解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The coronavirus disease 2019 (COVID-19) pandemic has created an urgent need for therapeutics that inhibit the SARS-COV-2 virus and suppress the fulminant inflammation characteristic of advanced illness. Here, we describe the anti-COVID-19 potential of PTC299, an orally bioavailable compound that is a potent inhibitor ...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2020.198246
更新日期:2021-01-15 00:00:00
abstract::Tmprss2 is an emerging molecular target which guides cellular infections of SARS-CoV-2, has been earmarked for interventions against the viral pathologies. The study aims to computationally screen and identifies potential miRNAs, following in vitro experimental validation of miRNA-mediated suppression of Tmprss2 for e...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2020.198275
更新日期:2021-01-08 00:00:00
abstract::African horse sickness (AHS) is a devastating viral disease affecting equines and has resulted in many disastrous epizootics. To date, no successful therapeutic treatment exists for AHS, and commercially used live-attenuated vaccines have various undesirable side effects. Previous studies have shown that mice inoculat...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2020.198284
更新日期:2021-01-06 00:00:00
abstract::Seneca Valley virus (SVV) is a novel Picornaviridae that is closely associated with porcine idiopathic vesicular disease (PIVD). Here, a novel SVV strain (CH-GX-01-2019) was detected and isolated from swine in Guangxi Province, China. The complete genomic sequence of CH-GX-01-2019 exhibited 93.3-98.9 % identify with o...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2020.198177
更新日期:2021-01-02 00:00:00
abstract::Singapore grouper iridovirus (SGIV) is a large double-stranded DNA virus that is a major threat to grouper aquaculture. The pathogenesis of SGIV is not well understood so far. Previous studies have revealed that ICP18, an immediate early protein encoded by SGIV ORF086R gene, promotes viral replication by regulating ce...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2020.198218
更新日期:2021-01-02 00:00:00
abstract::The main objective of this narrative review is to describe the available evidence on the possible antiviral activity of ozone in patients with COVID-19 and its therapeutic applicability through hospital protocols. Amongst different possible therapies for SARS-CoV-2 pneumonia, ozone therapy seems to have an immunologic...
journal_title:Virus research
pub_type: 杂志文章,评审
doi:10.1016/j.virusres.2020.198207
更新日期:2021-01-02 00:00:00
abstract::Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is recognized as one of the life-threatening viruses causing the most destructive pandemic in this century. The genesis of this virus is still unknown. To elucidate its molecular evolution and regulation of gene expression, the knowledge of codon usage is a...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2020.198113
更新日期:2020-10-15 00:00:00
abstract::Viral infections are dangerous diseases for human health worldwide, which lead to significant morbidity and mortality each year. Because of their importance and the lack of effective therapeutic approaches, further attempts should be made to discover appropriate alternative or complementary treatments. Melatonin, a mu...
journal_title:Virus research
pub_type: 杂志文章,评审
doi:10.1016/j.virusres.2020.198108
更新日期:2020-10-02 00:00:00
abstract::Zika virus is an emergent arbovirus that has caused a public health emergency in South America. Zika virus infection is known to cause microcephaly and other congenital defects and Guillain-Barré syndrome. Unfortunately no direct antiviral treatments are available at present. IFN-stimulated gene 15 (ISG15) is one of t...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2020.198087
更新日期:2020-10-02 00:00:00
abstract::When the hepatitis B virus (HBV) enters target cells, there are complex trans-regulatory mechanisms involved in the interactions between the virus and the target cells. In the present study, a new gene screened from the hepatoblastoma cell line HepG2 using suppression subtractive hybridization, referred to as lncRNA H...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2020.198104
更新日期:2020-10-02 00:00:00
abstract::Ubiquitin Specific Protease 7 (USP7) is a deubiquitinating enzyme (DUB) that plays critical roles in the regulation of many cellular processes including epigenetics, tumour suppression, oncogenesis, DNA damage response, immunity and viral infection. USP7 was the first DUB associated with viral infection. Since then ot...
journal_title:Virus research
pub_type: 杂志文章,评审
doi:10.1016/j.virusres.2020.198076
更新日期:2020-09-01 00:00:00
abstract::Potato virus Y (PVY) is a member of the genus Potyvirus, family Potyviridae, is considered one of the most devastating pest affecting economically important crops, such as potato, tobacco, tomato and pepper, representing a serious threat due to high incidence and worldwide distribution. Its economic significance as we...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2020.198077
更新日期:2020-09-01 00:00:00
abstract::Comprehensive pathogenesis studies on Peste des Petits Ruminants virus (PPRV) have been delayed so far by the absence of a small animal model reproducing the disease or an in vitro biological system revealing virulence differences. In this study, a mouse 10T1/2 cell line has been identified as presenting different sus...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2020.198035
更新日期:2020-09-01 00:00:00
abstract::The morbidity and mortality of coxsackievirus A10 (CVA10)-associated hand, foot, and mouth disease (HFMD) have been increasing in recent years, while few studies on the vaccine and animal model of CVA10 have been reported. Here, we first established a CVA10-infected gerbil model and employed it to evaluate the immunop...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2020.198067
更新日期:2020-09-01 00:00:00
abstract::MicroRNAs play vital roles in regulating the battle between pathogens and host cells during viral challenging. MiR-4331 aggravates transmissible gastroenteritis virus (TGEV) -induced mitochondrial damage, also suppresses transcription of TGEV gene 7 via targeting cellular CDCA7. Otherwise, miR-4331-5p affects H1N1/200...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2020.198064
更新日期:2020-09-01 00:00:00
abstract::Porcine epidemic diarrhea virus (PEDV) infection in neonatal piglets can cause up to 100% mortality, resulting in significant economic loss in the swine industry. Like other coronaviruses, PEDV N protein is a nucleocapsid protein and abundantly presents at all stages of infection. Previously, we reported that the N pr...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2020.198026
更新日期:2020-08-01 00:00:00
abstract::Helminthosporium victoriae virus 190S (HvV190S) is the type species of the genus Victorivirus under the family Totiviridae. To date, HvV190S has never been found in places outside of the USA and has Helminthosporium victoriae as its only know natural host fungus in the field. Here, we report the identification of 4 do...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2020.197941
更新日期:2020-08-01 00:00:00
abstract::Broad and potent human monoclonal neutralizing antibodies have considerable potential in the prevention and treatment of acquired immunodeficiency syndrome (AIDS). To identify the key amino acid recognition site contacted with neutralizing antibody Y498, peptides were panned from the PhD-12 peptide library and predict...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2020.198001
更新日期:2020-08-01 00:00:00
abstract::Rosellinia necatrix is responsible for the white rot root disease of avocado in Southern Spain. Entoleuca sp. is a fungus isolated from roots of these same trees, but it is not pathogenic in avocado. Here, we describe two new species of partitiviruses detected in isolates of the avocado sympatric fungi Entoleuca sp. a...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2020.198020
更新日期:2020-08-01 00:00:00
abstract::Rhabdoviruses cause devastating diseases in aquaculture, resulting in enormous economic losses. Our previous studies indicated that imidazole arctigenin derivatives possessed antiviral activities against aquatic rhabdoviruses. Based on the data of structure-activity relationship, a new imidazole arctigenin derivative,...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2020.198019
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:This paper aims to explore the effect of four virus inactivation methods on the rapid detection results of COVID-19 nucleic acid. METHODS:Collected samples of nasopharyngeal swabs from 2 patients diagnosed with COVID-19 at the First People's Hospital of Zhaoqing City, each of sample was divided into 5 groups...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2020.197988
更新日期:2020-08-01 00:00:00
abstract::Emergent agricultural pathogens cause severe damage worldwide and their invasive potential is significantly increased by global trade, crop intensification and climate change. Standard surveillance and diagnostic protocols need to be evaluated and implemented, particularly with diseases caused by a wide range of patho...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2020.197959
更新日期:2020-08-01 00:00:00
abstract::Coronaviruses are responsible for a growing economic, social and mortality burden, as the causative agent of diseases such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), avian infectious bronchitis virus (IBV) and COVID-19. However, there is a lack of effective antiviral agents f...
journal_title:Virus research
pub_type: 杂志文章,评审
doi:10.1016/j.virusres.2020.197989
更新日期:2020-07-15 00:00:00
abstract::Post-translational modification of target proteins by the Small Ubiquitin-like Modifier (SUMO) plays a critical role in regulation of many cellular processes including transcription, RNA processing, protein trafficking, DNA repair, and chromosome segregation, and is also often hijacked by viral infections. Epstein-Bar...
journal_title:Virus research
pub_type: 杂志文章,评审
doi:10.1016/j.virusres.2020.197962
更新日期:2020-07-02 00:00:00
abstract::Cucurbit chlorotic yellows virus (CCYV) is a new member of the genus Crinivirus (family Closteroviridae) with a bi-partite genome. CCYV RNA 1-encoded p22 has recently been reported to be a weak local suppressor of RNA silencing for which an interaction with cucumber SKP1LB1 through an F-box-like motif was demonstrated...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2020.197887
更新日期:2020-04-02 00:00:00
abstract::Post-translational modifications (PTMs) are the chemical modifications of proteins after translation, and are very important to guarantee the proper biological functions of these proteins. Baculoviruses are pathogenic viruses that infect invertebrates and have large circular double-stranded DNA genomes. Many proteins ...
journal_title:Virus research
pub_type: 杂志文章,评审
doi:10.1016/j.virusres.2020.197865
更新日期:2020-04-02 00:00:00
abstract::Oryctes rhinoceros nudivirus (OrNV) has been an effective biocontrol agent against the insect pest Oryctes rhinoceros (Coleoptera: Scarabaeidae) for decades, but there is evidence that resistance could be evolving in some host populations. We detected OrNV infection in O. rhinoceros from Solomon Islands and used Oxfor...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2020.197864
更新日期:2020-03-01 00:00:00
abstract::Aphids vector many plant viruses in a non-persistent manner i.e., virus particles bind loosely to the insect mouthparts (stylet). This means that acquisition of virus particles from infected plants, and inoculation of uninfected plants by viruliferous aphids, are rapid processes that require only brief probes of the p...
journal_title:Virus research
pub_type: 杂志文章,评审
doi:10.1016/j.virusres.2019.197845
更新日期:2020-02-01 00:00:00
abstract::Cytoplasmic RNA granules consist of microscopic agglomerates of mRNAs and proteins and occur when the translation is reversibly and temporally halted (stress granules, SGs) or mRNAs are targeted for decapping (processing bodies, PBs). The induction of RNA granules formation by virus infection is a common feature of ma...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2019.197823
更新日期:2020-01-15 00:00:00
abstract::Human parainfluenza virus type 3 (HPIV3) fuses the viral envelope with the host cell membrane through the concerted action of the fusion (F) protein and the hemagglutinin-neuraminidase (HN). Upon HN binding to sialic acid (SA), the F protein in a metastable prefusion form is activated to undergo a series of structural...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2019.197791
更新日期:2020-01-02 00:00:00
abstract::The coat protein (CP) is the only structural protein present in the polyprotein of bean common mosaic virus. The well known characteristics of the CP are self-oligomerization and nucleic acid binding activity. The studies of the coat protein mutants revealed that the oligomeric property of CP solely depends on the ami...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2019.197755
更新日期:2019-11-01 00:00:00
abstract::Plant viruses express RNA silencing suppressor (RSS) proteins to counteract plant defence mechanisms. Here, we describe a method to assess the RSS activity based on an alfalfa mosaic virus (AMV) RNA 3 expression vector and transgenic Nicotiana tabacum plants that express the P1 and P2 subunits of the AMV replicase (P1...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2019.197733
更新日期:2019-10-15 00:00:00
abstract::Hepatitis E virus (HEV) infections constitute a significant health problem worldwide. The burden of hepatitis E in Italy seems low when compared with other European countries. In recent years, improved surveillance activities in Italy have revealed marked geographical differences in HEV epidemiology, with some regions...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2019.197710
更新日期:2019-10-15 00:00:00
abstract::Mammalian orthoreovirus (MRV) is the type species of the genus Orthoreovirus and causes a range of significant respiratory, nervous or enteric diseases in humans and animals. In 2016 a farmed white-tailed deer (Odocoileus virginianus) fawn became ill, displaying clinical signs of lethargy, dehydration, and profuse fou...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2019.197642
更新日期:2019-09-01 00:00:00
abstract::DNA polymerase (DNApol) is highly conserved in baculovirus and is required for viral DNA replication. However, little is known about gammabaculovirus DNApol. Here DNApol of the gammabaculovirus Neodiprion lecontei nucleopolyhedrovirus (NeleNPV) was cloned into a dnapol-null alphabaculovirus AcMNPV bacmid, creating Bac...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2019.04.005
更新日期:2019-06-01 00:00:00
abstract::In alfalfa samples analyzed by hightroughput sequencing, four de novo assembled contigs encoding gene products showing identities to alphapartitiviruses proteins were found based on BlastX analysis. The predicted amino acid (aa) sequences of two contigs presented 99-100% identity to the RNA-dependent RNA polymerase (R...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2019.03.021
更新日期:2019-05-01 00:00:00
abstract::Viruses frequently spread among cells or hosts in groups, with multiple viral genomes inside the same infectious unit. These collective infectious units can consist of multiple viral genomes inside the same virion, or multiple virions inside a larger structure such as a vesicle. Collective infectious units deliver mul...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2019.03.013
更新日期:2019-05-01 00:00:00
abstract::The complete sequence was obtained for two variants of raspberry vein chlorosis virus (RVCV), confirming that this virus is a rhabdovirus most closely related to the cytorhabdoviruses alfalfa dwarf virus and strawberry crinkle virus. The two RVCV variants share only a 68% nucleotide sequence identity so that the previ...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2019.03.004
更新日期:2019-05-01 00:00:00
abstract::RNA viruses exist as quasispecies containing many variants within their populations because of the error prone nature of viral RNA-dependent RNA polymerases. Quasispecies are not a simple collection of individual variants. Instead, internal interactions among variants provide quasispecies with unique evolvability. An ...
journal_title:Virus research
pub_type: 杂志文章,评审
doi:10.1016/j.virusres.2019.02.015
更新日期:2019-04-15 00:00:00
abstract::Numerous host factors are required for the efficient replication of rotavirus, including the activation and inactivation of several cell signaling pathways. One of the cellular structures that are reorganized during rotavirus infection is the actin cytoskeleton. In this work, we report that the dynamics of the actin m...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2019.01.003
更新日期:2019-04-02 00:00:00