Abstract:
:The objective of the study is to compare schizophrenic inpatients under antipsychotic monotherapy regarding simulated driving behaviour and psychomotor functions related to driving ability. Schizophrenic inpatients (n = 80) were tested before discharge to outpatient treatment. Data were collected with the computerized Act & React Testsystem and the Wiener Testsystem measuring visual perception, reaction time, attention, vigilance and stress-tolerance. Besides, patients underwent various driving simulations on a static driving simulator (FT-SR 200). Before discharge to outpatient treatment, about 25% of schizophrenic patients must be considered as severely impaired with respect to driving skills. Differences between treatment groups could be shown both in psychomotor measures and in driving simulator performance with a better test performance of patients treated with atypical antipsychotics. Controlling for age, psychopathologic symptoms and extrapyramidal signs, differences in psychomotor measures were most pronounced in concentration and vigilance. As mental disorders itself pose an increased risk of accidents, counselling patients with respect to differential effects of antipsychotic treatment is of great relevance. In addition to psychomotor tests computer-simulated driving seems to be a useful tool in assessing traffic safety under pharmacologic treatment.
journal_name
Eur Arch Psychiatry Clin Neurosciauthors
Brunnauer A,Laux G,Zwick Sdoi
10.1007/s00406-009-0014-4subject
Has Abstractpub_date
2009-12-01 00:00:00pages
483-9issue
8eissn
0940-1334issn
1433-8491journal_volume
259pub_type
临床试验,杂志文章abstract::Deficits in task-related attentional engagement in attention-deficit/hyperactivity disorder (ADHD) have been hypothesised to be due to altered interrelationships between attention, default mode and salience networks. We examined the intrinsic connectivity during rest within and between these networks. Six-minute resti...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-015-0630-0
更新日期:2016-06-01 00:00:00
abstract::Gamma oscillations are key in coordinating brain activity and seem to be altered in schizophrenia. In previous work, we studied the spatial distribution of a noise power measure (scalp-recorded electroencephalographic activity unlocked to stimuli) and found higher magnitudes in the gamma band related to symptoms and c...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-016-0673-x
更新日期:2016-12-01 00:00:00
abstract::Impairments in emotion recognition and psychosocial functioning are a robust phenomenon in schizophrenia and may affect motivational behavior, particularly during socio-emotional interactions. To characterize potential deficits and their interplay, we assessed social motivation covering various facets, such as implici...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-015-0589-x
更新日期:2015-10-01 00:00:00
abstract::A follow-up and family study was carried out of 16 first episode, DSM-III-R schizophreniform disorder patients with good prognostic features. Mean length of follow-up was 52.3 months. It was found that 62.5% had affective episodes, 31.2% had schizophreniform episodes. No case of schizophrenia was observed. Outcome was...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/BF02191558
更新日期:1992-01-01 00:00:00
abstract::The diagnosis of muscle cramp is based on clinical features. Algorithms are presented for the diagnosis of muscle cramp and cramp syndromes. ...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章,评审
doi:10.1007/BF02191149
更新日期:1991-01-01 00:00:00
abstract::The relationship between cannabis and cognitive performance is controversial. While both acute administration and long-term cannabis use impair cognitive performance in healthy subjects, several studies have shown improved cognitive outcomes in patients with schizophrenia spectrum disorders who use cannabis. The aim o...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-013-0404-5
更新日期:2013-12-01 00:00:00
abstract::This study concerns the validation of an instrument, the SAB2, designed to measure child behaviour and to help identify emotional problems which arise because the child has been a victim of child sexual abuse. Clinically disturbed children, mainstream school children and sexually abused youngsters were assessed. Relia...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/BF02916247
更新日期:1997-01-01 00:00:00
abstract::Alzheimer's disease (AD) is characterized neuropathologically by the presence of amyloid plaques, neuritic plaques, and neurofibrillary tangles (NFTs). These lesions occur not only in demented individuals with AD but also in non-demented persons. In non-demented individuals, amyloid and neuritic plaques are usually ac...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-013-0449-5
更新日期:2013-11-01 00:00:00
abstract::The transcription nuclear factor-erythroid factor 2-related factor 2 (Nrf2) plays a key role in inflammation that is involved in depression. We previously reported that Nrf2 knock-out (KO) mice exhibit depression-like phenotypes through systemic inflammation. (R)-ketamine, an enantiomer of ketamine, has rapid-acting a...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-020-01208-w
更新日期:2020-11-12 00:00:00
abstract::Although classical and atypical antipsychotics may have different neurotoxic effects, their underlying mechanisms remain to be elucidated, especially regarding neuroglial function. In the present study, we compared the atypical antipsychotic risperidone (0.01-10 μM) with the typical antipsychotic haloperidol (0.01-10 ...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-009-0095-0
更新日期:2010-09-01 00:00:00
abstract::Nocturnal sleep was studied in 14 human immunodeficiency virus (HIV)-positive patients without opportunistic infections of the central nervous system. Seven patients had no bodily complaints at the time of the investigation. Patients exhibited an impaired nocturnal sleep with longer sleep onset latency, reduced total ...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/BF02190756
更新日期:1991-01-01 00:00:00
abstract::The excitatory amino acid glutamate plays an important role in the mammalian CNS. Studies conducted from 1940 to 1950 suggested that oral administration of glutamate could have a beneficial effect on normal and retardate intelligence. The neurotoxic nature of glutamate resulting in excitotoxic lesions (neuronal death)...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章,评审
doi:10.1007/BF02189982
更新日期:1990-01-01 00:00:00
abstract::Attention deficit and hyperactivity disorder (ADHD) is a prevalent childhood disorder that is often maintained throughout the development and persists into adulthood. Established etiology models suggest that deficient inhibition underlies the core ADHD symptoms. While experimental evidence for impaired motor inhibitio...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-017-0790-1
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Only few studies have investigated executive impairment in the euthymic phase of unipolar affective disorders, yielding diverging results. The role of impulsivity/orbitofrontal associated executive functioning in remitted depression has not yet been examined. METHODS:Partly remitted male out-patients (n = 1...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-007-0740-4
更新日期:2007-10-01 00:00:00
abstract::In this review, we discuss current structural and functional imaging data on ADHD in a neurological and neuroanatomical framework. At present, the literature on adult ADHD is somewhat sparse, and so results from imaging have to therefore be considered mainly from the childhood or adolescence perspective. Most work has...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章,评审
doi:10.1007/s00406-006-1005-3
更新日期:2006-09-01 00:00:00
abstract::Some studies suggest seasonality of suicide attempts in females, but not in males. The reasons for this gender difference remain unclear. Only few studies addressed the question whether gender differences in seasonality of suicide attempts reflect gender differences in the choice of method for suicide attempts, with i...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-009-0086-1
更新日期:2010-08-01 00:00:00
abstract:PURPOSE:Mental health is one of the priorities of the European Commission. Studies of the use and cost of mental health facilities are needed in order to improve the planning and efficiey of mental health resources. We analyze the patterns of mental health service use in multiple clinical settings to identify factors a...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-007-0763-x
更新日期:2008-03-01 00:00:00
abstract::The aim of this study was to reexamine and compare the characteristics of the deficit and nondeficit schizophrenic patients. This cross-sectional study consisted of 62 in- and out-patients, 18-65 years of age, diagnosed with schizophrenia according to DSM-IV. The sociodemographic variables, premorbid adjustment, clini...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-003-0434-5
更新日期:2003-10-01 00:00:00
abstract::Three groups of married women were studied with each defined by their experience of a different stressful incident (the target event). In the first (the Coronary Group), the husband had suffered a non-fatal myocardial infarction whilst in the second (the Bereaved Group), he had recently died. In the third (the Refuge ...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/BF02189968
更新日期:1993-01-01 00:00:00
abstract::Family history and psychosocial background factors were studied in married patients with a DSM-III diagnosis of schizoaffective disorder (n = 17, partners n = 16), married patients with diabetes (n = 10, partners n = 10) and married healthy individuals (n = 8, partners n = 8). The two latter groups were comparison con...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/BF02188956
更新日期:1996-01-01 00:00:00
abstract::Although the Bonn Scale for the Assessment of Basic Symptoms (BSABS) [13] has come into use in several European countries, its diagnostic validity has not yet been sufficiently examined. That is why we have assessed BSABS items on a sample of 243 consecutive admissions to the Department of Psychiatry at the RWTH Unive...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 临床试验,杂志文章
doi:10.1007/BF02189116
更新日期:1996-01-01 00:00:00
abstract::Eating disorders and, in particular, anorexia nervosa (AN) have morbidity and mortality rates that are among the highest of any mental disorders and are associated with significant functional impairment. More than 25 years ago, several researchers hypothesised that the prerequisite for the development of AN was a fami...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章,评审
doi:10.1007/s00406-011-0246-y
更新日期:2011-11-01 00:00:00
abstract::Various factors contribute to the development and maintenance of delusions in the context of schizophrenic psychoses. Studies with functional and structural MRI were able to detect neurobiological correlates of paranoid symptoms. Consistent with the neurodevelopmental hypothesis of schizophrenic psychosis, which impli...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章,评审
doi:10.1007/s00406-008-5008-0
更新日期:2008-11-01 00:00:00
abstract::Two sisters with muscular dystrophy of Becker-like clinical features presented. Muscle weakness was most prominent in the pelvic girdle, but in the elder sister the distal muscles of the lower extremities were also affected. The progression was different in the siblings: The older sister showed a more pronounced deter...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/BF02191875
更新日期:1995-01-01 00:00:00
abstract::Astrocytes are the most numerous cell type within the central nervous system. Early during development they act as guiding structures for migratory neurons; later they are not only the main source for nutrients and growth factors in the brain, but they are also communication partners of neighboring neurons. For this p...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章,评审
doi:10.1007/s004060170036
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVE:Several predictors of Alzheimer's disease (AD) have been identified. However, the relevance and independent contribution of risk factors and of possible early signs such as mild cognitive impairment and subjective memory impairment on the development of AD has not been investigated prospectively in a cohort o...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-005-0596-4
更新日期:2006-02-01 00:00:00
abstract::MAOA and, to a lesser extent, MAOB polymorphisms have been related to aggression traits and suicidality. We aimed to investigate the role of MAOA and MAOB in suicidal versus non-suicidal participants and interactions between genetic variation and suicidal status on aggression and anger-related traits. The sample was c...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-012-0378-8
更新日期:2013-08-01 00:00:00
abstract::Childhood maltreatment and low socioeconomic status (SES) are considered stressful environmental events with lasting detrimental effects on adult mental health and associated cognitive performance, such as memory. However, the association between childhood maltreatment and low SES remains unclear, probably due to desi...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-012-0382-z
更新日期:2013-08-01 00:00:00
abstract::As a result of the multifactorial etiopathology of schizophrenia, a treatment strategy combining drug therapy with psychosocial measures is indicated. Depending on the stage of the disease and on the individual condition of the patient, the accent is set alternatively more on one approach or on the other. However, und...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章,评审
doi:10.1007/BF02190273
更新日期:1996-01-01 00:00:00
abstract::Obstetric complications play a role in the pathophysiology of schizophrenia. However, the biological consequences during neurodevelopment until adulthood are unknown. Microarrays have been used for expression profiling in four brain regions of a rat model of neonatal hypoxia as a common factor of obstetric complicatio...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-010-0159-1
更新日期:2010-11-01 00:00:00