The association of GABRB2 SNPs with cognitive function in schizophrenia.

Abstract:

:Cognitive impairment is one of the core symptoms of schizophrenia. Multiple domains of cognition are affected in patients with schizophrenia, which has a major effect on the functional outcome. Recent studies indicate that SNPs in the gamma-aminobutyric acid type A receptor beta 2 subunit (GABRB2) gene are associated with the risk of schizophrenia, however, the effect of these SNPs on cognitive function in patients with schizophrenia has not been explored. In this study, we first performed a case-control analysis of three SNPs (rs187269 allele A vs. G, rs252944 allele C vs. G, and rs194072 allele A vs. G) in 100 patients and 90 controls, then conducted a meta-analysis and found the SNP rs194072 was associated with schizophrenia (OR = 0.86, P = 0.0119), and survived after Bonferroni correction. The haplotype analysis suggested that the haplotype ACA, comprising the three SNPs (rs187269, rs252944 and rs194072) was also significantly associated with schizophrenia (P = 0.049).Then, we performed an association analysis of three SNPs (rs187269, rs252944 and rs194072) in GABRB2 gene with cognitive performance in patients with first episode schizophrenia. We found that the allele G of rs187269 in the GABRB2 gene was significantly associated with better cognitive flexibility (P = 0.005), a major aspect of executive function, in patients with first episode schizophrenia. The haplotype ACA was significantly associated with cognitive flexibility in patients with schizophrenia (P = 0.023). Our study showed that SNPs in GABRB2 may have a significant effect on cognitive function in patients with schizophrenia, suggesting that modulating GABRB2 may have therapeutic potential to improve cognitive function of patients with schizophrenia.

authors

Zhang Q,Zhang X,Song S,Wang S,Wang X,Yu H,Han H,Zhou X,Li G,Wu Y

doi

10.1007/s00406-019-00985-3

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

443-449

issue

4

eissn

0940-1334

issn

1433-8491

pii

10.1007/s00406-019-00985-3

journal_volume

270

pub_type

杂志文章
  • The Munich Diagnostic Checklist for the assessment of DSM-III-R Personality Disorders for use in routine clinical care and research.

    abstract::Diagnostic checklists for the assessment of DSM-III-R Axis I diagnoses have proven to be a reliable and feasible instrument in research and routine clinical care. Therefore, a checklist for the assessment of the DSM-III-R Personality Disorders (MDCL-P) has been developed. An English version of the MDCL-P is available....

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/BF02191550

    authors: Bronisch T,Garcia-Borreguero D,Flett S,Wolf R,Hiller W

    更新日期:1992-01-01 00:00:00

  • Neuroleptic treatment increases soluble IL-2 receptors and decreases soluble IL-6 receptors in schizophrenia.

    abstract::The cytokines interleukin-2 (IL-2) and interleukin-6 (IL-6) increase during immune activation, they are released from activated astrocytes and microglial cells in the central nervous system (CNS), and they are able to enhance the catecholaminergic neurotransmission. This study focused on the soluble receptors of IL-2 ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02922260

    authors: Müller N,Empl M,Riedel M,Schwarz M,Ackenheil M

    更新日期:1997-01-01 00:00:00

  • Cannabis use in pregnancy and early life and its consequences: animal models.

    abstract::Cannabinoid receptors and their endogenous ligands have been detected from the earliest stages of embryonic development. The endocannabinoid system appears to play essential roles in these early stages for neuronal development and cell survival, although its detailed involvement in fundamental developmental processes ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,评审

    doi:10.1007/s00406-009-0026-0

    authors: Schneider M

    更新日期:2009-10-01 00:00:00

  • Impairment of theory of mind in patients in remission following first episode of schizophrenia.

    abstract::The aim of this study was to investigate theory of mind (ToM) ability in patients in remission after the first episode of schizophrenia. A ToM task which contained four pictures was given to 30 patients with schizophrenia in remission and 30 matched healthy controls. Patients with schizophrenia in remission showed sta...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-006-0608-z

    authors: Inoue Y,Yamada K,Hirano M,Shinohara M,Tamaoki T,Iguchi H,Tonooka Y,Kanba S

    更新日期:2006-08-01 00:00:00

  • Reduced density of hypothalamic VGF-immunoreactive neurons in schizophrenia: a potential link to impaired growth factor signaling and energy homeostasis.

    abstract::Protein expression of VGF (nonacronymic) is induced by nerve/brain-derived growth factor, neurotrophin 3, and insulin. VGF is synthesized by neurons in the paraventricular (PVN) and supraoptic (SON) nuclei of the hypothalamus. After enzymatic processing, smaller VGF-derived peptides are secreted into the cerebrospinal...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-011-0282-7

    authors: Busse S,Bernstein HG,Busse M,Bielau H,Brisch R,Mawrin C,Müller S,Sarnyai Z,Gos T,Bogerts B,Steiner J

    更新日期:2012-08-01 00:00:00

  • Using the cognitive assessment interview to screen cognitive impairment in psychosis.

    abstract::Cognitive impairment in psychosis is closely related to functional outcome, so research into psychotic disorders is focusing most effort on treatments for improving cognition. New treatments must show not only an improvement on neuropsychological tests but also in co-primary measures of cognition. The cognitive assess...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-016-0700-y

    authors: Sánchez-Torres AM,Elosúa MR,Lorente-Omeñaca R,Moreno-Izco L,Peralta V,Ventura J,Cuesta MJ

    更新日期:2016-10-01 00:00:00

  • The different conceptions of catatonia: historical overview and critical discussion.

    abstract::The present article outlines the different conception of catatonia from its initial description by Kahlbaum to current viewpoints. Originally considered to be an independent disease entity characterized by mental and motor abnormalities, catatonia was later viewed as a subtype of schizophrenia as it is the case in cur...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 历史文章,杂志文章

    doi:10.1007/pl00014199

    authors: Pfuhlmann B,Stöber G

    更新日期:2001-01-01 00:00:00

  • Depression and anxiety in Swedish primary health care: prevalence, incidence, and risk factors.

    abstract::The aim of this study was to estimate the prevalence and incidence of mood disorders, anxiety disorders, and stress and adjustment disorders in primary health care in Sweden and to analyse the relationship between socioeconomic and demographic factors and incidence of these disorders. Prevalence and incidence data on ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-013-0422-3

    authors: Lejtzén N,Sundquist J,Sundquist K,Li X

    更新日期:2014-04-01 00:00:00

  • Psychopathology in dual diagnosis and non-addicted schizophrenics--are there differences?

    abstract::In a previous publication we reported lifetime and 3-month prevalence estimates for substance use in two large samples of schizophrenic inpatients (Soyka et al. 1993). A subsequent analysis of psychopathological findings assessed by means of the AMDP Manual (Guy and Ban 1982) in schizophrenic in-patients of the Haar M...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s004060170032

    authors: Soyka M,Albus M,Immler B,Kathmann N,Hippius H

    更新日期:2001-10-01 00:00:00

  • Non-neuroleptic approaches to treating negative symptoms in schizophrenia.

    abstract::The novel/atypical neuroleptics have proven to be effective in treating negative symptoms but although clinical experience appears to show that they have advantages over the traditional neuroleptics in treating negative symptoms, superiority has not always been statistically confirmed and the treatment results in indi...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,评审

    doi:10.1007/s00406-004-0503-4

    authors: Möller HJ

    更新日期:2004-04-01 00:00:00

  • Cannabinoids and glial cells: possible mechanism to understand schizophrenia.

    abstract::Clinical and neurobiological findings have reported the involvement of endocannabinoid signaling in the pathophysiology of schizophrenia. This system modulates dopaminergic and glutamatergic neurotransmission that is associated with positive, negative, and cognitive symptoms of schizophrenia. Despite neurotransmitter ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,评审

    doi:10.1007/s00406-018-0874-6

    authors: de Almeida V,Martins-de-Souza D

    更新日期:2018-10-01 00:00:00

  • Phenoconversion of CYP2D6 by inhibitors modifies aripiprazole exposure.

    abstract::The efficacy of aripiprazole therapy and the risk of adverse reactions are influenced by substantial inter-individual variability in aripiprazole metabolizing capacity. In vitro studies assigned the potential role in aripiprazole metabolism to CYP2D6 and CYP3A enzymes; therefore, the association between the steady-sta...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-018-0975-2

    authors: Kiss Á,Menus Á,Tóth K,Déri M,Sirok D,Gabri E,Belic A,Csukly G,Bitter I,Monostory K

    更新日期:2020-02-01 00:00:00

  • Psychiatric aspects of acute pandysautonomia.

    abstract::Five cases of acute pandysautonomia and one case of acute autonomic and sensory neuropathy are described with special reference to psychiatric symptoms. They originally presented as psychiatric disorders, such as hysterical neurosis, epilepsy, anorexia nervosa and hypochondriacal neurosis. Psychiatric symptoms arise f...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/BF02189983

    authors: Okada F

    更新日期:1990-01-01 00:00:00

  • Articulation and testing of a personality-centred model of psychopathology: evidence from a longitudinal community study over 30 years.

    abstract::Advances in psychopathological research advocate a personality-centred model of common mental disorders (CMD). We tested four hypotheses to test such a model. First, personality relates to critical life events; second, both personality and critical life events relate to CMD; third, interaction effects between personal...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-017-0796-8

    authors: Hengartner MP,Tyrer P,Ajdacic-Gross V,Angst J,Rössler W

    更新日期:2018-08-01 00:00:00

  • Episodic course in obsessive-compulsive disorder.

    abstract::The course of obsessive-compulsive disorder (OCD) is variable, ranging from episodic to chronic. We hypothesised that the former course is more likely to be related to bipolar mood disorders. With the use of a specially constructed OCD questionnaire, we studied 135 patients fulfilling DSM-III-R criteria for OCD with a...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s004060050044

    authors: Perugi G,Akiskal HS,Gemignani A,Pfanner C,Presta S,Milanfranchi A,Lensi P,Ravagli S,Maremmani I,Cassano GB

    更新日期:1998-01-01 00:00:00

  • Acute placebo-controlled sleep laboratory studies and clinical follow-up with pramipexole in restless legs syndrome.

    abstract::In a single-blind, placebo-controlled crossover trial, the acute efficacy of the dopamine agonist pramipexole was investigated in 11 restless legs syndrome (RLS) patients by sleep laboratory methods, with a clinical follow-up for 4 weeks. In 3 nights (pre-treatment, placebo and drug night), objective sleep quality was...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00406-002-0380-7

    authors: Saletu M,Anderer P,Saletu-Zyhlarz G,Hauer C,Saletu B

    更新日期:2002-08-01 00:00:00

  • The psychosis continuum in the general population: findings from the São Paulo Epidemiologic Catchment Area Study.

    abstract::The aim of the study was to examine the psychosis continuum in a Latin-American community setting. Data were from the Brazilian São Paulo Epidemiologic Catchment Area Study, a cross-sectional survey conducted in two boroughs of the city of São Paulo. The Composite International Diagnosis Interview (version 1.1) was ap...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-011-0204-8

    authors: Loch AA,Wang YP,Rössler W,Tófoli LF,Silveira CM,Andrade LH

    更新日期:2011-10-01 00:00:00

  • Identification of items which predict later development of depression in primary health care.

    abstract::To improve recognition and treatment of depression in primary care it would be advantageous to have criteria for identification of later depression. Only a few studies were performed on primary care samples to examine risk factors for new depressive episodes. These were mostly cross-sectional and did not include psych...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/BF03035122

    authors: Barkow K,Heun R,Ustün TB,Maier W

    更新日期:2001-01-01 00:00:00

  • Gender differences in depression. Epidemiological findings from the European DEPRES I and II studies.

    abstract:BACKGROUND:While there is ample evidence that the prevalence rates for major depressive disorder (MDD) in the general population are higher in women than in men, there is little data on gender differences as regard to symptoms, causal attribution, help-seeking, coping, or the consequences of depression. METHOD:The lar...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-002-0381-6

    authors: Angst J,Gamma A,Gastpar M,Lépine JP,Mendlewicz J,Tylee A,Depression Research in European Society Study.

    更新日期:2002-10-01 00:00:00

  • Periodic limb movements during sleep in alcohol dependent patients.

    abstract::Complaints of sleep disturbances are common among alcohol dependent patients during subacute abstinence. Recovered patients may show persistent sleep abnormalities for months or even years. In the present study we studied the issue whether periodic limb movements in sleep and disturbances of nocturnal respiration are ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-002-0371-8

    authors: Gann H,Feige B,Fasihi S,van Calker D,Voderholzer U,Riemann D

    更新日期:2002-06-01 00:00:00

  • Cerebral blood flow responses during prosaccade and antisaccade preparation in major depression.

    abstract::While impairments in executive functions have been well established in major depressive disorder (MDD), specific deficits in proactive control have scarcely been studied so far. Proactive control refers to cognitive processes during anticipation of a behaviorally relevant event that facilitate readiness to react. In t...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-018-0956-5

    authors: Hoffmann A,Ettinger U,Montoro C,Reyes Del Paso GA,Duschek S

    更新日期:2019-10-01 00:00:00

  • Imaging the deluded brain.

    abstract::Various factors contribute to the development and maintenance of delusions in the context of schizophrenic psychoses. Studies with functional and structural MRI were able to detect neurobiological correlates of paranoid symptoms. Consistent with the neurodevelopmental hypothesis of schizophrenic psychosis, which impli...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,评审

    doi:10.1007/s00406-008-5008-0

    authors: Knobel A,Heinz A,Voss M

    更新日期:2008-11-01 00:00:00

  • Two subgroups of schizophrenia identified by systematic cognitive neuropsychiatric mapping.

    abstract::The description of the heterogeneous phenomenological, pathophysiological, and etiological nature of schizophrenia is under way; however, the relationships between heterogeneity levels are still unclear. We performed a robust cross-sectional study, including a systematic neuropsychological battery, assessment of clini...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-009-0073-6

    authors: Szendi I,Racsmány M,Cimmer C,Csifcsák G,Kovács ZA,Szekeres G,Galsi G,Tóth F,Nagy A,Garab EA,Boda K,Gulyás G,Kiss JG,Dombi J,Pléh C,Janka Z

    更新日期:2010-04-01 00:00:00

  • Prospective long-term follow-up of depressed patients with and without suicide attempts.

    abstract::This 4-6-year prospective follow-up study compared reactive depressives with (n = 48) and without suicide attempts before index admission (n = 24). Both groups showed a favourable course and outcome concerning psychiatric diagnoses (DSM-III), psychopathology, social integration, and social functioning as well as displ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/BF02190337

    authors: Bronisch T,Hecht H

    更新日期:1992-01-01 00:00:00

  • Brain serotonin critically contributes to the biological effects of electroconvulsive seizures.

    abstract::Compounds targeting serotonin (5-HT) are widely used as antidepressants. However, the role of 5-HT in mediating the effects of electroconvulsive seizure (ECS) therapy remains undefined. Using Tph2-/- mice depleted of brain 5-HT, we studied the effects of ECS on behavior and neurobiology. ECS significantly prolonged th...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-018-0924-0

    authors: Kronenberg G,Petermann M,Dormann C,Bader M,Gass P,Hellweg R,Klempin F

    更新日期:2018-12-01 00:00:00

  • Neuropsychological performance in partly remitted unipolar depressive patients: focus on executive functioning.

    abstract:BACKGROUND:Only few studies have investigated executive impairment in the euthymic phase of unipolar affective disorders, yielding diverging results. The role of impulsivity/orbitofrontal associated executive functioning in remitted depression has not yet been examined. METHODS:Partly remitted male out-patients (n = 1...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-007-0740-4

    authors: Westheide J,Wagner M,Quednow BB,Hoppe C,Cooper-Mahkorn D,Strater B,Maier W,Kuhn KU

    更新日期:2007-10-01 00:00:00

  • Prevention of rehospitalization in schizophrenia: results of an integrated care project in Germany.

    abstract::The goal of this study was to prevent rehospitalizations and thus to optimize satisfaction with treatment and quality of life in patients suffering by schizophrenia or schizoaffective disorder. A complex intervention with improved cooperation between in- and outpatient services was applied to 46 "high utilizing" patie...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00406-009-0056-7

    authors: Schmidt-Kraepelin C,Janssen B,Gaebel W

    更新日期:2009-11-01 00:00:00

  • Glutamate level detection by magnetic resonance spectroscopy in patients with post-stroke depression.

    abstract::In recent studies, the glutamate (Glu) level has been quantified using the modified STEAM sequence on 3T MRI. We enrolled 15 healthy volunteers and a group of 51 patients who experienced stroke for the first time and had a good prognosis. The patients with infarction were divided into three groups according to their s...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-011-0209-3

    authors: Wang X,Li YH,Li MH,Lu J,Zhao JG,Sun XJ,Zhang B,Ye JL

    更新日期:2012-02-01 00:00:00

  • Savoxepine versus haloperidol. Reasons for a failed controlled clinical trial in patients with an acute episode of schizophrenia.

    abstract::Savoxepine, an atypical neuroleptic compound developed in the 1980s, was believed to act via selective limbic dopamine D(2)-receptor blockade. The results of the presented double-blind, randomised, controlled clinical trial comparing savoxepine (n = 58) with haloperidol (n = 29) did not confirm the preclinical data su...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s00406-002-0364-7

    authors: Volz HP,Möller HJ,Gerebtzoff A,Bischoff S

    更新日期:2002-04-01 00:00:00

  • Long-term functional outcome in adult prison inmates with ADHD receiving OROS-methylphenidate.

    abstract::In a recent randomized, double-blind, placebo-controlled trial, we established a robust efficacy (Cohen's d = 2.17) of osmotic release oral system-methylphenidate (OROS-methylphenidate) delivered 72 mg daily for 5 weeks versus placebo on attention deficit hyperactivity disorder (ADHD) symptoms, global severity and glo...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00406-012-0317-8

    authors: Ginsberg Y,Hirvikoski T,Grann M,Lindefors N

    更新日期:2012-12-01 00:00:00