Sleep homeostasis in alcohol-dependent, depressed and healthy control men.

Abstract:

:Visually scored and power spectral analyses (PSA) of polysomnography (PSG) recordings reveal abnormalities in alcohol dependence (AD) and major depressive disorder (MDD), including deficiencies in slow wave activity (SWA) during non-rapid eye movement (NREM) sleep. SWA parameters reflect the integrity of the homeostatic sleep drive, which have not been compared in those with AD or MDD. Ten men with AD were compared with 10 men with MDD and 10 healthy controls (HCs), all aged 20-40 years. They maintained an 11 pm to 6 am sleep schedule for 5-7 days, followed by 3 consecutive nights of PSG in the laboratory: night 1 for adaptation/screening; night 2 for baseline recordings; and night 3 as the challenge night, delaying sleep until 2 am. SWA was quantified with PSA across 4 NREM periods. Men with AD generated the least SWA at baseline. In response to sleep delay, HC men showed the expected SWA enhancement and a sharper exponential decline across NREM periods. Both the MDD and the AD groups showed a significantly blunted SWA response to sleep delay. Men with MDD had the least SWA in the first NREM period (impaired accumulation of sleep drive), whereas men with AD had the slowest SWA decay rate (impaired dissipation of sleep drive). These results suggest that both SWA generation and its homeostatic regulation are impaired in men with either AD or MDD. Finding interventions that selectively improve these different components of sleep homeostasis should be a goal of treatment for AD and MDD.

authors

Brower KJ,Hoffmann R,Conroy DA,Arnedt JT,Armitage R

doi

10.1007/s00406-011-0195-5

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

559-66

issue

8

eissn

0940-1334

issn

1433-8491

journal_volume

261

pub_type

杂志文章
  • Perception and evaluation of women's bodies in adolescents and adults with anorexia nervosa.

    abstract::Body image disturbance in anorexia nervosa (AN) has been widely studied with regard to the patient's own body, but little is known about perception of or attitude towards other women's bodies in AN. The aim of the present study was to investigate how 20 girls aged 12-18 years and 19 adult women suffering from AN compa...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-015-0603-3

    authors: Horndasch S,Heinrich H,Kratz O,Mai S,Graap H,Moll GH

    更新日期:2015-12-01 00:00:00

  • Cannabis use influence on peripheral brain-derived neurotrophic factor levels in antipsychotic-naïve first-episode psychosis.

    abstract::The objective of this study is to determine whether cannabis influences BDNF levels in patients with psychosis (FEP) and healthy volunteers (HV) to help understand the role of BDNF in psychosis. We assessed the association between BDNF and cannabis in a cohort of FEP antipsychotic-naïve patients and HV, whilst control...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-020-01117-y

    authors: Toll A,Bergé D,Burling K,Scoriels L,Treen D,Monserrat C,Marmol F,Duran X,Jones PB,Pérez-Solà V,Fernandez-Egea E,Mané A

    更新日期:2020-10-01 00:00:00

  • Identification of items which predict later development of depression in primary health care.

    abstract::To improve recognition and treatment of depression in primary care it would be advantageous to have criteria for identification of later depression. Only a few studies were performed on primary care samples to examine risk factors for new depressive episodes. These were mostly cross-sectional and did not include psych...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/BF03035122

    authors: Barkow K,Heun R,Ustün TB,Maier W

    更新日期:2001-01-01 00:00:00

  • Binocular rivalry transitions predict inattention symptom severity in adult ADHD.

    abstract::Attention deficit and hyperactivity disorder (ADHD) is a prevalent childhood disorder that is often maintained throughout the development and persists into adulthood. Established etiology models suggest that deficient inhibition underlies the core ADHD symptoms. While experimental evidence for impaired motor inhibitio...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-017-0790-1

    authors: Jusyte A,Zaretskaya N,Höhnle NM,Bartels A,Schönenberg M

    更新日期:2018-06-01 00:00:00

  • Surface morphology of the orbitofrontal cortex in individuals at risk of psychosis: a multicenter study.

    abstract::Changes in the surface morphology of the orbitofrontal cortex (OFC), such as a fewer orbital sulci and altered sulcogyral pattern of the 'H-shaped' orbital sulcus, have been reported in schizophrenia, possibly reflecting abnormal neurodevelopment during gestation. However, whether high-risk subjects for developing psy...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00406-018-0890-6

    authors: Nakamura M,Takahashi T,Takayanagi Y,Sasabayashi D,Katagiri N,Sakuma A,Obara C,Koike S,Yamasue H,Furuichi A,Kido M,Nishikawa Y,Noguchi K,Matsumoto K,Mizuno M,Kasai K,Suzuki M

    更新日期:2019-06-01 00:00:00

  • Diagnosis and treatment of rapidly cycling bipolar disorder.

    abstract::The conceptualization of rapidly cycling bipolar disorder remains controversial. The DSM-IV definition of rapid cycling, although very reliable, may be not sufficiently inclusive (i.e., it may exclude patients with very short episodes of very high frequency, who are very typical in terms of external validators, and ar...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/BF03035130

    authors: Maj M

    更新日期:2001-01-01 00:00:00

  • The National Institute on Aging-Alzheimer's Association research criteria for mild cognitive impairment due to Alzheimer's disease: predicting the outcome.

    abstract::The National Institute on Aging-Alzheimer's Association (NIA-AA) clinical research criteria for mild cognitive impairment (MCI) due to Alzheimer's disease (AD) incorporate the use of biomarkers to classify patients according to the likelihood of the presence of AD pathology. The aim of the study was to compare the ris...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-012-0349-0

    authors: Guo LH,Alexopoulos P,Eisele T,Wagenpfeil S,Kurz A,Perneczky R

    更新日期:2013-06-01 00:00:00

  • Early traumatic life events, parental rearing styles, family history of mental disorders, and birth risk factors in patients with social anxiety disorder.

    abstract:OBJECTIVE:Childhood traumatic experiences, rearing styles, familial mental disorders and birth risk factors have been associated with the development of social anxiety disorder. METHOD:Patients with social anxiety disorder (n=50) and healthy controls (n=120) were investigated using a retrospective interview with 203 q...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-004-0521-2

    authors: Bandelow B,Charimo Torrente A,Wedekind D,Broocks A,Hajak G,Rüther E

    更新日期:2004-12-01 00:00:00

  • A 10-year matched-pairs study comparing azathioprine and no immunosuppression in multiple sclerosis.

    abstract::In a retrospective matched-pairs study the efficacy of azathioprine treatment was compared with no treatment over a period of at least 10 years. Of 277 patients with clinically definite multiple sclerosis seen during the years 1973 and 1974, 42 pairs were selected by similarity in disability score, sex, age and diseas...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/BF02190090

    authors: Kappos L,Heun R,Mertens HG

    更新日期:1990-01-01 00:00:00

  • Effects of atypical (risperidone) and typical (haloperidol) antipsychotic agents on astroglial functions.

    abstract::Although classical and atypical antipsychotics may have different neurotoxic effects, their underlying mechanisms remain to be elucidated, especially regarding neuroglial function. In the present study, we compared the atypical antipsychotic risperidone (0.01-10 μM) with the typical antipsychotic haloperidol (0.01-10 ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-009-0095-0

    authors: Quincozes-Santos A,Bobermin LD,Tonial RP,Bambini-Junior V,Riesgo R,Gottfried C

    更新日期:2010-09-01 00:00:00

  • Remitted schizophrenia-spectrum patients with spared working memory show information processing abnormalities.

    abstract::Working memory and information processing abnormalities are often reported in schizophrenia. The aim of this study was to examine visual backward masking (BM) functions in remitted schizophrenia-spectrum patients with spared working memory functions. Seventy-two patients with DSM-IV schizophrenia-spectrum disorders we...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s004060170054

    authors: Kéri S,Szendi I,Kelemen O,Benedek G,Janka Z

    更新日期:2001-01-01 00:00:00

  • The neural correlates of ego-disturbances (passivity phenomena) and formal thought disorder in schizophrenia.

    abstract::Ego-disturbances (passivity phenomena) and formal thought disorder are two hallmark symptoms of schizophrenia. Formal thought disorder has been highlighted already very early by Eugen Bleuler in his concept of basic symptoms (Grundsymptome). In contrast ego-disturbances (Ich-Störungen) or passivity phenomena have been...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,评审

    doi:10.1007/s00406-008-5017-z

    authors: Leube D,Whitney C,Kircher T

    更新日期:2008-11-01 00:00:00

  • Early-onset Alzheimer's disease due to mutations of the presenilin-1 gene on chromosome 14: a 7-year follow-up of a patient with a mutation at codon 139.

    abstract::Mutations in the presenilin-1 gene (PS-1 gene) on chromosome 14 have recently been identified as a cause of familial early-onset Alzheimer's disease (EOAD). To our knowledge, only two German EOAD patients with mutations in the PS-1 gene have been identified thus far. Herein we report the case of a German EOAD patient ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s004060050028

    authors: Hüll M,Fiebich BL,Dykierek P,Schmidtke K,Nitzsche E,Orszagh M,Deuschl G,Moser E,Schumacher M,Lücking C,Berger M,Bauer J

    更新日期:1998-01-01 00:00:00

  • Anatomical and functional brain imaging in adult attention-deficit/hyperactivity disorder (ADHD)--a neurological view.

    abstract::In this review, we discuss current structural and functional imaging data on ADHD in a neurological and neuroanatomical framework. At present, the literature on adult ADHD is somewhat sparse, and so results from imaging have to therefore be considered mainly from the childhood or adolescence perspective. Most work has...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,评审

    doi:10.1007/s00406-006-1005-3

    authors: Schneider M,Retz W,Coogan A,Thome J,Rösler M

    更新日期:2006-09-01 00:00:00

  • Periodic limb movements during sleep in alcohol dependent patients.

    abstract::Complaints of sleep disturbances are common among alcohol dependent patients during subacute abstinence. Recovered patients may show persistent sleep abnormalities for months or even years. In the present study we studied the issue whether periodic limb movements in sleep and disturbances of nocturnal respiration are ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-002-0371-8

    authors: Gann H,Feige B,Fasihi S,van Calker D,Voderholzer U,Riemann D

    更新日期:2002-06-01 00:00:00

  • Cannabinoids and glial cells: possible mechanism to understand schizophrenia.

    abstract::Clinical and neurobiological findings have reported the involvement of endocannabinoid signaling in the pathophysiology of schizophrenia. This system modulates dopaminergic and glutamatergic neurotransmission that is associated with positive, negative, and cognitive symptoms of schizophrenia. Despite neurotransmitter ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,评审

    doi:10.1007/s00406-018-0874-6

    authors: de Almeida V,Martins-de-Souza D

    更新日期:2018-10-01 00:00:00

  • Intoxicated persons showing challenging behavior demand complexity interventions: a pilot study at the interface of the ER and the complexity intervention unit.

    abstract::Intoxicated persons showing challenging behavior (IPCBs) under influence of alcohol and/or drugs frequently have trouble finding appropriate acute care. Often IPCBs are stigmatized being unwilling or unable to accept help. Separated physical and mental healthcare systems hamper integrated acute care for IPCBs. This pi...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-020-01162-7

    authors: Verheesen SMH,Ten Doesschate F,van Schijndel MA,van der Gaag RJ,Cahn W,van Waarde JA

    更新日期:2020-07-12 00:00:00

  • Expressed and perceived emotion over time: does the patients' view matter for the caregivers' burden?

    abstract::While the impact of mentally ill patients' perceptions of their key relatives' expressed emotion is well examined with regard to relapse, there is a paucity of evidence concerning the impact on their key relatives' burden. The present study aims to evaluate the relative prognostic value of expressed and perceived emot...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-010-0178-y

    authors: Möller-Leimkühler AM,Jandl M

    更新日期:2011-08-01 00:00:00

  • The impact of emotional faces on social motivation in schizophrenia.

    abstract::Impairments in emotion recognition and psychosocial functioning are a robust phenomenon in schizophrenia and may affect motivational behavior, particularly during socio-emotional interactions. To characterize potential deficits and their interplay, we assessed social motivation covering various facets, such as implici...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-015-0589-x

    authors: Radke S,Pfersmann V,Derntl B

    更新日期:2015-10-01 00:00:00

  • Facial expressivity in the course of schizophrenia and depression.

    abstract::This study investigates the nosological specificity and time stability of reduced facial expressivity in schizophrenia by means of objective measurement. Facial expression in an emotional interview was evaluated using the "Facial Action Coding System" in 33 acute schizophrenia patients and 23 acute depressive patients...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-004-0510-5

    authors: Gaebel W,Wölwer W

    更新日期:2004-10-01 00:00:00

  • Overactive performance monitoring in obsessive-compulsive disorder is independent of symptom expression.

    abstract::Overactive performance monitoring has been consistently reported in obsessive-compulsive disorder (OCD). OCD is a clinically heterogeneous disorder and is characterized by several symptom dimensions that may have partially distinct neural correlates. We examined whether performance-monitoring alterations are related t...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-014-0499-3

    authors: Riesel A,Kathmann N,Endrass T

    更新日期:2014-12-01 00:00:00

  • The association of GABRB2 SNPs with cognitive function in schizophrenia.

    abstract::Cognitive impairment is one of the core symptoms of schizophrenia. Multiple domains of cognition are affected in patients with schizophrenia, which has a major effect on the functional outcome. Recent studies indicate that SNPs in the gamma-aminobutyric acid type A receptor beta 2 subunit (GABRB2) gene are associated ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-019-00985-3

    authors: Zhang Q,Zhang X,Song S,Wang S,Wang X,Yu H,Han H,Zhou X,Li G,Wu Y

    更新日期:2020-06-01 00:00:00

  • Apparent motion perception in patients with paranoid schizophrenia.

    abstract::Impaired perceptual inference has been suggested to be at the core of positive symptoms in schizophrenia. Apparent motion (AM) is a visual illusion in which perceptual inference gives rise to the experience of a single object moving back and forth when two spatially separated objects are flashed in alternation. Here, ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-012-0344-5

    authors: Sanders LL,de Millas W,Heinz A,Kathmann N,Sterzer P

    更新日期:2013-04-01 00:00:00

  • The cognitive, affective motivational and clinical longitudinal determinants of apathy in schizophrenia.

    abstract::Apathy is a frequent and debilitating condition with few treatment options available in schizophrenia patients. Despite evidence of its multidimensional structure, most of past studies have explored apathy through a categorical approach. The main objective of this study was to identify the cognitive, emotional, motiva...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-018-0907-1

    authors: Raffard S,Bortolon C,Yazbek H,Lançon C,Benoit M,Norton J,Capdevielle D

    更新日期:2019-12-01 00:00:00

  • Psychopathology in dual diagnosis and non-addicted schizophrenics--are there differences?

    abstract::In a previous publication we reported lifetime and 3-month prevalence estimates for substance use in two large samples of schizophrenic inpatients (Soyka et al. 1993). A subsequent analysis of psychopathological findings assessed by means of the AMDP Manual (Guy and Ban 1982) in schizophrenic in-patients of the Haar M...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s004060170032

    authors: Soyka M,Albus M,Immler B,Kathmann N,Hippius H

    更新日期:2001-10-01 00:00:00

  • Diagnosis and six-month stability of negative symptoms in psychotic disorders.

    abstract::Negative symptoms were examined in 150 primarily first-admission patients diagnosed with schizophrenia, schizoaffective disorder, psychotic depression, psychotic bipolar disorder, and 'other' psychoses. The analysis focused on patients who were rated on the Scale for the Assessment of Negative Symptoms (SANS) within 4...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02274895

    authors: Fennig S,Bromet EJ,Galambos N,Putnam K

    更新日期:1996-01-01 00:00:00

  • Human CLOCK gene-associated attention deficit hyperactivity disorder-related features in healthy adults: quantitative association study using Wender Utah Rating Scale.

    abstract::Circadian rhythm disturbance is highly prevalent in attention deficit hyperactivity disorder (ADHD). Recently, the association between the CLOCK gene and ADHD has been demonstrated in clinical samples, and the CLOCK gene's role was thought to be mediated by rhythm dysregulation. Meanwhile, ADHD has been suggested as t...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-013-0443-y

    authors: Jeong SH,Yu JC,Lee CH,Choi KS,Choi JE,Kim SH,Joo EJ

    更新日期:2014-02-01 00:00:00

  • Kraepelin and modern psychiatry.

    abstract::A summarised account is given of Emil Kraepelin's research in the field of mental disorder, underlining his emphasis on objectivity and natural science and the need for a multi-disciplinary approach. At the same time attention is drawn to the limitations of his general outlook and to his political views, which in thei...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 传,历史文章,杂志文章

    doi:10.1007/BF02191796

    authors: Shepherd M

    更新日期:1995-01-01 00:00:00

  • Substance P-like immunoreactivity and somatostatin-like immunoreactivity in the ventricular fluid of patients with chronic pain syndromes.

    abstract::Substance P-like and somatostatin-like immunoreactivities (SPLI and SLI) were determined in ventricular fluid of patients with chronic pain syndromes and in a comparison group with multiple sclerosis, essential tremor, epilepsy and postanoxic myoclonus. Concentrations of SPLI and SLI were non-significantly decreased b...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/BF02191152

    authors: Jost S,Reuner C,Geiger J,Mohadjer M,Milios E,Cramer H

    更新日期:1991-01-01 00:00:00

  • Exploring deficient emotion regulation in adult ADHD: electrophysiological evidence.

    abstract::Emotional dysregulation (ED) is being increasingly recognized as a core feature of attention-deficit/hyperactivity disorder (ADHD), but the pathophysiological underpinnings remain unclear. In this study, we provide meaningful electrophysiological evidence of ED in adult patients with ADHD (n = 39) compared to healthy ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-017-0826-6

    authors: Shushakova A,Ohrmann P,Pedersen A

    更新日期:2018-06-01 00:00:00