated cell death in acute kidney injury (AKI) and represents results in the formation of casts that appear in the urine sedimentation, referred to as muddy brown casts, which are part of the diagnosis of AKI. Pathologists referred to this typical feature as acute tubular necrosi...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2016.03.002

    authors: Kers J,Leemans JC,Linkermann A

    更新日期:2016-05-01 00:00:00

  • Iron Treatment Strategies in Nondialysis CKD.

    abstract::In contrast to managing patients on hemodialysis in whom iron strategies are more focused on intravenous iron, nondialysis chronic kidney disease (CKD) patients may receive either oral or intravenous iron. There are advantages and disadvantages for both strategies. Oral iron is simple and cheap to administer and does ...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2016.02.003

    authors: Macdougall IC

    更新日期:2016-03-01 00:00:00

  • Antiphospholipid Syndrome and the Kidney.

    abstract::The antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by a combination of arterial and/or venous thrombosis, pregnancy morbidity, and the persistent presence of circulating antiphospholipid antibodies (aPL). APS has been described as primary APS when it occurs in the absence of any featur...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2015.08.009

    authors: Sciascia S,Baldovino S,Schreiber K,Solfietti L,Roccatello D

    更新日期:2015-09-01 00:00:00

  • Stroke and Chronic Kidney Disease: Epidemiology, Pathogenesis, and Management Across Kidney Disease Stages.

    abstract::Cerebrovascular disease and stroke are very common at all stages of chronic kidney disease (CKD), likely representing both shared risk factors as well as synergy among risk factors. More subtle ischemic brain lesions may be particularly common in the CKD population, with subtle manifestations including cognitive impai...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2015.06.003

    authors: Dad T,Weiner DE

    更新日期:2015-07-01 00:00:00

  • APOL1 Kidney Disease Risk Variants: An Evolving Landscape.

    abstract::Apolipoprotein L1 (APOL1) genetic variants account for much of the excess risk of chronic and end-stage kidney disease, which results in a significant global health disparity for persons of African ancestry. We estimate the lifetime risk of kidney disease in APOL1 dual-risk allele individuals to be at least 15%. Exper...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2015.04.008

    authors: Dummer PD,Limou S,Rosenberg AZ,Heymann J,Nelson G,Winkler CA,Kopp JB

    更新日期:2015-05-01 00:00:00

  • Et and diabetic nephropathy: preclinical and clinical studies.

    abstract::The incidence of progressive kidney disease associated with diabetes continues to increase worldwide. Only partial renoprotection is achieved by current standard therapy with angiotensin-converting enzyme inhibitors and/or angiotensin-receptor blockers, increasing the need for novel therapeutic approaches. Experimenta...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2015.03.003

    authors: Gagliardini E,Zoja C,Benigni A

    更新日期:2015-03-01 00:00:00

  • Sepsis-associated acute kidney injury: macrohemodynamic and microhemodynamic alterations in the renal circulation.

    abstract::Traditionally, renal ischemia has been regarded as central to the pathogenesis of sepsis-associated acute kidney injury (SA-AKI). Accordingly, hemodynamic management of SA-AKI has emphasized restoration of renal perfusion, whereas, experimentally, ischemia reperfusion models have been emphasized. However, in human bei...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2015.01.007

    authors: Prowle JR,Bellomo R

    更新日期:2015-01-01 00:00:00

  • When, how, and why a bone biopsy should be performed in patients with chronic kidney disease.

    abstract::In chronic kidney disease the excessive production of parathyroid hormone increases the bone resorption rate and leads to histologic bone signs of secondary hyperparathyroidism. However, in other situations, the initial increase in parathyroid hormone and bone remodeling may be slowed down excessively by a multitude o...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2014.09.004

    authors: Torres PU,Bover J,Mazzaferro S,de Vernejoul MC,Cohen-Solal M

    更新日期:2014-11-01 00:00:00

  • Progenitor cells and podocyte regeneration.

    abstract::The very limited ability of adult podocytes to proliferate in vivo is clinically significant because podocytes form a vascular barrier that is functionally critical to the nephron, podocyte hypoplasia is a characteristic of disease, and inadequate regeneration of podocytes is a major cause of persistent podocyte hypop...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2014.06.008

    authors: Shankland SJ,Pippin JW,Duffield JS

    更新日期:2014-07-01 00:00:00

  • Comparison of agents that affect aldosterone action.

    abstract::The first aldosterone blocker, spironolactone, initially was used as a diuretic but was accompanied by a significant amount of side effects that necessitated the withdrawal of the drug in a relevant number of patients. The discovery of the many receptor-mediated actions of aldosterone in several different organs great...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2014.04.005

    authors: Tamargo J,Solini A,Ruilope LM

    更新日期:2014-05-01 00:00:00

  • Laboratory abnormalities in CKD-MBD: markers, predictors, or mediators of disease?

    abstract::Chronic kidney disease-mineral and bone disorder (CKD-MBD) is characterized by bone abnormalities, vascular calcification, and an array of laboratory abnormalities. The latter classically include disturbances in the parathyroid hormone/vitamin D axis. More recently, fibroblast growth factor 23 (FGF23) and klotho also ...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2014.02.007

    authors: Evenepoel P,Rodriguez M,Ketteler M

    更新日期:2014-03-01 00:00:00

  • Autophagy and immune response in kidneys.

    abstract::Autophagy is a ubiquitous intracellular catabolic process that contributes to homeostatic maintenance and regulates the balance between health and disease. Emerging evidence from both the immunology and renal literature suggests that important relationships exist between the immune system and renal autophagy that may ...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2013.11.008

    authors: Leventhal JS,He JC,Ross MJ

    更新日期:2014-01-01 00:00:00

  • Role of sodium restriction and diuretic therapy for "resistant" hypertension in chronic kidney disease.

    abstract::In patients with chronic kidney disease, an impaired capacity of the kidney to excrete sodium is a major contributor to hypertension. We discuss the role of sodium restriction and diuretic therapy for resistant hypertension in chronic kidney disease. Independent of increasing blood pressure, a sustained high sodium in...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2014.08.005

    authors: Sinnakirouchenan R,Kotchen TA

    更新日期:2014-01-01 00:00:00

  • Complement in ANCA-associated vasculitis.

    abstract::Antineutrophil cytoplasmic autoantibodies (ANCA) are the likely cause for necrotizing small-vessel vasculitis and crescentic glomerulonephritis. Unlike other forms of crescentic glomerulonephritis induced by immune complexes or anti-glomerular basement membrane antibodies that have conspicuous vessel wall immunoglobul...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2013.08.006

    authors: Charles Jennette J,Xiao H,Hu P

    更新日期:2013-11-01 00:00:00

  • Fibroblast growth factor 23, vitamin D, and health disparities among African Americans with chronic kidney disease.

    abstract::Compared with Caucasians, African Americans have lower circulating concentrations of 25-hydroxyvitamin D (25(OH)D), the major storage form of vitamin D, leading to the widespread assumption that African Americans are at higher risk of vitamin D deficiency. However, the finding that African Americans maintain better in...

    journal_title:Seminars in nephrology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semnephrol.2013.07.006

    authors: Saxena N,Gutiérrez OM

    更新日期:2013-09-01 00:00:00

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