abstract：:The coronavirus disease 2019 (COVID-19) pandemic has created an urgent need for therapeutics that inhibit the SARS-COV-2 virus and suppress the fulminant inflammation characteristic of advanced illness. Here, we describe the anti-COVID-19 potential of PTC299, an orally bioavailable compound that is a potent inhibitor ...

journal_title：Virus research

authors： Luban J,Sattler RA,Mühlberger E,Graci JD,Cao L,Weetall M,Trotta C,Colacino JM,Bavari S,Strambio-De-Castillia C,Suder EL,Wang Y,Soloveva V,Cintron-Lue K,Naryshkin NA,Pykett M,Welch EM,O'Keefe K,Kong R,Goodwin E,Jac

更新日期：2021-01-15 00:00:00

abstract：:Tmprss2 is an emerging molecular target which guides cellular infections of SARS-CoV-2, has been earmarked for interventions against the viral pathologies. The study aims to computationally screen and identifies potential miRNAs, following in vitro experimental validation of miRNA-mediated suppression of Tmprss2 for e...

journal_title：Virus research

authors： Kaur T,Kapila S,Kapila R,Kumar S,Upadhyay D,Kaur M,Sharma C

更新日期：2021-01-08 00:00:00

abstract：:African horse sickness (AHS) is a devastating viral disease affecting equines and has resulted in many disastrous epizootics. To date, no successful therapeutic treatment exists for AHS, and commercially used live-attenuated vaccines have various undesirable side effects. Previous studies have shown that mice inoculat...

journal_title：Virus research

authors： Fearon SH,Dennis SJ,Hitzeroth II,Rybicki EP,Meyers AE

更新日期：2021-01-06 00:00:00

abstract：:Seneca Valley virus (SVV) is a novel Picornaviridae that is closely associated with porcine idiopathic vesicular disease (PIVD). Here, a novel SVV strain (CH-GX-01-2019) was detected and isolated from swine in Guangxi Province, China. The complete genomic sequence of CH-GX-01-2019 exhibited 93.3-98.9 % identify with o...

journal_title：Virus research

authors： Zhang J,Zhang H,Sun W,Jiao C,Xiao P,Han J,Nan F,Xie C,Ha Z,Li Z,Xie Y,Meng Y,Lu H,Jin N

更新日期：2021-01-02 00:00:00

abstract：:Singapore grouper iridovirus (SGIV) is a large double-stranded DNA virus that is a major threat to grouper aquaculture. The pathogenesis of SGIV is not well understood so far. Previous studies have revealed that ICP18, an immediate early protein encoded by SGIV ORF086R gene, promotes viral replication by regulating ce...

journal_title：Virus research

authors： Wu G,Lin Q,Lim TK,Zhang Y,Aweya JJ,Zhu J,Yao D

更新日期：2021-01-02 00:00:00

abstract：:The main objective of this narrative review is to describe the available evidence on the possible antiviral activity of ozone in patients with COVID-19 and its therapeutic applicability through hospital protocols. Amongst different possible therapies for SARS-CoV-2 pneumonia, ozone therapy seems to have an immunologic...

journal_title：Virus research

authors： Cattel F,Giordano S,Bertiond C,Lupia T,Corcione S,Scaldaferri M,Angelone L,De Rosa FG

更新日期：2021-01-02 00:00:00

abstract：:Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is recognized as one of the life-threatening viruses causing the most destructive pandemic in this century. The genesis of this virus is still unknown. To elucidate its molecular evolution and regulation of gene expression, the knowledge of codon usage is a...

journal_title：Virus research

authors： Dutta R,Buragohain L,Borah P

更新日期：2020-10-15 00:00:00

abstract：:Viral infections are dangerous diseases for human health worldwide, which lead to significant morbidity and mortality each year. Because of their importance and the lack of effective therapeutic approaches, further attempts should be made to discover appropriate alternative or complementary treatments. Melatonin, a mu...

journal_title：Virus research

authors： Bahrampour Juybari K,Pourhanifeh MH,Hosseinzadeh A,Hemati K,Mehrzadi S

更新日期：2020-10-02 00:00:00

abstract：:Zika virus is an emergent arbovirus that has caused a public health emergency in South America. Zika virus infection is known to cause microcephaly and other congenital defects and Guillain-Barré syndrome. Unfortunately no direct antiviral treatments are available at present. IFN-stimulated gene 15 (ISG15) is one of t...

journal_title：Virus research

authors： Wang Y,Ren K,Li S,Yang C,Chen L

更新日期：2020-10-02 00:00:00

abstract：:When the hepatitis B virus (HBV) enters target cells, there are complex trans-regulatory mechanisms involved in the interactions between the virus and the target cells. In the present study, a new gene screened from the hepatoblastoma cell line HepG2 using suppression subtractive hybridization, referred to as lncRNA H...

journal_title：Virus research

authors： Lun YZ,Pan ZP,Liu SA,Sun J,Han M,Liu B,Dong W,Pan LH,Cheng J

更新日期：2020-10-02 00:00:00

abstract：:Ubiquitin Specific Protease 7 (USP7) is a deubiquitinating enzyme (DUB) that plays critical roles in the regulation of many cellular processes including epigenetics, tumour suppression, oncogenesis, DNA damage response, immunity and viral infection. USP7 was the first DUB associated with viral infection. Since then ot...

journal_title：Virus research

authors： Bojagora A,Saridakis V

更新日期：2020-09-01 00:00:00

abstract：:Potato virus Y (PVY) is a member of the genus Potyvirus, family Potyviridae, is considered one of the most devastating pest affecting economically important crops, such as potato, tobacco, tomato and pepper, representing a serious threat due to high incidence and worldwide distribution. Its economic significance as we...

journal_title：Virus research

authors： Gómez MM,de Mello Volotão E,Assandri IR,Peyrou M,Cristina J

更新日期：2020-09-01 00:00:00

abstract：:Comprehensive pathogenesis studies on Peste des Petits Ruminants virus (PPRV) have been delayed so far by the absence of a small animal model reproducing the disease or an in vitro biological system revealing virulence differences. In this study, a mouse 10T1/2 cell line has been identified as presenting different sus...

journal_title：Virus research

authors： Comerlato J,Albina E,Puech C,Franco AC,Minet C,Eloiflin RJ,Rodrigues V,Servan de Almeida R

更新日期：2020-09-01 00:00:00

abstract：:The morbidity and mortality of coxsackievirus A10 (CVA10)-associated hand, foot, and mouth disease (HFMD) have been increasing in recent years, while few studies on the vaccine and animal model of CVA10 have been reported. Here, we first established a CVA10-infected gerbil model and employed it to evaluate the immunop...

journal_title：Virus research

authors： Chen C,Xia Y,Zhu S,Xu F,Sun Y,Lu H,Gao M,Yang Z,Mao Z,Ge Q,Miao Z,Zhu H,Yao P

更新日期：2020-09-01 00:00:00

abstract：:MicroRNAs play vital roles in regulating the battle between pathogens and host cells during viral challenging. MiR-4331 aggravates transmissible gastroenteritis virus (TGEV) -induced mitochondrial damage, also suppresses transcription of TGEV gene 7 via targeting cellular CDCA7. Otherwise, miR-4331-5p affects H1N1/200...

journal_title：Virus research

authors： Ren T,Wang Y,Chen H,Wang K,Gao X,Liu L,Zhang Y,Sun Y

更新日期：2020-09-01 00:00:00

abstract：:Porcine epidemic diarrhea virus (PEDV) infection in neonatal piglets can cause up to 100% mortality, resulting in significant economic loss in the swine industry. Like other coronaviruses, PEDV N protein is a nucleocapsid protein and abundantly presents at all stages of infection. Previously, we reported that the N pr...

journal_title：Virus research

authors： Oh C,Kim Y,Chang KO

更新日期：2020-08-01 00:00:00

abstract：:Helminthosporium victoriae virus 190S (HvV190S) is the type species of the genus Victorivirus under the family Totiviridae. To date, HvV190S has never been found in places outside of the USA and has Helminthosporium victoriae as its only know natural host fungus in the field. Here, we report the identification of 4 do...

journal_title：Virus research

authors： Wu R,Yang Y,Duan X,An H,Du Z,Zhang S,Zhang X

更新日期：2020-08-01 00:00:00

abstract：:Broad and potent human monoclonal neutralizing antibodies have considerable potential in the prevention and treatment of acquired immunodeficiency syndrome (AIDS). To identify the key amino acid recognition site contacted with neutralizing antibody Y498, peptides were panned from the PhD-12 peptide library and predict...

journal_title：Virus research

authors： Cao W,Li B,Liu H,Cheng X,Liu Y,Zhao X,Qiao Y

更新日期：2020-08-01 00:00:00

abstract：:Rosellinia necatrix is responsible for the white rot root disease of avocado in Southern Spain. Entoleuca sp. is a fungus isolated from roots of these same trees, but it is not pathogenic in avocado. Here, we describe two new species of partitiviruses detected in isolates of the avocado sympatric fungi Entoleuca sp. a...

journal_title：Virus research

authors： Velasco L,López-Herrera C,Cretazzo E

更新日期：2020-08-01 00:00:00

abstract：:Rhabdoviruses cause devastating diseases in aquaculture, resulting in enormous economic losses. Our previous studies indicated that imidazole arctigenin derivatives possessed antiviral activities against aquatic rhabdoviruses. Based on the data of structure-activity relationship, a new imidazole arctigenin derivative,...

journal_title：Virus research

authors： Shen YF,Liu YH,Li BY,Liu TQ,Wang GX

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:This paper aims to explore the effect of four virus inactivation methods on the rapid detection results of COVID-19 nucleic acid. METHODS:Collected samples of nasopharyngeal swabs from 2 patients diagnosed with COVID-19 at the First People's Hospital of Zhaoqing City, each of sample was divided into 5 groups...

journal_title：Virus research

authors： Wang Y,Song W,Zhao Z,Chen P,Liu J,Li C

更新日期：2020-08-01 00:00:00

abstract：:Emergent agricultural pathogens cause severe damage worldwide and their invasive potential is significantly increased by global trade, crop intensification and climate change. Standard surveillance and diagnostic protocols need to be evaluated and implemented, particularly with diseases caused by a wide range of patho...

journal_title：Virus research

authors： Siriwan W,Jimenez J,Hemniam N,Saokham K,Lopez-Alvarez D,Leiva AM,Martinez A,Mwanzia L,Becerra Lopez-Lavalle LA,Cuellar WJ

更新日期：2020-08-01 00:00:00

abstract：:Coronaviruses are responsible for a growing economic, social and mortality burden, as the causative agent of diseases such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), avian infectious bronchitis virus (IBV) and COVID-19. However, there is a lack of effective antiviral agents f...

journal_title：Virus research

authors： Mani JS,Johnson JB,Steel JC,Broszczak DA,Neilsen PM,Walsh KB,Naiker M

更新日期：2020-07-15 00:00:00

abstract：:Post-translational modification of target proteins by the Small Ubiquitin-like Modifier (SUMO) plays a critical role in regulation of many cellular processes including transcription, RNA processing, protein trafficking, DNA repair, and chromosome segregation, and is also often hijacked by viral infections. Epstein-Bar...

journal_title：Virus research

authors： Zhang Y,Wang Y,Zhu C,Robertson ES,Cai Q

更新日期：2020-07-02 00:00:00

abstract：:Cucurbit chlorotic yellows virus (CCYV) is a new member of the genus Crinivirus (family Closteroviridae) with a bi-partite genome. CCYV RNA 1-encoded p22 has recently been reported to be a weak local suppressor of RNA silencing for which an interaction with cucumber SKP1LB1 through an F-box-like motif was demonstrated...

journal_title：Virus research

authors： Salavert F,Navarro JA,Owen CA,Khechmar S,Pallás V,Livieratos IC

更新日期：2020-04-02 00:00:00

abstract：:Post-translational modifications (PTMs) are the chemical modifications of proteins after translation, and are very important to guarantee the proper biological functions of these proteins. Baculoviruses are pathogenic viruses that infect invertebrates and have large circular double-stranded DNA genomes. Many proteins ...

journal_title：Virus research

authors： Chen N,Kong X,Zhao S,Xiaofeng W

更新日期：2020-04-02 00:00:00

abstract：:Oryctes rhinoceros nudivirus (OrNV) has been an effective biocontrol agent against the insect pest Oryctes rhinoceros (Coleoptera: Scarabaeidae) for decades, but there is evidence that resistance could be evolving in some host populations. We detected OrNV infection in O. rhinoceros from Solomon Islands and used Oxfor...

journal_title：Virus research

authors： Etebari K,Filipović I,Rašić G,Devine GJ,Tsatsia H,Furlong MJ

更新日期：2020-03-01 00:00:00

abstract：:Aphids vector many plant viruses in a non-persistent manner i.e., virus particles bind loosely to the insect mouthparts (stylet). This means that acquisition of virus particles from infected plants, and inoculation of uninfected plants by viruliferous aphids, are rapid processes that require only brief probes of the p...

journal_title：Virus research

authors： Carr JP,Tungadi T,Donnelly R,Bravo-Cazar A,Rhee SJ,Watt LG,Mutuku JM,Wamonje FO,Murphy AM,Arinaitwe W,Pate AE,Cunniffe NJ,Gilligan CA

更新日期：2020-02-01 00:00:00

abstract：:Cytoplasmic RNA granules consist of microscopic agglomerates of mRNAs and proteins and occur when the translation is reversibly and temporally halted (stress granules, SGs) or mRNAs are targeted for decapping (processing bodies, PBs). The induction of RNA granules formation by virus infection is a common feature of ma...

journal_title：Virus research

authors： Robles-Luna G,Furman N,Barbarich MF,Carlotto N,Attorresi A,García ML,Kobayashi K

更新日期：2020-01-15 00:00:00

abstract：:Human parainfluenza virus type 3 (HPIV3) fuses the viral envelope with the host cell membrane through the concerted action of the fusion (F) protein and the hemagglutinin-neuraminidase (HN). Upon HN binding to sialic acid (SA), the F protein in a metastable prefusion form is activated to undergo a series of structural...

journal_title：Virus research

authors： Liu Y,Xie W,Chi M,Wen H,Zhao L,Song Y,Liu N,Chi L,Wang Z

更新日期：2020-01-02 00:00:00

abstract：:The coat protein (CP) is the only structural protein present in the polyprotein of bean common mosaic virus. The well known characteristics of the CP are self-oligomerization and nucleic acid binding activity. The studies of the coat protein mutants revealed that the oligomeric property of CP solely depends on the ami...

journal_title：Virus research

authors： Kumar S,Karmakar R,Garg DK,Gupta I,Patel AK

更新日期：2019-11-01 00:00:00

abstract：:Plant viruses express RNA silencing suppressor (RSS) proteins to counteract plant defence mechanisms. Here, we describe a method to assess the RSS activity based on an alfalfa mosaic virus (AMV) RNA 3 expression vector and transgenic Nicotiana tabacum plants that express the P1 and P2 subunits of the AMV replicase (P1...

journal_title：Virus research

authors： Martínez-Pérez M,Navarro JA,Pallás V,Sánchez-Navarro JA

更新日期：2019-10-15 00:00:00

abstract：:Hepatitis E virus (HEV) infections constitute a significant health problem worldwide. The burden of hepatitis E in Italy seems low when compared with other European countries. In recent years, improved surveillance activities in Italy have revealed marked geographical differences in HEV epidemiology, with some regions...

journal_title：Virus research

authors： Di Profio F,Melegari I,Palombieri A,Sarchese V,Arbuatti A,Fruci P,Marsilio F,Martella V,Di Martino B

更新日期：2019-10-15 00:00:00

abstract：:Mammalian orthoreovirus (MRV) is the type species of the genus Orthoreovirus and causes a range of significant respiratory, nervous or enteric diseases in humans and animals. In 2016 a farmed white-tailed deer (Odocoileus virginianus) fawn became ill, displaying clinical signs of lethargy, dehydration, and profuse fou...

journal_title：Virus research

authors： Ahasan MS,Subramaniam K,Sayler KA,Loeb JC,Popov VL,Lednicky JA,Wisely SM,Campos Krauer JM,Waltzek TB

更新日期：2019-09-01 00:00:00

abstract：:DNA polymerase (DNApol) is highly conserved in baculovirus and is required for viral DNA replication. However, little is known about gammabaculovirus DNApol. Here DNApol of the gammabaculovirus Neodiprion lecontei nucleopolyhedrovirus (NeleNPV) was cloned into a dnapol-null alphabaculovirus AcMNPV bacmid, creating Bac...

journal_title：Virus research

authors： Chen G,Fang Y,Yan Q,Li P,Wu L,Feng G

更新日期：2019-06-01 00:00:00

abstract：:In alfalfa samples analyzed by hightroughput sequencing, four de novo assembled contigs encoding gene products showing identities to alphapartitiviruses proteins were found based on BlastX analysis. The predicted amino acid (aa) sequences of two contigs presented 99-100% identity to the RNA-dependent RNA polymerase (R...

journal_title：Virus research

authors： Bejerman N,Debat H,Nome C,Cabrera-Mederos D,Trucco V,de Breuil S,Lenardon S,Giolitti F

更新日期：2019-05-01 00:00:00

abstract：:Viruses frequently spread among cells or hosts in groups, with multiple viral genomes inside the same infectious unit. These collective infectious units can consist of multiple viral genomes inside the same virion, or multiple virions inside a larger structure such as a vesicle. Collective infectious units deliver mul...

journal_title：Virus research

authors： Leeks A,Sanjuán R,West SA

更新日期：2019-05-01 00:00:00

abstract：:The complete sequence was obtained for two variants of raspberry vein chlorosis virus (RVCV), confirming that this virus is a rhabdovirus most closely related to the cytorhabdoviruses alfalfa dwarf virus and strawberry crinkle virus. The two RVCV variants share only a 68% nucleotide sequence identity so that the previ...

journal_title：Virus research

authors： Jones S,McGavin W,MacFarlane S

更新日期：2019-05-01 00:00:00

abstract：:RNA viruses exist as quasispecies containing many variants within their populations because of the error prone nature of viral RNA-dependent RNA polymerases. Quasispecies are not a simple collection of individual variants. Instead, internal interactions among variants provide quasispecies with unique evolvability. An ...

journal_title：Virus research

authors： Shirogane Y,Watanabe S,Yanagi Y

更新日期：2019-04-15 00:00:00

abstract：:Numerous host factors are required for the efficient replication of rotavirus, including the activation and inactivation of several cell signaling pathways. One of the cellular structures that are reorganized during rotavirus infection is the actin cytoskeleton. In this work, we report that the dynamics of the actin m...

journal_title：Virus research

authors： Trejo-Cerro O,Aguilar-Hernández N,Silva-Ayala D,López S,Arias CF

更新日期：2019-04-02 00:00:00