Repurposing of CNS drugs to treat COVID-19 infection: targeting the sigma-1 receptor.

abstract：:The aim of the study was to explore whether the individual burden of ADHD is the same in the elderly as in younger ages even though the symptomatological impact of ADHD seems to remain stable over the lifespan. To assess ADHD symptoms and ADHD-associated problems in daily life, standardised questionnaires were conduct...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Philipp-Wiegmann F,Retz-Junginger P,Retz W,Rösler M

更新日期：2016-06-01 00:00:00

abstract：:Despite clues indicating high Bullying at the Work Place (BWP) rates in French hospitals, there has been no quantitative study so far. To determine the prevalence of repeated BWP in a national sample of French young physicians; its risk factors, and the mental health consequences of BWP. The study is a cross-sectional...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Messiaen M,Duba A,Boulangeat C,Boucekine M,Bourbon A,Viprey M,Auquier P,Lançon C,Boyer L,Fond G

更新日期：2020-05-27 00:00:00

abstract：:The excitatory amino acid glutamate plays an important role in the mammalian CNS. Studies conducted from 1940 to 1950 suggested that oral administration of glutamate could have a beneficial effect on normal and retardate intelligence. The neurotoxic nature of glutamate resulting in excitotoxic lesions (neuronal death)...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Sahai S

更新日期：1990-01-01 00:00:00

abstract：:The National Institute on Aging-Alzheimer's Association (NIA-AA) clinical research criteria for mild cognitive impairment (MCI) due to Alzheimer's disease (AD) incorporate the use of biomarkers to classify patients according to the likelihood of the presence of AD pathology. The aim of the study was to compare the ris...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Guo LH,Alexopoulos P,Eisele T,Wagenpfeil S,Kurz A,Perneczky R

更新日期：2013-06-01 00:00:00

abstract：:Proof of efficacy of a psychotropic medicinal product is the key point of clinical psychopharmacology. This especially concerns the licensing of a new compound, but apart from this special case, lots of efficacy questions need to be answered in clinical psychopharmacology, such as, e.g. the question of the efficacy of...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Möller HJ,Broich K

更新日期：2010-02-01 00:00:00

abstract：:The aim of this study was to estimate the prevalence and incidence of mood disorders, anxiety disorders, and stress and adjustment disorders in primary health care in Sweden and to analyse the relationship between socioeconomic and demographic factors and incidence of these disorders. Prevalence and incidence data on ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Lejtzén N,Sundquist J,Sundquist K,Li X

更新日期：2014-04-01 00:00:00

abstract：:Affective and non-affective psychoses are severe and frequent psychiatric disorders. Amongst others, they not only have a profound impact on affected individuals through their symptomatology, but also regarding cognition, brain structure and function. Cognitive impairment influences patients' quality of life as well a...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Malchow B,Reich-Erkelenz D,Oertel-Knöchel V,Keller K,Hasan A,Schmitt A,Scheewe TW,Cahn W,Kahn RS,Falkai P

更新日期：2013-09-01 00:00:00

abstract：:The novel/atypical neuroleptics have proven to be effective in treating negative symptoms but although clinical experience appears to show that they have advantages over the traditional neuroleptics in treating negative symptoms, superiority has not always been statistically confirmed and the treatment results in indi...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Möller HJ

更新日期：2004-04-01 00:00:00

abstract：:A follow-up and family study was carried out of 16 first episode, DSM-III-R schizophreniform disorder patients with good prognostic features. Mean length of follow-up was 52.3 months. It was found that 62.5% had affective episodes, 31.2% had schizophreniform episodes. No case of schizophrenia was observed. Outcome was...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Benazzi F,Mazzoli M,Rossi E

更新日期：1992-01-01 00:00:00

abstract：:A study was carried out involving 134 neurotic-depressive inpatients (according to ICD-9) treated with cognitive behaviour therapy and in a subgroup additionally with antidepressants. Using standardized rating instruments, a large set of potential predictor variables was tested. After cross-validation according to the...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Möller HJ,Krokenberger M,von Zerssen D

更新日期：1993-01-01 00:00:00

abstract：:In the present study, quantitative EEG analysis was performed at rest and during 10 Hz photic stimulation in 14 drug-naive patients with first-episode paranoid schizophrenia and 20 sex- and age-matched control subjects. Compared with the normal controls, the patients had significantly lower alpha-2 band amplitude in t...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Wada Y,Takizawa Y,Kitazawa S,Jiang ZY,Yamaguchi N

更新日期：1994-01-01 00:00:00

abstract：:Poor sleep is linked to poorer daily functioning and increased risk of psychiatric symptoms. With respect to pain, the relation is bi-directional; poor sleep exacerbates pain, while greater pain adversely affects sleep. Moreover, perception of pain is subject to cognitive-emotional processes. Surprisingly, no data are...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Brand S,Gerber M,Pühse U,Holsboer-Trachsler E

更新日期：2010-10-01 00:00:00

abstract：:In electroconvulsive therapy (ECT), remifentanil is often used concurrently with anesthetics. The objective of this study was to provide an up-to-date and comprehensive review on how the addition of remifentanil to anesthetics affects seizure duration and circulatory dynamics in mECT. We performed a meta-analysis of R...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Takekita Y,Suwa T,Sunada N,Kawashima H,Fabbri C,Kato M,Tajika A,Kinoshita T,Furukawa TA,Serretti A

更新日期：2016-12-01 00:00:00

abstract：:Those who as adults will be admitted to a psychiatric ward with a psychotic illness can be distinguished (on the basis of group differences) from others by their behaviour and academic performance at the ages of 7 and 11 years. Pre-schizophrenic boys are anxious and hostile towards adults and peers at the age of 7 yea...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Crow TJ,Done DJ,Sacker A

更新日期：1995-01-01 00:00:00

abstract：:This report presents the rationale and design of a multi-center clinical trial that examines the efficacy and safety of antipsychotic combination treatment in acutely ill schizophrenia patients compared to antipsychotic monotherapy. Antipsychotic combination treatment is common in clinical practice worldwide, despite ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Schmidt-Kraepelin C,Feyerabend S,Engelke C,Riesbeck M,Meisenzahl-Lechner E,Gaebel W,Verde PE,Kolbe H,Correll CU,Leucht S,Heres S,Kluge M,Makiol C,Neff A,Lange C,Englisch S,Zink M,Langguth B,Poeppl T,Reske D,Gouzou

更新日期：2020-02-01 00:00:00

abstract：:Increases in seizure threshold (ST) over a course of brief pulse ECT can be predicted by decreases in EEG quality, informing ECT dose adjustment to maintain adequate supra-threshold dosing. ST increases also occur over a course of right unilateral ultrabrief (RUL UB) ECT, but no data exist on the relationship between ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Gálvez V,Hadzi-Pavlovic D,Waite S,Loo CK

更新日期：2017-12-01 00:00:00

abstract：:The impact of obsessive-compulsive symptoms on functioning in schizophrenia is still debated. This study investigated the relationship between OC symptoms and functioning along a severity gradient of obsessive-compulsive dimension. Sixty patients affected by schizophrenia completed the SCID-IV, the Positive and Negati...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Tonna M,Ottoni R,Paglia F,Ossola P,De Panfilis C,Marchesi C

更新日期：2016-02-01 00:00:00

abstract：:Advances in psychopathological research advocate a personality-centred model of common mental disorders (CMD). We tested four hypotheses to test such a model. First, personality relates to critical life events; second, both personality and critical life events relate to CMD; third, interaction effects between personal...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Hengartner MP,Tyrer P,Ajdacic-Gross V,Angst J,Rössler W

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:The prevalence and consequences of co-morbid axis-I and axis-II disorders as well as personality traits were examined in a large cohort of adult attention-deficit/hyperactivity disorder (AADHD) at a tertiary referral center. METHODS:In- and outpatients referred for diagnostic assessment of AADHD were screene...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Jacob CP,Romanos J,Dempfle A,Heine M,Windemuth-Kieselbach C,Kruse A,Reif A,Walitza S,Romanos M,Strobel A,Brocke B,Schäfer H,Schmidtke A,Böning J,Lesch KP

更新日期：2007-09-01 00:00:00

abstract：:The transcription nuclear factor-erythroid factor 2-related factor 2 (Nrf2) plays a key role in inflammation that is involved in depression. We previously reported that Nrf2 knock-out (KO) mice exhibit depression-like phenotypes through systemic inflammation. (R)-ketamine, an enantiomer of ketamine, has rapid-acting a...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Qu Y,Shan J,Wang S,Chang L,Pu Y,Wang X,Tan Y,Yamamoto M,Hashimoto K

更新日期：2020-11-12 00:00:00

abstract：:The aim of the study was to report on the clinical utility of naturalistic adjunctive treatment with valproate (VPA) in a group of panic disorder (PD) patients with comorbid bipolar disorder (BD) or otherwise resistant to antidepressants. The hypothesis was that these patients might not respond because of coexisting l...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Perugi G,Frare F,Toni C,Tusini G,Vannucchi G,Akiskal HS

更新日期：2010-10-01 00:00:00

abstract：:Attention deficit and hyperactivity disorder (ADHD) is a prevalent childhood disorder that is often maintained throughout the development and persists into adulthood. Established etiology models suggest that deficient inhibition underlies the core ADHD symptoms. While experimental evidence for impaired motor inhibitio...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Jusyte A,Zaretskaya N,Höhnle NM,Bartels A,Schönenberg M

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:Fluoxetine and its active metabolite norfluoxetine have long half-lives. We postulate that, owing to the long elimination half-life and the time to reach steady-state level in plasma is nearly four weeks, patients diagnosed with major depressive disorder might be treated with fluoxetine taken once every third...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Tural U,Onder E

更新日期：2003-12-01 00:00:00

abstract：:Evidence-based medicine (EBM) is becoming the guiding principle for clinical treatment decisions. But evidence remains a loosely defined term. Multiple criteria for evidence criteria have been proposed. Most influential evidence criteria give priority to meta-analyses because they promise an objective procedure to com...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Maier W,Möller HJ

更新日期：2010-02-01 00:00:00

abstract：:Despite the lack of clinical data about the role of the endocannabinoid system (ECS) in affective disorders, preclinical work suggests that the ECS is relevant in both with regard to the etiology of depression as well as the mediation of antidepressant effects. We measured the intraindividual levels of the endocannabi...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Kranaster L,Hoyer C,Aksay SS,Bumb JM,Leweke FM,Janke C,Thiel M,Lutz B,Bindila L,Sartorius A

更新日期：2017-12-01 00:00:00

abstract：:Family history and psychosocial background factors were studied in married patients with a DSM-III diagnosis of schizoaffective disorder (n = 17, partners n = 16), married patients with diabetes (n = 10, partners n = 10) and married healthy individuals (n = 8, partners n = 8). The two latter groups were comparison con...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Nettelbladt P,Svensson C,Serin U

更新日期：1996-01-01 00:00:00

abstract：:For the functional psychoses of late life, epidemiological information comes from two sources: studies of persons who have reached psychiatric services; and surveys of elderly persons sampled from the general population. A conspectus of published data from both sources leads to the following conclusions: States phenom...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Henderson AS,Kay DW

更新日期：1997-01-01 00:00:00

abstract：:The description of the heterogeneous phenomenological, pathophysiological, and etiological nature of schizophrenia is under way; however, the relationships between heterogeneity levels are still unclear. We performed a robust cross-sectional study, including a systematic neuropsychological battery, assessment of clini...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Szendi I,Racsmány M,Cimmer C,Csifcsák G,Kovács ZA,Szekeres G,Galsi G,Tóth F,Nagy A,Garab EA,Boda K,Gulyás G,Kiss JG,Dombi J,Pléh C,Janka Z

更新日期：2010-04-01 00:00:00

abstract：:We performed an updated meta-analysis of randomized double-blind placebo-controlled trials (RCTs) on the effects of varenicline adjuvant therapy for smoking cessation in people with schizophrenia, on the basis of a previous meta-analysis (Tsoi in Cochrane Database Syst Rev 2:CD007253, 2013). We searched PubMed, the Co...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Kishi T,Iwata N

更新日期：2015-04-01 00:00:00

abstract：:Emil Kraepelin is well known due to his development of the psychiatric classification. The ICD-10 and DSM-IV classification is based on the dichotomy of endogenous psychoses into affective psychoses and schizophrenia as early as 1899. Moreover, beside his classification system he put enormous impact on the development...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Hippius H,Müller N

更新日期：2008-06-01 00:00:00