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Higher BDNF plasma levels are associated with a normalization of memory dysfunctions during an antidepressant treatment.

Abstract：

:One important symptom of patients with major depressive disorder (MDD) is memory dysfunction. However, little is known about the relationship between memory performance and depression severity, about the course of memory performance during antidepressant treatment as well as about the relationship between memory performance and brain-derived neurotrophic factor (BDNF). Memory function [learning and delayed recall) was assessed in 173 MDD patients (mean age 39.7 ± 11.3 years] treated by a pre-defined treatment algorithm within the early medication change (EMC) study at baseline, days 28 and 56. Depression severity was assessed in weekly intervals, BDNF plasma levels were measured at baseline, days 14 and 56, BDNF exon IV and p11 methylation status at baseline. Linear mixed regression models revealed that the course of depression severity was not associated with the course of learning or delayed recall in the total group. 63 (36%) of the investigated patients showed memory deficits (percent range ≤ 16) at baseline. Of those, 26(41%) patients experienced a normalization of their memory deficits during treatment. Patients with a normalization of their delayed recall performance had significantly higher plasma BDNF levels (p = 0.040) from baseline to day 56 than patients with persistent deficits. Baseline BDNF exon IV promoter and p11 gene methylation status were not associated with memory performance. Our results corroborate a concomitant amelioration of learning and delayed recall dysfunctions with successful antidepressant therapy in a subgroup of patients and support a role of BDNF in the neural mechanisms underlying the normalization of memory dysfunctions in MDD. ClinicalTrials.gov number: NCT00974155; EudraCT: 2008-008280-96.

journal_name

Eur Arch Psychiatry Clin Neurosci

journal_title

European archives of psychiatry and clinical neuroscience

authors

Engelmann J,Wagner S,Wollschläger D,Kaaden S,Schlicht KF,Dreimüller N,Braus DF,Müller MB,Tüscher O,Frieling H,Tadić A,Lieb K

doi

10.1007/s00406-019-01006-z

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

183-193

issue

eissn

0940-1334

issn

1433-8491

pii

10.1007/s00406-019-01006-z

journal_volume

270

pub_type

杂志文章

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Higher BDNF plasma levels are associated with a normalization of memory dysfunctions during an antidepressant treatment.