abstract：:The novel coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The escalating number of SARS-CoV-2-infected individuals has conferred the viral spread with the status of global pandemic. However, there are no prophylactic or therapeutic drugs available on the m...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Hashimoto K

更新日期：2021-01-05 00:00:00

abstract：:Suicide is a tremendous threat to global public health, and a large number of people who committed suicide suffered the pain of mental diseases, especially major depressive disorder (MDD). Previous study showed that ketamine could reduce suicidal ideation (SI), potentially by improving the impaired working memory (WM)...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Chen X,Wang M,Hu Y,Zhan Y,Zhou Y,Zheng W,Liu W,Wang C,Zhong X,Li H,Lan X,Ning Y,Zhang B

更新日期：2021-01-01 00:00:00

abstract：:Obesity is highly prevalent worldwide and results in a high disease burden. The efforts to monitor and predict treatment outcome in participants with obesity using functional magnetic resonance imaging (fMRI) depends on the reliability of the investigated task-fMRI brain activation. To date, no study has investigated ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Bach P,Grosshans M,Koopmann A,Kienle P,Vassilev G,Otto M,Bumb JM,Kiefer F

更新日期：2020-12-17 00:00:00

abstract：:The differential diagnosis of obsessive-compulsive disorder (OCD) and schizophrenia-spectrum disorders can be difficult. In the current diagnostic criteria, basic concepts such as obsession and delusion overlap. This study examined lifetime schizophrenia-spectrum psychopathology, including subtle schizotypal symptomat...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Rasmussen AR,Nordgaard J,Parnas J

更新日期：2020-12-01 00:00:00

abstract：:Abnormalities of the cerebellum and default-mode network (DMN) in patients with obsessive-compulsive disorder (OCD) have been widely reported. However, alterations of reciprocal functional connections between the cerebellum and DMN at rest in OCD remain unclear. Forty patients with OCD and 38 gender-, age-, and educat...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Lv D,Ou Y,Chen Y,Yang R,Zhong Z,Jia C,Sun L,Wang Y,Zhang G,Sun Z,Wang W,Wang Y,Wang X,Guo W,Li P

更新日期：2020-12-01 00:00:00

abstract：:The transcription nuclear factor-erythroid factor 2-related factor 2 (Nrf2) plays a key role in inflammation that is involved in depression. We previously reported that Nrf2 knock-out (KO) mice exhibit depression-like phenotypes through systemic inflammation. (R)-ketamine, an enantiomer of ketamine, has rapid-acting a...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Qu Y,Shan J,Wang S,Chang L,Pu Y,Wang X,Tan Y,Yamamoto M,Hashimoto K

更新日期：2020-11-12 00:00:00

abstract：:The objective of this study is to determine whether cannabis influences BDNF levels in patients with psychosis (FEP) and healthy volunteers (HV) to help understand the role of BDNF in psychosis. We assessed the association between BDNF and cannabis in a cohort of FEP antipsychotic-naïve patients and HV, whilst control...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Toll A,Bergé D,Burling K,Scoriels L,Treen D,Monserrat C,Marmol F,Duran X,Jones PB,Pérez-Solà V,Fernandez-Egea E,Mané A

更新日期：2020-10-01 00:00:00

abstract：:Cannabinoid 1 receptor and glutamatergic dysfunction have both been implicated in the pathophysiology of schizophrenia. However, it remains unclear if cannabinoid 1 receptor alterations shown in drug-naïve/free patients with first episode psychosis may be linked to glutamatergic alterations in the illness. We aimed to...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Borgan F,Veronese M,Reis Marques T,Lythgoe DJ,Howes O

更新日期：2020-09-28 00:00:00

abstract：:Our social activity is heavily influenced by the process of introspection, with emerging research suggesting a role for the Default Mode Network (DMN) in social cognition. We hypothesize that oxytocin, a neuropeptide with an important role in social behaviour, can effectively alter the connectivity of the DMN. We test...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Kumar J,Iwabuchi SJ,Völlm BA,Palaniyappan L

更新日期：2020-08-01 00:00:00

abstract：:Low social integration is commonly described in acutely suicidal individuals. Neural mechanisms underlying low social integration are poorly understood in depressed and suicidal patients. We sought to characterize the neural response to low social integration in acutely suicidal patients. Adult depressed patients with...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Cáceda R,James GA,Stowe ZN,Delgado PL,Kordsmeier N,Kilts CD

更新日期：2020-08-01 00:00:00

abstract：:Intoxicated persons showing challenging behavior (IPCBs) under influence of alcohol and/or drugs frequently have trouble finding appropriate acute care. Often IPCBs are stigmatized being unwilling or unable to accept help. Separated physical and mental healthcare systems hamper integrated acute care for IPCBs. This pi...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Verheesen SMH,Ten Doesschate F,van Schijndel MA,van der Gaag RJ,Cahn W,van Waarde JA

更新日期：2020-07-12 00:00:00

abstract：:It has been suggested that dopaminergic neurotransmission plays important roles for the psychotic symptoms and probably etiology of schizophrenia. In our recent preliminary study, we demonstrated that the specific allele combinations of dopamine-related functional single nucleotide polymorphisms (SNPs), rs10770141, rs...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Oishi K,Niitsu T,Kanahara N,Sato Y,Iwayama Y,Toyota T,Hashimoto T,Sasaki T,Takase M,Shiina A,Yoshikawa T,Iyo M

更新日期：2020-07-04 00:00:00

abstract：:Cognitive impairment is one of the core symptoms of schizophrenia. Multiple domains of cognition are affected in patients with schizophrenia, which has a major effect on the functional outcome. Recent studies indicate that SNPs in the gamma-aminobutyric acid type A receptor beta 2 subunit (GABRB2) gene are associated ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Zhang Q,Zhang X,Song S,Wang S,Wang X,Yu H,Han H,Zhou X,Li G,Wu Y

更新日期：2020-06-01 00:00:00

abstract：:Despite clues indicating high Bullying at the Work Place (BWP) rates in French hospitals, there has been no quantitative study so far. To determine the prevalence of repeated BWP in a national sample of French young physicians; its risk factors, and the mental health consequences of BWP. The study is a cross-sectional...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Messiaen M,Duba A,Boulangeat C,Boucekine M,Bourbon A,Viprey M,Auquier P,Lançon C,Boyer L,Fond G

更新日期：2020-05-27 00:00:00

abstract：:Accelerated repetitive transcranial magnetic stimulation (rTMS) protocols are being increasingly studied because of their potential to provide quicker and enhanced treatment efficacy. However, there is a lack of accelerated deep TMS with H1-coil (adTMS) treatment research. This randomized pilot study investigated the ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Filipčić I,Šimunović Filipčić I,Sučić S,Milovac Ž,Gereš N,Matić K,Čelić-Ružić M,Zečević Penić S,Orgulan I,Požgaj V,Bajić Ž

更新日期：2020-05-24 00:00:00

abstract：:Quality indicators are vital for monitoring the transformation of institution-based mental health services towards the provision of person-centered mental healthcare. While several mental healthcare quality indicators have been identified as relevant and valid, their actual usability and utility for routine monitoring...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Gaebel W,Lehmann I,Chisholm D,Hinkov H,Höschl C,Kapócs G,Kurimay T,Tosevski DL,Milosavljevic M,Nakov V,Winkler P,Zielasek J

更新日期：2020-04-08 00:00:00

abstract：:Smartphone applications ("apps") may contribute to closing the treatment gap for depression by reaching large populations at relatively low costs. The general public seems open towards the use of apps for mental disorders but less is known about the attitudes of health care professionals. Therefore, the aim of this st...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Kerst A,Zielasek J,Gaebel W

更新日期：2020-03-01 00:00:00

abstract：:One important symptom of patients with major depressive disorder (MDD) is memory dysfunction. However, little is known about the relationship between memory performance and depression severity, about the course of memory performance during antidepressant treatment as well as about the relationship between memory perfo...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Engelmann J,Wagner S,Wollschläger D,Kaaden S,Schlicht KF,Dreimüller N,Braus DF,Müller MB,Tüscher O,Frieling H,Tadić A,Lieb K

更新日期：2020-03-01 00:00:00

abstract：:Comorbid disorders are common in psychiatric diseases and understanding the risk of secondary diseases can aid successful clinical treatment. The objective of this study was to compare the frequency of comorbid dementia, affective disorders, and inflammatory polyarthropathies. Healthcare data obtained via the German H...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Vogelgsang J,Heßmann P,Wolff-Menzler C,Gyßer S,Müller GA,Wiltfang J

更新日期：2020-03-01 00:00:00

abstract：:The efficacy of aripiprazole therapy and the risk of adverse reactions are influenced by substantial inter-individual variability in aripiprazole metabolizing capacity. In vitro studies assigned the potential role in aripiprazole metabolism to CYP2D6 and CYP3A enzymes; therefore, the association between the steady-sta...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Kiss Á,Menus Á,Tóth K,Déri M,Sirok D,Gabri E,Belic A,Csukly G,Bitter I,Monostory K

更新日期：2020-02-01 00:00:00

abstract：:This report presents the rationale and design of a multi-center clinical trial that examines the efficacy and safety of antipsychotic combination treatment in acutely ill schizophrenia patients compared to antipsychotic monotherapy. Antipsychotic combination treatment is common in clinical practice worldwide, despite ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Schmidt-Kraepelin C,Feyerabend S,Engelke C,Riesbeck M,Meisenzahl-Lechner E,Gaebel W,Verde PE,Kolbe H,Correll CU,Leucht S,Heres S,Kluge M,Makiol C,Neff A,Lange C,Englisch S,Zink M,Langguth B,Poeppl T,Reske D,Gouzou

更新日期：2020-02-01 00:00:00

abstract：:Our previous study has found that a long duration of untreated prodromal symptoms (DUPrS) does not increase the conversion risk to psychosis in individuals with attenuated psychosis syndrome (APS). However, whether a long DUPrS will lead to other poor outcomes remains unknown. The purpose of this study was to analyse ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Zhang T,Xu L,Tang Y,Cui H,Tang X,Wei Y,Wang Y,Hu Q,Qian Z,Liu X,Li C,Wang J

更新日期：2019-12-01 00:00:00

abstract：:Apathy is a frequent and debilitating condition with few treatment options available in schizophrenia patients. Despite evidence of its multidimensional structure, most of past studies have explored apathy through a categorical approach. The main objective of this study was to identify the cognitive, emotional, motiva...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Raffard S,Bortolon C,Yazbek H,Lançon C,Benoit M,Norton J,Capdevielle D

更新日期：2019-12-01 00:00:00

abstract：:Obsessive-compulsive symptoms (OCS) in patients with schizophrenia are a common co-occurring condition, often associated with additional impairments. A subgroup of these patients develops OCS during treatment with second-generation antipsychotics (SGAs), most importantly clozapine and olanzapine. So far, little is kno...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Mier D,Schirmbeck F,Stoessel G,Esslinger C,Rausch F,Englisch S,Eisenacher S,de Haan L,Meyer-Lindenberg A,Kirsch P,Zink M

更新日期：2019-12-01 00:00:00

abstract：:While impairments in executive functions have been well established in major depressive disorder (MDD), specific deficits in proactive control have scarcely been studied so far. Proactive control refers to cognitive processes during anticipation of a behaviorally relevant event that facilitate readiness to react. In t...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Hoffmann A,Ettinger U,Montoro C,Reyes Del Paso GA,Duschek S

更新日期：2019-10-01 00:00:00

abstract：:Cognitive models suggest that top-down and emotional processes increase false perceptions in schizophrenia spectrum disorders (SSD). However, little is still known about the interaction of these processes in false auditory perceptions. The present study aimed at investigating the specific as well as joint impacts of e...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Gawęda Ł,Moritz S

更新日期：2019-09-06 00:00:00

abstract：:Antisocial personality disorder is characterized by a stable, lifelong pattern of disregard for and violation of others' rights. Disruptions in the representation of fairness norms may represent a key mechanism in the development and maintenance of this disorder. Here, we investigated fairness norm considerations and ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Mayer SV,Rauss K,Pourtois G,Jusyte A,Schönenberg M

更新日期：2019-09-01 00:00:00

abstract：:Endophenotypes mediate pathways between genetic variations and the psychiatric phenotype, or share genetic risk with the psychiatric phenotype. Identifying endophenotypes is an important step to unravel disease pathways underlying complex psychiatric phenotypes such as ADHD. Potential viable endophenotypes for ADHD ac...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Boxhoorn S,Lopez E,Schmidt C,Schulze D,Hänig S,Cholemkery H,Freitag CM

更新日期：2019-09-01 00:00:00

abstract：:Physical activity is a common adjunctive therapy in psychiatric and psychosomatic hospitals. In the present study, we assessed the effects of an exercise program, integrated into routine inpatient treatment, on cognitive performance and subjective severity of depression in a sample of patients suffering from major dep...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Buschert V,Prochazka D,Bartl H,Diemer J,Malchow B,Zwanzger P,Brunnauer A

更新日期：2019-08-01 00:00:00

abstract：:Schizophrenia is a severe neuropsychiatric disease that is associated with neurobiological alterations in multiple brain regions and peripheral organs. Negative symptoms and cognitive deficits are present in about half of patients and are difficult to treat, leading to an unfavorable functional outcome. To investigate...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Maurus I,Hasan A,Röh A,Takahashi S,Rauchmann B,Keeser D,Malchow B,Schmitt A,Falkai P

更新日期：2019-08-01 00:00:00

abstract：:Changes in the surface morphology of the orbitofrontal cortex (OFC), such as a fewer orbital sulci and altered sulcogyral pattern of the 'H-shaped' orbital sulcus, have been reported in schizophrenia, possibly reflecting abnormal neurodevelopment during gestation. However, whether high-risk subjects for developing psy...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Nakamura M,Takahashi T,Takayanagi Y,Sasabayashi D,Katagiri N,Sakuma A,Obara C,Koike S,Yamasue H,Furuichi A,Kido M,Nishikawa Y,Noguchi K,Matsumoto K,Mizuno M,Kasai K,Suzuki M

更新日期：2019-06-01 00:00:00

abstract：:Although cognitive behavioral therapy (CBT) is highly effective in the treatment of anxiety disorders, many patients still do not benefit. This study investigates whether a history of traumatic event experience is negatively associated with outcomes of CBT for panic disorder. The moderating role of the monoamine oxida...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Trautmann S,Richter J,Muehlhan M,Höfler M,Wittchen HU,Domschke K,Ströhle A,Hamm AO,Weber H,Kircher T,Arolt V,Gerlach AL,Alpers GW,Fydrich T,Lang T,Reif A

更新日期：2019-03-01 00:00:00

abstract：:Obsessive-compulsive symptoms (OCS) are frequently reported in patients with schizophrenia and have been associated with subjective distress and higher impairment. Recent studies suggest fluctuation in co-occurring OCS and associations with the course of psychotic symptoms. Current evidence is limited by few studies w...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Schirmbeck F,Konijn M,Hoetjes V,Zink M,de Haan L,For Genetic Risk and Outcome of Psychosis (GROUP).

更新日期：2019-03-01 00:00:00

abstract：:Early life maltreatment (ELM) has long-lasting effects on social interaction. When interacting with their own child, women with ELM often report difficulties in parenting and show reduced maternal sensitivity. Sensitive maternal behavior requires the recognition of the child's emotional state depicted in its facial em...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Neukel C,Herpertz SC,Hinid-Attar C,Zietlow AL,Fuchs A,Moehler E,Bermpohl F,Bertsch K

更新日期：2019-03-01 00:00:00

abstract：:The Cognitive Behavioral Analysis System of Psychotherapy (CBASP) is a relatively new approach in the treatment of chronic depression (CD). Adapted as group psychotherapy for inpatients, CBASP is attracting increasing attention. In this naturalistic multicenter trial, we investigated its feasibility after 10 sessions ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Sabaß L,Padberg F,Normann C,Engel V,Konrad C,Helmle K,Jobst A,Worlitz A,Brakemeier EL

更新日期：2018-12-01 00:00:00

abstract：:Compounds targeting serotonin (5-HT) are widely used as antidepressants. However, the role of 5-HT in mediating the effects of electroconvulsive seizure (ECS) therapy remains undefined. Using Tph2-/- mice depleted of brain 5-HT, we studied the effects of ECS on behavior and neurobiology. ECS significantly prolonged th...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Kronenberg G,Petermann M,Dormann C,Bader M,Gass P,Hellweg R,Klempin F

更新日期：2018-12-01 00:00:00

abstract：:Auditory verbal hallucinations (AH) are core symptoms of schizophrenia. They are often severely distressing and refractory to therapy. Their perception is associated with increased activity in temporoparietal areas of the brain. Repetitive transcranial magnetic stimulation (rTMS) can reduce focal brain hyperactivity a...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Plewnia C,Brendel B,Schwippel T,Martus P,Cordes J,Hasan A,Fallgatter AJ

更新日期：2018-10-01 00:00:00

abstract：:Clinical and neurobiological findings have reported the involvement of endocannabinoid signaling in the pathophysiology of schizophrenia. This system modulates dopaminergic and glutamatergic neurotransmission that is associated with positive, negative, and cognitive symptoms of schizophrenia. Despite neurotransmitter ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： de Almeida V,Martins-de-Souza D

更新日期：2018-10-01 00:00:00

abstract：:The purpose of this study was to investigate the relationship between specific symptom severity and D2/3 receptor availability in extrastriatal regions in outpatients with schizophrenia to shed light on the role of extrastriatal dopaminergic neurotransmission in the pathophysiology of symptoms of schizophrenia. Sixtee...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Joo YH,Kim JH,Son YD,Kim HK,Shin YJ,Lee SY,Kim JH

更新日期：2018-09-01 00:00:00

abstract：:Advances in psychopathological research advocate a personality-centred model of common mental disorders (CMD). We tested four hypotheses to test such a model. First, personality relates to critical life events; second, both personality and critical life events relate to CMD; third, interaction effects between personal...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Hengartner MP,Tyrer P,Ajdacic-Gross V,Angst J,Rössler W

更新日期：2018-08-01 00:00:00