Sleep homeostasis in alcohol-dependent, depressed and healthy control men.

Abstract:

:Visually scored and power spectral analyses (PSA) of polysomnography (PSG) recordings reveal abnormalities in alcohol dependence (AD) and major depressive disorder (MDD), including deficiencies in slow wave activity (SWA) during non-rapid eye movement (NREM) sleep. SWA parameters reflect the integrity of the homeostatic sleep drive, which have not been compared in those with AD or MDD. Ten men with AD were compared with 10 men with MDD and 10 healthy controls (HCs), all aged 20-40 years. They maintained an 11 pm to 6 am sleep schedule for 5-7 days, followed by 3 consecutive nights of PSG in the laboratory: night 1 for adaptation/screening; night 2 for baseline recordings; and night 3 as the challenge night, delaying sleep until 2 am. SWA was quantified with PSA across 4 NREM periods. Men with AD generated the least SWA at baseline. In response to sleep delay, HC men showed the expected SWA enhancement and a sharper exponential decline across NREM periods. Both the MDD and the AD groups showed a significantly blunted SWA response to sleep delay. Men with MDD had the least SWA in the first NREM period (impaired accumulation of sleep drive), whereas men with AD had the slowest SWA decay rate (impaired dissipation of sleep drive). These results suggest that both SWA generation and its homeostatic regulation are impaired in men with either AD or MDD. Finding interventions that selectively improve these different components of sleep homeostasis should be a goal of treatment for AD and MDD.

authors

Brower KJ,Hoffmann R,Conroy DA,Arnedt JT,Armitage R

doi

10.1007/s00406-011-0195-5

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

559-66

issue

8

eissn

0940-1334

issn

1433-8491

journal_volume

261

pub_type

杂志文章
  • The relation between sleep and pain among a non-clinical sample of young adults.

    abstract::Poor sleep is linked to poorer daily functioning and increased risk of psychiatric symptoms. With respect to pain, the relation is bi-directional; poor sleep exacerbates pain, while greater pain adversely affects sleep. Moreover, perception of pain is subject to cognitive-emotional processes. Surprisingly, no data are...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-010-0113-2

    authors: Brand S,Gerber M,Pühse U,Holsboer-Trachsler E

    更新日期:2010-10-01 00:00:00

  • Kynurenine pathway and white matter microstructure in bipolar disorder.

    abstract::Decreased availability of serotonin in the central nervous system has been suggested to be a central factor in the pathogenesis of depression. Activation of indoleamine 2-3 dioxygenase following a pro-inflammatory state could reduce the amount of tryptophan converted to serotonin and increase the production of tryptop...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-016-0731-4

    authors: Poletti S,Myint AM,Schüetze G,Bollettini I,Mazza E,Grillitsch D,Locatelli C,Schwarz M,Colombo C,Benedetti F

    更新日期:2018-03-01 00:00:00

  • The association of GABRB2 SNPs with cognitive function in schizophrenia.

    abstract::Cognitive impairment is one of the core symptoms of schizophrenia. Multiple domains of cognition are affected in patients with schizophrenia, which has a major effect on the functional outcome. Recent studies indicate that SNPs in the gamma-aminobutyric acid type A receptor beta 2 subunit (GABRB2) gene are associated ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-019-00985-3

    authors: Zhang Q,Zhang X,Song S,Wang S,Wang X,Yu H,Han H,Zhou X,Li G,Wu Y

    更新日期:2020-06-01 00:00:00

  • Mental health care in Germany: current state and trends.

    abstract::Germany turned towards community-based mental health care in the mid seventies, during a general climate of social and political reform. The continuing deinstitutionalisation process and the implementation of community mental health services was considerably affected by the reunification of East and West Germany in 19...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,评审

    doi:10.1007/s00406-006-0696-9

    authors: Salize HJ,Rössler W,Becker T

    更新日期:2007-03-01 00:00:00

  • Increased plasma levels of soluble TNF receptor I in patients with bipolar disorder.

    abstract::Bipolar disorder (BD) has been associated with a proinflammatory state in which TNF-α seems to play a relevant role. The aim of the present study was to evaluate the plasma levels of TNF-α and its soluble receptors (sTNFR1 and sTNFR2) in BD patients in mania and euthymia in comparison with control subjects. We evaluat...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-010-0116-z

    authors: Barbosa IG,Huguet RB,Mendonça VA,Sousa LP,Neves FS,Bauer ME,Teixeira AL

    更新日期:2011-03-01 00:00:00

  • Pathology of clinical and preclinical Alzheimer's disease.

    abstract::Alzheimer's disease (AD) is characterized neuropathologically by the presence of amyloid plaques, neuritic plaques, and neurofibrillary tangles (NFTs). These lesions occur not only in demented individuals with AD but also in non-demented persons. In non-demented individuals, amyloid and neuritic plaques are usually ac...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-013-0449-5

    authors: Thal DR,von Arnim C,Griffin WS,Yamaguchi H,Mrak RE,Attems J,Upadhaya AR

    更新日期:2013-11-01 00:00:00

  • Binocular rivalry transitions predict inattention symptom severity in adult ADHD.

    abstract::Attention deficit and hyperactivity disorder (ADHD) is a prevalent childhood disorder that is often maintained throughout the development and persists into adulthood. Established etiology models suggest that deficient inhibition underlies the core ADHD symptoms. While experimental evidence for impaired motor inhibitio...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-017-0790-1

    authors: Jusyte A,Zaretskaya N,Höhnle NM,Bartels A,Schönenberg M

    更新日期:2018-06-01 00:00:00

  • Long-term plasma exchange in a case of Refsum's disease.

    abstract::Refsum's disease (Heredopathia atactica polyneuritiformis) is caused by accumulation of phytanic acid in all body tissues due to an inherited failure of alpha-oxidation of branched chain fatty acids. Plasmapheresis has been reported to be beneficial by removal of phytanic acid from the blood. We describe a patient wit...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/BF02191145

    authors: Leppert D,Schanz U,Burger J,Gmür J,Blau N,Waespe W

    更新日期:1991-01-01 00:00:00

  • Oxytocin modulates the effective connectivity between the precuneus and the dorsolateral prefrontal cortex.

    abstract::Our social activity is heavily influenced by the process of introspection, with emerging research suggesting a role for the Default Mode Network (DMN) in social cognition. We hypothesize that oxytocin, a neuropeptide with an important role in social behaviour, can effectively alter the connectivity of the DMN. We test...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-019-00989-z

    authors: Kumar J,Iwabuchi SJ,Völlm BA,Palaniyappan L

    更新日期:2020-08-01 00:00:00

  • The relationship between excitement symptom severity and extrastriatal dopamine D2/3 receptor availability in patients with schizophrenia: a high-resolution PET study with [18F]fallypride.

    abstract::The purpose of this study was to investigate the relationship between specific symptom severity and D2/3 receptor availability in extrastriatal regions in outpatients with schizophrenia to shed light on the role of extrastriatal dopaminergic neurotransmission in the pathophysiology of symptoms of schizophrenia. Sixtee...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-017-0821-y

    authors: Joo YH,Kim JH,Son YD,Kim HK,Shin YJ,Lee SY,Kim JH

    更新日期:2018-09-01 00:00:00

  • The National Institute on Aging-Alzheimer's Association research criteria for mild cognitive impairment due to Alzheimer's disease: predicting the outcome.

    abstract::The National Institute on Aging-Alzheimer's Association (NIA-AA) clinical research criteria for mild cognitive impairment (MCI) due to Alzheimer's disease (AD) incorporate the use of biomarkers to classify patients according to the likelihood of the presence of AD pathology. The aim of the study was to compare the ris...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-012-0349-0

    authors: Guo LH,Alexopoulos P,Eisele T,Wagenpfeil S,Kurz A,Perneczky R

    更新日期:2013-06-01 00:00:00

  • Increased cerebellar-default-mode network connectivity at rest in obsessive-compulsive disorder.

    abstract::Abnormalities of the cerebellum and default-mode network (DMN) in patients with obsessive-compulsive disorder (OCD) have been widely reported. However, alterations of reciprocal functional connections between the cerebellum and DMN at rest in OCD remain unclear. Forty patients with OCD and 38 gender-, age-, and educat...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-019-01070-5

    authors: Lv D,Ou Y,Chen Y,Yang R,Zhong Z,Jia C,Sun L,Wang Y,Zhang G,Sun Z,Wang W,Wang Y,Wang X,Guo W,Li P

    更新日期:2020-12-01 00:00:00

  • A systematic review of research findings on the efficacy of interpersonal therapy for depressive disorders.

    abstract:OBJECTIVE:Interpersonal psychotherapy (IPT) is a time-limited psychotherapy for major depression. The aim of this study is to summarize findings from controlled trials of the efficacy of IPT in the treatment of depressive spectrum disorders (DSD) using a meta-analytic approach. METHODS:Studies of randomized clinical t...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,评审

    doi:10.1007/s00406-004-0542-x

    authors: de Mello MF,de Jesus Mari J,Bacaltchuk J,Verdeli H,Neugebauer R

    更新日期:2005-04-01 00:00:00

  • Signs of rapidly progressive dementia in a case of intravascular lymphomatosis.

    abstract::Intravascular lymphomatosis (IVL), a rare type of non-Hodgkin's lymphoma, is an uncommon cause of progressive dementia, usually followed by death within a few months of onset of clinical disease. Often this aggressive tumor is only diagnosed at autopsy, because of misleading clinical features mimicking a broad spectru...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-004-0551-9

    authors: Albrecht R,Krebs B,Reusche E,Nagel M,Lencer R,Kretzschmar HA

    更新日期:2005-08-01 00:00:00

  • Diagnostic validity of basic symptoms.

    abstract::Although the Bonn Scale for the Assessment of Basic Symptoms (BSABS) [13] has come into use in several European countries, its diagnostic validity has not yet been sufficiently examined. That is why we have assessed BSABS items on a sample of 243 consecutive admissions to the Department of Psychiatry at the RWTH Unive...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02189116

    authors: Klosterkötter J,Ebel H,Schultze-Lutter F,Steinmeyer EM

    更新日期:1996-01-01 00:00:00

  • Cognitive predictors of skill acquisition on social problem solving in patients with schizophrenia.

    abstract::The aim of the study was to evaluate the relationship between social problem solving ability, clinical features and cognitive functions, and determine the predictors of benefit from social problem solving training in 63 patients with schizophrenia. We administered Brief Psychiatric Rating Scale (BPRS), Wisconsin Card ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00406-006-0651-9

    authors: Uçok A,Cakir S,Duman ZC,Dişcigil A,Kandemir P,Atli H

    更新日期:2006-09-01 00:00:00

  • Psychiatric morbidity among repatriated Greek migrants in a rural area.

    abstract::This paper reports on psychiatric case identification by the application of the Structured Clinical Interview for DSM-III-R (SCID) in a sample of 198 Greek migrants repatriated from western europe in a northwestern province of Greece. The current (1 month) prevalence of psychiatric morbidity, based on the total number...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF02191542

    authors: Bilanakis N,Madianos MG,Liakos A

    更新日期:1995-01-01 00:00:00

  • A follow-up and family study of DSM-III-R schizophreniform disorder with good prognostic features.

    abstract::A follow-up and family study was carried out of 16 first episode, DSM-III-R schizophreniform disorder patients with good prognostic features. Mean length of follow-up was 52.3 months. It was found that 62.5% had affective episodes, 31.2% had schizophreniform episodes. No case of schizophrenia was observed. Outcome was...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/BF02191558

    authors: Benazzi F,Mazzoli M,Rossi E

    更新日期:1992-01-01 00:00:00

  • Cerebral connectivity and psychotic personality traits. A diffusion tensor imaging study.

    abstract::This study aims to investigate the relationship between regional connectivity in the brain white matter and the presence of psychotic personality traits, in healthy subjects with psychotic traits. Thirteen healthy controls were administered the MMPI-2, to assess psychotic traits and, according to MMPI results, a dicho...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-007-0796-1

    authors: Volpe U,Federspiel A,Mucci A,Dierks T,Frank A,Wahlund LO,Galderisi S,Maj M

    更新日期:2008-08-01 00:00:00

  • Postmortem proteomic analysis in human amygdala of drug addicts: possible impact of tubulin on drug-abusing behavior.

    abstract::Besides the ventral tegmental area and the nucleus accumbens as the most investigated brain reward structures, several reports about the relation between volume and activity of the amygdala and drug-seeking behavior have emphasized the central role of the amygdala in the etiology of addiction. Considering its proposed...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-010-0129-7

    authors: Zill P,Vielsmeier V,Büttner A,Eisenmenger W,Siedler F,Scheffer B,Möller HJ,Bondy B

    更新日期:2011-03-01 00:00:00

  • "A stitch in time" ... the scope for preventive strategies in early psychosis.

    abstract::Preventive endeavours in psychotic disorders have been hampered by many obstacles over the past century. One important barrier has been the corrosive pessimism which has attached to the treatment prospects for schizophrenia in particular since the time of Kraepelin, and the isolation of this disorder from progressive ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,评审

    doi:10.1007/s004060050014

    authors: McGorry PD

    更新日期:1998-01-01 00:00:00

  • Facial expressivity in the course of schizophrenia and depression.

    abstract::This study investigates the nosological specificity and time stability of reduced facial expressivity in schizophrenia by means of objective measurement. Facial expression in an emotional interview was evaluated using the "Facial Action Coding System" in 33 acute schizophrenia patients and 23 acute depressive patients...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-004-0510-5

    authors: Gaebel W,Wölwer W

    更新日期:2004-10-01 00:00:00

  • Impairment of theory of mind in patients in remission following first episode of schizophrenia.

    abstract::The aim of this study was to investigate theory of mind (ToM) ability in patients in remission after the first episode of schizophrenia. A ToM task which contained four pictures was given to 30 patients with schizophrenia in remission and 30 matched healthy controls. Patients with schizophrenia in remission showed sta...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-006-0608-z

    authors: Inoue Y,Yamada K,Hirano M,Shinohara M,Tamaoki T,Iguchi H,Tonooka Y,Kanba S

    更新日期:2006-08-01 00:00:00

  • Evidence for separate diseases?: Stages of one disease or different combinations of symptom dimensions?

    abstract:OBJECTIVE:We tested Kraepelin's dichotomy model by studying the separability of schizophrenia and depression on the basis of symptoms and illness course. MATERIALS AND METHODS:Matched untreated patients with schizophrenia and depression (n = 130 each) and 130 "healthy" controls were assessed from onset to first admiss...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-008-2011-4

    authors: Häfner H,an der Heiden W,Maurer K

    更新日期:2008-06-01 00:00:00

  • Does prior traumatization affect the treatment outcome of CBT for panic disorder? The potential role of the MAOA gene and depression symptoms.

    abstract::Although cognitive behavioral therapy (CBT) is highly effective in the treatment of anxiety disorders, many patients still do not benefit. This study investigates whether a history of traumatic event experience is negatively associated with outcomes of CBT for panic disorder. The moderating role of the monoamine oxida...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00406-017-0823-9

    authors: Trautmann S,Richter J,Muehlhan M,Höfler M,Wittchen HU,Domschke K,Ströhle A,Hamm AO,Weber H,Kircher T,Arolt V,Gerlach AL,Alpers GW,Fydrich T,Lang T,Reif A

    更新日期:2019-03-01 00:00:00

  • Cerebral blood flow responses during prosaccade and antisaccade preparation in major depression.

    abstract::While impairments in executive functions have been well established in major depressive disorder (MDD), specific deficits in proactive control have scarcely been studied so far. Proactive control refers to cognitive processes during anticipation of a behaviorally relevant event that facilitate readiness to react. In t...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-018-0956-5

    authors: Hoffmann A,Ettinger U,Montoro C,Reyes Del Paso GA,Duschek S

    更新日期:2019-10-01 00:00:00

  • A pilot investigation of accelerated deep transcranial magnetic stimulation protocols in treatment-resistant depression.

    abstract::Accelerated repetitive transcranial magnetic stimulation (rTMS) protocols are being increasingly studied because of their potential to provide quicker and enhanced treatment efficacy. However, there is a lack of accelerated deep TMS with H1-coil (adTMS) treatment research. This randomized pilot study investigated the ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-020-01141-y

    authors: Filipčić I,Šimunović Filipčić I,Sučić S,Milovac Ž,Gereš N,Matić K,Čelić-Ružić M,Zečević Penić S,Orgulan I,Požgaj V,Bajić Ž

    更新日期:2020-05-24 00:00:00

  • Premenstrual dysphoric symptoms amongst Brazilian college students: factor structure and methodological appraisal.

    abstract:OBJECTIVES:The present study aims to assess the factor structure of the DSM-IV Premenstrual Dysphoric Disorder (PMDD) symptoms and its relationship with depressive symptoms. METHODS:We evaluated retrospectively PMDD symptoms in 513 female college students, through a self-reporting questionnaire based on DSM-IV criteri...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-004-0535-9

    authors: Teng CT,Filho AH,Artes R,Gorenstein C,Andrade LH,Wang YP

    更新日期:2005-02-01 00:00:00

  • Surface morphology of the orbitofrontal cortex in individuals at risk of psychosis: a multicenter study.

    abstract::Changes in the surface morphology of the orbitofrontal cortex (OFC), such as a fewer orbital sulci and altered sulcogyral pattern of the 'H-shaped' orbital sulcus, have been reported in schizophrenia, possibly reflecting abnormal neurodevelopment during gestation. However, whether high-risk subjects for developing psy...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00406-018-0890-6

    authors: Nakamura M,Takahashi T,Takayanagi Y,Sasabayashi D,Katagiri N,Sakuma A,Obara C,Koike S,Yamasue H,Furuichi A,Kido M,Nishikawa Y,Noguchi K,Matsumoto K,Mizuno M,Kasai K,Suzuki M

    更新日期:2019-06-01 00:00:00

  • The cognitive, affective motivational and clinical longitudinal determinants of apathy in schizophrenia.

    abstract::Apathy is a frequent and debilitating condition with few treatment options available in schizophrenia patients. Despite evidence of its multidimensional structure, most of past studies have explored apathy through a categorical approach. The main objective of this study was to identify the cognitive, emotional, motiva...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-018-0907-1

    authors: Raffard S,Bortolon C,Yazbek H,Lançon C,Benoit M,Norton J,Capdevielle D

    更新日期:2019-12-01 00:00:00