Abstract：
:Evidence-based medicine (EBM) is becoming the guiding principle for clinical treatment decisions. But evidence remains a loosely defined term. Multiple criteria for evidence criteria have been proposed. Most influential evidence criteria give priority to meta-analyses because they promise an objective procedure to combine the outcomes of all informative, putatively conflicting studies on the same issue in an overall score. However, we claim that meta-analyses are of limited informative value for the following six reasons: (1) meta-analyses are often "overpowered" with clinically irrelevant results that might emerge as highly significant; (2) there is serious concern of publication biases with "negative" studies not being published; (3) meta-analyses consider the variation in the results of the empirical studies included to be random noise, however, the variability of results across studies can be informative; (4) the result of a meta-analysis depends on the strategy used to identify the included empirical studies; (5) the quality of conclusions from meta-analyses depends on the statistical tests used to combine the results of the separate studies; (6) the qualitative conclusions drawn from the meta-analytical combination of individual studies may depend on specific design aspects of the individual studies. Thus, meta-analyses are primarily a method to generate hypotheses through an a posteriori analysis of treatment effects.
journal_name
Eur Arch Psychiatry Clin Neurosciauthors
Maier W,Möller HJdoi
10.1007/s00406-009-0068-3subject
Has Abstractpub_date
2010-02-01 00:00:00pages
17-23issue
1eissn
0940-1334issn
1433-8491journal_volume
260pub_type
杂志文章abstract：:The efficacy of aripiprazole therapy and the risk of adverse reactions are influenced by substantial inter-individual variability in aripiprazole metabolizing capacity. In vitro studies assigned the potential role in aripiprazole metabolism to CYP2D6 and CYP3A enzymes; therefore, the association between the steady-sta...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-018-0975-2
更新日期：2020-02-01 00:00:00
abstract：:In this review, we discuss current structural and functional imaging data on ADHD in a neurological and neuroanatomical framework. At present, the literature on adult ADHD is somewhat sparse, and so results from imaging have to therefore be considered mainly from the childhood or adolescence perspective. Most work has...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,评审
doi：10.1007/s00406-006-1005-3
更新日期：2006-09-01 00:00:00
abstract：:Cognitive impairment in psychosis is closely related to functional outcome, so research into psychotic disorders is focusing most effort on treatments for improving cognition. New treatments must show not only an improvement on neuropsychological tests but also in co-primary measures of cognition. The cognitive assess...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-016-0700-y
更新日期：2016-10-01 00:00:00
abstract：:Studies addressing the relationship between a history of obstetric complications (OCs) and neurological abnormalities in schizophrenia have produced contradictory findings. Using a pre-posttreatment design in a neuroleptic-naive sample of psychotic patients, we examined the relationship of a history of OC to primary a...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-006-0653-7
更新日期：2006-10-01 00:00:00
abstract：:It has been suggested that dopaminergic neurotransmission plays important roles for the psychotic symptoms and probably etiology of schizophrenia. In our recent preliminary study, we demonstrated that the specific allele combinations of dopamine-related functional single nucleotide polymorphisms (SNPs), rs10770141, rs...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-020-01158-3
更新日期：2020-07-04 00:00:00
abstract：:Some studies suggest seasonality of suicide attempts in females, but not in males. The reasons for this gender difference remain unclear. Only few studies addressed the question whether gender differences in seasonality of suicide attempts reflect gender differences in the choice of method for suicide attempts, with i...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-009-0086-1
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVE:Interpersonal psychotherapy (IPT) is a time-limited psychotherapy for major depression. The aim of this study is to summarize findings from controlled trials of the efficacy of IPT in the treatment of depressive spectrum disorders (DSD) using a meta-analytic approach. METHODS:Studies of randomized clinical t...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,评审
doi：10.1007/s00406-004-0542-x
更新日期：2005-04-01 00:00:00
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journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-013-0428-x
更新日期：2014-03-01 00:00:00
abstract：:In a retrospective study, hospital stay in two hospitals was compared for depressive patients. The mean amount of accumulated light impinging the patient's area was 86,145 lux/light period in Hospital Universitari Son Dureta and 258,909 lux/light period in Hospital Universitari Son Espases (~300 % increase). The media...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-015-0601-5
更新日期：2016-04-01 00:00:00
abstract：:Besides the ventral tegmental area and the nucleus accumbens as the most investigated brain reward structures, several reports about the relation between volume and activity of the amygdala and drug-seeking behavior have emphasized the central role of the amygdala in the etiology of addiction. Considering its proposed...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-010-0129-7
更新日期：2011-03-01 00:00:00
abstract：:Proof of efficacy of a psychotropic medicinal product is the key point of clinical psychopharmacology. This especially concerns the licensing of a new compound, but apart from this special case, lots of efficacy questions need to be answered in clinical psychopharmacology, such as, e.g. the question of the efficacy of...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-009-0071-8
更新日期：2010-02-01 00:00:00
abstract：:Nocturnal sleep was studied in 14 human immunodeficiency virus (HIV)-positive patients without opportunistic infections of the central nervous system. Seven patients had no bodily complaints at the time of the investigation. Patients exhibited an impaired nocturnal sleep with longer sleep onset latency, reduced total ...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/BF02190756
更新日期：1991-01-01 00:00:00
abstract：:The deficit syndrome is thought to be specific to and a subtype of schizophrenia; however, there are scarce or no data on the prevalence and characteristics of this syndrome in non-schizophrenic psychoses. The aim of this study was to explore the prevalence and correlates of different types of negative symptoms (NegS)...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-004-0464-7
更新日期：2004-06-01 00:00:00
abstract：:The goal of this study was to prevent rehospitalizations and thus to optimize satisfaction with treatment and quality of life in patients suffering by schizophrenia or schizoaffective disorder. A complex intervention with improved cooperation between in- and outpatient services was applied to 46 "high utilizing" patie...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 临床试验,杂志文章
doi：10.1007/s00406-009-0056-7
更新日期：2009-11-01 00:00:00
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journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-019-01015-y
更新日期：2020-03-01 00:00:00
abstract：:Severe psychiatric disorders such as schizophrenia are related to cognitive and negative symptoms, which often are resistant to current treatment approaches. The glutamatergic system has been implicated in the pathophysiology of schizophrenia and affective disorders. A key component is the dysfunction of the glutamate...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,评审
doi：10.1007/s00406-013-0399-y
更新日期：2013-08-01 00:00:00
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journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s004060050081
更新日期：1999-01-01 00:00:00
abstract：:Although the Bonn Scale for the Assessment of Basic Symptoms (BSABS) [13] has come into use in several European countries, its diagnostic validity has not yet been sufficiently examined. That is why we have assessed BSABS items on a sample of 243 consecutive admissions to the Department of Psychiatry at the RWTH Unive...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 临床试验,杂志文章
doi：10.1007/BF02189116
更新日期：1996-01-01 00:00:00
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journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 临床试验,杂志文章
doi：10.1007/s00406-009-0014-4
更新日期：2009-12-01 00:00:00
abstract：:Our social activity is heavily influenced by the process of introspection, with emerging research suggesting a role for the Default Mode Network (DMN) in social cognition. We hypothesize that oxytocin, a neuropeptide with an important role in social behaviour, can effectively alter the connectivity of the DMN. We test...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-019-00989-z
更新日期：2020-08-01 00:00:00
abstract：:Savoxepine, an atypical neuroleptic compound developed in the 1980s, was believed to act via selective limbic dopamine D(2)-receptor blockade. The results of the presented double-blind, randomised, controlled clinical trial comparing savoxepine (n = 58) with haloperidol (n = 29) did not confirm the preclinical data su...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00406-002-0364-7
更新日期：2002-04-01 00:00:00
abstract：:There are gender-related differences in the prevalence, course and treatment response characteristics of schizophrenia and mood disorders. Gonadal steroids exert potent effects on mood, cognition and behavior, and there is little doubt that androgens are crucial for differentiating to each gender. Serum level of total...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-003-0424-7
更新日期：2003-08-01 00:00:00
abstract：:Based on the original data from two double-blind, randomized, placebo-controlled clinical trials and the acute phase of a long-term study that investigated the antidepressant efficacy of St. John's wort extract WS 5570, we present a re-analysis of a subset of patients suffering from an acute episode of mild depression...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00406-007-0779-2
更新日期：2008-02-01 00:00:00
abstract：:This European Psychiatric Association (EPA) guidance paper is a result of the Working Group on Mental Health Consequences of Economic Crises of the EPA Council of National Psychiatric Associations. Its purpose is to identify the impact on mental health in Europe of the economic downturn and the measures that may be ta...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,评审
doi：10.1007/s00406-016-0681-x
更新日期：2016-03-01 00:00:00
abstract：:The purpose of this study was to investigate the relationship between specific symptom severity and D2/3 receptor availability in extrastriatal regions in outpatients with schizophrenia to shed light on the role of extrastriatal dopaminergic neurotransmission in the pathophysiology of symptoms of schizophrenia. Sixtee...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-017-0821-y
更新日期：2018-09-01 00:00:00
abstract：:Poor sleep is linked to poorer daily functioning and increased risk of psychiatric symptoms. With respect to pain, the relation is bi-directional; poor sleep exacerbates pain, while greater pain adversely affects sleep. Moreover, perception of pain is subject to cognitive-emotional processes. Surprisingly, no data are...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-010-0113-2
更新日期：2010-10-01 00:00:00
abstract：:Physical activity is a common adjunctive therapy in psychiatric and psychosomatic hospitals. In the present study, we assessed the effects of an exercise program, integrated into routine inpatient treatment, on cognitive performance and subjective severity of depression in a sample of patients suffering from major dep...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00406-018-0916-0
更新日期：2019-08-01 00:00:00
abstract：:Anger is a common and potentially destructive emotion that has considerable social and public health importance. The occurrence of anger, irritability and hostility in depression have been known for many years, but the prevalence, significance for treatment and prognosis and the mechanisms involved remain poorly under...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,评审
doi：10.1007/s00406-004-0539-5
更新日期：2005-08-01 00:00:00
abstract：:The conceptualization of rapidly cycling bipolar disorder remains controversial. The DSM-IV definition of rapid cycling, although very reliable, may be not sufficiently inclusive (i.e., it may exclude patients with very short episodes of very high frequency, who are very typical in terms of external validators, and ar...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/BF03035130
更新日期：2001-01-01 00:00:00
abstract：:The National Institute on Aging-Alzheimer's Association (NIA-AA) clinical research criteria for mild cognitive impairment (MCI) due to Alzheimer's disease (AD) incorporate the use of biomarkers to classify patients according to the likelihood of the presence of AD pathology. The aim of the study was to compare the ris...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-012-0349-0
更新日期：2013-06-01 00:00:00
